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Effect of Active Synthetic 2-Substituted Quinazolinones on Anti-Platelet Aggregation and the Inhibition of Superoxide Anion Generation by Neutrophils

  • Chang, Fang-Rong;Wu, Chin-Chung;Hwang, Tsong-Long;Patnam, Ramesh;Kuo, Reen-Yen;Wang, Wei-Ya;Lan, Yu-Hsuan;Wu, Yang-Chang
    • Archives of Pharmacal Research
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    • v.26 no.7
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    • pp.511-515
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    • 2003

  • Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

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