• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3223-3228
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• 2013

Gene expression profiling (GEP) has identified several molecular subtypes of breast cancer, with different clinico-pathologic features and exhibiting different responses to chemotherapy. However, GEP is expensive and not available in the developing countries where the majority of patients present at advanced stage. The St Gallen Consensus in 2011 proposed use of a simplified, four immunohistochemical (IHC) biomarker panel (ER, PR, HER2, Ki67/Tumor Grade) for molecular classification. The present study was conducted in 75 newly diagnosed patients of breast cancer with large (>5cm) tumors to evaluate the association of IHC surrogate molecular subtype with the clinical response to presurgical chemotherapy, evaluated by the WHO criteria, 3 weeks after the third cycle of 5 flourouracil, adriamycin, cyclophosphamide (FAC regimen). The subtypes of luminal, basal-like and HER2 enriched were found to account for 36.0 % (27/75), 34.7 % (26/75) and 29.3% (22/75) of patients respectively. Ten were luminal A and 14 luminal B (8 HER2 negative and 6HER2 positive). The triple negative breast cancer (TNBC) was most sensitive to chemotherapy with 19% achieving clinical-complete-response (cCR) followed by HER2 enriched (2/22 (9%) cCR), luminal B (1/6 (7%) cCR) and luminal A (0/10 (0%) cCR). Heterogeneity was observed within each subgroup, being most marked in the TNBC although the most responding tumors, 8% developing clinical-progressive-disease. The study supports association of molecular subtypes with response to chemotherapy in patients with advanced breast cancer and the existence of further heterogeneity within subtypes.

• 정보교육학회논문지
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• 제12권1호
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• pp.1-8
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• 2008

본 연구는 초등학교에서 정보처리 능력 향상을 위한 교수 방법에 대한 연구이다. 현 시대의 학생들은 정보의 홍수 속에서 '정보를 활용하여 새로운 지식을 창출해 낼 수 있느냐?' 하는 정보 처리 능력이 중요하게 요구된다. 그러나 초등컴퓨터 교육 현장은 '정보 처리 능력'에 대한 교육이 미비한 실정이다. 본 연구는 Barrow의 문제해결학습 모형을 적용하여 정보처리 능력을 신장 시킬 수 있는 방안을 제안하고 적용하였다. 학생들은 컴퓨터를 이용하여 주어진 문제들을 해결하는 과정 속에서 자연스럽게 새로운 정보를 창출할 수 있고, 정보의 연관성을 표현할 수 있는 능력을 기르도록 하였다. 연구방법은 부산의 초등학교 5학년 23명을 대상으로 8개월간 적용하여, 적용 전후를 비교하는 실험연구를 중심으로 하였다. 연구 결과 '정보의 정선', '정보의 신뢰성 확보', '정보의 분류 분석 비교', '정보의 내면화' 등에서 주목할 만한 발전적인 변화가 있었다.

• Journal of Korean Neurosurgical Society
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• 제45권5호
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• pp.271-274
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• 2009

Objective: We retrospectively analyzed the surgical outcomes of 42 patients with growth hormone (GH)-secreting pituitary adenoma to evaluate the clinical manifestations and to determine which preoperative factors that significantly influence the remission. Methods: Forty-two patients with GH-secreting pituitary adenoma underwent transsphenoidal surgery (TSS) between 1995 and 2007. The patient group included 23 women and 19 men, with a mean age of 40.2 (range 13-61) years, and a mean follow-up duration of 49.4 (range 3-178) months after the operation. For comparable radiological criteria, we classified parasellar growth into five grades according to the Knosp classification. We analyzed the surgical results of the patients according to the most recent stringent criteria for cure. Results: The overall rate of endocrinological remission in the group of 42 patients after primary TSS was 64% (26 of 42). The remission rate was 67% (8 of 12) for microadenoma and 60% (18 of 30) for macroadenoma. The remission rate was 30%(3 of 10) for the group with cavernous sinus invasion and 72% (23 of 32) for the group with intact cavernous sinus. Cavernous sinus invasion in Knosp grade III and IV was significantly correlated with the remission rate. There was a significant relationship between preoperative mean GH concentration and early postoperative outcome, with most patients in remission having a lower preoperative GH concentration. Conclusion: TSS is thought to be an effective primary treatment for GH-secreting pituitary adenomas according to the most recent criteria of cure. Because the remission rate in cases with cavernous sinus invasion is very low, early detection of the tumor before it extends into the cavernous sinus and a long-term endocrinological and radiological follow-up are necessary in order to improve the remission rate of acromegaly.

• 한국균학회지
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• 제13권2호
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• pp.105-109
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• 1985

버섯 재배상(栽培床에)서 Trichoderma속(屬)을 분리, 동정하고 아울러 Trichoderma속(屬)이 생산하는 항생물질(抗生物質)이 느타리버섯균의 생육에 미치는 영향을 검토하여 다음과 같은 결과를 얻었다. 1) 분리된 Trichoderma속(屬)은 Rifai의 검색표에 따라 동정한 결과 Trichoderma hamatum, Trichoderma viride, Trichoderma koningii로 확인되었다. 2) 분리 동정된 Trichoderma속(屬) 중에서 Trichoderma viride(No. 10)이 느타리 버섯균 생육(生育)에 대한 저해율이 제일 높았다. 3) 각종 버섯균 중에서 Trichoderma viride(No. 10)에 의한 저해는 Pleurotus ostreatus와 Pleurotus sajor-caju가 제일 심했고 그 다음으로는 Lentinus edodes, Flammulina velutipes, Auricularicula auricula순이었다. 4) 추출된 백색 침상 결정 항균력(抗菌力)은 각각 1/10의 농도와 500ppm의 농도에서 cycloheximide $100{\sim}200ppm$의 항균력(抗菌力)에 해당하였다.

• 보건행정학회지
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• 제26권4호
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• pp.289-304
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• 2016

Background: Rehabilitations in subacute phase are different from acute treatments regarding the characteristics and required resource consumption of the treatments. Lack of accuracy and validity of the Korean Diagnosis Related Group and Korean Out-Patient Group for the acute patients as the case-mix and payment tool for rehabilitation inpatients have been problematic issues. The objective of the study was to develop the Korean Rehabilitation Patient Group (KRPG) reflecting the characteristics of rehabilitation inpatients. Methods: As a retrospective medical record survey regarding rehabilitation inpatients, 4,207 episodes were collected through 42 hospitals. Considering the opinions of clinical experts and the decision-tree analysis, the variables for the KRPG system demonstrating the characteristics of rehabilitation inpatients were derived, and the splitting standards of the relevant variables were also set. Using the derived variables, we have drawn the rehabilitation inpatient classification model reflecting the clinical situation of Korea. The performance evaluation was conducted on the KRPG system. Results: The KRPG was targeted at the inpatients with brain or spinal cord injury. The etiologic disease, functional status (cognitive function, activity of daily living, muscle strength, spasticity, level and grade of spinal cord injury), and the patient's age were the variables in the rehabilitation patients. The algorithm of KRPG system after applying the derived variables and total 204 rehabilitation patient groups were developed. The KRPG explained 11.8% of variance in charge for rehabilitation inpatients. It also explained 13.8% of variance in length of stay for them. Conclusion: The KRPG version 1.0 reflecting the clinical characteristics of rehabilitation inpatients was classified as 204 groups.

• 한국식품영양학회지
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• 제11권2호
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• pp.165-170
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• 1998

교통사고로 인한 척추골절 환자 S75에서 손상부위에 따른 진단방사선학 및 보존적 치료 소견을 임상 문헌과 함께 고찰해 본 결과 다음과 같은 결론을 얻었다. 1. 흉요추 좌측방 단순필름에서 L1 요추에 설상변형 정도가 약 10%인 쐐기형 압박골절이 확인되었다. 2. L1 요추의 CT촬영 결과 추체부 전면에 궁형의 불규칙한 골 절편을 관찰할 수 있었으며, T12∼L1는 구조상 손상빈도가 높은 부위로 밝혀졌으며, Denis의 골절형태는 중간주와 후방주가 잘 보존된 전방주의 다발성 압박골절로 분류되었고, Cobb의 척추 만각증은 없었으며, Frankel의 신경손상 분류형태는 E형이었다. 3. 정형외과적 치료방법은 비수술 요법의 보존적 치료를 원칙으로 하였고, 수분·전해질, 영양 및 혈장제 대용으로 공급하는 수액과 함께 브스테로이드성 항염진통제, 근육 이완제를 투여하면서 철저한 침상안정을 유도하였다. 4. 수상후 3주째는 폴리에틸렌 back corset를 착용하고 조기재활을 시도하였으며, 수상 8주 후에도 경도의 불편감이 남아 있었으나, 추시 관찰한 결과 일정기간이 지나면서 점차 척추는 안정성을 찾게 되었다.

• 한국콘텐츠학회논문지
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• 제8권8호
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• pp.235-243
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• 2008

본 연구에서는 신한승이 택견을 국가 무형문화재로 지정하기 위하여 어떻게 체계화하고 구성하였는지를 살펴보는데 초점을 맞추었고, 다음과 같은 결론과 의의를 찾을 수 있었다. 첫째, 근대 택견의 전수자로 유일한 송덕기 택견의 기술 구성은 일정한 체계가 없는 낱기술 중심의 놀이 형태로 전래 되었으나, 신한승에 의하여 체계적인 구성을 가진 무예로 발전하게 되고, 급기야 무형문화재로 인정받게 되는 쾌거를 이루었다. 둘째, 신한승은 낱기술로 전래되어 오던 택견을 체계화 하면서 유도, 검도, 합기도, 태권도, 가라테의 수련체계와 기술을 일부 차용하여 근대화 시켰다. 이 과정에서 송덕기 택견이 원형대로 전수되지 않고 변형되었다는 비판이 제기되고 있는 실정이다. 셋째, 신한승은 정통 택견에는 없던 급수 구분제도와 실기심사, 태권도의 품새에 해당하는 본대뵈기 12마당 등을 만들고, 스포츠화를 추구하여 현대적인 학습체계와 대중화에 기여하였다. 본 연구를 통해 택견의 원래 형태와 기술변천 및 구성에 대한 시대적 환경적 윤관을 재조명 할 수 있었으며, 전통화 과정에서 혼재되고 있는 각종 택견 단체들의 논쟁을 이해하는 중요한 참고 자료를 제공할 수 있었다.

• 한국환경교육학회지:환경교육
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• 제19권3호
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• pp.40-56
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• 2006

The purpose of this study is to enhance elementary students' awareness of environment-friendly life and help them to prepare for a better life in the future. To achieve this purpose we examined the effect typical environmental experience-based learning activities, which were based on the local circumstances with high environmental-educational potential, have on the attitudes toward environment-friendly life. This study was carried out on the basis of typical environmental experience-based learning in the small class size. The research group used was composed of one sixth grade elementary school class called Sangroksu, whose total students were 9. The research period lasted from March 2005 to February 2006. To analyze the result of this study, two research methods were applied simultaneously : quantitative research methods and qualitative research methods. Especially statistical analysis in quantitative research methods by self-administrated questionnaire was done with SAS program. Qualitative research methods were analyzed in a cyclic pattern, including the processes of domain analysis, classification analysis, and factor analysis which continued to be associated with data-collecting methods. This research shows the following results. First of all, students have shown meaningful differences after typical environmental experience-based learning activities.(p<.05). Followings are fields of the differences - students‘ interest on the subject, their understanding levels of necessity for basic environmental facilities around us as well as for the kinds of environmental experience-based learning, awareness levels of various environmental problems, consciousness on environment conservation, and the practicing ability of environment - friendly lifestyles. Secondly, We have discovered improvements in the following fields after this study - the knowledge and understanding levels on our environment and human relationships, students' fundamental abilities to work out environmental problems, right ideas and appropriate attitudes on environment protection, the practicing ability of environment-friendly life styles, and their parents' understanding levels on the education related to environment. In conclusion, typical environmental experience-based learning activities have a positive effect on the improvement of elementary school students' environment-friendly life styles.

• 한국수학교육학회지시리즈A:수학교육
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• 제46권3호
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• pp.245-261
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• 2007

This paper deals with the possible problems which may arise when students learn the names of elementary geometric figures in the languages of Korean, Chinese, English. The names of some simple geometric figures in these languages are analyzed, and a specially designed test was administered to some grade eight students from the three language groups to explore the possible influence of the characteristics of the languages on students' capability in identifying the figures, the way students define the figures, and students' understanding of the inclusive relationship among figures. It was found that the usage of the terms to describe geometric figures may indeed have affected students' understanding of the figures. The names of geometric figures borrowed from those of everyday life objects may cause students to fix on some attributes of the objects which may not be consistent with the definition of the figures. Even when the names of the geometric figures depict the features of the figures, the words used in the naming of the figures may still affect students' understanding of the inclusive relations. If there is discrepancy between the definition of a geometric figure and the features that the name depicts, it may affect students' understanding of the definition of the figure, and if there is inconsistency in the classification of figures, it may affect students' understanding of the inclusive relationship involving those figures. Some implications of the study are then discussed.

• Journal of Acupuncture Research
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• 제30권4호
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• pp.189-196
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• 2013

Objectives : The aim of this study was to find out the therapeutic effect of bee venom acupuncture in the treatment of patient with trigger finger accompany side effects by steroid injection. Methods : As the effect of bee venom acupuncture about various articulation diseases observed, we tried to treat a case that was diagnosed trigger finger with side effects by steroid injection by using bee venom acupuncture. Result : After three times bee venom acupuncture treatments, 'VAS' score and triggering grade decreased quite noticeably, and other symptoms as have improved as well. Conclusions : Bee venom acupuncture have shown fairly effective to trigger finger accompany side effects by steroid injection.