• Proceedings of the Korean Society of Computer Information Conference
• /
• 2016.07a
• /
• pp.21-24
• /
• 2016

전장유전체 연관성 연구에서 상위성 탐색은 많은 단일염기다형성 수로 인해 계산이 어렵기 때문에 네트워크에서의 탐색을 이용한 방법이 사용되고 있다. 그러나 전장유전체 연관성 연구에서 단일염기다형성들의 상위성 네트워크의 구성 역시 큰 계산 비용을 필요로 한다. 본 논문에서는 단일염기다형성과 표현형의 상호정보량을 이용한 네트워크를 구성하는데 드는 시간을 줄이는 알고리즘을 제안한다. 또한 표본 크기별로 계산 시간을 실험해 보았으며, 기존의 방법과 비교해 실행 속도가 향상됨을 보였다.

• Journal of Plant Biotechnology
• /
• v.44 no.1
• /
• pp.19-26
• /
• 2017

Rapid progress in epigenetic studies has resulted in genome wide information of genetic functions, other than DNA sequence information. However, insufficient understanding and unclear research direction in epigenetics has failed to attract many researchers. Here, we review the sexual reproduction processes that are particularly related to epigenetics in plants. We aim to elucidate the roles of epigenetic information and molecular mechanisms involved in the complex sexual reproduction process of plants, and examine their biological significance.

• 대한임상약리학회:학술대회논문집
• /
• 2008.05a
• /
• pp.3-6
• /
• 2008

See Full Text

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.11 no.sup2
• /
• pp.59-66
• /
• 2008

Genome-wide association studies using large case-control samples and several hundred thousand genetic markers efficiently and powerfully assay common genetic variations. The application of these studies to inflammatory bowel disease has led to the identification of susceptibility genes and affirmed the importance of innate and adaptive immunity in the pathogenesis of disease. Efforts directed towards the identification of environmental factors have implicated commensal bacteria as determinants of dysregulated immunity and inflammatory bowel disease. Host genetic polymorphisms most likely interact with functional bacterial changes to stimulate aggressive immune responses that lead to chronic tissue injury.

• 한국약용작물학회:학술대회논문집
• /
• 2011.04a
• /
• pp.106-107
• /
• 2011

• BMB Reports
• /
• v.45 no.11
• /
• pp.604-611
• /
• 2012

Recent advances in genome and transcriptome analysis have enabled identification of numerous members of a new class of noncoding RNA, long noncoding RNA (lncRNA). lncRNAs are broadly defined as RNA molecules greater than 200 nt in length and lacking an open reading frame. Recent studies provide evidence that lncRNAs play central roles in a wide range of cellular processes through interaction with key component proteins in the gene regulatory system, and that alteration of their cell- or tissue-specific expression and/or their primary or secondary structures is thought to promote cell proliferation, invasion and metastasis. The biological and molecular characteristics of the large majority of lncRNAs remains unknown, and it is anticipated that improved understanding of the roles played by lncRNAs in cancer will lead to the development of novel biomarkers and effective therapeutic strategies.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.10a
• /
• pp.219-219
• /
• 2017

• Journal of Microbiology and Biotechnology
• /
• v.26 no.10
• /
• pp.1824-1828
• /
• 2016

AcrR, the toxic-compounds-response regulator, regulates motility in microorganisms, presumably to escape from toxic environments. In this study, the genome-wide target genes of AcrR were investigated in a ΔacrR mutant strain by microarray analysis. In the absence of AcrR, the transcription of most flagella/motility genes was highly increased. In addition, flagella formation was increased in this mutant strain. Motility assays revealed that AcrR modulates swimming motility, but not swarming.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.18
• /
• pp.8059-8065
• /
• 2016

Nasopharyngeal carcinoma (NPC) is a common tumor in southern China and south-eastern Asia. Effective strategies for the prevention or screening of NPC are limited. Exploring effective biomarkers for the early diagnosis and prognosis of NPC continues to be a rigorous challenge. Evidence is accumulating that DNA methylation alterations are involved in the initiation and progression of NPC. Over the past few decades, aberrant DNA methylation in single or multiple tumor suppressor genes (TSGs) in various biologic samples have been described in NPC, which potentially represents useful biomarkers. Recently, large-scale DNA methylation analysis by genome-wide methylation platform provides a new way to identify candidate DNA methylated markers of NPC. This review summarizes the published research on the diagnostic and prognostic potential biomarkers of DNA methylation for NPC and discusses the current knowledge on DNA methylation as a biomarker for the early detection and monitoring of progression of NPC.

• Genomics & Informatics
• /
• v.11 no.1
• /
• pp.52-54
• /
• 2013

Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.