• Title/Summary/Keyword: Group action

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Effect of Hydrocortisone infused into a Renal Artery on the Diuretic Actions of Acetazolamide and Aminophylline (Hydrocortisone의 신동맥 주입이 acetazolamide 및 aminophylline의 이뇨작용에 미치는 영향)

  • Lee, Jong-Hha;Lee, Duck-Hee;Cho, Kyu-Chul
    • The Korean Journal of Pharmacology
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    • v.10 no.2
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    • pp.63-74
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    • 1974
  • This study was carried out to observe the direct effect of hydrocortisone on renal function by infusing it into a renal artery. Hydrocortisone (5mg/kg) or saline (0.5 ml/kg) was infused directly into the left renal artery of the rabbit, the right kidney was left intact to serve as a control for general action of acetazolamide (10 mg/kg) or aminophylline (10 mg/kg), which was administered intravenously 30 minutes after the direct infusion of pretreated drugs (hydrocortisone or saline). The changes of urine volume, pH, urinary excretion rates of $Na^+,\;K^+\;and\;Cl^-$, and the clearances of inulin and PAH were measured at an interval of 10 minutes for half an hour after the direct infusion of hydrocortisone or saline, and for one hour after intravenous administration of acetazolamide or aminophylline. The results of the experiment were as follows: 1. Significant changes in urine volume and urinary electrolytes (excreted rates of $Na^+,\;K^+\;and\;Cl^-$) were observed in the hydrocortisone-infused group 10 minutes after the administration of acetazolamide, compared with the saline-infused group. Especially, the effect was more potent on the infused (left) side than on the contralateral (right) side. 2. Significant changes in urine volume and urinary electrolytes were also observed in all the aminophylline-treated groups, but no remarkable difference was noticed between the hydrocortisone-infused group and the saline-infused group, nor between the left and right sides. 3. No signicant changes in the clearances of inulin and PAH were in the infused (left) side of all the experimental groups, as compared with the contralateral (right) side. From the above results, it is obvious that hydrocortisone infused into a renal artery exerts diuretic action when administered in combination with acetazolamide, and the mechanism of action rests not on its hemodynamic change for renal blood flow, but on the potentiation of carbonic anhydrase inhibiting action. However, the exact mode of action remains yet to be clarified.

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The Importance of Age as a Factor of Carpal Tunnel Syndrome management (수근관 증후군 치료결정의 한 요인으로 연령의 중요성)

  • Kim, Ja-Young;Park, Hae-Yoon;Kang, Sung-Soo
    • Annals of Clinical Neurophysiology
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    • v.3 no.1
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    • pp.15-20
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    • 2001
  • Background : Carpal tunnel syndrome(CTS) is the most common entrapment neuropathy that refers to a group of signs and symptoms resulting from compression of the median nerve at the wrist. The course of CTS in older patients is different from the younger patients. This difference may be the result of different underlying mechanisms. The different nerve conduction studies of CTS may signify different approaches in management. This study was done to assess the differences in nerve conduction study of CTS in younger and older patients. Methods : This study involved 224 patients who visited Gachon Medical School, Gil Medical Center and was diagnosed by nerve conduction study from October 1997 to October 1999. We compared the results of nerve conduction study to age, especially in between those under 60 years and those 60 years or over CTS patients. Nerve conduction study consists of motor studies of both median nerves(terminal latency, compound action potential) and sensory studies(nerve conduction velocity, nerve action potential). And we also evaluated the variables between younger and older patients group. Those variables include sex, symptom period, laterality, abnormal physical findings and radiculopathy. Results : We found that a significant increase of terminal latency(p<0.1), but a decrease in compound motor action potential(p<0.05) in older patient's group. There was no significant differences in sensory nerve conduction velocity and action potential between those under 60 years and those 60 years or even patients. And also there was no significant difference in sex, symptom period, laterality, abnormal physical findings, radiculopathy between older and younger patients. Conclusions : This study showed a significant increase in the terminal latency and a decrease in compound action potential in older patients. The different nerve conduction studies of CTS by age effect may need different approaches in management.

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Effect of Saponin on Sodium-Potassium activated ATPase in Rabbit Red Cell Membrane (Saponin이 토끼 적혈구막의 $Na^{+}-K^{+}-ATPase$의 활성도에 미치는 영향)

  • Kang, Byoung-Nam;Koh, Il-Sup
    • The Korean Journal of Physiology
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    • v.8 no.1
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    • pp.67-76
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    • 1974
  • The effect of saponin on the sodium plus potassium activated ATPase activity was studied in the rabbit red cell ghosts and the experiments were also designed to determine the mechanism of action of saponin on the APTase activity. The following results were observed. 1. The ATPase activity of rabbit red cell ghosts is inhibited by low concentration of saponin but increased by high concentration. The activating effect of saponin on the $Na^{+}-K^{+}-ATPase$ activity is inhibited by ouabain but the stimulation of the $Mg^{++}-ATPase$ by high concentration of saponin is not inhibited by ouabain. 2. The activity ratio of $Na^{+}-K^{+}-ATPase$ by high concentration of saponin is decreased by raising the potassium concentration, and is increased by raising the sodium concentration. 3. The ATPase activity is increased by small amounts of calcium but inhibited by larger amounts. The activity ratio of the enzyme by saponin is decreased by raising the calcium concertration 4. The action on the ATPase activity was not related to the amino group of lysine, the hydroxyl group of threonine, the imidazole group of histidine, or the carboxyl group of aspartic acid. 5. The action of saponin on the ATPase activity is due to sulfhydryl group of the enzyme of $Na^{+}-K^{+}-ATPase$.

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Action of Theobromine on Sodium-Potassium activated ATPase in Red Cell Membrane (Theobromine이 적혈구막의 NaK ATPase의 활성도에 대한 작용)

  • Koh, Il-Sup
    • The Korean Journal of Physiology
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    • v.12 no.1_2
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    • pp.25-34
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    • 1978
  • The action of theobromine on the sodium plus potassium activated ATPase activity In the rabbit red cell membrane has teen investigated and the experiments were also designed to determine the mechanism of action of theobromine on the ATPase activity. The following results were observed. 1. The activity of the NaK ATPase from red fell membrane is stimulated by theobromine, and the concentration of theobromine for maximal activity is about 3mM. 2. The activating effect of theobromine on the ATPase, with a given concentration of potassium in the medium, is increased by raising the sodium concentration but activity ratio is decreased. 3. The activating effect of theobromine on the ATPase, with a given concentration of sodium in the medium. is increased by the raising the potassium concentration but activity ratio is decreased. 4. The NaK ATPase activity is increased by small amounts of calcium but decreased by larger amounts. The activity of the enzyme by theobromine is increased by small amounts of calcium but decreased by larger amounts. 5. The activating effect of theobromine on the ATPase was not related to the hydroxyl group of threonine and imidazole group of histicline. 6. The activating effect of theobromine on the ATPase is due to sulfhydryl group, amino group and carboxyl group of the enzyme of NaK ATPase.

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The Effects of Action Learning on Nurses' Problem Solving, Communication, Emotional Creativity and Innovation Behavior (액션러닝이 간호사의 문제해결능력, 의사소통, 정서창의성 및 혁신행동에 미치는 효과)

  • Lee, Sook-Ja;Jang, Keum-Seong
    • The Korean Journal of Health Service Management
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    • v.8 no.2
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    • pp.73-87
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    • 2014
  • The purpose of this study was to investigate the effects of a Action Learning(AL) program in terms of problem solving, communication skills, emotional creativity and innovation behaviors. Design for this was a nonequivalent control group quasi-experimental study. The participants were C-hospital staff nurses in G city (Experimental group=29, Control group=30). The AL program was composed of fourteen sessions in eight weeks. Data were collected and the program was conducted from May. 26 to July. 18, 2008. Data were analyzed with ${\chi}^2$-test, Fisher's exact test, t-test and ANCOVA, and utilized the SPSS win 20.0 program. There were significant increases in problem solving skills, communication skills and emotional creativity in the experimental group compared to the control group. Considering the above results, AL program has proven to be an effective educational program for improving the problem solving, communication skills and emotional creativity of nurses.

Action of Pilocarpine on Sodium-Potassium activated ATPase in Rabbit Red Cell Membrane (Pilocarpine이 토끼 적혈구막의 NaK ATPase의 활성도에 대한 작용)

  • Koh, Il-Sup
    • The Korean Journal of Physiology
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    • v.11 no.1
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    • pp.11-20
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    • 1977
  • The action of pilocarpine on the sodium plus potassium activated ATPase activity in the rabbit red cell membrane has been investigated and the experiments were also designed to determine the mechanism of action of pilocarpine on the ATPase activity. The following results were observed. 1. The activity of the NaK ATPase from red cell membrane is stimulated by pilocarpine, and the concentration of pilocarpine for maximal activity is about 3 mM. The pH optimum for the pilocarpine sensitive component is 8.0. 2. The activating effect of pilocarpine on the ATPase, with a given concentration of sodium .in the medium, is increased by raising the potassium concentration but activity ratio is decreased 3. The activating effect of pilocarpine on the ATPase, with a given concentration of Potassium in the medium, is increased by raising the sodium concentration but activity ratio is decreased 4. The NaK ATPase activity is increased by small amounts of calcium but decreased by 'larger amounts. The activity ratio of the enzyme by pilocarpine is decreased by small amounts .of calcium but decreased by larger amounts. 5. The activating effect of pilocarpine on the ATPase was not related to the sulfhydryl group of cysteine, the hydroxyl group of threonine or the imidazole group of histidine. 6. The activating effect of pilocarpine on the ATPase is due to amino group and carboxyl group of the enzyme of NaK ATPase

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Design and Implementation of Group Behaviors for Doves by Using a Finite State Machine (유한상태기계를 사용한 비둘기들에 대한 집단행동의 설계 및 구현)

  • Lee, Jae-Moon;Cho, Sae-Hong
    • Journal of Korea Game Society
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    • v.10 no.3
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    • pp.93-102
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    • 2010
  • This paper is to design and implement the system to simulate spontaneously the group behaviors for the various states of doves. To do this, the group behaviors of doves were divided into the four action models such as 'Flying', 'Landing', 'Eating' and 'Taking off'. The steering forces composing of each action model were found and each action model was designed by using the finite state machine. The designed system was implemented by integrating the Ogre engine. From the simulations of the implemented system, the values of the parameters for the steering forces were found so that it can represent the spontaneous group behaviors of doves.

Exploring the Play-centered Curriculum Action Competence of Early Childhood Teachers Based on FGI Analysis (FGI 분석을 통한 유아교사의 놀이중심교육과정 실행 역량 탐색)

  • Lee, Wonmi;Kwon, Yeonhee
    • Korean Journal of Childcare and Education
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    • v.16 no.4
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    • pp.93-110
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    • 2020
  • Objective: The purpose of this study was to explore the early childhood education teacher's ability to implement play-centered curriculum that is recognized by an early childhood education expert based on an analysis of focus group interviews. Methods: Two professors of early childhood education, two directors of daycare centers, and two early childhood education teachers participated in the focus group interview. The interview was conducted three times. The interviewed data were categorized and compared. Results: The action competence of the play-centered curriculum required for early childhood teachers were categorized into the following categories; comprehending play, recognizing play, and practicing child-centered play. Detailed factor competencies were required for understanding play, reflective thinking, reading play, recording play, playing like a child, and supporting play. Conclusion/Implications: For actualizing play-centered curriculum, early childhood education teachers needed to comprehend, recognize, and practice for child's play. Furthermore, we discussed the necessity and direction of teacher education to improve the teacher's action competence for play-centered curriculum.

Hypotensive Action of Coptis Rhizoma in Rabbit (황련성분의 혈압하강 작용)

  • Kwak I.S.;Lee S.B.;Cho B.H.;Cho K.C.
    • The Korean Journal of Pharmacology
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    • v.12 no.2 s.20
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    • pp.61-65
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    • 1976
  • Coptis rhizoma had been applied in the chines medicine as well as in the folk remidies and it was advocated that coptis rhizoma exerts good therapeutic effect in some case of alimentary disorders and other hypotensive ailments. However the basic pharmacology and the mechanism of hypotensive action are not clear. This experiment was carried out in order to reevaluate the pharmacology, especially hypotensive action of coptis rhizoma and to clarify the mechanism of action, in the rabbits and also $LD_{50}$ of coptis rhizoma was determined using mice as experimental animals. The results of the experiment were as follows. 1) $LD_{50}$ to the mice was 69 mg/kg. 2) Blood pressure manifested gradual responses by the fall of -17, -26, -62 mmHg in proportion to the administration of 3, 5, 10 mg/kg of coptis rhizoma extract respectively. 3) No significant differance was observed in heart rate between the normal control group and the coptis rhizoma extract treated group. 4) Administration of coptis rhizoma extract 5 mg/kg to the rabbit pretreated with atropine or avil did not show any significant difference in the blood pressure compared with that of control group. 5) In the rabbit pretreated with coptis rhizoma extract 5mg/kg, the hypotensive effect of epinephrine was significantly inhibited in comparison with that of normal rabbit.

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Effects of Action Observation Training and Mirror Therapy on the Electroencephalograms of Stroke Patients

  • Lee, Ho Jung;Lee, Jong Su;Kim, Young Mi
    • The Journal of Korean Physical Therapy
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    • v.33 no.2
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    • pp.106-113
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    • 2021
  • Purpose: This study examined the effectiveness of action observation training (AOT) and mirror therapy in improving the electroencephalograms (EEG) of stroke patients. Methods: Patients were allocated randomly to three groups: an action observation training with activity (AOTA) group (n=12), a mirror therapy with activity (MTA) group (n=11), and an AOT-only group (n=12). All groups received conventional physiotherapy in five 60-minute sessions over six weeks. The AOTA, MTA, and AOT groups practiced AOTA, MTA, and AOT, respectively, in three 30-minute sessions over six weeks. The differences between the pre- and post-treatment EEGs were assessed using a paired t-test. Comparisons between the groups were performed using one-way ANOVA. Results: The participants in the AOTA and MTA groups showed significant improvement in the EEG. AOTA improved the alpha waves of the prefrontal, temporal, and parietal lobes significantly (p<0.05). MTA improved the alpha waves of the temporal lobe significantly (p<0.05). AOT did not result in significant improvement Conclusion: AOTA and MTA improve stroke patients' EEGs. Mirror neuron activation combined with conventional stroke physiotherapy promotes motor recovery and functioning. The effect is enhanced when the actions are executed after observation. Further research into mirror neuron activation will be needed to develop methods to improve the EEGs of stroke patients.