Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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In vivo Anti-inflammatory, Antipyretic, and Analgesic Activities of the Aquaculturable Green Seaweed Codium fragile Extracts in Mice

양식산 녹조류 청각(Codium fragile) 추출물의 항염증, 해열 및 진통에 대한 생체활성

  • Received : 2012.03.12
  • Accepted : 2012.05.23
  • Published : 2012.06.30
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Abstract

Dichloromethane, ethanol, and boiling water extracts of the green seaweed Codium fragile, used as an herbal medicine and known as an invasive species over the world, were examined for anti-inflammatory, antipyretic, and analgesic activities in mice. The dichloromethane and ethanol extracts inhibited inflammatory symptoms of mouse ear edema and erythema by 74% or higher. The extracts also demonstrated inhibition of pyrexia, similar to that of acetyl salicylic acid. Eicosapentaenoic acid was isolated from the seaweed as the main active anti-inflammatory compound. These findings are consistent with various claims that the seaweed can be used as remedies for inflammation-related symptoms.

한약재의 원료 및 전세계적 외래종으로 알려져 있는 녹조류 청각(Codium fragile)의 디클로로메탄, 에탄올, 열수 추출물을 대상으로 하여 생쥐에서의 항 염증, 해열, 및 진통 활성을 조사하였다. 청각의 디클로로메탄과 에탄올 추출물은 phorbol 12-myristate 13-acetate로 유도된 생쥐 귀의 부종과 충혈에 대한 염증 증상을 74% 이상의 높은 저해 작용을 보였으며, 이들 추출물은 acetyl salicylic acid와 유사하게 발열증상을 억제하였다. 청각으로부터 주된 항 염증 활성물질은 eicosapentaenoic acid인 것으로 분리되었다. 이러한 결과는 청각이 여러 염증 관련 증상에 대처할 약제로서도 사용되어 질 수 있다는 사실을 뒷받침해 준다.

Keywords

References

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