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StrokeBase: A Database of Cerebrovascular Disease-related Candidate Genes

  • Kim, Young-Uk;Kim, Il-Hyun;Bang, Ok-Sun;Kim, Young-Joo
    • Genomics & Informatics
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    • v.6 no.3
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    • pp.153-156
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    • 2008
  • Complex diseases such as stroke and cancer have two or more genetic loci and are affected by environmental factors that contribute to the diseases. Due to the complex characteristics of these diseases, identifying candidate genes requires a system-level analysis of the following: gene ontology, pathway, and interactions. A database and user interface, termed StrokeBase, was developed; StrokeBase provides queries that search for pathways, candidate genes, candidate SNPs, and gene networks. The database was developed by using in silico data mining of HGNC, ENSEMBL, STRING, RefSeq, UCSC, GO, HPRD, KEGG, GAD, and OMIM. Forty candidate genes that are associated with cerebrovascular disease were selected by human experts and public databases. The networked cerebrovascular disease gene maps also were developed; these maps describe genegene interactions and biological pathways. We identified 1127 genes, related indirectly to cerebrovascular disease but directly to the etiology of cerebrovascular disease. We found that a protein-protein interaction (PPI) network that was associated with cerebrovascular disease follows the power-law degree distribution that is evident in other biological networks. Not only was in silico data mining utilized, but also 250K Affymetrix SNP chips were utilized in the 320 control/disease association study to generate associated markers that were pertinent to the cerebrovascular disease as a genome-wide search. The associated genes and the genes that were retrieved from the in silico data mining system were compared and analyzed. We developed a well-curated cerebrovascular disease-associated gene network and provided bioinformatic resources to cerebrovascular disease researchers. This cerebrovascular disease network can be used as a frame of systematic genomic research, applicable to other complex diseases. Therefore, the ongoing database efficiently supports medical and genetic research in order to overcome cerebrovascular disease.

Influence Analysis of Sampling Points on Accuracy of Storage Reliability Estimation for One-shot Systems (원샷 시스템의 저장 신뢰성 추정 정확성에 대한 샘플링 시점의 영향 분석)

  • Chung, Yong H.;Oh, Bong S.;Lee, Hong C.;Park, Hee N.;Jang, Joong S.;Park, Sang C.
    • Journal of Applied Reliability
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    • v.16 no.1
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    • pp.32-40
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    • 2016
  • Purpose: The purpose of this study is to analyze the effect of sampling points on accuracy of storage reliability estimation for one-shot systems by assuming a weibull distribution as a storage reliability distribution. Also propose method for determining of sampling points for increase the accuracy of reliability estimation. Methods: Weibull distribution was divided into three sections for confirming the possible to estimate the parameters of the weibull distribution only some section's sample. Generate quantal response data for failure data. And performed parameter estimation with quantal response data. Results: If reduce sample point interval of 1 section, increase the accuracy of reliability estimation although sampling only section 1. Even reduce total number of sampling point, reducing sampling time interval of the 1 zone improve the accuracy of reliability estimation. Conclusion: Method to increase the accuracy of reliability estimation is increasing number of sampling and the sampling points. But apply this method to One-shot system is difficult because test cost of one-shot system is expensive. So propose method of accuracy of storage reliability estimation of one-shot system by adjustment of the sampling point. And by dividing the section it could reduce the total sampling point.

Mobile Camera Processor Design with Multi-lane Serial Interface (멀티레인을 지원하는 모바일 카메라용 직렬 인터페이스 프로세서 설계)

  • Hyun, Eu-Gin;Kwon, Soon;Lee, Jong-Hun;Jung, Woo-Young
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.44 no.7 s.361
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    • pp.62-70
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    • 2007
  • In this paper, we design a mobile camera processor to support the MIPI CSI-2 and DPHY specification. The lane management sub-layer of CIS2 handles multi-lane configuration. Thus conceptually, the transmitter and receiver have each independent buffer on multi lanes. In the proposed architecture, the independent buffers are merged into a single common buffer. The single buffer architecture can flexibly manage data on multi lanes though the number of supported lanes are mismatched in a camera processor transmitter and a host processor. For a key issue for the data synchronization problem, the synchronization start codes are added as the starting for image data. We design synchronization logic to synchronize the received clock and to generate the byte clock. We present the verification results under proposed test bench. And we show the waves of simulation and logic synthesis results of the designed processor.

Forecasting the Port Trading Volumes for Improvement of Port Competitive Power (항만경쟁력 제고를 위한 항만교역량 예측)

  • Son, Yong-Jung
    • Journal of Korea Port Economic Association
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    • v.25 no.1
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    • pp.1-14
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    • 2009
  • This study predicted Port trade volume by considering Korea's export to China and import Com China separately using ARIMA model (Multiplicative Seasonal ARIMA Model). We predicted monthly Port trade volumes for 27 months from October 2008 to December 2010 using monthly data from September 2008 to January 2001 using monthly data. As a result of prediction, we found that the export volume decreased in January, February, August and September while the import volume decreased in February, March, August and September. As the decrease period was clearly differentiated, it was possible to predict export and import volumes. Therefore, it is believed that the results of this study will generate useful basic data for policy makers or those working for export and import enterprises when they set up policies and management plans. And to improve competitive power of Port trade, this study suggests privatization of Port, improvement of information capability, improvement of competitive power of Port management companies, support for Port distribution companies, plans for active encouragement of transshipment, and management of added value creation policy.

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Comparison between wind load by wind tunnel test and in-site measurement of long-span spatial structure

  • Liu, Hui;Qu, Wei-Lian;Li, Qiu-Sheng
    • Wind and Structures
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    • v.14 no.4
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    • pp.301-319
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    • 2011
  • The full-scale measurements are compared with the wind tunnel test results for the long-span roof latticed spatial structure of Shenzhen Citizen Center. A direct comparison of model testing results to full-scale measurements is always desirable, not only in validating the experimental data and methods but also in providing better understanding of the physics such as Reynolds numbers and scale effects. Since the quantity and location of full-scale measurements points are different from those of the wind tunnel tests taps, the weighted proper orthogonal decomposition technique is applied to the wind pressure data obtained from the wind tunnel tests to generate a time history of wind load vector, then loads acted on all the internal nodes are obtained by interpolation technique. The nodal mean wind pressure coefficients, root-mean-square of wind pressure coefficients and wind pressure power spectrum are also calculated. The time and frequency domain characteristics of full-scale measurements wind load are analyzed based on filtered data-acquisitions. In the analysis, special attention is paid to the distributions of the mean wind pressure coefficients of center part of Shenzhen Citizen Center long-span roof spatial latticed structure. Furthermore, a brief discussion about difference between the wind pressure power spectrum from the wind tunnel experiments and that from the full-scale in-site measurements is compared. The result is important fundament of wind-induced dynamic response of long-span spatial latticed structures.

The Development of Infrared Thermal Imaging Safety Diagnosis System Using Pearson's Correlation Coefficient (피어슨 상관계수를 이용한 적외선 열화상 안전 진단 시스템 개발)

  • Jung, Jong-Moon;Park, Sung-Hun;Lee, Yong-Sik;Gim, Jae-Hyeon
    • Journal of the Korean Solar Energy Society
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    • v.39 no.6
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    • pp.55-65
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    • 2019
  • With the rapid development of the national industry, the importance of electrical safety was recognized because of a lot of new electrical equipment are installing and the electrical accidents have been occurring annually. Today, the electrical equipments is inspect by using the portable Infrared thermal imaging camera. but the most negative element of using the camera is inspected for only state of heating, the reliable diagnosis is depended with inspector's knowledge, and real-time monitoring is impossible. This paper present the infrared thermal imaging safety diagnosis system. This system is able to monitor in real time, predict the state of fault, and diagnose the state with analysis of thermal and power data. The system consists of a main processor, an infrared camera module, the power data acquisition board, and a server. The diagnostic algorithm is based on a mathematical model designed by analyzing the Pearson's Correlation Coefficient between temperature and power data. To test the prediction algorithm, the simulations were performed by damaging the terminals or cables on the switchboard to generate a large amount of heat. Utilizing these simulations, the developed prediction algorithm was verified.

A Segmented Morphology Filter for Airborne LiDAR Data (Airborne LiDAR 필터에 관한 연구)

  • Choi, Seung-Sik;Song, Nak-Hyeon;Cho, Woo-Sug
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.25 no.1
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    • pp.55-62
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    • 2007
  • Recent advances in airborne LiDAR technology allow rapid and inexpensive measurements of topography over large areas. The generation of DTM/DEM is essential to numerous applications such as the fields of civil engineering, environment, city planning and flood modeling. The demand for LiDAR data is increasing due to the reduced cost for DTM generation and the increased reliability, precision and completeness. In order to generate DTM, measurements from non-ground features such as building and vegetation have to be classified and removed. In this paper, a segmented morphology filter was developed to detect non-ground LiDAR measurements. First, segments LiDAR point clouds based on the elevation. Secondly classifies those protruding segments into non-ground points. Those non-ground points such as building and vegetation are removed, while ground points are preserved for DTM generation. For experiments, data sets used in Comparison of Filters (ISPRS, 2003) depicting urban and rural areas were selected. The experimental results show that the proposed filter can remove most of the non-ground points effectively with less commission and omission errors.

Sequence Mining based Manufacturing Process using Decision Model in Cognitive Factory (스마트 공장에서 의사결정 모델을 이용한 순차 마이닝 기반 제조공정)

  • Kim, Joo-Chang;Jung, Hoill;Yoo, Hyun;Chung, Kyungyong
    • Journal of the Korea Convergence Society
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    • v.9 no.3
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    • pp.53-59
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    • 2018
  • In this paper, we propose a sequence mining based manufacturing process using a decision model in cognitive factory. The proposed model is a method to increase the production efficiency by applying the sequence mining decision model in a small scale production process. The data appearing in the production process is composed of the input variables. And the output variable is composed the production rate and the defect rate per hour. We use the GSP algorithm and the REPTree algorithm to generate rules and models using the variables with high significance level through t-test. As a result, the defect rate are improved by 0.38% and the average hourly production rate was increased by 1.89. This has a meaning results for improving the production efficiency through data mining analysis in the small scale production of the cognitive factory.

An Analysis of the 2017 Korean Presidential Election Using Text Mining (텍스트 마이닝을 활용한 2017년 한국 대선 분석)

  • An, Eunhee;An, Jungkook
    • Journal of the Korea Convergence Society
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    • v.11 no.5
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    • pp.199-207
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    • 2020
  • Recently, big data analysis has drawn attention in various fields as it can generate value from large amounts of data and is also used to run political campaigns or predict results. However, existing research had limitations in compiling information about candidates at a high-level by analyzing only specific SNS data. Therefore, this study analyses news trends, topics extraction, sentiment analysis, keyword analysis, comment analysis for the 2017 presidential election of South Korea. The results show that various topics had been generated, and online opinions are extracted for trending keywords of respective candidates. This study also shows that portal news and comments can serve as useful tools for predicting the public's opinion on social issues. This study will This paper advances a building strategic course of action by providing a method of analyzing public opinion across various fields.

A Study on the quantitative Evaluation of Spasticity Implementing Pendulum Test (진자실험을 통한 경직의 정량적 평가에 관한 연구)

  • Lim H.K.;Cho K.H.;Kim B.O.;Chae J.M.;Lee Y.S.
    • Journal of Biomedical Engineering Research
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    • v.21 no.3 s.61
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    • pp.303-309
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    • 2000
  • An accurate quantitative biomechanical evaluation for the spasticity caused by the disorder of central nervous system was made in this study. A sudden leg dropper was designed to generate objective testing environment at every trial. 3-dimensional motion analysis system(Elite. B.T.S. Italy) was used to measure kinematic data which were angle. and angular velocity of a lower limb. A program was developed to analyze the kinematic data of lower limb motion. and dynamic EMG data at the same time. To evaluate spasticity quantitatively. total 26 parameters including 14 parameters newly driven were analyzed, and statistical analysis were made for bilateral correlations. Results showed possibility to make accurate quantitative and objective evaluation for spasticity with various new parameters using new devices and program.

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