• 한국수학사학회지
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• 제36권3호
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• pp.37-57
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• 2023

In the history of elementary school mathematics education in Korea, the period led by the Government-General of Joseon during the Japanese colonial period cannot be omitted. As a way to grasp the real state of elementary school mathematics education at that time, there is a method of analyzing elementary school mathematics textbooks published by the Government-General of Joseon. However, the actual state of the publication of them was not sufficiently known. For this reason, this study surveys the actual state of the publication of those textbooks. To this end, real information on textbooks owned currently by various institutions and information on the publication of those textbooks in the official gazette and documents of the Government-General of Joseon were checked and organized.

• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.133-137
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• 2005

Underlying neuropathies combined with amyotrophic lateral sclerosis (ALS) cast doubt on the diagnosis of ALS when present. Abnormal sural nerve conductions were found in 3 patients with clinically definite ALS. Pathologically demyelinating, axonal, or vasculitic neuropathy was suggested respectively. High dose oral corticosteroid had no effect and clinical courses were deteriorating in all the patients. The causes of combined neuropathies were unclear. Possibility of direct consequence of ALS, concomitant neuropathies, or rare variants of ALS should be considered in these cases.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1990년도 제29차 춘계학술대회
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• pp.199-200
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• 1990

• Korean Journal of Radiology
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• 제24권3호
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• pp.173-176
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• 2023

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 제51차 추계학술대회
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• pp.153.2-154
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• 2006

• Advances in nano research
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• 제12권6호
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• pp.639-652
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• 2022

The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.

• 수산해양교육연구
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• 제22권1호
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• pp.25-37
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• 2010

This study was attempted to analyze the change process of fisheries track's high school curriculum related with the 5th-7th revised national curriculum. To accomplish this goal, the nature and goals of fisheries track's high school were reviewed. First, it was found that the fisheries track's high school was classified into three groups; high school for special goal, characterization, and industry. And the goal of fisheries track's high school was designated to harmonize the general education and vocational education in high school goal. Second, the legal basis and system of national curriculum in fisheries track's high school were discussed. The legal basis of national curriculum in fisheries track's high school was prescribed to the 'Elementary and Secondary Education Act'. The system of national curriculum was composed the general guideline and subjects. Third, the change process of fisheries track's high school national curriculum was discussed. The system of decision, general guideline, and subjects in fisheries track's high school national curriculum were seemingly to be studied on the basis of the autonomy or diversity. In conclusion, the concrete content of fisheries track's high school national curriculum was not changed compared to the 5th-7th revised curriculum.

• Tuberculosis and Respiratory Diseases
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• 제77권5호
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• pp.209-214
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• 2014

Background: Bronchiectasis and asthma are different in many respects, but some patients have both conditions. Studies assessing the effect of bronchiectasis on asthma exacerbation are rare. The aim of this study is to investigate the effect of bronchiectasis on asthma exacerbation. Methods: We enrolled 2,270 asthma patients who were followed up in our hospital. Fifty patients had bronchiectasis and asthma. We selected fifty age- and sex-matched controls from the 2,220 asthma patients without bronchiectasis, and assessed asthma exacerbation and its severity based on the annual incidence of total asthma exacerbation, annual prevalence of steroid use, and frequency of emergency room visits and hospitalizations due to asthma exacerbation in each group. Results: Fifty patients (2.2%) had bronchiectasis and asthma. The annual incidence of asthma exacerbation was higher in patients with asthma and bronchiectasis than in patients with asthma alone ($1.08{\pm}1.68$ vs. $0.35{\pm}0.42$, p=0.004). The annual prevalence of steroid use ($0.9{\pm}1.54$ vs. $0.26{\pm}0.36$, p=0.006) and the frequency of emergency room visits ($0.46{\pm}0.84$ vs. $0.02{\pm}0.13$, p=0.001) due to asthma exacerbation were also higher in patients with asthma and bronchiectasis than in patients with asthma alone. Conclusion: Bronchiectasis is associated with difficult asthma control.

• 한국학교보건학회지
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• 제17권2호
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• pp.151-160
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• 2004

Purpose: The purpose of this study was to identify needs of health education of the students, parents, general teachers, and health teacher of the elementary, middle, and high schools. Method: 279 schools of elementary, middle, and high school were sampled nonproportionally during the period from June 28 to July 26, 2004 The data were collected by the questionnaire from 1,888 students, 1,876 parents, 1,695 general teachers, 279 health teachers. A frequency, % and $x^2-test$ were used to analysis by SAS program. Result: 1. It showed that 98.1% of elementary school students, 92.3% of middle school students, 89.6% of high school students answered that they need health education. The most of students, parents, and general teachers had high interests in health education. 2. In the case of students, main causes of needs of health education was 'to prevent diseases or accidents'. But parents answered that it was 'to build up a healthier behavior'. General teachers answered that it was 'more effective systematic and continuous health education'. 3. Over 80% of students, parents, and general teachers about the question of who qualified person is to teach health education as a regular class responded that health teacher is available. Especially 93% of elementary school students answered like that. 4. The most of students, parents, and general teachers answered that health education in the classroom is favorable 1 to 2 hours per week. Conclusion: As results of the study, the majority of students, parents, general teachers agreed needs of health education. Therefore, on the basis of this study, systematic and continuous health education is necessary. Additionally the establishment of independent health subject is required certainly.

• 비교교육연구
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• 제24권3호
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• pp.71-99
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• 2014

본 연구는 고교 다양화 및 특성화고 육성 정책으로 인해 상대적으로 불이익을 받고 있는 일반고의 교육역량 강화 방안을 탐색 제시하기 위해 교육수요자인 학생과 학부모들의 일반고 교육프로그램에 대한 만족도와 선호도를 분석하였다. 이를 토대로 장 단기적인 관점에서 경상북도 일반고의 교육역량을 제고하기 위한 시사점을 도출하는데 그 목적이 있다. 연구대상으로는 경상북도 소재 일반고 총 31개교의 학부모 3,383명, 학생 7,953명의 설문 응답결과를 분석하였다. 분석결과 전반적으로 교육역량강화 정책에서 추진되고 있는 프로그램에 대한 만족도는 중간수준이며, 학부모와 비교했을 때 학생의 만족도가 상대적으로 낮게 나타났다. 학교규모별에서는 소규모학교의 교육프로그램에 대한 학생들과 학부모들의 만족도가 높게 나타나, 소규모 학교가 가지는 협동적 학교조직 문화형성의 중요성이 부각되었다. 실천 전략의 선호도에서는 학교규모별, 신분별로 통계적으로 유의한 차이를 보였다. 향후 일반고 교육역량 강화 전략 수립에서 교육 수요자들의 다양한 요구를 조화롭게 반영할 수 있도록 단위학교별로 전략수립에 자율성을 확대해야 할 것이다.