Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Administration of CCl$_{4}$ on Liver Function in Rats 2. Serum Enzyme Activities

사염화탄소(CCl$_{4}$)의 투여가 쥐의 간기능에 미치는 영향 2. 혈청 효소 활성치

  • 강정부 (경상대학교 수의과대학(동물의학 연구소)) ;
  • 이은석 (마산 창생동물병원) ;
  • 허주헝 (부평 고려동물병원)
  • Published : 1997.06.01
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Abstract

Several serum enzyme activities were measured after intraBeritoneal administration of 0.01 ml $CCl_{4}$ per 100 g of body weight in Sprague Dawley rats. Senun AST activity increased significantly after administration of CCl$_{4}$ (P<0.05). The serum AST activity at 2 hours after $CCl_{4} administration (475 {\pm} 10^{6} IU/L)$ was significantly higher than that of control group $(65 {\pm} 14 IU/L)$. The high level of serum AST activity maintained up to 48 hours. Serum ALT activity in $CCl_{4}$-treated groups was also significantly higher from 4 hours after treatment companied to control group and the high level maintained up to 48 hours. Serum ALP and ${\gamma} GTP activities in CCl_{4}$-treated groups were significantly higher from 8 hours after treatment compared to control group and the level maintained up to 48 hours.

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