• Asian-Australasian Journal of Animal Sciences
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• v.26 no.5
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• pp.609-624
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• 2013

The objective of this study was to get a comprehensive understanding of how genes in chicken shell gland modulate eggshell strength at the early stage of active calcification. Four 32-week old of purebred Xianju hens with consistent high or low shell breakage strength were grouped into two pairs. Using Affymetrix Chicken Array, a whole-transcriptome analysis was performed on hen's shell gland at 9 h post oviposition. Gene ontology enrichment analysis for differentially expressed (DE) transcripts was performed using the web-based GOEAST, and the validation of DE-transcripts was tested by qRT-PCR. 1,195 DE-transcripts, corresponding to 941 unique genes were identified in hens with strong eggshell compared to weak shell hens. According to gene ontology annotations, there are 77 DE-transcripts encoding ion transporters and secreted extracellular matrix proteins, and at least 26 DE-transcripts related to carbohydrate metabolism or post-translation glycosylation modification; furthermore, there are 88 signaling DE-transcripts. GO term enrichment analysis suggests that some DE-transcripts mediate reproductive hormones or neurotransmitters to affect eggshell quality through a complex suite of biophysical processes. These results reveal some candidate genes involved with eggshell strength at the early stage of active calcification which may facilitate our understanding of regulating mechanisms of eggshell quality.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.159.2-159.2
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• 2014

간접띠간격(indirect bandgap)을 갖는 층상형 반도체 $MoS_2$는 두께가 줄어들어 단일층이 되면 층간 상호작용의 변화로 인해 ~1.8 eV의 직접띠간격(direct bandgap)을 갖게 된다. 이러한 초박형 $MoS_2$의 발광 특성을 활용하기 위해서는 원자 크기 수준에서 두께와 물성을 조절할 수 있는 화학적 표면개질법에 대한 이해가 필요하다. 최근 아르곤(Ar) 플라즈마를 이용한 $MoS_2$의 층상(layer-by-layer) 식각과 표면제어에 관한 연구결과가 보고되었으나 자세한 반응 메커니즘은 알려져 있지 않다. 본 연구에서는 산소 플라즈마에 의한 단일층 및 복층 $MoS_2$의 산화반응을 원자힘 현미경(AFM), 광전자 분광법(XPS), 라만 및 광발광 분광법을 통해 관찰하고 반응 메커니즘을 이해하고자 한다. 플라즈마로 생성된 산소라디칼과의 반응시간이 증가함에 따라 $E{^1}_{2g}$와 $A_{1g}$-진동모드에서 기인하는 라만 신호, 그리고 A와 B-엑시톤에서 유래하는 광발광의 세기가 감소함을 확인하였다. XPS와 AFM을 통해 반응이 진행됨에 따라 $MoS_2$의 상층이 $MoO_3$로 산화되면서 나노입자로 응집되어 표면형태가 변화하는 것을 확인하였다. 이 결과는 플라즈마 산화반응을 이용하여 $MoS_2$ 표면에 구조적 결함(defect)과 층상 식각을 유발하고 광발광 특성 제어를 위해 전자구조를 조절할 수 있다는 가능성을 보여준다.

• Journal of Korea Water Resources Association
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• v.33 no.4
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• pp.419-426
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• 2000

It is very important to establish sufficiently long and reliable annual maximum rainfall data in estimating areal rainfall quantiles of Han River Basin. The data from 9 gauging stations measured by Korea Meteorological Administration may meet such a requirement, however the number of these data sets is too small to estimate overall areal rainfall quantiles in large basin such as Han River Basin. In order to solve such a problem, the space correlations of many sites' data measured by Korea Ministry of Construction and Transportation and Korea Water Resources Corporation (the number of sites is 59) were used for modification of rainfall measure density. And areal rainfall quantiles according to each sub-basin were estimated based on regression analysis.

• Korean Journal of Health Education and Promotion
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• v.2 no.1
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• pp.63-78
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• 2000

This survey provides, at a participation rate of 70％, 4,790 examinees. The purpose of this study is to study the association of the failed rest after work with 34 diseases including cardiovascular diseases. The index of the failed rest after work was composed of 4 questions about "thinking of work for several hours", "feeling exhausted", feeling unsatisfied or depressed", and "needing to go to bed early for next day′s work". Estimation of correlation among 4 variables, factor analysis, and ANCOVA adjusted for sex, age and job were carried out. A self-rating questionnaire of one′s own disease history and the "London School of Hygiene Cardiovascular Questionnaire" were used in order to discriminate each morbid group from the opposite group. Brief explanations of the result are as follows: 1) Every variable of failed rest after work shows significant difference between the morbid group and the no morbid group for possible infarction; for angina pectoris in the total, and men. 2) Among 4 variables ′exhaustion′ best discriminates the infarction group from the no infarction group, and the angina group from the no angina group. 3) The factor of failed rest after work is a significant factor that distinguishes the infarction group from the no infarction group, and the angina pectoris group from the no angina group. Therefore, stress management through health education and promotion such as behavioral modification can be used to reduce cardiovascular diseases and stress as perceived by an individual.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.05a
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• pp.122-123
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• 2018

Recently, CM at Risk delivery system(CM@R) that could solve the problems of Design Bid Build delivery(DBB) system has been emerging. In the CM@R delivery system, the contractor negotiates for a maximum guaranteed price(GMP) with the client at the design stage, and the contractor carries out the construction within the GMP. In CM @ R, the construction company with expertise in construction participates from the design stage to reflects the construction know-how in the design. On the other hand, the modification design frequently occurs due to the change of the construction cost when negotiating the GMP. In addition, uncertainties are inherent in the GMP calculation because the calculation is based on unfinished drawings and documents. This study proposes a probabilistic GMP estimation method applying MCS to the BIM - based cost prediction model, in order to extract the accurate quantity information when estimating the GMP and to cope with the change of the construction cost inherent in uncertainty.

• Journal of the Korean Operations Research and Management Science Society
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• v.39 no.2
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• pp.131-140
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• 2014

Customer networks go through constant changes. They may expand or shrink once they are formed. In dynamic environments, it is a critical corporate challenge to identify and manage influential customer groups in a cost effective way. In this context, we apply inverse optimization theory to suggest an efficient method to manage customer networks. In this paper, we assume that there exists a subset of nodes that might have a large effect on the network and that the network can be modified via some strategic actions. Rather than making efforts to find influential nodes whenever the network changes, we focus on a subset of selective nodes and perturb as little as possible the interaction between nodes in order to make the selected nodes influential in the given network. We define the following problem based on the inverse optimization. Given a graph and a prescribed node subset, the objective is to modify the structure of the given graph so that the fixed subset of nodes becomes a minimum dominating set in the modified graph and the cost for modification is minimum under a fixed norm. We call this problem the inverse dominating set problem and investigate its computational complexity.

• Journal of the Korean Society of Safety
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• v.16 no.4
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• pp.194-199
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• 2001

The present situation of Korea already shone various symptoms of the aged society, and many kinds of data reported by the National Statistical Office demonstrate those facts. However, to my regret, sufficient efforts for aged workers are not taken in the area of industrial safety. In this research, work arrangement and industrial accidents of middle-aged and aged workers over last 5 years were analyzed. According to research results, proportion of industrial accidents involved middle-aged and aged workers was as high as 40%, and that of aged workers alone was so high as 25%. In addition, proportion of accidents were higher than that of worker population f3r aged wetters. Considering ages, it was demonstrated that as workers get older, mean number of accidents shows the tendency of going higher, and that as years go by, mean lost work-days are increasing regardless of age group. Main accident types were Fall followed by Slip, and Work-Related Disease, furthermore proportion of Slip was highest than any other types for aged workers. Based upon these results, it was emphasized thai careful attention should be paid to functional characteristics of aged workers, and that modification of accident prevention policy would be necessary.

• BMB Reports
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• v.54 no.10
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• pp.522-527
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• 2021

Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1^SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1^SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.

• Corrosion Science and Technology
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• v.22 no.4
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• pp.257-264
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• 2023

Ti-6Al-4V alloys are mainly used as dental materials due to their excellent biocompatibility, corrosion resistance, and chemical stability. However, they have a low bioactivity with bioinertness in the body. Therefore, they could not directly bond with human bone. To improve their applications, their bone bonding ability and bone formation capacity should be improved. Thus, the objective of this study was to improve the bioinert surface of titanium alloy substrate to show bioactive characteristics by performing surface modification using wollastonite powder. Commercial bioactive wollastonite powder was successfully deposited onto Ti-6Al-4V alloy using a room temperature spray process. It was found that wollastonite-coated layer showed homogeneous microstructure and uniform thickness. Corrosion resistance of Ti-6Al-4V alloy was also improved by plasma electrolytic oxidation treatment. Its wettability and bioactivity were also greatly increased by wollastonite coating. Results of this study indicate that both plasma electrolytic oxidation treatment and wollastonite coating by room temperature spray process could be used to improve surface bioactivity of Ti-6Al-4V alloy substrate.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.33 no.2
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• pp.90-96
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• 1997

Until now the research was usually related in the fishing basket for crab charybdis japonica, concentrated one's effort to modification on the construction, shape, number of entrance of fishing basket etc.. But there's not make good used to the basically habit, shelter behavior of crab. etc., and was not fundamentally modified to the ability attracting the crab on net fishing basket. In this paper, first of all investigated to the behavior of crab in water tank and then two types modification fishing baskets could the increasing to ability attracting of crab on fishing basket were designed from the result obtained in this experiment and compared with modificated net fishing basket by Kim.Go(1987.1990) at a field and tank experiment. The results obtained are summarized as follows : 1. Being the fishing baskets had dropped in the tank bottom, the touched rate and reacted rate of crab according the elapsed time agree with to experiment of Kim.Go(1987.1990)in the mainly. however, in case of plate type tangle net, the touched rate of crab increased for a short time and then decreased and the reacted rate increased in a hurry to show a maximum and then was established. 2. The beginning catch time of crab was shortest in the plate type tangle net than the any fishing baskets because it's immediately entangled if the crab was touched only a part of body on net and latest in the net fishing basket. 3. A distance of between the touched rate and the reacted rate curve were the most short, wide in the plate type tangle net. therefore, the ability attracting of crab was excellent than the any fishing baskets and in case of pipe type fishing baskets, between the 150mm and 250mm seemed not difference and showed a tendency to increasing against the net fishing baskets. 4. Pipe type fishing baskets seemed to become a good shelting place for the crab because it showed a tendency to stagnate at the inside in that. 5. The mean catch per pot of crab among the net fishing basket, pipe type fishing baskets, plate type tangle net were highest in the pipe type fishing baskets than the net fishing basket and lowest plate type tangle net. Therefore it showed to difference against the tank experiment.