• 사상체질의학회지
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• 제9권2호
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• pp.203-225
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• 1997

Jihwangbakhotang(地黃白虎楊) is made by Li Je Ma, the creator of the Four Constitutional Medicine. Single and 13 weeks oral repeated dose toxicity studies were conducted in Sprague Dawley rats of both sexes to elucidate the potential acute and subchronic toxicity of JBT extract and reversibility of any effects. In the single dose study, JBT extract was administered orally to rats with the dose of 2 g/kg and 8 g/kg. In the long term administration of 13 weeks, the JBT extract of 125 mg/kg/day, 500 mg/kg/day, 2000 mg/kg/day was administered to rats. The change of blood weight, urine volume, electrolyte in urine, hematological change, the change of blood chemistry, autopsy finding, and histological observation were researched, the results were as follows; 1. The lethal dose of JBT extract seems to be over 10 g/kg, the single administration of JBT extract 8 g/kg showed no toxical signs except little increase of urine volume. 2. The change of body weight had the trend of decrease in the group of, but has no significance, and also the consumption of food and water had no changes. 3. The hematological changes induced by the 13 weeks administration of JBT extract showed the significance in the item of Hb, MCH, MCV, WBC in the group of 125 mg/kg/day. 4. In the test of blood chemistry, total cholesterol showed little decrease and A/G ratio showed little increase, but the change was not clear, and the standard error was large. So the result was obtained insignificantly and the toxicity of JBT extract was not observed. 5. In the male group after recovery period, the level of cholesterol and triglyceride decreased slightly, but the result was not significant. 6. In the urine test, the little change of electrolyte was appeared, but it seemed not to be the result induced by the toxicity of JBT extract. 7. In each group of male and female rats, the weight change of organ and the serum histological changes was observed, but the result did not showed the dose dependent toxicity. So the toxicity of JBT extract was not regarded. In the conclusion, the toxicity of JBT extract was not observed in the single dose treatment and long term repetitive administration of JBT extract.

• 한국산학기술학회논문지
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• 제12권2호
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• pp.805-812
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• 2011

이 연구의 목적은 고강도로 실시되는 12주간의 웨이트 트레이닝을 통하여 노인 여성들의 신체조성 및 기능적 체력에 어떠한 변화가 있는지를 규명하는 것이다. 연구대상자들은 U경로당에 정기적으로 출입하는 70세 이상 노인 여성 중에 실험의 취지를 알고 자발적 참여의사를 가진 24명을 선정하였다. 선정된 24명을 무선할당 방법을 통해 두 개의 운동집단인 고강도 저항성 운동 집단 (High intensity resistance group, n=8), 저강도 저항성 운동 집단(Low intensity resistance group, n=8) 그리고 비교군 (Control group, n=8)으로 나누었다. 운동집단은 12주간의 고강도 및 저강도 저항성 운동을 실시하였으며, 비교군은 12주간 어떠한 운동에도 참가하지 못하도록 제한하였다. 연구결과, 12주간 실시된 고강도 웨이트 트레이닝은 근력과 민첩성을 유의하게 향상시켰으며, 체지방률과 체지방량은 유의하게 감소시켰다(p<0.05). 평형성 및 심폐능력은 향상되었으나 통계적 유의성은 없었다. 종합해보면 정기적인 고강도 웨이트 트레이닝은 노인 여성들의 체력 개선에 도움을 줄 수 있는 운동이라 사료된다.

• Journal of Acupuncture Research
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• 제33권2호
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• pp.77-87
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• 2016

Objectives : This is a pilot study for a large randomized controlled trial to investigate the efficacy and safety of a newly developed contrast therapy device-- alternating topical heat and cold -- for patients with chronic low back pain. The main objective of this study is to confirm the feasibility of the study design. Methods : The design was a randomized, 2-arm, parallel-group, single-blind, placebo controlled trial. Patients in each group received real or sham contrast therapy in an acupuncture point 10 times over four weeks. The primary outcome measure was pain intensity on a 100-mm visual analogue scale (VAS). The secondary outcomes were back-related dysfunction based on the Oswestry Disability Index (ODI), the Roland-Morris disability questionnaire (RMDQ), and range of motion of lumbar spine based on the modified Schober test (mSchober test), Finger-to-Floor distance (FTF distance), and Finger-to-Thigh distraction (FTT distraction). Results : A total of 30 subjects with chronic low back pain were randomly assigned to a contrast therapy group (n＝15) or a sham group (n＝15). A repeated-measures analysis of variance showed statistically significant group time interaction for VAS, RMDQ, mSchober test and FTF distance (p<0.05). The treatment group showed significant improvement in pain intensity and functional disability as compared to the sham group. Conclusion : Contrast therapy may be an effective and safe treatment for chronic low back pain.

• Neonatal Medicine
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• 제25권2호
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• pp.58-65
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• 2018

Purpose: The purpose of this study is to describe the rate of cytomegalovirus (CMV) virolactia, and the prevalence of breast milk (BM)-transmitted postnatal CMV infection among premature infants after freeze-thawing (FT) and Holder pasteurization (HP) of breast milk. Methods: This is a single-center, retrospective study of 312 infants born at less than 32 weeks of gestation, or with a birth weight less than 1,500 g from January 2013 to June 2017. All infants were screened for CMV-specific immunoglobulin (Ig) G and IgM at birth. Initial CMV specific polymerase chain reaction (PCR) and CMV culture were performed on mothers' BM and babies' urine within the first 21 days of life. FT and HP of BM was used to prevent the transmission of CMV. For the surveillance of postnatal CMV infection, CMV culture and CMV specific PCR of urine from babies were repeated one to two months after the initial screening. Screening for viremia and viruria was performed if postnatal CMV infection was suspected. Results: Among 178 BM samples obtained from mothers of CMV-IgG-seropositive infants, 80 (44.9%) were CMV PCR positive. CMV deoxyribonucleic acid (DNA) was detected in five of the 22 BM samples (22.7%) obtained from the mothers of CMV-IgG seronegative infants. When CMV DNA load in BM was measured before and after HP, various results were shown. Sixty-three infants out of 232 (27.2%) were evaluated for postnatal CMV infection and four infants out of 63 (6.3%) were infected. Conclusion: Interventions to prevent BM-transmitted CMV infection can reduce the chance of postnatal CMV infection, but not completely eliminate it.

• 한국지하수토양환경학회지:지하수토양환경
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• 제25권1호
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• pp.25-36
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• 2020

In a redox transition zone, geochemical reactions are facilitated by active bacteria that mediate reactions involving electrons, and arsenic (As) and iron (Fe) cycles are the major electron transfer reactions occurring at such a site. In this study, the effect of repetitive redox changes on soil bacterial community in As-contaminated soil was investigated. The results revealed that bacterial community changed actively in response to redox changes, and bacterial diversity gradually decreased as the cycle repeated. Proportion of strict aerobes and anaerobes decreased, while microaerophilic species such as Azospirillum oryzae group became the predominant species, accounting for 72.7% of the total counts after four weeks of incubation. Bacterial species capable of reducing Fe or As (e.g., Clostridium, Desulfitobacterium) belonging to diverse phylogenetic groups were detected. Indices representing richness (i.e., Chao 1) and phylogenetic diversity decreased from 1,868 and 1,926 to 848 and 1,121, respectively. Principle component analysis suggests that repetitive redox fluctuation, rather than oxic or anoxic status itself, is an important factor in determining the change of soil bacterial community, which in turn affects the cycling of As and Fe in redox transition zones.

• 대한물리의학회지
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• 제12권1호
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• pp.35-42
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• 2017

PURPOSE: The purpose of this study was to examine the effects of treadmill gait training in an adjusted position from the functional training system on the gait and balance of chronic stroke patients. METHODS: Thirty chronic stroke patients were randomly assigned to either the experimental group, who received treadmill gait training in an adjusted position, or the control group, who received regular treadmill gait training. Both groups underwent a 30-minute comprehensive rehabilitation treatment before receiving an additional 20-minute treadmill gait training. This routine was repeated five times a week for four weeks. To measure the difference before and after training in walking and balance, patients were scored on the following: 10 m walking test (10 MWT), 6 minute walking distance (6 MWD), timed up and go test (TUG), and static standing balance test (stability index). RESULTS: While post-training scores of 10 MWT, 6 MWD, TUG, and stability index for both groups increased significantly compared with pre-training (p<.05), the experimental group showed greater improvement than the control group (p<.05). The scores of the experimental group increased significantly by 9% in the 10 MWT, 11% in 6 MWD, 13% in the TUG, 8% in the stability Index (eye opened), and 10% in the stability index (eye closed). CONCLUSION: Treadmill gait training in an adjusted position from the functional training system would be a useful gait training method to improve walking and balance of chronic stroke patients.

• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.103-111
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• 2011

최근 만성질환을 예방하고 건강을 증진시킬 목적으로 신체활동에 대한 중요성이 인식되면서 신체활동 연구가 활발히 진행되고 있다. 본 연구에서는 3축 가속도 동작감지기 x, y, z축에 대한 $cm/s^2$의 가속도 합인 SVM(Signal Vector Magnitude)를 이용하여 신체활동 에너지 소비량 알고리즘을 구현하였다. 기존 실험을 통해 타당도가 입증된 COUNT 방식의 Freedson, Hendelman, Leenders, Yngve 알고리즘에 SVM 방식을 적용하여 구현 하였다. COUNT와 SVM 상관관계 분석을 위하여 총 10명의(성인 남성 5명, 여성 5명, 20 ~ 30 대) 피험자를 대상으로 실험을 진행하였다. 피험자는 트레드밀위에서 3단계 신체활동 (걷기: 3km/h, 빨리 걷기: 5km/h, 러닝: 8km/h)을 1주 간격으로 4주 간 반복 실험을 진행하였다. 실험결과 얻어진 COUNT와 SVM의 간의 상관관계를 분석하여 다양한 신체활동에 따른 맞춤형 에너지 측정 알고리즘을 구현하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2391-2395
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• 2015

Objective: The aim of this retrospective study was to evaluate the feasibility and efficacy of response to continuous-infusion ifosfamide and doxorubicin combination as second-line chemotherapy for patients with recurrent or refractory osteosarcoma. Materials and Methods: Eighteen recurrent or refractory osteosarcoma patients who were treated with continuous-infusion ifosfamide and doxorubicin combination between May 1999 and April 2011 were included in the analysis. Ifosfamide at $12g/m^2$ was administered by intravenous continuous infusion over 3 days, and doxorubicin $60mg/m^2$ was administered as an intravenous bolus injection on day 1. The combination therapy was repeated every 3 weeks. Treatment was continued until evidence of disease progression or unacceptable toxicity. Results: The patients (ages 7-53 years) received a total of 42 cycles of chemotherapy (median: 2 courses; range: 2-5 courses). The overall response rate was 0% and the disease control rate was 22.3%, with four patients having stable disease. The median time to progression and overall survival time were 2 months (range: 2-5 months) and 9 months (range: 3-29 months), respectively. Major severe toxicities were leucopenia 7 (38.9%), nausea and vomiting 3 (16.7%) and alopecia 9 (50%). There were no treatment-related deaths. Conclusions: In our experience, continuous-infusion ifosfamide and doxorubicin combination therapy at this dosage and schedule was found to be well tolerated and moderate effective, which could be considered as salvage therapy for patients with recurrent or refractory osteosarcoma. Further assessment is necessary to confirm the safety and efficacy of this treatment.

• Environmental Analysis Health and Toxicology
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• 제21권2호
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• pp.173-184
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• 2006

From the harmfulness expectation test conducted through a toxicity anticipation program, methylcyclohexane turned out to be harmful and simulative, but no carcinogenicity was anticipated. In a four-hour acute inhalation toxicity test, the result showed that lethal concentration ($LC_{50}$) was 3,750 ppm (15,054 mg/L), which was identified as a harmful substance on the basis of the harmful substance classification standard $2 of the Industrial safety and health law. methylcyclohexane fell under the category $4(2,500 substance from the GHS standard acute toxicity harmfulness classification. Also, from subchronic inhalation toxicity test that included 6 hours a day, five days a week, and for 13 weeks, we could observe weight, activity, long term weight, blood and blood biochemical influence from the exposure of test substance. No-observed effect level (NOEL) was determined below $100{\sim}400ppm$ inboth male and female. This material falls under the Category 2 ($50{\sim}250ppm/6hours/90days$) in the GHS (Globally Harmonized System) standard trace long-term whole body toxicity repeated exposure, and can be classified as a harmful substance in accordance with the Industrial Safety and Health Law harmful substance standard $NOEL{\leq}0.5mg/L/6hr/90day$ (rat).

• 재활복지공학회논문지
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• 제5권1호
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• pp.27-33
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• 2011

3축 가속도 동작감지기를 이용하여 x, y, z축에 대한 가속도 합인 SVM(Signal Vector Magnitude)를 적용한 신체활동 에너지 소비량과 신체활동 강도 예측 알고리즘을 구현하였다. 신체 건강한 20~30대 성인 남성 5명, 여성 5명을 대상으로 골반 장골능에 엑티그라프(LLC, USA)와 피트미터(Fit.life. korea)를 착용하고 트레드밀위에서 3단계 신체활동(걷기: 3km/h, 빨리 걷기: 5km/h, 러닝: 8km/h)을 수행하였다. 각 신체활동 단계별로 7분간 신체활동을 수행하고 5분간 휴식을 통하여 각 신체활동 단계별로 안정화된 상태에서 실험하였다. 이러한 실험을 1주 간격으로 4주간 반복 실험을 진행하였다. 실험결과 얻어진 엑티그라프와 피트미터의 600여개 데이터 상관관계를 분석하여 METs와 kcal 그리고 신체활동 강도를 구분하는 알고리즘을 구현하였다.