• Journal of the Korean Chemical Society
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• v.7 no.4
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• pp.230-237
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• 1963

The synthesis of 2-methyl-5,5'-gem-disubstituted-$\Delta^2$-thiazolines has been undertaken by two methods. The first involves the preparation of gem-disubstituted N-or S-acetylamino mercaptan intermediates by ring opening of the corresponding thiiranes with ammonia. The second consists of the ring opening of gem-disubstituted ethylene imines using thiolacetic acid. The thiirane rings have never been opened under conditions as vigorous as that of using sodium amide in liquid ammonia. This is probably due to retardation by the gem-disubstituents. In contrast to this, the corresponding ethylene imine ring opens easily, in spite of the same stereochemical situation. The stabilization of gem-disubstituted cyclic compounds has been discussed from a stereochemical point of view. It has been concluded from the results of this work that the compression effect of gem-disubstitution is not due to bond angle deformation, which was observed by Thorpe and Ingold, but mostly to an electronic bond interaction of the gem-disubstituents and to the hetero atom(s), if any.

• Ocean and Polar Research
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• v.37 no.4
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• pp.265-278
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• 2015

We analyzed the North Pacific Intermediate Water (NPIW) that was simulated in 25 coupled general circulation models (CGCMs) using historical and Representative Concentration Pathway 4.5 (RCP4.5) scenario experiments of Coupled Model Intercomparison Project Phase 5 (CMIP5), focusing on the evaluation of the performance of HadGEM2-AO. A large inter-model diversity in salinity, density, and depth of the NPIW exists even though the multi-model ensemble mean (MME) is comparable to observations. It was found that the depth of the NPIW tends to be deeper in the models in which the NPIW is relatively saltier. HadGEM2-AO simulates the lightest NPIW having the lowest salinity at shallower depth, compared with other CGCMs. Future projections of the NPIW show that the temperature of the NPIW increases, but the density decreases in all CMIP5 models. It was shown that the salinity of the NPIW decreases in most models and the decrease tends to be larger in models simulating the lighter NPIW. The HadGEM2-AO projects moderate changes in the temperature and density of the NPIW out of the CMIP5 models.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2129-2132
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• 2012

Objective: To explore improved treatment by retrospectively comparing survival time of gemcitabine-based concurrent chemoradiotherapy (GemRT) versus chemotherapy (Gem) alone in patients with locally advanced pancreatic cancer (LAPC). Methods: From January 2005 to June 2010, 56 patients with LAPC from Subei People's Hospital were treated either with Gem (n=21) or GemRT (n=35). Gem consisted of 4-6 cycles gemcitabine alone (1000 mg/m2 on Days 1, 8, 15, 28-day a cycle). GemRT consisted of 50.4Gy/28F radiotherapy with concurrent 2 cycles of gemcitabine (1000 $mg/m^2$ on days of radiation 1, 8, 15, 21-day a cycle). Radiation was delivered to the gross tumor volume plus 1-1.5 cm by use of a three-dimensional conformal technique. The follow-up time was calculated from the time of diagnosis to the date of death or last contact. Kaplan-Meier methodology wes used to evaluate survival. Results: Patient characteristics were not significantly different between treatment groups. The disease control rate and the objective response rate of GemRT versus Gem was 97.1% vs 71.4%, 74.3% vs 38.1%. The overall survival (OS) was significantly better for GemRT compared to Gem (median 13 months versus 8 months; 51.4% versus 14.3% at 1 year, respectively). Conclusion: Radiation therapy at 50.4Gy with 2 concurrent cycles of gemcitabine results in favorable rates of OS. Concurrent chemoradiotherapy should be the first choice for patients with LAPC.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.5B
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• pp.429-436
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• 2011

The G-PON is an efficient solution to implement the FTTH and have GEM frame to accomodate various protocols like Ethernet frames, IP packets, and TDM signals. Above all, the Ethernet is one of the most widely used 2nd layer protocol in the campus, the subscriber access, and the carrier service. So G-PON system has to provide an Ethernet interface with top priority. In this paper, we implement a gigabit Ethernet adapter based on Ethernet over GEM in the ITU-T G.984.3 to accommodate Ethernet protocol in the G-PON TC chip. The adapter maps each Ethernet frame to a single or multiple GEM frames and has several functions including generation of the GEM header, encapsulation of frames and the SAR. In particular, the adapter have converter (LUT) MAC address to port-ID which is a key to identify logical connections though it is not defined in specification but important. We implement the adapter with a FPGA and verify the functions of segmentation and reassembling, MAC address learning, and throughput with the logic analyzer and the Ethernet analyzer.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.32-32
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• 2017

기후변화에 따른 이상가뭄과 홍수의 영향으로 하천의 수문과 수리적 요소가 변화되고 그로인해 발생하는 지형변화와 그에 따른 수질변화 분석이 필요하다. 낙동강의 효율적인 수질관리를 위해서는 수질과 더불어 유역관리도 함께 이루어져야 한다. 기후변화로 인한 가뭄이나 홍수 등 극한 사상이 보 같은 인공구조물이 설치되어 정체성 수역이 된 낙동강 수계에 어떠한 수질변화가 일어나는지에 대한 연구가 필요하며 이를 고려한 체계적이고 통합적인 수질관리대책이 필요하다. 본 연구에서는 낙동강 유역의 합천창녕보와 창녕함안보 구간에서 HadGEM3-RA RCP 4.5와 8.5를 적용하여 미래기후시나리오를 예측하여 수문분석을 수행하였다. 수문분석 결과인 유출량을 하상변동모형의 입력자료로 적용하여 상?하류 구간의 지형변화에 미치는 영향을 분석하고자 하였다. 마지막으로 지형변화가 수질에 미치는 영향을 분석하고자 QUAL-MEV 수질모형을 적용하여 지형변화에 따른 수질분석의 상대적 비교를 통해 기후변화와 지형변화의 영향을 분석하고자 하였다. 연구결과, 기후시나리오의 경우 HadGEM3-RA RCP 4.5 보다 8.5에서 강수가 6% 증가하는 결과를 나타내고 그에 따라 유출량도 증가하고 있다. 하상변동 분석결과, 유량이 많은 풍수년에 침식과 퇴적양상이 크게 나타나고 RCP 8.5에서 변동 폭이 크게 나타났다. 하천지형변화를 고려한 수질분석결과, 유량의 증가에 따라 수질도 개선되는 결과를 나타내고 있다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.5B
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• pp.469-479
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• 2009

The GEM frame is used a mean to deliver the variable length user data and consists of the header and the payload in the G-PON system. The HEC field of header protects contents of the header and is used to maintain GEM frame synchronization at the same time. When an LCDG (Loss of GEM Channel Delineation) occurs while receiving frames, the receiver have to discard corrupted frames until acquiring the synchronization again. Accordingly, high-speed synchronization method is required to minimize the frame loss. In this paper, we suggest not only a main state machine but a sub-state machine to reduce the frame loss when undetectable errors occurred in the GEM header. Also, we provide a more efficient and fast parallel structure to detect the starting point of the header. Finally, the proposed method is implemented with the FPGA and verified by the logic analyzer.

• Korean Journal of Microbiology
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• v.30 no.2
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• pp.88-95
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• 1992

The genetically engineered microorganisms (GEMS) could be released accidentally or ii)rexperimental purposes, as the genetic engineering, technique ha:. become very popular inany laboratories of biological sciences. But there have been littlt: informations on transkrbehavior of the genetically ~nodified genes in the natural en\ironmentx. In this stutly.antibiotic resistant bacteria were isolated from nat.ural waters. and then GEM strains wereconstructed i'rom the natural isolate (NI) by ~noclification oi' the Km' plasmitl. Thetransferability of the plasmids in the GEM and NI strains were examinetl by con-jugationin Luria-Bertani broth :it 30$^{\circ}$C. Also the cff'ccts 01' mating strain and pH on their transferfrequency and rearrangement of the plasmids in tl-~ec o~ijugantsM ere comp:irati\ely stuclictl.I'hc transkr frequency of Km' plasmid in donor of GEM and N1 strains wah similar a.;about 10 ' when co~ljugation was conducted wit11 M'I'I strain is recipient at pH 7. butthat of 1)KCOOI was lowered to 1.2X 10 '. And when the lab. stlain was uhccl as recipient.the transfer tendency of the plasmid was about same in both (;EM and NI strains usedas donor. All thc tionor 5trains. except for I)KC601. showecl the Ilighcs~ frequency of about10 ' at pH 7 and the frequcncics were lowered at both pH 5 and 9. Hut the mocliliedKm' plasmid in the cloned strain of DKC601 was transferred hy very low frequency of10 "at pH 5 ant1 7 comparing to other GEM strains. especiall! any co~~.jugantws ere notobtained at pH 4 and 9 even after conjugation for 6 hours. Rearrangement of the plasmidstranskrred into the lab. strain was not found in the conjugants. I\ulcornerut a lot of rearrangclncntwas ohservecl nlhen they were transferred into the NI strain. Such a rearrangement wasmore severe when donor was GEM strain rather then NI strain Hut such ;r phenomenonwas less affected by p!-l values.r phenomenon was less affected by p!-l values.

• Journal of Industrial Convergence
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• v.20 no.10
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• pp.219-224
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• 2022

This study is to propose a alternative gem that is expressed in various ways instead of jewelry with limited output. It was investigated what materials were used in the alternative gem used in the jewelry design thesis over the past five years. In addition, as a result of a survey to understand the needs of customers, it was found that customers also use resin among resins as an alternative gem, like as research trends. Based on this, the scope of resin use as a alternative gem was expanded and applied to jewelry design rather than the existing method of using resin. As a result, it was found out a various uses of resin as an alternative gem. However, the demand and traditionality that correspond to the conditions of jewelry remain challenges to be established through various jewelry design studies in the future. Therefore, in order to utilize the popular preference of alternative gem, continuous research on applying jewelry design to alternative gem should be continued.

• Korean Journal of Microbiology
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• v.28 no.3
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• pp.219-228
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• 1990

A kanamycin resistance($Km^r$) gene was studied for its transfer in natural freshwater environments by using the natural bacterial isolate(M1) of DK1 and the DKC601 strain, $Km^r$ plasmid of which was genetically engineered from the NI strain. The transfer frequency ofthe $Km^r$ gene and rearrangement of the $Km^r$ plasmid were compared between the gnetically engineered microorganism(GEM) and the NI parental strain by conjugation with the same recipient strain. The transfer frequency of the $Km^r$ gene was about $9.1\times 10^{-12}-1.8\times 10^{-11}$ in both the GEM and NI strains at 5 to $10^{\circ}C$, but the frequency of the NI was about 10 times higher than that of the GEM at 20 to $30^{\circ}C$. The $Km^r$ plasmid in the transconjugants obtained by conjugation of the NI with the MY1 strain as a ricipient showed alot of rearrangement, but the $Km^r$ plasmid transferred from the GEM was stable without alteration of its size. When the MT2 strain was used as a recipient, however, such a rearrangement of the $Km^r$ plamid was observed in the transconjugants obtained from the GEM as well as the NI strain. In those transconjugants obtained from different mating pairs and water environments, the plasmid were appeared to decrease in their number as the period of conjugation time was prolonged, but only the $Km^r$ plasmid transferred from the GEM kept having its size of 52kb. Therefore, the $Km^r$ gene was transferred at the same rate from the GEM and NI strains in natural freshwater environment, but the gene of the GEM strain was more stable than the NIduring conjugation and the $Km^r$ plasmid was rearranged by changing the recipient strain for conjugation in any water environments.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.343-343
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• 2012

미래 극한사상의 초과확률을 산정하기 위하여 저해상도의 전지구 기후변화 시나리오 자료를 그대로 사용하거나 이를 역학적 또는 통계적 방법으로 상세화한 고해상도 기후변화 시나리오 자료를 활용한다. 통계적 상세화는 전지구 또는 지역기후모델의 현재기후 모의 자료와 관측 자료와의 통계적 관계를 미래 예측자료에 적용하는 방법으로, 현재와 미래 기후의 시공간적 분포가 동일하다는 가정을 포함하고 있다. 반면 역학적 상세화 방법은 기후변화 강제력을 고려하는 지역기후모델을 이용하여 기후시스템의 역학 및 물리과정, 기후시스템간 의 상호작용, 기후변화의 비정상성 등을 고려할 수 있고, 변수간의 시공간적 상관성을 지구시스템의 물리 역학적 과정으로 해석할 수 있다는 장점이 있다. 이에 국립기상연구소에서는 영국 기상청의 통합모델(UM)기반의 지역기후모델(HadGEM3)을 사용하여 50 km 및 12.5 km 격자 단위로 역학적 상세화(dynamic downscaling)를 수행하였다. 본 연구에서는 역학적 상세화로 생산된 HadGEM3-RA 자료를 이용하여 현재기후(1980-2005), 가까운 미래(2020-2049)와 21세기말(2070-2099)의 20년 빈도 강수량을 비교하였다. 연구결과, 남한에 걸쳐 현재기후에 비하여 미래에는 극한강수의 크기와 빈도가 전반적으로 증가하는 경향을 확인할 수 있었다. 20년에 한번씩 발생하였던 일 극한강수는 RCP8.5를 고려한 21세기말에는 약 4년에 한번씩 발생하리라 전망되었다.