• 대한의용생체공학회:의공학회지
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• 제11권1호
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• pp.31-38
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• 1990

Image correction of the fluorescein angiogram with the low contrast and geometrically distorted is studied. The procedure is divided into two steps : A template matching step and a geometrical transformation step. Based on the sequential similiarity detection algorithm, more Improved matching results are obtained with edge enhanced image. For the reference points and the corresponding matchimg points, the geometrical transformationss by the use of the average value of the X, Y translational shifts and a pair of these points, respectively are described. Then the corrected images are obtained using bilinear interpolation. It is proven that the usefullness of this study for the image correction of the ocular fundus fluoresceln angiogram with low contrast and geometrically distorted mainly due to the eye movements.

• 대한수의학회지
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• 제37권1호
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• pp.1-8
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• 1997

The relative frequency and distribution of occurrence of immunoreactive cells in the proventriculus, diverticulum, cardia, fundus and pylorus of the stomach of pigs were investigated by PAP method using specific antisera against BCG, Gas/CCK, 5-HT, somatostatin, glucagon, BPP, motilin and insulin. In the diverticulum and cardia, BCG-, 5-HT-, somatostatin- and glucagon-immunoreactive cells were detected. In the fundus, BCG-, 5-HT- and somatostatin-immunoreactive cells were also found. In the pylorus, BCG-, Gas/CCK-, 5-HT-, somatostatin- and glucagon-immunoreactive cells were observed. However, no BPP-, motilin- and insulin-immunoreactive cells were found in the stomach epithelium of the pigs. These results showed that the occurrence of the endocrine cells confirmed in the diverticulum as the cardia and suggest that the function of diverticulum may be similar to that of cardia in the pigs.

• 대한수의학회지
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• 제59권2호
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• pp.113-117
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• 2019

A 6-year-old intact male Maltese dog presented with a history of blindness and ataxia. Neuro-ophthalmic examination revealed dilated pupils with absent pupillary light reflexes and menace response in both eyes. Mild peripapillary edema was noted in the fundus of the right eye. After magnetic resonance imaging, the dog was provisionally diagnosed with meningoencephalitis of unknown etiology. Follow-up funduscopy was performed to monitor the condition of the optic discs for three years. Despite of the treatment with prednisolone, the optic nerve progressed to atrophy and the dog couldn't restore vision.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.124-126
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• 2021

본 연구에서는 당뇨망막병증 의증 진단을 위해 영상처리 알고리즘을 이용하여 안저영상을 분석하고, 비트 플레인(Bit Plane) 기법을 활용한 당뇨망막병증 질환의 특징인 경성삼출물 및 망막 출혈 등의 특정 부위를 추출한다. 분석된 안저영상을 기반으로 당뇨망막병증의 특징을 수치화하고 자동으로 진단이 가능한 시스템을 제안한다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2023년도 추계학술발표대회
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• pp.632-633
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• 2023

Diabetic retinopathy (DR) is a prevalent complication of diabetes that can lead to vision impairment if not diagnosed and treated promptly. This study presents a novel approach for the automated grading of diabetic retinopathy in ultra-widefield fundus images (UFI) using deep learning techniques. We propose a method that involves preprocessing UFIs by cropping the central region to focus on the most relevant information. Subsequently, we employ state-of-the-art deep learning models, including ResNet50, EfficientNetB3, and Xception, to perform DR grade classification. Our extensive experiments reveal that Xception outperforms the other models in terms of classification accuracy, sensitivity, and specificity. his research contributes to the development of automated tools that can assist healthcare professionals in early DR detection and management, thereby reducing the risk of vision loss among diabetic patients.

• 대한수의학회지
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• 제44권2호
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• pp.171-177
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• 2004

The regional distributions and frequencies of argentaffin endocrine cells in gastrointestinal (GI) tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied by Masson-Hamperl silver stain. The experimental animals were divided into two groups, one is non-ovariectomized group (Sham) and the other is ovariectomized group (OVX). Samples were collected from each part of GI tract (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) at 10th week after ovariectomy or sham operation. Argentaffin cells were detected throughout the entire GI tract with various frequencies regardless of ovariectomy except for the rectum of OVX in which no cells were detected. Most of these argentaffin cells in the mucosa of GI tract were generally spherical or spindle in shape (open type cell) while cells showing round in shape (close type cell) were rarely found in gland regions. Significant decrease of argentaffin cells was detected in OVX compared to that of Sham except for the fundus and jejunum. However, in the fundus and jejunum, argentaffin cells in OVX showed similar frequency compared to that of Sham. In conclusion, the endocrine cells are the anatomical units responsible for the production of gut hormones that regulate gut motility and digestion including absorption, and a change in their density would reflect the change in the capacity of producing these hormones and regulating gut motility and digestion. Ovariectomy induced severe quantitative changes of GI argentaffin endocrine cell density, and the abnormality in density of GI endocrine cells may contribute to the development of gastrointestinal symptoms in osteoporosis such as impairments of calcium and some lipids, frequently encountered in patients with postmenopausal osteoporosis.

• 보건행정학회지
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• 제26권3호
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• pp.207-218
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• 2016

Background: This study was performed to identify factors associated with the utilization of tests for diabetes complication and hemoglobin A1c (HbA1c) among diabetes patients in Jeollanam-do, Korea. Methods: The study subjects were 2,310 diabetes patients participated in 2014 community health survey in Jeollanam-do, Korea. Dependent variables were the utilizations of fundus examination, microalbuminuria test, and HbA1c test. The used statistical analysis methods were chi-square test and hierarchical regression analysis with weight in consideration of complex sample design. Results: The utilization rates of fundus examination, microalbuminuria test, and HbA1c test were 25.8%, 27.4%, and 12.3%, respectively. In the results of hierarchical regression, fundus examination was significantly related to age, education level in predisposing factors, residential area in enabling factors and recognition of blood sugar, drug therapy, and subjective health status in need factors. Microalbuminuria examination was significantly related to monthly income, residential area in predisposing and health screening, recognition of blood sugar, drug therapy, diabetic education, number of chronic disease, and subjective health status in need factors. HbA1c examination was significantly related to age, education level, marital status in predisposing factors, residential area in enabling factors and drinking, recognition of blood sugar, drug therapy, and diabetic education in need factors. Conclusion: The results of this study were shown that perception of their disease seriousness, education about diabetes management, and accessibility of tests were important to utilization of test for diabetes complication and HbA1c. It might be necessary to the develop and strength strategies for enhancing the utilization of tests for diabetes complication and management in diabetes patients.

• 대한수의학회지
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• 제39권3호
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• pp.472-477
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• 1999

To elucidate the action of the cholinergic and adrenergic nerve on isolated gastric fundus smooth muscle of rabbit, the effects of electrical transmural stimulation were investigated in the presence of atropine, cholinergic receptor blocker; phentolamine, nonselective ${\alpha}$-adrenergic receptor blocker; propranolol, nonselective ${\beta}$-adrenergic receptor blocker and L-arginine from the isometric contraction of physiological recording system. 1. The contractile response induced by electrical transmural stimulation was increased as the frequency(1~32Hz)-dependent manner on the isolated gastric fundus smooth muscle. 2. The contractile response induced by electrical transmural stimulation was markedly inhibited by the pretreatment of atropine($1{\mu}M$). 3. The contractile response induecd by electrical transmutal stimulation was inhibited by the pretreatment of phentolamine($1{\mu}M$). 4. The relaxative response induced by electrical transmural stimulation on presence of atropine ($1{\mu}M$) was inhibited by the pretreatment of propranolol($1{\mu}M$). 5. The relaxative responses on precontraction induced by histamine($10{\mu}M$) with guanethidine ($50{\mu}M$) and atropine($1{\mu}M$) by electrical transmural stimulation were increased by L-arginine (1mM). These findings suggest that it was the excitatory action of cholinergic and ${\alpha}$-adrenergic nerve, and the inhibitory action of ${\beta}$-adrenergic nerve and nonadrenergic noncholinergic nerve on the isolated gastric fundus smooth muscle of rabbit.

• 사상체질의학회지
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• 제27권2호
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• pp.254-269
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• 2015

Objectives This study aimed to observe the effect of Taeumjowi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups, each of 8 rats per group, were used in this study. Saline and distilled water treated control rats were intact vehicle control group. Delayed gastrointestinal motility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Taeumjowi-tang aqueous extracts(TJ) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th cisplatin treatment(TJ group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as TJ(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA(malondialdehyde), GSH(glutathione) contents and SOD(superoxide dismutase), CAT(catalase) activities, TPH(tryptophanhydroxylase) and MAO(monoamine oxidase) activities, pyloric gastrin and serotonin contents with their immunoreactive cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results 1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in TJ, ondansetron group. 2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in TJ, ondansetron group. 3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in TJ group. 4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased and the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in TJ group. 5) The pylorus atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of TJ group. Conclusions The results obtained in this study suggest that TJ favorably retarded the cisplatin related GI(gastrointestinal) dysfunctions and constipation through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems.

• 인터넷정보학회논문지
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• 제25권3호
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• pp.19-25
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• 2024

전 세계적인 인구 고령화 현상으로, 녹내장, 백내장, 황반변성과 같은 실명을 초래할 수 있는 주요 안질환의 발병률이 상승하고 있다. 이에 안과 분야에서는 실명률을 줄이기 위해 예방이 어려운 질환의 진단에 관심이 집중되고 있다. 본 연구는 기존보다 적은 양의 데이터를 활용하여 안저 사진 내의 안질환을 정확하게 진단하는 딥러닝 방안을 제안한다. 이를 위해 적은 데이터로도 효과적인 학습이 가능한 Convolutional Neural Network (CNN) 모델을 선정하여 다양한 안질환 환자의 Conventional Fundus Image (CFI)를 분류 한다. 선정된 CNN 모델들은 Accuracy, Precision, Recall, F1-score에서 우수한 성능을 기록함으로써 CFI 내 안질환의 정확한 분류에 탁월한 성능을 보였다. 이러한 접근법은 안과 전문의들의 수작업 분석을 줄이고, 진료 시간을 단축하며, 리소스가 제한된 환경에서도 일관성 있는 진단 결과를 제공함으로써 의료 현장에 효율적이고 정확한 진단의 보조 도구로 기여할 수 있다.