• 대한수의학회지
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• 제15권1호
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• pp.23-25
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• 1975

Eight cattle and ten sheep were administrated various degree of PMA-B and EPN, and S-GOT, S-GPT and serum cholinesterase activity were tested. Serum cholinesterase activity showed no typical tendency, however, S-GOT/S-GPT ratios were decreased by the administration of PMA-B. It was suggested some degree of liver damage by the administration of the chemicals was recognized.

• 한국동물학회지
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• 제17권3호
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• pp.131-138
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• 1974

成熟한 Sprague-Dawley 系의 雄性흰쥐를 $30\\pm 0.5^\\circ C$에서 240時間 그리고 $33\\pm 0.5^\\circ C$에서 64時間 各各 溫熱曝露시켰으며, 溫熱曝露 期間中 여러 時間區에서 血淸 glutamic oxaloacetic transaminase (GOT)와 血淸 glutamic pyruvic transaminase (GPT)의 活性을 Reitman 및 Frankel (1957)의 方法에 依해서 Coleman-Model 295E Spectrophotometer로서 各各 550m$\\mu$에서 測定하였다. $23\\pm 1^\\circ C$인 對照群에 比較하여 보면, $30\\pm 0.5^\\circ C$ 및 $33\\pm 0.5^\\circ C$에서 溫熱曝露된 흰쥐는 各各 血淸의 GOT 및 GPT의 活性이 有意性있게 上昇되었다. 서로 다른 高溫의 溫熱에 曝露된 흰쥐의 血淸 GOT 活性은 16 및 30時間 區間中에서 또한 64 및 72時間 區間中에서 各各 有意性있게 上昇되었다. 한편 $30\\pm 0.5^\\circ C$에서 72時間後에는 血淸 GOT 活性은 正常群으로 되돌아가는 傾向이 나타났다. 서로 다른 高熱의 溫熱로 曝露된 흰쥐의 血淸GPTdml 活性은 初期인 4時間區에서 有意性있게 上昇되었으며, 이어서 16時間區와 64 및 72時間 區間中에서 各各 上昇되었다. 한편 $30\\pm 0.5^\\circ C$에서는 114時間後에 약간 增加하는 傾向이 나타났다. $30\\pm 0.5^\\circ C$와 $33\\pm 0.5^\\circ C$에서 各各 溫熱曝露된 흰쥐의 酵素活性을 比較하여 보면, $33\\pm 0.5^\\circ C$에 曝露된 흰쥐의 血淸 GOT 및 血淸 GPT의 活性은 各各 16, 30 및 64時間區에서 有意性있게 높은 活性을 나타내었다. 이러한 結果로 미루어 보아 連續的 溫熱曝露는 非正常의 아미노基 轉移代謝를 招來하는 것으로 思料된다.

• 약학회지
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• 제43권3호
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• pp.391-396
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• 1999

In order to evaluate the protective effects of extracts of Mori cortex radicis on carbon tetrachloride-induced hepatotoxicity, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, malondiadehyde values and glutathione S-transferase activity were measured in ICR mice. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride-treatment were markedly increased than normal control but those levels were significantly decreased by the treatment of butanol fraction of Mori cortex radicis mathanol extract. Glutathione S-transferase activity was decreased by carbon tetrachloride than control, but that also inhibited by the treatment of butanol fraction of Mori cortex radicis methanol extract. These results demonstrate a possible hepatoprotective role of extract role of extract of Mori cortex radicis against ${CCl_4}-induced$ hepatoxicity in vivo.

• 약학회지
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• 제47권4호
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• pp.206-211
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• 2003

This study was performed to investigate the effect of Mori Folium and Crataegus pinnatifida leave extracts on liver damage induced by CC1$_4$ in rats. 30％ and 60％ methanol extracts of Mori Folium and Crataegus pinnatifida leaves were administered orally at the dose of 10 mg/kg on every day for 6 days and liver damage was induced by intraperitoneal injection of $CCl_4$ (0.4 ml/kg) on 6th day. 30％ Methanol extracts of Mori Folium treated group showed significant protective effect on hepatotoxicity with the lowest Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT). The low density lipoprotein (LDL) levels of 30％ methanol extracts of Mori Folium and Crataegus pinnatifida leave and 60％ methanol extracts of Mori Folium treated groups were significantly lower than normal group, respectively. In particular, LDL level of 30％ Mori Folium extracts treated group was significantly decreased compared to $CCl_4$ treated group. These results support that Mori Folium and Crataegus pinnatifida leave extracts are hepatoprotective effects against hepatotoxicity induced by $CCl_4$.

• Toxicological Research
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• 제7권2호
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• pp.165-171
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• 1991

Effects of forced physical exercise on the CCl4 hepatotoxicity were examined in adult female rats. Rats were treated with CCl4 (2 mmol/kg, ip) and introduced into a cylindrical cage rotating at 9 rpm for 20 min/hr for 6 hr. Eighteen hr following the termination of exercise serum sorbitol dehydrogenase (SDH), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) activities and glucose-6-phosphatase activity were determined as parameters for hepatotoxicity. Physical exercise inhibited the $CCI_{4-}$induced increases in SDH, GOT, GPT activity, and glucose-6-phosphatase activity were determined as parameters for hepatotoxicity.

• KSBB Journal
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• 제13권4호
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• pp.364-368
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• 1998

The optimum conditions of the production of exo-polymer by Ganoderma lucidum WK-003 and it's hepatoprotective effect was studied. Optimum conditions for the production of exo-polymer (3.18 g/$\ell$) by using shaken flask culture of G. lucidum WK-003 were pH 4.5, 30$^{\circ}C$, 120 rpm for 18 days cultivation. Also exo-polymer productio (7.15 g/$\ell$) was optimized by 5$\ell$ jar fermenter cultivation with condition of pH 4.5, 30$^{\circ}C$, 200 rpm, 1.0 vvm for 6 days cultivation. Glutamic pyruvic transaminase(GPT) activities in serum of intoxicated Sprague-Dawley rat were decreased from 704 IU/L to 330 IU/L by oral administration of the exo-polymer (20mg/kg$.$day)f or 4 consecutive days.

• Toxicological Research
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• 제9권2호
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• pp.253-262
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• 1993

The effects of dichloromethane (DCM) on carbon tetrachloride (CT) toxicity were examined in adult male rats. A concomitant treatment of rats with DCM (0.3, 0.6, 1.2 g/kg, po) significantly potentiated the hepatotoxicity of CT (1.0 g/kg, po) as determined by increase in serum GPT (glutamic pyruvic transaminase), GOT (glutamic oxaloacetic transaminase), and SDH (sorbitol dehydrogenase) activity 24 hr following the treatments. Serum LDH (lactate dehydrogenase) activity was increased by either DCM or CT treatment.

• 생명과학회지
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• 제10권5호
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• pp.490-495
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• 2000

규산염 광물질인 맥반석을 3%수준으로 식이중에 첨가하여 십자매에 2주간 급여한 후 생리적 및 생화학적 성상에 미치는 영향에 대하여 검토하였다. 체중 증가량, 식이 섭취량, 식이 효율, 상대적 간장 및 심장 무게는 대조군과 맥반석 첨가군 사이에 유의적인 차이가 없었고, 상대적 신장 및 근위 무게는 맥반석 첨가군에서 각각 증가 및 감소하였다. 혈청 총 단백질, 혈당, 알부민, 중성지질, 콜레스테롤 농도는 두군 사이에 차이가 없었다. 간기능 지표인 GOT및 ALP 활성은 맥반석 첨가군에서 각각 증가 및 감소하였으나, GTP 활성은 유의적인 차이가 없었다. 따라서, 맥반석 3% 수준의 식이중첨가는 십자매의 생리적 및 생화학적 상태에는 영향을 미치지 않으며, 식이의 영양효율을 증가시키는 것으로 사료된다.

• 한방비만학회지
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• 제9권1호
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• pp.59-69
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• 2009

Objectives This study was designed to evaluate the difference of between Kyungohkgo and Kyungohkgo Ga Nokyong effects of growth Methods We divided male Spraque-Dawley rats into 6 groups. They were Normal group, Growth deficiency rat with insufficient nutrition diet group, Growth deficiency rat with 0.1% Kyungohkgo group, Growth deficiency rat with 0.2% Kyungohkgo group, Growth deficiency rat with 0.1% Kyungohkgo Ga Nokyong group and Growth deficiency rat with 0.2% Kyungohkgo Ga Nokyong group. They were administered for 5 weeks. We measured body weight, serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, RBC, concentration of Hb and PCV ratio, total WBC and its composition, the values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities. Results 1. In body weight, Kyungohkgo 0.1%, Kyungohkgo Ga Nokyong 0.1%, 0.2% groups were showed sighnificantly different than control group. But That groups were not showed significantly different than each others. 2. In serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, we obtained the results of tendency to increase in Kyungohkgo Ga Nokyong group, however these values showed no significantly different. 3. In the counts of RBC, Kyungohkgo group and Kyungohkgo Ga Nokyong group were showed significantly different than control group. But these values showed no significantly different. In the concentration of Hb, Kyungohkgo Ga Nokyong 0.2%group was showed significantly different than control group. Kyungohkgo Ga Nokyong 0.2% group and Kyungohkgo 0.2% group were showed significantly different than control group. 4. The counts of total WBC and its composition showed no significantly different in all treatment groups. 5. The values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities showed no significantly different in all treatment groups. Conclusions So Kyungohkgo Ga Nokyong and Kyungohkgo have an effect of promoting growth of rats. And We know that the effect of Kyungohkgo Ga Nokyong is better than Kyungohkgo.

• 한국동물학회지
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• 제12권2호
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• pp.50-56
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• 1969

붕어, 비둘기, 흰쥐의 肝組織內의 蛋白質含量과 蛋白質代謝에 관하여는 GDH, GOT 및 GPT의 活性과 比較活性, 그리고 GDH 同位酵素를 測定하였다. 1. 蛋白質含量은 흰쥐, 비둘기가 各各 22.0$\pm$0.01mg/ml 및 22.0$\pm$0.16으로서 거의 같은 量의 蛋白質含量으로 組成되었으나 붕어의 肝臟組織內 蛋白質含量은 約 60%에 該當하는 13.0$\pm$0.09이었다(p < 0.01). 2. Glutamic transaminase는 흰쥐, 비둘기, 붕어의 순위로 그 活性度가 낮았다. 卽 GPT의 比較活性은 各各 3.77$\pm$0.18 unit/mg, 1.93$\pm$0.01 및 0.71$\pm$0.07 이었으며 GOT는 8.23$\pm$0.06 unit/mg, 3.95$\pm$0.09 및 0.92$\pm$0.01이었다(p < 0.01). 3. GOT/GDT 比는 흰쥐, 비둘기, 붕어에서 各各 0.20$\pm$0.004, 0.22$\pm$0.005 및 0.20$\pm$0.002로서 별 차이 없었다. 4. GDH 比較活性은 비둘기가 가장 높은 35.7$\pm$0.81 unit/mg이고 붕어는 9.6$\pm$0.16, 흰쥐는 20.5$\pm$0.81이었다. 5. Glutamic transaminase 와 GDH 比較活性이 動物의 種類에 따라 병행하였으며 特히 進化過程과 一致되는 것으로 思料된다. 6. GDH 同位酵素의 樣相은 種特異性이 뚜렷하였다. 흰쥐에서는 음극이 遲延性易動度區劃의 活性이 가장 높았으나, 비둘기에서는 兩極性區劃의 活性이 가장 높았다. 特히 魚類에서는 陰極性區劃이 全然 發見되지 않았으나 兩極性에 4個의 區劃을 볼수 있었다.