• Journal of Microbiology and Biotechnology
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• v.20 no.11
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• pp.1484-1490
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• 2010

In the Streptomyces hygroscopicus JCM4427 geldanamycin biosynthetic gene cluster, five putative regulatory genes were identified by protein homology searching. Among those genes, gel14, gel17, and gel19 are located downstream of polyketide synthase genes. Gel14 and Gel17 are members of the LAL family of transcriptional regulators, including an ATP/GTP-binding domain at the N-terminus and a DNA-binding helix-turn-helix domain at the C-terminus. Gel19 is a member of the TetR family of transcriptional regulators, which generally act to repress transcription. To verify the biological significance of the putative regulators in geldanamycin production, they were individually characterized by gene disruption, genetic complementation, and transcriptional analyses. All three genes were confirmed as positive regulators of geldanamycin production. Specifically, Gel17 and Gel19 are required for gel14 as well as gelA gene expression.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.455-458
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• 2001

A twelve-month old female, shih-tzu, was presented to diagnose a hind limb ataxia to the Animal Teaching Hospital, Gyeongsang National University. Even though a variety of physical and neurological examination was performed, the cause of the ataxia was not understood. In serum analysis, an elevated levels of ALT, $\gamma$-GTP and LDH were found. A gallstone was subsequently observed at the right 9 and 10th intercostal region on ultrasonography and radiography. Cholelithiasis was diagnosed, and then cholecystotomy was undertaken. No complications were occurred after the operation. The gallstone removed by cholecystotomy was composed of calcium, carbonate and oxalate, identified by a black pigment gallstone.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.183-183
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• 1998

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. Telomerase activation and telomere shortening in human somatic cells have been implicated in cell tumorigenesis and immortalization. In order to find the potential inhibitors against telomerase activitiy which can be used as potential anticancer agents, we screened about 100 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from methanol extracts. The inhibitory effects of these materials against telomerase enzyme activity were tested in 293T cell culture using telomeric repeat amplification protocol(TRAP). The incorporation of $\^$32/P-dGTP into amplified DNA was measured by adsorption to Whatman DE81 paper instead of using TRAP assay for screening the extracts of natural products. Strong effective compounds were not found in this study but DE81 filter spotting method may be a useful model for the screening. Some of the compounds which showed somewhat inhibitory effects had cytotoxic effects also.

• Journal of Food Hygiene and Safety
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• v.10 no.4
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• pp.249-254
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• 1995

In order to study the effects of Aloe vera Linne treatment on the clinical chemistry in patients with liver disease, seven patients were administered orally with 800~1, 600 mg of Aloe vera Linne four times day for six months. The high levels of serum AST, ALT, ALP, ${\gamma}$-GTP and total bilirubin in patients were significantly reduced by adminstration of Aloe vera L. The reduced serum albumin/globulin value was increased by Aloe vera L. treatment. But other blood parameters of clinical chemistry values were not affected by Aloe vera L. treatment. These data suggest that Aloe vera L. can be effective in treatment of the patients with liver disease.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2001.05a
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• pp.69-70
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• 2001

인터넷의 폭발적인 증가와 다양한 무선 서비스에 대한 계속적인 수요 증가에 따라 용량이 크고, 데이터 전송 속도가 빠르며, 멀티미디어를 지원할 수 있는 무선 서비스가 필요하게 되었다. 비동기식 제3세대 이동통신시스템에서 단말과 인터넷망을 연결하는 GPRS network에서 GGSN의 인터넷 패킷 트래픽을 효과적으로 처리할 수 있는 방안이 연구되어져야 한다. GGSN은 기존의 라우터 처럼 하드웨어적으로 구현되는 것이 이상적이지만 GTP(GPRS Tunneling Protocol) 가 추가되므로 좀더 복잡한 형태의 gateway가 초기단계에서는 소프트웨어적으로 구현되어 질것이다. 이러한 GGSN의 성능과 용량을 최적화 시키기 위한 패킷 트래픽 처리방안에 대한 연구가 필요하다. 본 논문에는 GGSN의 하향 링크상에 서 입력되는 각 클래스별 크래픽 모델을 정립하고 트래픽에 대한 특성과 버퍼 관리에 대해 살펴본다.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.6
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• pp.944-947
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• 1997

Docosahexaenoic acid (DHA) rich oil was obtained from blue fin tuna (Thunnus thynnus orientalis) orbital tissue with centrifugation of 12,000 rpm under vaccum $(10^{-1}\;Torr)\;at\;4^{\circ}C$. The effect of DHA rich oil (DHA content; $27.8\%$) on $CCl_4-induced$ acute injury was investigated biochemically and histopathologically. Dosage of DHA rich oil on 24h before $ CCl_4-administration$ prevented significantly the increase of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GTP) values. No necrosis of hepatocytes was observed in rat livers treated with DHA oil on 24h prior to $CCl_4-administration$. These results suggested that DHA oil controls the accumulation of fat in the liver and prevented the liver injury.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.273-278
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• 1997

Several serum enzyme activities were measured after intraBeritoneal administration of 0.01 ml $CCl_{4}$ per 100 g of body weight in Sprague Dawley rats. Senun AST activity increased significantly after administration of CCl$_{4}$ (P<0.05). The serum AST activity at 2 hours after $CCl_{4} administration (475 {\pm} 10^{6} IU/L)$ was significantly higher than that of control group $(65 {\pm} 14 IU/L)$. The high level of serum AST activity maintained up to 48 hours. Serum ALT activity in $CCl_{4}$-treated groups was also significantly higher from 4 hours after treatment companied to control group and the high level maintained up to 48 hours. Serum ALP and ${\gamma} GTP activities in CCl_{4}$-treated groups were significantly higher from 8 hours after treatment compared to control group and the level maintained up to 48 hours.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.11b
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• pp.1431-1434
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• 2002

현재 통신 시장의 패러다임이 음성 서비스 위주에서 IP 기반의 데이터 서비스 중심으로 변화하고, 개방화된 유무선 인터넷 서비스를 제공하려고 함에 따라 이동 통신망과 인터넷 망을 연동하는 개방형 유무선 게이트웨이는 필수적인 사항이 되었다. 이를 위해서 UMTS 이동 통신 시스템에서는 GGSN 이라는 개방형 유무선망 연동 게이트웨이를 제공하고 있다. UMTS 이동 통신 망에서는 무선 인터페이스를 통해 전달되는 IP 패킷을 위한 GPRS 망을 정의하고 있다. UMTS GPRS 망은 패킷 스위치 기능을 하는 SGSN 과 무선망과 인터넷망간에 연동을 위한 GGSN 을 중심 축으로 하여 구성되어 있으며, 이들간은 GTP 프로토콜를 이용하여 통신을 한다. 본 논문에서는 개방형 유무선 연동 게이트웨이인 GGSN 기능 구현을 위한 프래임웍 설계 및 구현에 관한 논문이다.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2419-2422
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• 2012

• Clinical and Experimental Reproductive Medicine
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• v.38 no.1
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• pp.1-5
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• 2011

The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.