• Journal of Korean Biological Nursing Science
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• 제16권1호
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• pp.26-32
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• 2014

Purpose: Needlestick injuries (NSI) is the most frequent occupational hazard for healthcare personnel (HCP), and immediate report and adequate post-exposure prophylaxis (PEP) is essential in preventing occupational transmission of blood-borne pathogens. Methods: From June 2010 to October 2010, 544 NSI were reported through websites from 21 general hospitals in Korea. Among those, 499 cases of NSI were analyzed to identify the rate of follow-up treatment completion and for seroconversion. Results: 88.2% of the cases were completed with follow-up treatment, 8.8% of the NSI were not completed with follow-up treatment, and 5 cases were unavailable to trace. 4.2% cases of NSI required a hepatitis B vaccination concurrent with hepatitis B immunoglobulin. 41.1% of the cases and 31.1% of the cases needed to be tested for anti HCV and anti HIV, respectively. Prophylaxis medication for HIV was prescribed in 3 cases, and all cases completed required 1 month of medication. There was 1 case (0.2%) of seroconversion to HCV. Conclusion: The PEP completion rate was not satisfactory, and the importance of completion of PEP treatment should be emphasized through education and counseling. Also, a careful risk assessment is needed for HCP who are exposed to HCV or HIV.

• 보건교육건강증진학회지
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• 제11권2호
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• pp.33-47
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• 1994

AIDS preventional efforts need to be guided by well trained health care personnel especially by school nurses for the adolescents. This study was designed to get basic data about AIDS educational program development for school nurses. The objectives of this study were to 1) identify AIDS knowledg of school nurses 2) identify AIDS attitudes of school nurses and 3) identify association between AIDS knowledge and sociodemographic characteristics. Data were collected from 173 subjects in Chonbuk province. Self-reporting questionnaire were administered during the period from 1st of June to 30th of June, 1994. AIDS related knowledge was measured by using 44 questions on cause(3 items), testing(3 items), mode of transmission(15 items), clinical manifestations(5 items), treatment(3 items), prevention(5 items), complication(4 items), infection control(3 items) and Using resources(3 items). AIDS related attitudes were measured by five point Likert scales using 13 questions on perceived threats from AIDS crisis (4 items), perceived severity to AIDS(2 items), perceived needs about psychosocial care for HIV infected patients(3 items) and perceived educational needs of AIDS(4 items). The collected data were analyzed by SPSS/PC/sup +/, using percentages, Mean and S.D. descriptive purpose and t-test or F for comparing the variables. The major findings were as follows: 1. Respondents ranged in knowledge of AIDS between 0 and 44 with the 33.79 mean score. Percentage of correctly answered respondents to each categories - mode of transmission : 87.0% - clinical manifestation : 85.0% - cause : 82.5% - prevention : 81.5% - treatment : 76.1% - infection control : 72.8% - testing of HIV infection 71.8% - using community resourses : 50.9% - complication : 45.8% 2. The respondents' attitudes of AIDS The majority(70%) showed higher perceived threat The majority(91.3%) showed higher perceived severity to AIDS crisis As a whole, perceived needs about psychosocial care for HIV infected patients negative The majority (over 96.5%) showed highly perceived educational needs of AIDS. 3. The relationship between AIDS knowledge and each of those general character. AIDS knowledge shows significant difference with age(F=3.50, p<.016), years of professional experience(F=4.14, p<.007) and received lecture about AIDS(F=4.54, p<.000). There was no significant difference between AIDS knowledge and job satisfaction.

• 한국보건간호학회지
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• 제12권2호
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• pp.201-220
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• 1998

Given the gloval impact of the AIDS pandemic. it is necessary to take every measure to prevent an epidemic this disease in Korea. Health care givers. especially nurses, have the primary responsibility of AIDS prevention and providing comfort care of those patient with HIV/AIDS. In spite of this responsibility, many nurses are afraid of AIDS patients and refuse to care the patient with HIV/AIDS because they have a little information of AIDS and a fear of HIV infection from AIDS patient at worksite. The purpose of this descriptive study was (1) to examine nursing students' knowledge and attitude to AIDS patient. (2) to identify demographic variables influencing knowledge and attitude to AIDS patient. and (3) to examine correlation between knowledge and attitude. The subject of this study was 162 nursing students. The findings of this study can be summarized as follows. 1) The mean overall knowledge score was estimated to be 61.33 of 101. especially the mean score of transmission route according to sexual behavior was estimated to be 3.03 of 7. 2) The mean attitude score was estimated to be 32.37 of 45. 3) The total knowledge score of AIDS was influenced by these two factors; the experience of AIDS education class and religion. In the end, the study concludes that it is necessary to develop comprehensive AIDS education programs to improve knowledge about the disease as well as to allay the fears and anxiety of the nurses.

• 한국치위생학회지
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• 제1권2호
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• pp.181-192
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• 2001

The purpose of this was to evaluate the level of knowledge about Hepatitis B and AIDS among dental hygiene students at six dental hygiene educational programs in nationwide, compare the findings to those of Song's study. 1703 dental hygiene students surveyed by mail and answered a questionnaire, using the questionnaire used developed by DiClemente el al., on Hepatitis B vaccination, antibody production, experience of unintentional needle stick injuries, experience of surgical operation and blood transfusion, personal risk factors for HBV and HIV, management of HBV and HIV postexposure management et al. The data indicated that dental hygiene students (79.0%) in this study had more HIV vaccination than dental hygiene(74.3%) in Song's study. As for recognition of antibody production after Hepatitis B vaccination, only 34.6% of respondents answered they knew having antibody production and 95% of respondents knew not having antibody production. Over one-half of the respondents (55%) answered they didn't even recognize having antibody production. 52.3 percent of dental hygiene students experienced unintentional needle stick injuries. The findings on the knowledge about Hepatitis B and AIDS were that dental hygienists (76.5 points) received higher mean score than those of dental hygiene students (71.0 points) and that the distribution of right answer rate also showed wider range in dental hygiene students (27.7~97.5%) than those of dental hygienist (41.2~99.5%). There were no statistical differences among dental hygiene education programs. Finding of this study support that the curriculum of dental hygiene program should include instruction on sources and methods of transmission of infectious diseases, risk of virus transmission in the workplace and principles of infection control. Furthermore, infection-control practices should be utilized routinely and their application to dental personnel, management of HBV and HIV postexposure management. Furthermore, for preventing the further spread of infectious diseases (HBV, HIV and AIDS${\cdots}$) caused by bloodborne viruses, imposing an obligation rather than recommendation on Hepatitis B vaccination to all dental personnel and routinely utilizing infection-control guidelines for all dental patients in dental practices (include dental educational programs) should be accomplished by coordination the government agency.

• 대한간호학회지
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• 제31권2호
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• pp.292-303
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• 2001

The purpose of the study was to find out the level of knowledge, attitude, subjective norm, social interaction, and behavioral intention of nursing students regarding AIDS. It also identified factors that predict behavioral intentions and to provide care for patients with AIDS using Theory of Reasoned Action. The subjects consisted of 117 nursing students at three universities. Data was collected with self reporting in a questionnaire of with 67 items. Data was analyzed by an SPSS pc+ program. The results were as follows; 1. The mean age of the subjects was 20.98 years. The mean score for HIV/AIDS knowledge was 24.444 out of 32. Mostly Korean students were quite knowledgeable about the basic facts and symptoms of AIDS but confused about the made of transmission such as public toilets, prevention methods, and especially infection control. 2. This study found that social interaction, attitudes and subjective norms of Korean nursing students explained the intention to care for AIDS patients. The students who had a more positive attitude toward caring for AIDS patients and those who perceived more support from their significant others for caring the AIDS patients reported a more positive intention to care for AIDS patients. 3. In stepwise multiple regression analysis, 47.58% of the variance in AIDS patient care intention was accounted for by social interaction (33.41%), attitude (9.1%), and subjective norm (5.0 %). According to the finding of this study, and social interaction are the most significant predictors of intentions. Therefore it can be suggested that a HIV/AIDS prevention program should focus on transmission modes and prevention methods, especially in infection control. AIDS education efforts aimed at nursing students should place greater emphasis on correcting these kinds of misconceptions. Nursing intenvention for reducing fear of contagion, improving perception of social interaction, fostering positive attitudes and increasing intention to care for AIDS patients should be provided for nursing students. They also recommended that nursing students be adequately prepared to care for AIDS patients because of the increasing probability that they will encounter AIDS patients. Therefore it is important that education about HIV/AIDS should be incorporated within current undergraduate curriculum.

• 한국학교ㆍ지역보건교육학회지
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• 제9권1호
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• pp.63-83
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• 2008

본 연구는 서울시 중고등학생을 대상으로 인구학적 특성, 에이즈감염경로지식, 동성애자에 대한 태도, 에이즈 낙인, 에이즈 감염인에 대한 사회적 거리감 사이의 인과구조를 집단별로 규명하기 위한 것이다. 중학교 8개교, 고등학교 8개교에 배포된 설문지는 3,370부 중 수거된 설문지는 3,135였고, 불성실한 설문지 34부를 제외한 총 3,101부(98.9%)가 분석에 사용되었고, 유효하지 않은 사례는 일률적(listwise)으로 제거하여 유효사례 수는 2,977부였다. 분석방법으로 탐색적 요인분석(EFA), 확인적 요인분석(CFA), 공변량 구조분석 등을 시도하였고, 모형을 추정하기 위해 구조방정식 모형을 사용하였다. 모형검증의 추정결과, 첫째, 중학생과 고등학생 간에 에이즈 차별의식의 구성개념인 에이즈 낙인과 에이즈 감염인에 대한 사회적 거리감에서 뚜렷한 차이를 보이고 있었다. 둘째, 에이즈 낙인에 대한 의생변인인 동성애자에 대한 태도는 중학생(${\beta}=.407$), 고등학생(${\beta}=.401$) 모두 강한 정(+)의 인과적 영향을 보였으며, 셋째, 에이즈 감염인에 대한 사회적 거리감의 외생변인인 동성애자에 대한 태도는 중학생(${\beta}=.108$), 고등학생(${\beta}=.080$) 모두 약한 정(+)의 영향을 보였다. 넷째, 에이즈 감염경로 지식은 중학생(${\beta}=.313$), 고등학생(${\beta}=.301$) 모두 강한 정(+)의 인과적 영향을 미쳤고, 다섯째, 에이즈 감염인에 대한 사회적 거리감에 영향을 미치는 외생변인인 에이즈 감염경로 지식은 중학생(${\beta}=.160$), 고등학생(${\beta}=.134$) 모두 정(+)의 인과적 영향을 미쳤다. 여섯째, 에이즈 감염인에 대한 사회적 거리감에 영향을 미치는 외생변인인 에이즈 낙인은 중학생(${\beta}=.616$), 고등학생(${\beta}=.692$) 모두 강한 정(+)의 인과적 영향을 미쳤다. 이상의 분석결과 에이즈 감염인에 대한 낙인 및 사회적 거리감을 해소하기 위해서는 에이즈 지식 중 감염경로에 대한 지식을 높이고, 에이즈를 동성애자의 병으로 바라보는 시각을 해소시키는 것이 필요하다고 판단된다.

• Archives of Pharmacal Research
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• 제26권6호
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• pp.493-498
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• 2003

In this study we have investigated the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. Plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min after intravenous injection in mice. After intramuscular injection, plasmid DNA concentration in the injection site rapidly declined to less than 1 ％ of the initial concentration by 90 min post-injection. However, sub-picogram levels (per mg tissue) were occasionally detected for several days after injection. The relative proportions of the individual plasm ids of GX-12 remained relatively constant at the injection site until 90 min post-injection. The concentration of plasmid DNA in tissues other than the injection site peaked at 90 min post-injection and decreased to undetectable levels at 8 h post-injection. The rapid in vivo degradation of GX-12 and absence of persistence in non-target tissues suggest that the risk of potential gene-related toxicities by GX-12 administration, such as expression in non-target tissues, insertional mutagenesis and germline transmission, is minimal.

• Toxicological Research
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• 제19권1호
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• pp.13-19
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• 2003

GX-12 is a naked DNA vaccine developed by the DongA Pharmaceutical Co. Ltd. and Genexine for the treatment of HIV infection. This study was peformed to evaluate the biodistribution and expression of GX-12 mRNA in gonadal tissues, and to investigate the histopathological changes after the repeated intramuscular injection. GX-12 (400 $\mu\textrm{g}$/head) was injected into the left anterior tibialis once a week for four weeks. On day 1, 5, 15, 30 and 45 after the final administration, gonadal tissues (testes, epididymis, seminal vesicles, penis, prostate glands, ovaries, vagina, uterus) and the injection site (muscle) were harvested and examined for the expression of mRNA by RT-PCR. In addition, histopathological examination was peformed at each time point. At the injection site, mRNA expression of GX-12 was detected only at early time points (1 ~ 15 days after injection) but not thereafter. However, in gonadal tissues, mRNA expression was not identified at all time points both in male and female rats. There were no histopathological changes in all reproductive organs and muscle. Based on these results, it is unlikely that the plasmid DNAs of GX-12 was distributed to- and expressed in gonadal tissues, suggesting that the chance of germline integration and transmission is negligible.

• 대한간호학회지
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• 제27권1호
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• pp.201-211
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• 1997

This study was an evaluation study of AIDS education program. The purpose of this study was to clarify the education effects on AIDS for health care workers to develop a better next education program. This study was done by self reporting with a 67 items of structured questionnaire by 431 health care workers included doctors, nurses, laboratory technicians, and health educators. Data were collected at the time of completion of each AIDS education with the help of education program manager. Both the AIDS related knowledge score and the acceptance attitudes score were significantly higher in the male group, in the medical institution employer group, in the group who have met the HIV infected person, who has known the HIV positive person, and the group of laboratory technician, but the AIDS prevention intention score was statistically higher in the group of female and laboratory technician group. The post education scores of AIDS related knowledge. acceptance attitudes, and preventive intention were statistically higher than those of the preeducation. The most increased item among AIDS prevention intention list was 'I will provide the meeting between the HIV infected persons and the public (+21.9%)'. But even the decreased item among AIDS prevention intention list was 'I will advice to female not to have extra marital sexual contact to avoid AIDS(-3.1%)'. It could be concluded that the health care workers were ignorant of vertical transmission of AIDS, they were afraid of disclosing the infection status, and have less AIDS prevention intention. Therefore it is needed to take an assessment process before each new education trategy to increase AIDS related the effect of the education on AIDS.

• 한국전문물리치료학회지
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• 제2권1호
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• pp.71-79
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• 1995

The purpose of this paper is to review the literature of AIDS/HIV (acquired immune deficiency syndrome/human immunodeficiency virus) and to introduce physical therapy of the AIDS client. It was first reported that five young homosexual men, in 1981 in Los Angeles, died of pneumonia caused by pneumocystis carinii - called "pest of twentieth century". AIDS was implied a fatal breakdown of the functioning of the normal human immune system. The major routes of transmission has occurred via l)sexual contact between men, 2)heterosexual intercourse, 3)contaminated blood and blood products, and 4)intrauterine or pre-natal infection from mothers. AIDS clients who may require physical therapy for a wide range of problems due to respiratory, neurological, musculoskeletal and painful syndromes as well as general decline in fitness and function. AIDS is growing rapidly in our contury as well as all over the world. Therefore, physical therapist has to correct his understandings of AIDS in order to protect himself and to give proper physical therapy to the AIDS clients.