• Molecules and Cells
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• 제45권11호
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• pp.789-791
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• 2022

Targeting fibroblast growth factor receptors (FGFRs) has been slow compared to other targeted cancer therapies for receptor tyrosine kinases, such as epidermal growth factor receptors. The low efficacy and variable response have limited the growth of FGFR inhibitors in clinical use. Nevertheless, recent systematic and genomic approaches have identified the biological conditions for effectively targeting FGFRs and can accelerate the development of targeted drugs. Under clinical and preclinical trials, the inhibitors started fast growing furious races to target FGFRs. Finally, FGFRs will be more actionable and targetable with more precise and effective drugs at the end of the race, passing the finish line.

• 한국조경학회지
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• 제25권3호
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• pp.177-185
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• 1997

Hibiscus syriacus were surveyed to study the growing temperature, relative humidity and growing responses shown at different elevations of Kangwon Province, and results of the assessment are summarized as follows 1. Growing responses as represented by leaf length, leaf width, shoot length, number of flowers and flowering duration, were decreased as the elevation increased, while the degree of defoliation was increased. 2. The important factor determining the growing responses to the elevation was the maximum and minimum temperatures, particularly those of July, August, and September. 3. The aphid occurrence on Hibiscus syriacus decreased as the elevation increased. Leading factor determining the population was relative humidity which increased as the elevation increased.

• 대한기계학회논문집A
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• 제24권8호
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• pp.2007-2014
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• 2000

It has been reported that the dynamic stress intensity factor for a propagating crack is increasing or decreasing according to the increasement of the crack propagating velocity. It is confirmed in this study that the increasement or decreasement of stress intensity factor with crack growing velocity is accused by loading condition. When the crack propagates under a constant displacement along upper and lower boundary in finite plate, the dynamic stress intensity factor decreases according to the increasement of the propagating crack velocity. When the crack propagates under a constant stress along upper and lower boundary in finite plate, the dynamic stress intensity factor increases according to the increasement of the propagating crack velocity. The increasement or decreasement of stress intensity factor with crack growing velocity is greater in a fast crack propagation velocity than in a slow one.

• Journal of Animal Science and Technology
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• 제65권5호
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• pp.939-950
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• 2023

This study was conducted to assess the impact of growing condition variables on alfalfa (Medicago sativa L.) productivity. A total of 197 alfalfa yield results were acquired from the alfalfa field trials conducted by the South Korean National Agricultural Cooperative Federation or Rural Development Administration between 1983 and 2008. The corresponding climate and soil data were collected from the database of the Korean Meteorological Administration. Twenty-three growing condition variables were developed as explaining variables for alfalfa forage biomass production. Among them, twelve variables were chosen based on the significance of the partial-correlation coefficients or potential agricultural values. The selected partial correlation coefficients between the variables and alfalfa forage biomass ranged from -0.021 to 0.696. The influence of the selected twelve variables on yearly alfalfa production was summarized into three dominant factors through factor analysis. Along with the accumulated temperature variables, the loading scores of the daily mean temperature higher than 25℃ were over 0.88 in factor 1. The sunshine duration at temperature between 0℃-25℃ was 0.939 in factor 2. Precipitation days were 0.82, which was the greatest in factor 3. Stepwise regression applied with the three dominant factors resulted in the coefficients of factors 1, 2, and 3 for 0.633, 0.485, and 0.115, respectively, and the R-square of the model was 0.602. The environmental conditions limiting alfalfa growth, such as daily temperature higher than 25℃ or daily mean temperature affected annual alfalfa production most substantially among the growing condition variables. Therefore, future cultivar selection should consider the capability of alfalfa to be tolerant to extreme summer weather along with biomass production potential.

• 한국의류산업학회지
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• 제4권2호
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• pp.163-168
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• 2002

For the purpose of investigating the factor of foot and calf growth of primary-school children who are fast-growing during this period a group of the 1st graders of primary-school had been the subject of this measurement in 1995 and there after they became the subject again in 1997, 1999 when they were the 3th, 5th graders measurement was carried out in 30 items including status and weight and marthin-type measure and foot-print were used for this measurement as the result, stature is correlated with height items and length items of foot and calf weight is correlated with width and circumference items of foot and calf angle of the first toe showed the highest growth like 3rd graders, heel circumference had rapidly grown rather than in the part of foot circumference in the factor analysis df foot measurement of 10-year, the first, second factors, appeared the size of shoes, in case of 12-year the first factor with status appeared the size of shoes.

• Laboraroty Animal Research
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• 제34권4호
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• pp.185-194
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• 2018

The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in commercial pigs. Growing pigs (Landrace, both sex, 50-60 kg) with the C/C (n=4) and T/T (n=5) TCF7L2 genotypes were identified and intravenously injected with streptozotocin (STZ, 40 mg/kg) twice in weekly intervals, then a high-energy diet was offered. Oral glucose tolerance tests, blood analyses and the homeostasis model assessment-insulin resistance (HOMA-IR) index calculations were performed. The animals were sacrificed at the end of 12 weeks of treatment to reveal the pancreas histomorphometry. The results showed that all of the treated pigs grew normally despite exhibiting hyperglycemia at two weeks after the induction. The glycemic level of the fasting or postprandial pigs gradually returned to normal. The fasting insulin concentration was significantly decreased for the T/T carriers but not for the C/C carriers, and the resulting HOMA-IR index was significantly increased for the C/C genotype, indicating that the models of insulin dependence and resistance were respectively developed by T/T and C/C carriers. The histopathological results illustrated a significant reduction in the pancreas mass and insulin active sites, which suggested increased damage. The results obtained here could not be compared with previous studies because the TCF7L2 background has not been reported. Growing pigs may be an excellent model for diabetic in children if the animals are genetically pre-selected.

• 한국기후변화학회지
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• 제7권4호
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• pp.485-492
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• 2016

For reporting national greenhouse gas inventory in forest sector, the forest growing stock from the National Forest Inventory (NFI) system has used as activity data sources. The National Forest Inventory system was changed from rotation system by province to annual system by 5 years across the country. The forest growing stocks based on the new inventory system produced a different trend compared to the previous estimations. This study was implemented to recalculate previous forest growing stocks for time series consistency at a national level. The recalculation of forest growing stock was conducted in an overlap approach by the IPCC guideline. In order to support the more consistency data, we used calibration factors between applied stand volumes in 1985 and 2012, respectively. As a result, the time series of recalculated forest growing stock was to be consistency using the overlap approach and the calibration factor with the lower middle/middle site index. According to the applied overlap period, however, we will recalculate activity data using more complete data from national forest inventory system.

• Journal of Animal Science and Technology
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• 제61권4호
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• pp.204-215
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• 2019

This experiment was conducted to evaluate the effect of dietary energy and crude protein (CP) levels on growth performance, blood profiles, and carcass traits in growing-finishing pigs. A total of 180 crossbred pigs ([Yorkshire ${\times}$ Landrace] ${\times}$ Duroc) with an average body weight of $30.96{\pm}3.068kg$ were used for a 12-week feeding trial. Experimental pigs were allotted to a $2{\times}3$ factorial arrangement using a randomized complete block (RCB) design. The first factor was two levels of dietary metabolizable energy (ME) density (13.40 MJ/kg or 13.82 MJ/kg), and the second factor was three dietary CP levels based on subdivision of growing-finishing phases (high: 18%/16.3%/16.3%/13.2% middle: 17%/15.3%/15.3%/12.2% and low: 16%/14.3%/14.3%/11.2%). Average daily gain (ADG) and gain-feed ratio (G:F ratio) decreased as dietary CP level was decreased linearly (linear, p < 0.05; p < 0.05, respectively) in the early growing period, and G:F ration also decreased as dietary CP level was decreased linearly (linearly, p < 0.05) over the whole growing phase. Over the entire experimental period, G:F ratio decreased as dietary ME level decreased (p = 0.01). Blood urea nitrogen (BUN) concentration was increased as dietary energy level decreased in growing period (p < 0.01). During finishing period, total protein concentration was decreased by lower dietary energy level (p < 0.05). In this study, there were no significant differences in proximate factors, physiochemical properties, muscle TBARS assay results, pH changes, or color of pork by dietary treatments. However, saturated fatty acid (SFA) increased (p < 0.01) and polyunsaturated fatty acid (PUFA) decreased (p < 0.05) when ME was decreased by 0.42 MJ/kg in growing-finishing pig diets. In addition, monounsaturated fatty acid (MUFA) tended to increase when CP level was decreased in growing-finishing pig diets (p = 0.06). A growing-finishing diet of 13.82 MJ/kg diet of ME with the high CP level can improve growth performance and show better fatty acids composition of pork.

• 한국발생생물학회지:발생과생식
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• 제23권1호
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• pp.35-42
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• 2019

Fish shows great difference in growth rate between individuals during larval development and early growth. This difference seriously reduces the production efficiency in fish culture. Growth hormone (GH)/Insulin-like growth factor 1 (IGF1) system is said to play some pivotal roles in fish growth. In this study, we investigated differences of GH, IGF1 and GHR gene expressions in juvenile red spotted grouper (Epinephelus akaara) with different growth performance. Red spotted groupers were reared under the same environmental condition (water temperature $24{\pm}1^{\circ}C$, natural light) for 96 days after hatching. They were divided into 3 groups by size (fast growing, middle growing and slow growing groups: FGG, MGG, and SGG, respectively). RNA was extracted from the brain, liver and muscle tissues from each group, and target gene expression was examined by real-time PCR. In the brain with pituitary gland, expression of GH gene in FGG was significantly higher than the expression in SGG, but the expression of IGF1 and GHR genes in the muscle was highest in SGG. Difference of GHR and IGF1 mRNA in the liver between groups with different growth performance was less clear than that in other tissues, although level of IGF1 mRNA was higher in SGG than in MGG. These results suggest that hormonal governing of growth is not the same in fast growing and slow growing fish, and size grading could cause a shift of hormonal state and growth pattern in this species.

• 대한기계학회논문집A
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• 제27권9호
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• pp.1477-1485
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• 2003

The displacement vector field can be represented in terms of a scalar potential ${\phi}$ and a vector potential ${\phi}$. The scalar potential ${\phi}$ is related to dilatational waves and the vector potential ${\phi}$ is related to rotational waves. Using these two complex displacement potentials, the stress and displacement fields for steadily growing interface cracks in dissimilar materials are obtained. The energy release rate for steadily growing interface cracks in dissimilar materials are also obtained. And with photoelastic isochromatic patterns simulated by computer graphics, the stress intensity factors are discussed.