• Fisheries and Aquatic Sciences
• /
• v.22 no.5
• /
• pp.9.1-9.7
• /
• 2019

The study investigated the changes in growth performance, hematological parameters, plasma components, and stress indicators of juvenile starry flounder, Platichthys stellatus, depending on varying exposure to hexavalent chromium. P. stellatus was exposed to waterborne chromium at 0, 50, 100, 200, and 400 ppb for 4 weeks. The result showed that Cr exposure resulted in decreased daily length gain (DLG), daily weight gain (DWG), condition factor (CF), and hepatosomatic index (HIS) in P. stellatus. In terms of hematological parameters, red blood cell (RBC) count, hematocrit (Ht), and hemoglobin (Hb) significantly decreased at 400 ppb after 2 weeks. In terms of plasma components, inorganic analysis was unchanged and cholesterol, an organic component, considerably increased at 400 ppb after 4 weeks. Plasma enzyme components including glutamic oxalate transaminase (GOT) and glutamic pyruvate transaminase (GPT) were significantly increased. Stress indicators such as cortisol and glucose were notably increased over 100 ppb after 4 weeks with increasing chromium concentration. The results indicate that exposure to waterborne Cr induced toxic effects on growth, hematological parameters, plasma components, and stress indicators.

• Annual Conference on Human and Language Technology
• /
• 2022.10a
• /
• pp.71-76
• /
• 2022

목적 지향 대화 시스템은 사용자가 원하는 목적을 달성하기 위해 사용하는 시스템으로 일상 대화와 다르게 시스템이 정보를 명확히 전달하는 것이 중요하다. 따라서 최근 연구에서 목적 지향 대화 시스템을 위한 자연어 생성 모델은 정해진 대화 정책에 따라 알맞은 응답을 생성할 수 있도록 의도와 슬롯 정보를 담은 대화 행위(Dialog Act)를 활용한다. 하지만 대화 행위는 생성하는 문장을 탁월하게 제어하는 반면에 대화의 흐름과 상황에 맞게 다양한 문장을 생성하기 어렵다는 문제점을 가지고 있다. 이러한 문제점을 해소하고자 본 논문에서는 목적에 부합하는 내용을 명확하게 자연어로 생성하기 위해 대화 행위를 사용하면서 동시에 일상 대화 생성 모델과 같이 문맥을 고려하여 대화 흐름에 어울리는 자연스러운 문장을 생성할 수 있는 문맥 기반의 제어 가능한 자연어 생성 모델을 제안한다. 실험에서는 KoGPT2 사전 학습 모델과 한국어 대화 데이터셋을 사용하였으며 실험을 통해 대화 행위 기반의 자연어 생성 모델과 본 연구에서 제안한 문맥 기반의 제어 가능한 자연어 생성 모델을 비교하였다. 결과적으로 대화 행위를 단독으로 학습한 모델보다 일정 문맥을 함께 학습한 모델이 유의미한 BLEU 점수 향상을 보인다는 점을 확인하였다.

• Annual Conference on Human and Language Technology
• /
• 2022.10a
• /
• pp.531-534
• /
• 2022

신경망 기반 심층학습 기술은 대화처리 분야에서 대폭적인 성능 개선을 가져왔다. 특히 GPT-2와 같은 대규모 사전학습 언어모델을 백본 네트워크로 하고 특정 도메인 타스크 대화 데이터에 대해서 미세조정 방식으로 생성되는 종단형 대화모델의 경우, 해당 도메인 타스크에 대해서 높은 성능을 내고 있다. 하지만 이런 연구들은 대부분 하나의 도메인에 대해서만 초점을 맞출 뿐 싱글 모델로 두 개 이상의 도메인을 고려하고 있지는 않다. 특히 순차적인 미세 조정은 이전에 학습된 도메인에 대해서는 catastrophic forgetting 문제를 발생시킴으로써 해당 도메인 타스크에 대한 성능 하락이 불가피하다. 본 논문에서는 이러한 문제를 해결하기 위하여 MultiWoz 목적지향 대화 데이터에 오픈 도메인 칫챗 대화턴을 유사도에 기반하여 추가하는 데이터 증강 방식을 통해 사용자 입력 및 문맥에 따라 MultiWoz 목적지향 대화와 오픈 도메인 칫챗 대화를 함께 생성할 수 있도록 하였다. 또한 목적지향 대화와 오픈 도메인 칫챗 대화가 혼합된 대화에서의 시스템 응답 생성 성능을 평가하기 위하여 오픈 도메인 칫챗 대화턴을 수작업으로 추가한 확장된 MultiWoz 평가셋을 구축하였다.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2024.05a
• /
• pp.490-493
• /
• 2024

현재 다양한 분야에서 AI 가 사용되고 있다. 최근에는 소프트웨어공학 관점에서 요구 사항 분석에 Chat GPT 와 같은 LLM 모델을 적용하고 있다. 하지만 1) 대부분의 생성형 AI 는 불투명한 공정을 통해 3D 이미지가 생성하고, 3D 이미지를 생성할 때마다 다른 이미지를 생성한다. 이에 따라 동일한 인물이나 사물을 사용하고 싶은 사용자들은 동일한 객체가 들어간 그림을 일관성 있게 생성할 수 없다. 2) 또한 LLM 과 이미지 생성 AI 와의 결합이 시도 되고 있지만 문장 의미 분석 성능이 부족하다. 이를 해결하기 위해, 자연어 요구사항을 언어학적 기법을 통해 분석하고, 분석 결과를 기반으로 UML 시퀀스 다이어그램 및 3D 객체 생성 메커니즘을 제안한다. 즉 언어학적 분석 기법을 통해, 요구사항의 정확한 의미와 속성을 추출한다. 그런 다음 추출된 정보를 시퀀스 다이어그램과 매핑하여 3D 객체 이미지를 생성한다. 제안하는 방법을 통해 3D 객체 생성의 소프트웨어 개발 공정 사용으로 생산성을 높여 시간과 비용을 단축할 수 있을 것으로 기대한다.

• Herbal Formula Science
• /
• v.10 no.1
• /
• pp.169-180
• /
• 2002

This study was performed to investigate the effects of Radix Puerariae (RP), Flos Puerariae (FP) and Caules in Liquamen Phyllostachyos+Radix Puerariae water extracts on the alcohol dehydrogenase (ADH). transaminase (GOT, GPT) activities, and two hepatic antioxidant enzyme (SOD, catalase) activities in acute ethanol administered mice, and we have investigated the morphological changes that occur in hepatocytes of the experimental mice. The activities of ADH decreased compared with control group in the A1(66%), C1(57%), C2(54%) groups. The transaminase activites increased in the control groups compared with experimental groups. Ethanol treatment group without the RP or FP administration significantly lowered the activities of hepatic SOD and catalase, whereas MnSOD increased in the A1(27%) and B2(43%)groups, CuZnSOD increased in the B2(25%) and C2 groups. The catalase activites were increased in the A1(270%), A2(478%), B2(487%) and B1(770%) compared with control group, A lot of PAS-positive granules were observed in the A1, A2, C1 and C2 groups compared with the other groups. These results suggested that RP, FP and RP+Bamboo extracts administration may be prevent from liver damage in the alcohol treatment mice.

• BMB Reports
• /
• v.29 no.5
• /
• pp.429-435
• /
• 1996

To investigate the structure-antagonistic relationship of the cyclohexapeptide L-659,877, a selective NK-2 tachykinin receptor antagonist, seven analogues were chemically synthesized by a solid phase method. The agonistic and antagonistic activities of the analogues were evaluated by contraction assay using the smooth muscle of guinea pig trachea (GPT) containing the NK-2 receptor. It was shown that the aromatic ring of Phe at position 3 and the sulfur group of Met at position 6 in L-659,877 were essential for binding to the NK-2 receptor. Decrease in antagonistic activity of L-659,877 caused by substituting Leu for Nle at position 5 indicates that the ${\gamma}$ methyl group and side chain length of Leu plays an important role in its antagonistic action. Although the activity was slightly lower than L-659,877, cyclo $[{\beta}Ala^{8}]NKA(4-10)$ (analogue 1) showed potential antagonistic activity for the NK-2 receptor. It was confirmed that the expansion of the ring in L-659,877 by substitution of ${\beta}Ala$ for Gly at position 4 stabilized its conformation monitored by CD spectra. The results suggest that analogue 1 can be used as a new leader compound to design a more powerful, selective, and stable NK-2 receptor antagonist.

• Journal of the Korean Society of School Health
• /
• v.17 no.1
• /
• pp.55-69
• /
• 2004

Purpose ： To describe epidemiological characteristics and related factors in school personnel with hypertension. Method ： 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=100 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results ： Normotension was 20.13% in males and 48.65% in female, prehypertension 43.4% in males and 38.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a higher BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions ： It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.

• Journal of Veterinary Clinics
• /
• v.16 no.1
• /
• pp.86-94
• /
• 1999

To invstigate the available dosage and effects of xylazine as preanesthetics on the propofol anesthesia in the dog, the experimental animals were randomly divided into 3 groups (xylazine 0.55 mg/kg (group 1), 1 mg/kg (group 2) and 2 mg/kg (group 3) were premedicated) and, monitored analgesic and anesthetic effect, body temperature, respiratory rate (breaths/minute), heart rate (beats/minutes). Also, hematological and serum chemical changes were monitored. In all experimental groups, the animals were recumbent just after propofol injection and time difference was not detected. Except vomitting after xylazine injection and insignificant ataxia during recovery, no significant side effects were observed. In group 2, loss of toe-web needle prick response time was slightly longer than group 1 but the response in group 2 and group 3 were similar, In group 2 and 3, the duration of anesthesia was longer than group 1 (2 folds) but there was no difference between group 2 and 3. Recovery time was prolonged in proportion to administration dosage of xylazine. In all experimental groups, the body temperature of animals was decresed gradually according to experimental time but no significant changes were monitored. The heart rate and respiratory rate were significantly (p<0.01, p<0.05) decreased after propofol injection Hematologically, no significant changes were monitored in total leukocye numbers, total erythrocye numbers, MCV, MCH, MCHC, serum GOT and GPT values Significant changes in all groups were not observed except significant increase in BUN, total-protein and abumin values of group 3. On the basis of these result, premedication of xylazine can be helpful in decresing some side effects and the dosage of propofol. 1 mg/kg of xylazine as preanesthetics on the propofol anesthesia in the dog is considered to be available.

• Korean Journal of Agricultural Science
• /
• v.11 no.2
• /
• pp.303-314
• /
• 1984

In order to study the safety of ginseng ingested as a food substance, rats were fed ginseng added feed (subgroup 1: 0.625g/kg feed; subgroup 2: 1.25g/kg feed; subgroup 3: 2.5g/kg feed) for periods up to 6 months. Growth rates, blood composition, blood cell counts, and histopathological studies were carried out on both the control and test animals to study the effect of ingested ginseng. Following results were obtained: 1. The growth rates of the test and control animals were similar with the exception of the subgroup 3 in the 2-month fed animals who had a lower weight gain, and the subgroup 2 in the 4-month fed group who had a higher weight gain than the controls. 2. Liver, spleen, kidney, brain, lung and heart weights were similar between the test and the controls. 3. RBC, WBC, hematocrit, and hemoglobin values were similar between the test and control animals. the blood composition determination showed a similar level of alkaline phosphatase, triglyceride, total cholesterol, S-GOT, free cholesterol between the test and controls. However, free fatty acid, total lipid and S-GPT levels decreased while phospholipid, total protein, and HDL-cholesterol levels tended to increase. 4. Fl, F2 generations showed no abnormai values in blood count, organ weight and external appearance. 5. No histopathological differences were observed between the test and control animals even after a long-term administration of ginseng. However, there was evidence that ginseng promotes hematopoiesis in test animals. 6. These results suggest that ginseng is not only safe as a food substance but may indeed strengthen the body and help-prevent diseases of old age.

• The Korean Journal of Food And Nutrition
• /
• v.29 no.3
• /
• pp.382-391
• /
• 2016

The purpose of this experiment was designed to investigate the effects of medicinal herbs (MH) extracts on dementia induced by trimethyltin chloride (TMT) in rats. Six-week-old male Sprague-Dawley rats were randomly divided into five groups; normal group (group 1), control group (group 2), MH extracts group (250, 500 mg/kg) (group 3, group 4) and positive control group (tacrine group, group 5). In the control group to induce dementia, a 2.5 mg/kg of TMT intraperitoneal injection was used for 14 days (1 per day) in the rats. In the MH extracts group 250 mg/kg and 500 mg/kg of MH extracts were medicated in an oral inoculation for 20 days (1 per day). After 30 minutes, a 2.5 mg/kg of TMT intraperitoneal injection, which causes dementia, was used for 14 days (1 per day). In the positive control group (Tacrine group) 10 mg/kg of Tacrine, the dementia treatment, was medicated in an oral inoculation. After 30 mintues, 1 mg/kg of TMT intraperitoneal injection, which causes dementia, was used for 14 days (1 per day). The present author observed the passive avoidance performance test, and memory ability test (Y maze test), the values of MDA, acetlycholinesterase (AchE) activity in the brain and antioxidant enzyme in serum. MH extracts significantly improved memory of AD model rats in the Y-maze test, and also significantly improved memory of AD model rats in the passive avoidance test. MH extracts significantly reduced AChE activity, and significantly increased the SOD level, but not catalase and MDA. From the results above, MH extracts is thought to be effective in the improvement of antioxidant enzymes and memory ability.