• Korean Chemical Engineering Research
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• v.51 no.2
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• pp.226-232
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• 2013

To produce biobutanol, fermentation processes using clostridia that mainly produce acetone, butanol and ethanol are used. In this work, a dynamic model describing the metabolic reactions in an acetone-butanol-ethanol (ABE)-producing clostridium, Clostridium acetobutylicum ATCC824, was proposed. To estimate the 58 kinetic parameters of the metabolic network model with experimental data obtained from a batch fermentor, we used an efficient optimization method combining a genetic algorithm and the Levenberg-Marquardt method because of the complexity of the metabolism of the clostridium. For the verification of the determined parameters, the developed metabolic model was evaluated by experiments where genetically modified clostridium was used and the initial concentration of glucose was changed. Consequently, we found that the developed kinetic model for the metabolic network was considered to describe the dynamic metabolic state of the clostridium sufficiently. Thus, this dynamic model for the metabolic reactions will contribute to designing the clostridium as well as the fermentor for higher productivity.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.5
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• pp.225-234
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• 2015

Nowadays a Virtual Power Plant (VPP) represents an aggregation of distributed energy resource such as Distributed Generation (DG), Combined Heat and Power generation (CHP), Energy Storage Systems (ESS) and load in order to operate as a single power plant by using Information and Communication Technologies, ICT. The VPP has been developed and verified based on a single virtual plant platform which is connected with a number of various distributed energy resources. As the VPP's distributed energy resources increase, so does the number of data from distributed energy. Moreover, it is obviously inefficient in the aspects of technique and cost that a virtual plant platform operates in a centralized manner over widespread region. In this paper the concept of the large-scale VPP which can reduce a error probability of system's load and increase the robustness of data exchange among distributed energy resources will be proposed. In addition, it can directly control and supervise energy resource by making small size's virtual platform which can make a optimal resource scheduling to consider of variable and sensitive load in the large-scale VPP. It makes certain the result is verified by simulation.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.16 no.2
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• pp.70-78
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• 2016

21-hydroxylase deficiency (21-OHD), most common form of congenial adrenal hyperplasia, is categorized into classical forms, including the salt-wasting (SW) and the simple virilizing (SV) types, and nonclassical (NC) forms based on the severity of the disease. Newborn screening for 21-OHD has been performed in Korea since 2006. $17{\alpha}$-hydroxyprogesterone (17-OHP) is a marker for 21-OHD and is measured using a radioimmunoassay or a fluoroimmunoassay. Premature and low birth weight infants are likely to give false positive 17-OHP findings, therefore, cutoff values for these infants should be determined based on gestational weeks or birth weight. ACTH simulation test is helpful when the 17-OHP shows equivocal increase, and it is gold standard for diagnosis of NC type. Recently, liquid chromatography linked with tandem mass spectrometry was developed for rapid, highly specific, and sensitive analysis of multiple analytes. Molecular analysis of CYP21A2 is useful for confirming diagnosis of mild SV or NC type, predicting prognoses, and genetic counseling. In order to make newborn screening for 21-OHD more efficient, early detection of boy with SW type, early determination of girl with ambiguous genitalia, detection of NC type, and overcoming of false positive in premature and low birth weight infants should be considered. Above all, early treatment should be started when the patient is suspected as having 21- OHD clinically before confirming the diagnosis to prevent adrenal crisis. Here, author reviewed recent articles of guideline and proposed guideline for 21-OHD.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.12
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• pp.5151-5156
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• 2010

In the previous researches for storm sewer design, the flow paths in overall network were determined to minimize the construction cost and then, it was not considered the superposition effect of runoff hydrographs in the sewer pipes. However, in this research, the flow paths are determined considering the superposition effect to reduce the inundation risk by controlling and distributing the flows in the sewer pipes. This is accomplished by distributing the inflows that enter into each junction by changing the flow path in which pipes are connected between junctions. In this paper, the superposition effect and peak outflows at outlet were analyzed considering the changes of the flow paths in the sewer network. Then, the flow paths are determined using genetic algorithm and the objective function is to minimize the peak outflow at outlet. As the applied result for the sample sewer network, the difference between maximum and minimum peak outflows which are caused by the change of flow path was about 5.6% for the design rainfall event of 10 years frequency with 30 min. duration. Also, the typhoon 'Rusa' which occurred at 2002 was applied to verify the reduction of inundation risk for the excessive rainfall, and then, the amount of overflows was reduced to about 31%.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.9
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• pp.557-567
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• 2016

In this study, the optimal design of heat exchangers, including the evaporator and condenser of a solar-heating ocean thermal energy conversion (SH-OTEC), is investigated. The power output of the SH-OTEC is assumed to be 100 kW, and the SH-OTEC uses the working fluid of R134a and high-performance commercial tubes. The surface heat transfer area and the pressure drop were strongly dependent on the number of tubes, as well as the number of tube passes. To solve the reciprocal tendency between the heat transfer area and pressure drop with respect to the number of tubes, as well as the number of tube passes, a genetic algorithm (GA) with two objective functions of the heat transfer area (the capital cost) and operating cost (pressure drop) was used. Optimal results delineated the feasible regions of heat transfer area and operating cost with respect to the pertinent number of tubes and tube passes. Pareto fronts of the evaporator and condenser obtained from multi-objective GA provides designers or investors with a wide range of optimal solutions so that they can select projects suitable for their financial resources. In addition, the surface heat transfer area of the condenser took up a much higher percentage of the total heat transfer area of the SH-OTEC than that of the evaporator.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.5
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• pp.544-551
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• 2008

QUAL2K enhanced QUAL2E and applied in real fields efficiently incorporates denitrification process, sediment-water interaction process, bottom algae and detritus. Also, the CBOD of QUAL2K is divided into two real parts, one is slow CBOD(sCBOD) and another is fast CBOD(fCBOD). The simulation results of QUAL2E and QUAL2K models in Anyang Stream were compared and analyzed in water quality constituents of DO, BOD, Org-N, NH$_3$-N, NO$_3$-N, Org-P, Dis-P and Chl-a respectively. The similar results were shown in Org-N, NH$_3$-N, Org-P and Chl-a both QUAL2K and QUAL2E models. But the different results were revealed in DO, BOD, Dis-P and NO$_3$-N by the influence of new incorporating processes. DO was shown relatively low values in the effect of bottom algae. BOD which is influenced by particulate organic matter was revealed high values. NO$_3$-N was closed to the real values by the two processes of denitrification and sediment-water interaction. To evaluate the running results of QUAL2K and QUAL2E models, a simple statistical analysis was conducted. According to the statistical analysis, QUAL2K represented less relative error and coefficient of variation than QUAL2E in almost all of constituents. It was found that QUAL2K, which simulates the water quality more realistically, can be applied to control and manage the water problems of river or river-run reservoir effectively.

• Steel and Composite Structures
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• v.34 no.5
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• pp.681-698
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• 2020

The paper addresses contribution to the modeling and optimization of major machinability parameters (cutting force, surface roughness, and tool wear) in finish dry hard turning (FDHT) for machinability evaluation of hardened AISI grade die steel D₃ with PVD-TiN coated (Al₂O₃-TiCN) mixed ceramic tool insert. The turning trials are performed based on Taguchi's L₁₈ orthogonal array design of experiments for the development of regression model as well as adequate model prediction by considering tool approach angle, nose radius, cutting speed, feed rate, and depth of cut as major machining parameters. The models or correlations are developed by employing multiple regression analysis (MRA). In addition, statistical technique (response surface methodology) followed by computational approaches (genetic algorithm and particle swarm optimization) have been employed for multiple response optimization. Thereafter, the effectiveness of proposed three (RSM, GA, PSO) optimization techniques are evaluated by confirmation test and subsequently the best optimization results have been used for estimation of energy consumption which includes savings of carbon footprint towards green machining and for tool life estimation followed by cost analysis to justify the economic feasibility of PVD-TiN coated Al₂O₃+TiCN mixed ceramic tool in FDHT operation. Finally, estimation of energy savings, economic analysis, and sustainability assessment are performed by employing carbon footprint analysis, Gilbert approach, and Pugh matrix, respectively. Novelty aspects, the present work: (i) contributes to practical industrial application of finish hard turning for the shaft and die makers to select the optimum cutting conditions in a range of hardness of 45-60 HRC, (ii) demonstrates the replacement of expensive, time-consuming conventional cylindrical grinding process and proposes the alternative of costlier CBN tool by utilizing ceramic tool in hard turning processes considering technological, economical and ecological aspects, which are helpful and efficient from industrial point of view, (iii) provides environment friendliness, cleaner production for machining of hardened steels, (iv) helps to improve the desirable machinability characteristics, and (v) serves as a knowledge for the development of a common language for sustainable manufacturing in both research field and industrial practice.

• Steel and Composite Structures
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• v.34 no.5
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• pp.743-767
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• 2020

Due to the impressive flexural performance, enhanced compressive strength and more constrained crack propagation, Fibre-reinforced concrete (FRC) have been widely employed in the construction application. Majority of experimental studies have focused on the seismic behavior of FRC columns. Based on the valid experimental data obtained from the previous studies, the current study has evaluated the seismic response and compressive strength of FRC rectangular columns while following hybrid metaheuristic techniques. Due to the non-linearity of seismic data, Adaptive neuro-fuzzy inference system (ANFIS) has been incorporated with metaheuristic algorithms. 317 different datasets from FRC column tests has been applied as one database in order to determine the most influential factor on the ultimate strengths of FRC rectangular columns subjected to the simulated seismic loading. ANFIS has been used with the incorporation of Particle Swarm Optimization (PSO) and Genetic algorithm (GA). For the analysis of the attained results, Extreme learning machine (ELM) as an authentic prediction method has been concurrently used. The variable selection procedure is to choose the most dominant parameters affecting the ultimate strengths of FRC rectangular columns subjected to simulated seismic loading. Accordingly, the results have shown that ANFIS-PSO has successfully predicted the seismic lateral load with R² = 0.857 and 0.902 for the test and train phase, respectively, nominated as the lateral load prediction estimator. On the other hand, in case of compressive strength prediction, ELM is to predict the compressive strength with R² = 0.657 and 0.862 for test and train phase, respectively. The results have shown that the seismic lateral force trend is more predictable than the compressive strength of FRC rectangular columns, in which the best results belong to the lateral force prediction. Compressive strength prediction has illustrated a significant deviation above 40 Mpa which could be related to the considerable non-linearity and possible empirical shortcomings. Finally, employing ANFIS-GA and ANFIS-PSO techniques to evaluate the seismic response of FRC are a promising reliable approach to be replaced for high cost and time-consuming experimental tests.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.3 s.357
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• pp.7-17
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• 2007

An analysis and design theory of an aperture-coupled cavity-fed back-to-back microstrip directional coupler is presented for the efficient and optimized design. For this purpose, an equivalent network is developed, and simple but accurate calculations of circuit element values are described. Design equations of the coupler are derived based on the equivalent circuit. In order to determine various structural design parameters, the evolutionary hybrid optimization method based on the genetic algorithm and Nelder-Mead method is invoked. As a validation check of the proposed theory and optimized design method, a 10 dB directional coupler was designed and fabricated. The measured coupling was 10.3 dB at 3 GHz, and the return loss and isolation were 31.8 dB and 30.5 dB, respectively. The directional coupler also showed very good quadrature phase characteristics. Good agreements between the measured and the design specifications fully validate the proposed network analysis and design procedure.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.4
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• pp.155-165
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• 2004

Hydrological model which is proper to watershed characteristics and analysis purpose must be used when we analyze water resources. But, although proper model is used, if objectivity and reasonability of data is low it is difficult to get good results from the model. So it is very important to decide the data which is used in selected model and estimate parameters by using the applied data. In this study, temporal and spatial data was constructed as standard data of test site and stored in HyGIS (Hydrological Geographic Information System) DB. A system which extracts temporal and spatial data required to run hydrological model from HyGIS DB by connecting TOPMODEL with HyGIS was developed. In this system, we can extract temporal and spatial data which is needed to run TOPMODEL from HyGIS DB and estimate model parameters by using genetic algorithm. We found that HyGIS and the system connected with TOPMODEL was effective to make temporal and spatial data used in TOPMODEL and estimate model parameters. From this study, we suggested the possibility that HyGIS could be applied properly to another hydrological model, too.