• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.108-115
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• 2023

Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure-activity relationship (SAR) to their ability to inhibit dopamine (DA) reuptake; conducted docking simulation for two selected compounds; and identified their potential functionals. The compounds were subdivided into arylethylamines, 2-(alkyl amino)-1-arylalkan-1-one derivatives and alkyl 2-phenyl-2-(piperidin-2-yl)acetate derivatives. An aromatic group, alkyl group, and alkylamine derivative were attached to the arylethylamine and 2-(alkyl amino)-1-arylalkan-1-one derivatives. The inhibitory effect of the compounds on dopamine reuptake increased in the order of the compounds substituted with phenyl, thiophenyl, and substituted phenyl groups in the aromatic position; compounds with longer alkyl groups and smaller ring-sized compounds at the alkylamine position showed stronger inhibitory activities. Docking simulation conducted for two compounds, 9 and 28, showed that the (S)-form of compound 9 was more stable than the (R)-form, with a good fit into the binding site covered by helices 1, 3, and 6 of human dopamine transporter (hDAT). In contrast, the (R, S)-configuration of compound 28 was more stable than that of other isomers and was firmly placed in the binding pocket of DAT bound to DA. DA-induced endocytosis of dopamine D₂ receptors was inhibited when they were co-expressed with DAT, which lowered extracellular DA levels, and uninhibited when they were pretreated with compound 9 or 28. In summary, this study revealed critical structural features responsible for the inhibition of DA reuptake and the functional role of DA reuptake inhibitors in regulating D₂ receptor function.

• Journal of Biomedical Engineering Research
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• v.44 no.6
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• pp.392-403
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• 2023

This study presents a new hybrid fNIRS-EEG system to meet the demand for a lightweight and low-cost sleep pattern monitoring device. For multiple-channel configuration, a six-channel electroencephalogram (EEG) and a functional near-infrared spectroscopy (fNIRS) system with eight photodiodes (PD) and four dual-wavelength LEDs are designed. To enhance the convenience of signal measurement, the device is miniaturized into a patch-like form, enabling simultaneous measurement on the forehead. Due to its fully integrated functionality, the developed system is advantageous for performing sleep stage classification with high-temporal and spatial resolution data. This can be realized by utilizing a two-dimensional (2D) brain activation map based on the concentration changes in oxyhemoglobin and deoxyhemoglobin during sleep stage transitions. For the system verification, the phantom model with known optical properties was tested at first, and then the sleep experiment for a human subject was conducted. The experimental results show that the developed system qualifies as a portable hybrid fNIRS-EEG sleep pattern monitoring device.

• Clinics in Shoulder and Elbow
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• v.27 no.1
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• pp.39-44
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• 2024

Background: Displaced olecranon fractures constitute a challenging problem for elbow surgeons. The purpose of this study is to evaluate the role of suture anchor fixation for treating patients with displaced olecranon fractures. Methods: A retrospective review was performed for all consecutive patients with displaced olecranon fractures treated with suture anchor fixation with at least 2 years of clinical follow-up. Surgical repair was performed acutely in all cases with nonmetallic suture anchors in a double-row configuration utilizing suture augmentation via the triceps tendon. Osseous union and perioperative complications were uniformly assessed. Results: Suture anchor fixation was performed on 17 patients with displaced olecranon fractures. Functional outcome scores were collected from 12 patients (70.6%). The mean age at the time of surgery was 65.6 years, and the mean follow-up was 5.6 years. Sixteen of 17 patients (94%) achieved osseous union in an acceptable position. No hardware-related complications or fixation failure occurred. Mean postoperative shortened disabilities of the arm, shoulder, and hand (QuickDASH) score was 3.8±6.9, and mean Oxford Elbow Score was 47.5±1.0, with nine patients (75%) achieving a perfect score. Conclusions: Suture anchor fixation of displaced olecranon fractures resulted in excellent midterm functional outcomes. Additionally, this technique resulted in high rates of osseous union without any hardware-related complications or fixation failures.

• Journal of the Korea Society of Computer and Information
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• v.29 no.8
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• pp.67-75
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• 2024

Frequently changeable functional requirements in System Management CSCI Software make it difficult to reuse an overall application, but only the partial class codes repeatedly as a new version of Naval Combat Management System is developed. This structural environment leads to increasing development time and expenses. This is why modularization for System Management CSCI Software is proposed as a solution, leveraging the advantages of proper standardization and functional expandability offered by Standard Interface Architecture. This paper outlines the comparisons of modified class ratios as well as software reliability test runtime results between before and after implementing the modularization for System Management CSCI Software. The findings demonstrate there is sufficient improvement in areas, such as higher maintenance and reusability, supporting the application of modularization for System Management CSCI Software with the implementation of Standard Interface Architecture.

• The International Journal of Costume Culture
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• v.7 no.2
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• pp.87-102
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• 2004

By introducing Mondrian's creative world into the field of fashion design, I examined how its application can satisfy not only visual expressions but also the desire of fashion design for its simplicity, individuality, and sensitivity. As a program developing designs and guiding how to produce, the textile CAD system helps to develop a variety of textile systems. In case of dying or textile printing, a variety of free expressions of print patterns and functional color simulations are possible by the configuration of colors or enlargement of design. It can also confirm the flexible simulation with a variety of color changes through the monitor by treating the knit design with dots. Especially in case of consulting for the design with ordering customers, the system is very speedy and effective, because it is possible to correct on the spot those complicated elements of designs and color sensation and see the prints in the light of marketing, processing and artistic value. Mondrian's Art, beauty of balance and proportion in the Mondrian's plastic forms, the changes of coloring and texture were added into vertical and horizontal lines and the divisions of faces for the dressmaking. Whether they were the reciprocal action of human body, texture and color or the reciprocal action of human body and colors, these changes will be interpreted differently, depending on the individuals' experiences and psychological moods of situations. The emphases of the sense are also different, depending on the activity and functionality.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2033-2038
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• 2003

This paper describes an integrated navigation strategy for the autonomous service robot PSR. The PSR is under development at the KIST for service tasks in indoor public environments. The PSR is a multi-functional mobile-manipulator typed agent, which works in daily life. Major advantages of proposed navigation are as follows: 1) Structured control architecture for a systematic integration of various software modules. A Petri net based configuration design enables stable control flow of a robot. 2) A range sensor based generalized scheme of navigation. Any range sensor can be selectively applied using the proposed navigation scheme. 3) No need for modification of environments. (No use of artificial landmarks.) 4) Hybrid approaches combining reactive behavior as well as deliberative planner, and local grid maps as well as global topological maps. A presented experimental result shows that the proposed navigation scheme is useful for mobile service robot in practical applications.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3568-3584
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• 2016

In mobile opportunistic networks (MONs), human-carried mobile devices such as PDAs and smartphones, with the capability of short range wireless communications, could form various intermittent contacts due to the mobility of humans, and then could use the contact opportunity to communicate with each other. The dynamic changes of the network topology are closely related to the human mobility patterns. In this paper, we propose a social motivation-aware mobility model for MONs, which explains the basic laws of human mobility from the psychological point of view. We analyze and model social motivations of human mobility mainly in terms of expectancy value theory and affiliation motivation. Furthermore, we introduce a new concept of geographic functional cells, which not only incorporates the influence of geographical constraints on human mobility but also simplifies the complicated configuration of simulation areas. Lastly, we validate our model by simulating three real scenarios and comparing it with reality traces and other synthetic traces. The simulation results show that our model has a better match in the performance evaluation when applying social-based forwarding protocols like BUBBULE.

• Journal of KIBIM
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• v.6 no.1
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• pp.25-32
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• 2016

In BIM environments for infrastructures, civil structures such as road, bridge and tunnel etc., created into 3D objects, integrated with their properties, securing BIM design productivity is very critical during 3D modeling. To solve this issue, configuring BIM libraries so that the users can utilize prefabricating in advance 3D objects that have been applying repeatedly during BIM design is essential so much. Current BIM libraries have made focused on Ready-Made for architectural facilities. However, establishing environment for delivering BIM library for civil facilities is very sparse. Accordingly, this study developed a web-based sharing system for delivering BIM library contents based on standardized drawing for civil area. To do this, we have analyzed core features and operation system of BIM library sharing system in domestic and overseas. Besides, functional requirements that are necessary for developing BIM library sharing system was derived, and through operation scenario configuration, the web-based system was developed according to the detailed mechanism. It is expected that this system can enhance BIM design productivity during library based modeling, and can be utilized as construction supporting tools that can help construction managers to make a design change.

• Journal of the Korean Vacuum Society
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• v.15 no.2
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• pp.145-151
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• 2006

The molecular assembly of p-iodo-phenyl octadecyl ether (I-POE), p-iodo-phenyl docosyl ether (I-PDE) and a binary mixture of these two molecules on graphite has been studied using a scanning tunneling microscope. Each molecular system self-assembles on the graphite surface to form a stable monolayer with a head-to-tail configuration. For the binary system, the I-POE and I-PDE molecules do not mix on the surface, preferring instead to form isolated monolayer domains. Here, the I-POE molecules are preferentially adsorbed on the graphite surface, due to the effects of alkyl chain length and the functional group on the monolayer structure.

• Korean Journal of Childcare and Education
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• v.15 no.6
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• pp.41-57
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• 2019

Objective: The purpose of this study was to investigate the moderate effect of the physical environmental-level between infant teachers' positive play beliefs and teacher-infant interaction. Methods: The subjects of this study were 483 teachers in charge of one-year-old and two-year-old infants in child care centers located in metropolitan areas. The data were collected by asking the teachers to respond to a questionnaire and the data collected were analyzed through correlation and hierarchical multi- regression analysis. Results: First, the positive play beliefs of the infant teacher, the physical environment level, and the teacher-infant interaction showed significant proportional correlations. Second, the physical environment level moderated the influence of the teacher's positive play beliefs on teacher-infant interaction. In particular, results showed that functional interior space configuration, outdoor playground composition and facilities among the sub-variables of the physical environment level had a moderating effect. Conclusion/Implications: The results of this study show that teachers with positive play beliefs have positive teacher-infant interaction when there is sufficient space available for infants and teachers. This indicates that the human and physical environments of child care centers can promote teacher-child interaction.