• Title/Summary/Keyword: GD1a

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The luminescence properties of Eu3+ or Tb 3+ doped Lu2Gd1Ga2Al3O12 phosphors for X-ray imaging

  • M.J. Oh;Sudipta Saha;H.J. Kim
    • Nuclear Engineering and Technology
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    • v.55 no.12
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    • pp.4642-4646
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    • 2023
  • The Tb3+ or Eu3+-doped Lu2Gd1Ga2Al3O12 phosphor were fabricated by funace at 1500 ℃ for 12 h using a solid state reaction. The XRD (X-ray diffraction_Panalytical X'Pert Pro) and FE-SEM (field emission scanning electron microscope) are measured to confirm the crystalline structure and surface morphology of the phosphor. The Tb3+-doped Lu2Gd1Ga2Al3O12 phosphor emits the lights in 470~650 nm wavelength range due to transitions from 5D4 to 7Fj. Therefore, it shows the green region in the CIE chromaticity diagram under both UV and X-rays excitations. The Eu3+-doped Lu2Gd1Ga2Al3O12 phosphor emits the lights in 550~750 nm wavelength range because of 5Di to 7Fj. The emission is confirmed to be in the red region using the CIE chromaticity diagram. The Tb3+ or Eu3+-doped Lu2Gd1Ga2Al3O12 phosphor shows the characteristic f-f transition with a long decay time, which is about several milliseconds. They have the high efficiency of light emission for X-ray because of their high effective Z number (Zeff = 58.5) and density. Therefore, they are very much promising phosphors for X-ray imaging application in medical fields.

A Case of a 2-year-old Girl with Type I Gaucher Disease Presenting with Growth Retardation and Leg Pain (2세 여아에서 성장 부진과 다리 통증을 동반한 1형 고셔병 증례)

  • Park, Yesul;Hwang, Jae-Yeon;Hwang, Eun Ha;Cheon, Chong Kun;Lee, Beom Hee;Yoo, Han-Wook;Kim, Yoo-Mi
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.17 no.2
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    • pp.63-68
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    • 2017
  • Gaucher disease (GD) is caused by the deficiency of glucocerebrosidase. In pediatric patients with GD, especially Type I GD, enzyme replacement therapy (ERT) can reduce the hepatosplenomegaly and improve the hematologic finding and growth velocity. Herein, we report a 2-year-old girl with Type I GD presented with hepatosplenomegaly, bone pain and growth retardation. A 2 year-old-girl was referred to our hospital due to severe hepatosplenomegaly and growth retardation. She suffered from both leg pain and chronic fatigue. Simple x-ray showed widened distal long bones like that of an 'Erlenmeyer flask' which is associated with GD. The laboratory test showed anemia and thrombocytopenia. The enzyme activity was markedly reduced and the direct sequencing of the GBA gene showed the compound heterozygous mutations, p.G46E and p.L444P. As the G46E have been considered as the protective gene against neuronopathic genotype, we could assess the Type I GD in this patient. After one year of ERT, the growth velocity became 11 cm per year. Bone pain and fatigue disappeared. The volume of liver and spleen was reduced from $683cm^3$ and $703cm^3$ to $590cm^3$ and $235cm^3$, respectively. Although GD is an extremely rare disease in Korea, growth retardation and bone pain in children are the important signs which lead to early detection of GD and a simple radiologic finding is helpful to assess the GD at outpatient clinic. We highlight that the early diagnosis and early ERT is important for good growth and outcome for pediatric patients with GD.

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Superconductivity for HTS GdBCO CC with heat treatment

  • You, Jong Su;Yang, Jeong Hun;Song, Kyu Jeong
    • Progress in Superconductivity and Cryogenics
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    • v.23 no.1
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    • pp.12-16
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    • 2021
  • The magnetic properties of heat treated O-series high temperature superconducting (HTS) GdBCO coated conductor (CC) tapes which were formed of Ag/GdBCO/Buffer-layers/Stainless Steel (SS), were investigated by employing a Quantum Design PPMS-14. Using a modified Bean model, the critical current density Jc values have been estimated from the 𝚫mirr(H) data, which are obtained by measuring the magnetic moment m(H) loops. For a range of intermediate fields, which are interacting or collective flux pinning area, the magnetic flux behaviors were investigated from the relationship Jc ∝ H. In addition, the changes of irreversibility magnetic field Hirr line of heat-treated O-series HTS GdBCO CC tapes were analyzed, according as the annealing temperature under oxygen flowing increases. Both weak and strong break-downs were found by examining the changes of irreversibility magnetic field Hirr lines.

Preparation and Sintering Characteristics of Ce0.8Gd0.2O1.9 Powder by Ammonium Carbonate Co-precipitation (탄산암모늄 공침을 이용한 Ce0.8Gd0.2O1.9 분말의 합성 및 소결특성)

  • Yoo, Young-Chang;Chung, Byung-Joo;Sim, Soo-Man
    • Journal of the Korean Ceramic Society
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    • v.49 no.1
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    • pp.118-123
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    • 2012
  • GDC20($Ce_{0.8}Gd_{0.2}O_{1.9}$) powder was synthesized from Ce and Gd nitrate solutions using ammonium carbonate($(NH_4)_2CO_3$) as a precipitant. Attrition-milling of the powder, which had been calcined at $700^{\circ}C$ for 4 h, decreased an average particle size of 2.2 ${\mu}m$ to 0.5 ${\mu}m$. The milled powder consisted of nano-sized spherical primary particles. Due to the excellent sinterability of the powder, sintering of the powder compacts for 4 h showed relative densities of 80% at 1000 $^{\circ}C$ and 96.5% at $1200^{\circ}C$, respectively. Densification was found to almost complete at $1300^{\circ}C$, resulting in a dense and homogeneous microstructure with a relative density of 99.5%. The grains of ~0.2 ${\mu}m$ in size at $1200^{\circ}C$ grew to ~1 ${\mu}m$ in size at $1300^{\circ}C$ as a result of a rapid grain growth.

Crystal Growth and Scintillation Properties of CsI:Gd (CsI:Gd 결정 육성과 섬광 특성)

  • Cheon, Jong-Kyu;Kim, Sung-Hwan;Kim, Hong-Joo
    • Journal of Sensor Science and Technology
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    • v.21 no.4
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    • pp.293-297
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    • 2012
  • CsI:Gd crystal was grown by the Bridgeman method and its scintillation properties were investigated. The wavelength peak of the luminescence spectrum for the crystal excited by X-ray was 419 nm. The range of the spectrum was from 300 nm to 800 nm. The spectrum well matched to the quantum efficiency of a typical bi-alkali photo-multiplier tube(PMT). An energy resolution of 48.2 % was obtained for 662 keV ${\gamma}$-rays of $^{137}Cs$. The three decay times were obtained as a fast(557.4 ns, 42.2 %), intermediate (1.78 ${\mu}s$, 29.7 %) and slow (5.43 ${\mu}s$, 28.1 %) components, respectively.

Differential Expression of Gangliosides in the Ovary and Uterus of Streptozotocin-Induced and db/db Diabetic Mice

  • Kim, Sung-Min;Kwak, Dong-Hoon;Kim, Sun-Mi;Jung, Ji-Ung;Lee, Dae-Hoon;Lee, Seoul;Jung, Kyu-Yong;Do, Su-Il;Choo, Young-Kug
    • Archives of Pharmacal Research
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    • v.29 no.8
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    • pp.666-676
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    • 2006
  • Gangliosides are widely distributed in mammalian cells and play important roles in various functions such as cell differentiation and growth control. In addition, diabetes and obesity cause abnormal development of reproductive processes in a variety of species. However, the mechanisms underlying these effects, and how they are related, are not fully understood. This study examined whether the differential expression of gangliosides is implicated in the abnormal follicular development and uterine architecture of streptozotocin (STZ)-induced and db/db diabetic mice. Based upon the mobility on high-performance thin-layer chromatography, mouse ovary consisted of at least five different ganglioside components, mainly gangliosides GM3, GM1, GD1a and GT1b, and diabetic ovary exhibited a significant reduction in ganglioside expression with apparent changes in the major gangliosides. A prominent immunofluorescence microscopy showed a dramatic loss of ganglioside GD1a expression in the primary, secondary and Graafian follicles of STZ-induced and db/db diabetic mice. A significant decrease in ganglioside GD3 expression was also observed in the ovary of db/db mice. In the uterus of STZ-induced diabetic mice, expression of gangliosides GD1a and GT1b was obviously reduced, but gangliosides GM1, GM2 and GD3 expression was increased. In contrast, the uterus of db/db mice showed a significant increase in gangliosides GM1, GD1a and GD3 expression. Taken together, a complex pattern of ganglioside expression was seen in the ovary and uterus of normoglycemic ICR and $db/^+$ mice, and the correspoding tissues in diabetic mice are characterized by appreciable changes of the major ganglioside expression. These results suggest that alterations in ganglioside expression caused by diabetes mellitus may be implicated in abnormal ovarian development and uterine structure.

Corrosion and Wear Properties of Cold Rolled 0.087% Gd Lean Duplex Stainless Steels for Neutron Absorbing Material

  • Choi, Yong;Baik, Youl;Moon, Byung-Moon;Sohn, Dong-Seong
    • Nuclear Engineering and Technology
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    • v.48 no.1
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    • pp.164-168
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    • 2016
  • Lean duplex stainless steels with 0.087 wt.% gadolinium (Gd) were inert arc-melted and cast in molds of size $10mm{\times}10mm{\times}20mm$. The micro-hardnesses of the rolling direction (RD), transverse direction (TD) and short transverse (ST) direction were $258.5H_V$, $292.3H_V$, and $314.7H_V$, respectively. A 33% cold rolled specimen had the crystallographic texture that (100) pole was mainly concentrated to the normal direction (ND) and (110) pole was concentrated in the center of ND and RD. The corrosion potential and corrosion rate in artificial seawater and $0.1M\;H_2SO_4$ solution were in the range of $105.6-221.6mV_{SHE}$, $0.59-1.06mA/cm^2$, and $4.75-8.25mV_{SHE}$, $0.69-1.68mA/cm^2$, respectively. The friction coefficient and wear loss of the 0.087 w/o Gd-lean duplex stainless steels in artificial seawater were about 67% and 65% lower than in air, whereas the wear efficiency was 22% higher. The corrosion and wear behaviors of the 0.087 w/o Gd-lean duplex stainless steels significantly depended on the Gd phases.

First-principles Study on the Magnetic Properties of Gd doped Bithmuth-Telluride (Gd 도핑된 비스무스 텔루라이드의 자기적 성질에 대한 제일원리 계산 연구)

  • Van Quang, Tran;Kim, Miyoung
    • Journal of the Korean Magnetics Society
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    • v.26 no.2
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    • pp.39-44
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    • 2016
  • Determination of the structural, electronic, and magnetic properties of the magnetically doped bismuth-telluride alloys are drawing lots of interest in the fields of the thermoelectric application as well as the research on magnetic interaction and topological insulator. In this study, we performed the first-principles electronic structure calculations within the density functional theory for the Gd doped bismuth-tellurides in order to study its magnetic properties and magnetic phase stability. All-electron FLAPW (full-potential linearized augmented plane-wave) method is employed and the exchange correlation potentials of electrons are treated within the generalized gradient approximation. In order to describe the localized f-electrons of Gd properly, the Hubbard +U term and the spin-orbit coupling of the valence electrons are included in the second variational way. The results show that while the Gd bulk prefers a ferromagnetic phase, the total energy differences between the ferromagnetic and the antiferromagnetic phases of the Gd doped bismuth-telluride alloys are about ~1meV/Gd, indicating that the stable magnetic phase may be changed sensitively depending on the structural change such as defects or strains.

Reduction of Patient Dose Exposure and Improvement of Image Quality by Use of Additional Filtration in Digital Radiology (디지털 진단방사선촬영에서 부가여과판 사용에 따른 피폭선량 감소와 화질 개선)

  • Moon, Su-Jeong;Kim, Young-Keun;Lee, Seong-Kil
    • Korean Journal of Digital Imaging in Medicine
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    • v.12 no.1
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    • pp.19-25
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    • 2010
  • This study is mainly for the reduction of exposure dose by using a heavy elements filter(Gd) in the digital radiology. They contained heavy elements filter of Gd and X-ray beam hardening filters such as Al and Cu. According to the results of experimental evaluation, X-ray property was not changed with variety of kVp in the case of the Gd filter. The surface dose and absorption dose were increased in order of Cu and Al. The contrast of image showed the higher value in order of Cu, Al and Gd. While the use of Gd has increased the numerical value of the CR image, and grayscale has decreased noise value of the DR image.

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Defect Model for the Oxygen Potential of Urania doped wit Gadolinia (가돌리니아 첨가 이산화우라늄의 점결함 모델에 의한 산소포텐샬 연구)

  • Park, Kwang-Heon;Kim, Jang-Wook
    • Nuclear Engineering and Technology
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    • v.23 no.3
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    • pp.321-327
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    • 1991
  • A defect model e)[plaining the oxygen potential of Gadolinia doped urania based on the defect structure of pure urania has been developed. Gd-dopants are assumed to stay in the cation sites pushing away nearby oxygen interstitials reducing the number of interstitial sites. Gd-dopants also form dopant-vacancy clusters in the abundance of oxygen vacancies. This model explains the discontinuous change of the oxygen potential at O/M= as well as the increase of the potential with the dopant concentration.

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