• Korean Journal of Health Education and Promotion
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• v.15 no.1
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• pp.31-48
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• 1998

A study of 232 secondary school teachers was conducted to explore their knowledge, attitudes, behaviors, and interests concerning AIDS and HN infection, in order to develop in-service training program for teachers and effective teaching strategies across the curriculum for students. 1. Teachers of 12.9% reported that they had attended in-service training concerning AIDS and HIV. 2. Teachers of 75.4%, 68.2%, 73.7% offered correct answers to the knowledge section pertaining to the transmission of HN, prevention of mv infection, and HIV antibody testing. 3. Significant correlations were found among knowledge, attitudes, interests, and between interests and behaviors, related to AIDS and HIV. Teachers who had relatively more knowledge and positive attitudes related to AIDS, had an more interest in AIDS, expressed stronger intentions to care for, and took more positive attitudes toward working with and teaching AIDS patients than other teachers did.(Correlation through Factor Analysis).

• Parasites, Hosts and Diseases
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• v.53 no.6
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• pp.705-712
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• 2015

Intestinal parasitic infections are one of the major causes of diarrhea in human immunodeficiency virus (HIV) seropositive individuals. Antiretroviral therapy has markedly reduced the incidence of many opportunistic infections, but parasite-related diarrhea still remains frequent and often underestimated especially in developing countries. The present hospital-based study was conducted to determine the spectrum of intestinal parasitosis in adult HIV/AIDS (acquired immunodeficiency syndrome) patients with or without diarrhea with the levels of $CD4^+$ T-cell counts. A total of 400 individuals were enrolled and were screened for intestinal parasitosis. Of these study population, 200 were HIV seropositives, and the remaining 200 were HIV uninfected individuals with or without diarrhea. Intestinal parasites were identified by using microscopy as well as PCR assay. A total of 130 (32.5%) out of 400 patients were positive for any kinds of intestinal parasites. The cumulative number of parasite positive patients was 152 due to multiple infections. A significant association of Cryptosporidium (P<0.001) was detected among individuals with $CD4^+$ T-cell counts less than $200cells/{\mu}l$.

• Journal of Industrial Technology
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• v.26 no.B
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• pp.163-171
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• 2006

Human immunodeficiency virus type 1 (HIV-1) integrase plays a critical role in the life cycle of the HIV virus. An ability to accurately map its electrostatic potential, and then use this information to predict the manner in which DNA will bind to the active site of the catalytic domain could provide a foundation for inhibitory design. Attempts to discern the crystal structure of HIV-1 integrase have proven problematic, especially in the region of enzymatic activity, that being those residues involved in the catalysis of the integration of viral DNA into the host cell. However, there is a structural correlation in to the region of interest with avian sarcoma virus (ASV), so a homology model utilizing this similarity was constructed to approximate the behavior/structure of the undetermined portions of the HIV-1 integrase crystal. After this model was constructed and its energy minimized, electrostatic calculations were carried out on the substance, so that an electrostatic potential map was constructed. Using this information, it was determined that DNA binding was oriented so as to exploit the regions of positive potential nearby the active site, as well as the positive potential of the magnesium cofactors.

• Journal of Distribution Science
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• v.12 no.5
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• pp.41-47
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• 2014

Purpose - This paper investigates whether one's occupation influences one's attitude toward people with HIV/AIDS and suggests ways to counter HIV-related stigma in different work settings. Two samples comprising workers in different environments and occupations with contrasting personalities were chosen. Thus, security guards (authoritarian types) and catering workers (social types) were included. Research design, data, and methodology - The sample comprised246 service staff from the Rhodes University Catering Division and the Hi-Tec Security company, both in Grahamstown, South Africa, a small Eastern Cape province town. All employees at these organizations during the survey were eligible to participate. Results -The security sample displays significantly higher personal stigma scores than the catering sample, according to the Visser personal stigma scale (mean scores of 4.01 and 1.37, respectively; t=10.30, df=244, p=0.00). Similar results were found using Visser subscales. Conclusions - This study shows that occupation is a strong predictor of HIV-related stigma in the workplace, suggesting that workplace settings, by attracting particular personalities and influencing workers, may shape attitudes towards those who are HIV positive.

• Journal of the Korean Data and Information Science Society
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• v.25 no.2
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• pp.337-347
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• 2014

There is no known publication about assessment of quality of life (QOL) in Korean HIV patients. We aimed to assess the QOL of HIV patients. We developed Korean version of the WHOQOL-HIV BREF (short forms of WHOQOL-HIV, 31 questions with 6 domains). Survey data from 220 HIV-positive adults were obtained in 14 centers in South Korea. Male were dominant (202/220, 91.8%). Mean age was $40.6{\pm}12.1$. Mean CD4+ T-cell count was $414.9{\pm}226.6/ml$. Overall of WHOQOL-HIV BREF were $53.2{\pm}14.9$ (perfect score=100) (Cronbach's ${\alpha}$ = 0.942). It is similar score comparing to another country (Portugal: 54.75/100, measured by WHOQOL-HIV). Correlations of WHOQOL-HIV BREF score with patients' subjective QOL and with subjective satisfaction were 0.747 (p <0.01) and 0.651 (p <0.01), respectively. WHOQOL-HIV BREF have internal reliability. There is in need of monitoring for QOL of HIV patients in the clinical practice and trials. This survey tool could be used to assess the effect of intervention. Additionally, comparison across countries would be possible and promising.

• The Journal of Korean Society of Virology
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• v.30 no.3
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• pp.211-217
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• 2000

Nef is a lentiviral protein involved in pathogenesis of AIDS, but its molecular mechanism of action remains incompletely understood. Here we report the isolation of the interacting protein with the HIV-1 Nef, using the yeast two hybrid system for expression cloning. One of the positive colonies was selected as the final candidate for the interacting protein gene. The nucleotide sequencing revealed that this interacting protein is Human Ikaros/LyF-1. This protein interacted with the C-terminal region of Nef specifically in yeast system, not with the N-terminal region. This interaction was also confirmed by in vitro binding assay.

• Korean Journal of Social Welfare Studies
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• v.44 no.3
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• pp.347-369
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• 2013

Quality of life for people living with HIV/AIDS is significant as it concerns the treatment process, survival rate, HIV/AIDS prevention and treatment as well. Prevalent prejudice in our society significantly lowers the quality of patient's life. There is a need for an intervention and the effort to eliminate the stigma in order to lessen the negative effects as well. However, there are very few researches that examine the quality of life when it comes to people living with HIV/AIDS; even less when it comes to research that examines the stigma that affects the quality of life negatively. Therefore, this research seeks to verify the moderating effects of social support that seek to eliminate the stigma upon the quality of life in people living with HIV/AIDS. Research had been conducted with 102 people living with HIV/AIDS and the balancing effect of the social effort was verified through hierarchical regression analysis and a simple slope test. As the result of the research, control variables such as educational level and whether the patient has a job or not have significant effect and the stigma that the patient is aware of has significant negative effect. Social support had positive effect in quality of life and that it has a moderating effect on stigma which in turn affects the quality of life. Based on these results, social work related implications that were suggested are as follows; need for information and education as to better the quality of life for people living with HIV/AIDS and eliminate the social stigma and that group support program based on the local community which is needed for social support. Further research was advised based on the limitations of this research.

• The Journal of Korean Society of Virology
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• v.29 no.2
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• pp.107-118
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• 1999

To characterize the molecular nature of human immunodeficiency virus (HIV)-1, we determined the full-length HIV-1 sequences from cultured peripheral blood mononuclear cells (PBMC) of a Korean long-term nonprogressor (LTNP). Without antiretroviral therapy, the individual has maintained CD4+ T counts over $500/{\mu}l$ from 1989 to 1999. Plasma viral RNA copy was 992 U/ml in 1998. Culture supernatant showed positive from culture days 9. A series of 9 overlapping PCR products were amplified from cultured PBMC and cloned About 9.2 kb from R of 5' LTR to R of 3' LTR was determined by automated sequencing. The G-to-A hypermutations were shown throughout the entire region. As a result of G to A hypermutations, premature stop codon was found in integrase coding region. Though there was no recombination between subtypes over all genomes, TATA box in both LTRs was TAAAA which is detected in subtype E instead of TATAA in subtype B. And, there were nucleotide GC insertion between $NF-{\kappa}B$ I and Sp1 III, and duplication of $TCF-1{\alpha}$ in LTR. We could not find any deletion of amino acid in Nef, Gag, Pol and Env gene. This study is the first report on molecular nature of full genomes of HIV-1 isolated in Korea.

• Archives of Plastic Surgery
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• v.48 no.6
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• pp.685-690
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• 2021

Background Human immunodeficiency virus (HIV)-associated lipodystrophy is a known consequence of long-term highly active antiretroviral therapy (HAART). However, a significant number of patients on HAART therapy were left with the stigmata of complications, including fat redistribution. Few studies have described the successful removal of focal areas of lipohypertrophy with successful outcomes. This manuscript reviews the outcomes of excisional lipectomy versus liposuction for HIV-associated cervicodorsal lipodystrophy. Methods We performed a 15-year retrospective review of HIV-positive patients with lipodystrophy. Patients were identified by query of secure operative logs. Data collected included demographics, medications, comorbidities, duration of HIV, surgical intervention type, pertinent laboratory values, and the amount of tissue removed. Results Nine male patients with HIV-associated lipodystrophy underwent a total of 17 procedures. Of the patients who underwent liposuction initially (n=5), 60% (n=3) experienced a recurrence. There were a total of three cases of primary liposuction followed by excisional lipectomy. One hundred percent of these cases were noted to have a recurrence postoperatively, and there was one case of seroma formation. Of the subjects who underwent excisional lipectomy (n=4), there were no documented recurrences; however, one patient's postoperative course was complicated by seroma formation. Conclusions HIV-associated lipodystrophy is a disfiguring complication of HAART therapy with significant morbidity. Given the limitations of liposuction alone as the primary intervention, excisional lipectomy is recommended as the primary treatment. Liposuction may be used for better contouring and for subsequent procedures. While there is a slightly higher risk for complications, adjunctive techniques such as quilting sutures and placement of drains may be used in conjunction with excisional lipectomy.

• The Journal of Korean Society for School & Community Health Education
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• v.14 no.3
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• pp.77-87
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• 2013

Objective: The purpose of this study was to obtain the basic data for the establishment of the curriculum from the analysis of knowledge and attitudes about AIDS among dental hygiene students. Methods: Data was collected from the students of two colleges majoring in dental hygiene in Daegu, using questionnaire. They were the students of total 390. The analysis was made using t-test, (one-way ANOVA), and multiple linear regression analysis. These were conducted using SPSS 14.0 version. Results: The horizontal and vertical transmission in percent correct knowledge of HIV infection, most of the questions asked of respondents knew the correct answer, AIDS attitudes in the community education hours to receive AIDS education is important then the response was highest at 88.2 percent. AIDS knowledge is based on clinical practice, and AIDS attitudes in accordance with the educational experience of the average difference between groups investigated showed statistically significantly. HIV knowledge and attitudes, no oil, depending on the educational experience of the average difference between groups investigated showed statistically significantly. The grade, the higher knowledge of HIV was found to be lower in a statistically significant negative relationship showed (p<0.001), clinical experience, the more experience, knowledge of HIV was higher statistically significant positive showed a relationship (p<0.001), a higher attitude about HIV AIDS knowledge was higher showed a statistically significant positive relationship (p<0.001). Conclusion: Dental hygiene to prevent infection associated with AIDS in the curriculum and hands-on curriculum to enhance patient care through the AIDS patients in clinical management after graduating as a dental hygienist at the ethical responsibility is considered to be very strong.