• 제목/요약/키워드: Function Education

검색결과 3,488건 처리시간 0.027초

일부 노인장기요양환자의 구강실태 및 구강기능 (Dental Status and Oral Function in Some Long-term Care Elderly Patients)

  • 이윤희;윤희정;이희경;이성국
    • 보건교육건강증진학회지
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    • 제25권4호
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    • pp.55-65
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    • 2008
  • Objective: This study aims to investigate the relationship between dental status and oral function by analyzing those in some long-term care elderly patients. Methods: It performed oral examination and 4 oromotor function examinations such as repeated swallowing function, correct pronunciation function, saliva secretion rate and maximum mouth opening to 91 elderly patents aged 65 and older in the municipal geriatric hospital located in Cheonan. Results: Dental status of patients such as the number of dental caries, treated teeth, retained teeth and function teeth were better in mobile elderly patients than in immobile elderly patients. Attachment rate of dental plaque and the number of teeth being extracted were more in mobile patients than in immobile patients. More retained teeth, the number of function teeth and dental caries and the score in pronunciation status test were significantly higher. With more function teeth, the score in pronunciation status test was significantly higher. As saliva secretion rate is higher, repeated swallowing function was significantly better. repeated swallowing function rate is higher pronunciation status was significantly better. Conclusions: With the results of this study, it was found that among long-term care elderly patients, oral function was worse in immobile patients than in mobile patients. Therefore, it may be necessary to plan and perform an oral function improvement program preferentially for elderly patients requiring long-term care.

Ginseng-derived type I rhamnogalacturonan polysaccharide binds to galectin-8 and antagonizes its function

  • Yi Zheng;Yunlong Si;Xuejiao Xu;Hongming Gu;Zhen He;Zihan Zhao;Zhangkai Feng;Jiyong Su;Kevin H. Mayo;Yifa Zhou;Guihua Tai
    • Journal of Ginseng Research
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    • 제48권2호
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    • pp.202-210
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    • 2024
  • Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar KD values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

OUTLIER DETECTION BASED ON A CHANGE OF LIKELIHOOD

  • Kim, Myung-Geun
    • Journal of applied mathematics & informatics
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    • 제26권5_6호
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    • pp.1133-1138
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    • 2008
  • A general method of detecting outliers based on a change of likelihood by using the influence function is suggested. It can be applied to all kinds of distributions that are specified by parameters. For the multivariate normal case, specific computations are made to get the corresponding conditional influence function. A numerical example is provided for illustration.

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