• 방송공학회논문지
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• 제6권1호
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• pp.41-49
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• 2001

디지털 워터마킹은 워터마크의 성질에 따라 강성 워터마킹(robust watermarking)과 연성 워터마킹(fragile watermarking)으로 분류할 수 있다. 강성 워터마킹은 저작권 보호를 위한 기법이고, 연성 워터마킹은 데이터의 인증/무결성을 위한 기법으로 데이터의 진위를 확인하는 수단으로 이용할 수 있다. 일반적으로 연성 워터마킹은 영상을 변조하거나 위조하였을 때 이전에 삽입되어 있던 워터마크를 검출할 수 없게 되면 영상이 변조나 위조되었다고 판단한다. 영상의 화소 값은 비트의 조합으로 구성되므로 영상의 변조는 비트의 변경을 의미한다고 할 수 있다 따라서, 본 논문에서는 상위 비트 플레인(bit plane)과 하위 비트 플레인의 변조를 판단하기 위해 2개의 워터마크를 삽입하는 연성 워터마킹을 제안한다. 실험결과, 영상에 삽입된 워터마크는 시각적으로 영상 내에서 확인할 수 없으며. 영상에 변조를 가하였을 때 변조의 위치를 확인할 수 있었다.

• Fisheries and Aquatic Sciences
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• 제8권4호
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• pp.243-246
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• 2005

The addition of seaweed extracts was found to regulate the viability of cultures of the crustose coralline alga Lithophyllum yessoense. The viability was quantitated using a triphenyltetrazolium chloride assay, and the methanol-soluble extracts from 18 prevalent seaweed species were tested. Extracts from Codium fragile and Enteromorpha linza inhibited viability, and a Hizikia fusiform is extract slightly increased viability. The methanol extract of C. fragile, which had the strongest inhibitory activity, decreased viability to 72 or $52\%$ that of the control following addition of 0.2 or 2 mg/mL of extract to the culture, respectively. The main active compound in the C. fragile was lipid. This information is a preliminary result related to the exploration of seaweed restoration in the algal whitening area.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.231-238
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• 2017

Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin by wrapping processes in a spiral pattern around neuronal axons through myelin-related gene regulation. Since these events occur at a distance from the cell body, post-transcriptional control of gene expression has strategic advantage to fine-tune the overall regulation of protein contents in situ. Therefore, many research interests have been focused to identify RNA binding proteins and their regulatory mechanism in myelinating compartments. Fragile X mental retardation protein (FMRP) is one such RNA binding protein, regulating its target expression by translational control. Although the majority of works on FMRP have been performed in neurons, it is also found in the developing or mature glial cells including oligodendrocytes, where its function is not well understood. Here, we will review evidences suggesting abnormal translational regulation of myelin proteins with accompanying white matter problem and neurological deficits in fragile X syndrome, which can have wider mechanistic and pathological implication in many other neurological and psychiatric disorders.

• Journal of Information Processing Systems
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• 제13권5호
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• pp.1382-1396
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• 2017

In this paper, we analyze a recently proposed semi-fragile watermarking scheme based on local binary pattern (LBP) operators, and note that it has a fundamental flaw in the design. In this work, a binary watermark is embedded into image blocks by modifying the neighborhood pixels according to the LBP pattern. However, different image blocks might have the same LBP pattern, which can lead to false detection in watermark extraction process. In other words, one can modify the host image intentionally without affecting its watermark message. In addition, there is no encryption process before watermark embedding, which brings another potential security problem. To illustrate its weakness, two special copy-paste attacks are proposed in this paper, and several experiments are conducted to prove the effectiveness of these attacks. To solve these problems, an improved semi-fragile watermarking based on LBP operators is presented. In watermark embedding process, the central pixel value of each block is taken into account and Arnold transform is adopted to guarantee the security of watermark. Experimental results show that the improved watermarking scheme can overcome the above defects and locate the tampered region effectively.

• 한국해양생명과학회지
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• 제2권1호
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• pp.7-11
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• 2017

Sulfated polysaccharides are known to be immune-stimulators in mammals and can be used as food additives to enhance immunity. In this study, the immune-stimulating activity of water-soluble anionic macromolecules F₂ fractionation isolated from Codium fragile using ion-exchange chromatography was tested in olive flounder, Paralichythys olivaceus, in vitro and in vivo. The gene expression of interleukin (IL)-1β was adopted to check the immune-affection. As a result, in vitro study revealed that the expression of IL-1β was significantly upregulated in head kidney cells by 1 and 5 ㎍/ml of polysaccharides 4 h and by 5 ㎍/ml of polysaccharides at 24 h. In vivo, IL-1β gene expression in head kidney was significantly upregulated by 20 and 100 ㎍ of the polysaccharides at day 1 post-i.p. injection, while downregulated at day 3 but not significant. Meanwhile, in peritoneal cells, it was upregulated by 20 ㎍ of the polysaccharides at day 1 but the upregulation was sustained until day 3 though it was not significant. These results indicate that the sulfated polysaccharides from C. fragile are an immune-stimulator and might be potential feed additives for olive flounder.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.940-948
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• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

• 생명과학회지
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• 제22권6호
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• pp.852-856
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• 2012

한약재의 원료 및 전세계적 외래종으로 알려져 있는 녹조류 청각(Codium fragile)의 디클로로메탄, 에탄올, 열수 추출물을 대상으로 하여 생쥐에서의 항 염증, 해열, 및 진통 활성을 조사하였다. 청각의 디클로로메탄과 에탄올 추출물은 phorbol 12-myristate 13-acetate로 유도된 생쥐 귀의 부종과 충혈에 대한 염증 증상을 74% 이상의 높은 저해 작용을 보였으며, 이들 추출물은 acetyl salicylic acid와 유사하게 발열증상을 억제하였다. 청각으로부터 주된 항 염증 활성물질은 eicosapentaenoic acid인 것으로 분리되었다. 이러한 결과는 청각이 여러 염증 관련 증상에 대처할 약제로서도 사용되어 질 수 있다는 사실을 뒷받침해 준다.

• 전자공학회논문지
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• 제49권10호
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• pp.181-186
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• 2012

본 논문에서는 변수 불확실성과 필터이득 섭동을 가지는 시스템에 대한 견실비약성 $H_{\infty}$ 칼만형필터 설계기법을 제안한다. 필터가 존재할 충분조건과 견실비약성 $H_{\infty}$ 필터 설계기법을 선형행렬부등식 (LMI: Linear Matrix Inequality 접근법으로 제안하고 시스템과 필터의 불확실성을 매개변수화 선형행렬부등식(PLMI: Parameterized Linear Matrix Inequality)으로 구조화된 불확실성의 형태로 표현한 후 Lyapunov 함수를 통해 시스템의 불확실성과 더불어 필터이득섭동을 고려한 칼만형 $H_{\infty}$ 필터가 존재할 충분조건과 필터설계기법을 PLMI 형태로 보인다. PLMI는 무한개의 LMI의 형태로 나타나므로 완화기법(relaxation technique)을 적용하여 유한개의 LMI의 형태로 변환한 후 견실하고 최적화된 필터이득과 필터섭동범위를 계산하고, 예제와 모의실험을 통해 제시된 필터의 타당성을 검증한다.

• 전자공학회논문지SC
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• 제44권1호
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• pp.59-66
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• 2007

본 논문은 변수 불확실성과 제어기의 곱셈형 섭동을 가지는 특이시스템에 대한 비약성 강인 보장비용 제어기 설계 알고리듬을 제안한다. 제어기가 존재할 조건, 비약성 보장비용 제어기 설계 방법, 제어기에서의 비약성 척도와 보장비용 성능지수를 최소화하는 보장비용의 상한치(upper bound)를 선형행렬부등식 접근방벙으로 제안한다. 또한, 특이치분해와 변수치환 및 슈어 여수정리를 이용하여 구한 충분조건은 구하고자 하는 변수의 견지에서 볼록최적화(convex optimization)가 가능한 선형행렬부등식으로 변형된다. 따라서, 제안한 비약성 강인 보장비용 제어기는 변수 불확실성과 제어기의 곱셈형 섭동을 가지는 폐루프 특시이스템의 점근적 안정성과 보장비용 성능지수를 최소화하고 제어기의 섭동에 대해서도 안정성을 보장한다. 마지막으로, 수치예제를 통하여 제안한 알고리듬의 타당성을 검증한다.

• 한국수산과학회지
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• 제38권3호
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• pp.164-171
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• 2005

Codium fragile (Suringar) Hariot, an edible green alga is farmed in Korea by natural blooming zygotes attachment. Experiments were conducted to reveal the conditions for artificial seed production of C. fragile by sexual and asexual reproduction. Growth was compared between zygotes attachment (sexual reproduction) and isolated utricles with medullary filaments (asexual reproduction). Zygotes and isolated utricles with medullary filaments were cultured under different light conditions (10, 20, 40, 60 and $100\;{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$) and temperatures (5, 10, 15, 20 and $25^{\circ}C$) under 16:8LD. Maximum growth of zygote was $261.3{\pm}21.0\;{\mu}m$ under $15^{\circ}C$ and $20\;{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ after 13 days culture. Maximum regeneration of isolated medullary filament was $8.1{\pm}1.7\;mm$ per one isolated utricle under $20^{\circ}C$ and $100\;{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ after 15 days culture. After intermediate culture during two months in the field, morphogenesis occurred in both sexual and asexual reproduction, and growth of young thalli was not significantly different (p>0.05) between the both reproduction methods. Even though seed production of C. fragile is possible in both sexual and asexual reproduction, the mass artificial seed production of asexual reproduction is much more effective than that of sexual reproduction that is too much affected by maturity.