• 한국세라믹학회지
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• 제15권4호
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• pp.185-192
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• 1978

The effects of slag prticle size, $Na_2SO_4$ addition and sulphide in slag to the foam formation was investigated. This investigation showed that the slag particle size and the amount of $Na_2O$ had produced effects on the size of the foam, foam distribution and firing temperatures. In addition to that the amount of sulphide loss during the firing was controlling factor for the foam formation. The smaller slag particles and higher firing temperatures increased the loss of sulphide in the slag. The addition of $Na_2SO_4$ in the slag batch was likely to inhibit the foam formation. The larger slag particles resutled in the larger foam size and tended to be increasing the batch firing temperature. The main constituents of slag formed glass consisted of wallstonite and glassy phase. It is believed that the controlling the slag particle size and the amount of $Na_2SO_4$ in the slag batch will probably be main factors in foam formation.

• Industrial Engineering and Management Systems
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• 제1권1호
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• pp.19-28
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• 2002

An operation sequence of parts is one of the most important production factors in the design of cellular manufacturing systems. Many similarity coefficient method (SCM) based approaches have been proposed to solve cell formation problems in the literature. However, most of them do not consider the operation sequence factor. This study presents an operation sequence ratio (OSR) and modifies some existing similarity coefficients using the OSR to solver cell formation problems considering operation sequences. The computational results show that the OSR ratio is useful and robust in solving cell formation problems with operation sequences.

• 천문학회보
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• 제44권2호
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• pp.38.1-38.1
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• 2019

The formation and evolution of galaxies is known to be fundamentally linked to the local environment in which they reside. In the highest-density cluster environments, galaxies tend to be more massive, have lower star formation rates and dust content, and a higher fraction have elliptical morphologies. The stellar populations of these cluster galaxies are older implying that they formed the bulk of their stars much earlier and have since evolved passively. Quantifying the specific environmental factors that contribute to shaping cluster galaxies over the Hubble time and measuring their early evolution can only be accomplished by directly tracing the galaxy growth in young clusters and forming porto-clusters. In this talk, I will present a novel technique designed to map out the total dust obscured star formation relative to where existing stars lie. I will demonstrate that this technique can be used 1) to determine if/where/when the activity is heightened or suppressed in dense cluster environment; 2) to measure the total mass and spatial distribution of stellar populations; and 3) to better inform theoretical models. Our ongoing work to extend this analysis out to protoclusters (z~2-4) will be discussed.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제39권
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• pp.8.1-8.8
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• 2017

Background: For an effective bone graft for reconstruction of the maxillofacial region, an adequate vascular network will be required to supply blood, osteoprogenitor cells, and growth factors. We previously reported that the secretomes of bone marrow-derived mesenchymal stem cells (MSC-CM) contain numerous growth factors such as insulin-like growth factor (IGF)-1, transforming growth factor $(TGF)-{\beta}1$, and vascular endothelial growth factor (VEGF), which can affect the cellular characteristics and behavior of regenerating bone cells. We hypothesized that angiogenesis is an important step for bone regeneration, and VEGF is one of the crucial factors in MSC-CM that would enhance its osteogenic potential. In the present study, we focused on VEGF in MSC-CM and evaluated the angiogenic and osteogenic potentials of MSC-CM for bone regeneration. Methods: Cytokines in MSC-CM were measured by enzyme-linked immunosorbent assay (ELISA). Human umbilical vein endothelial cells (HUVECs) were cultured with MSC-CM or MSC-CM with anti-VEGF antibody (MSC-CM + anti-VEGF) for neutralization, and tube formation was evaluated. For the evaluation of bone and blood vessel formation with micro-computed tomography (micro-CT) and for the histological and immunohistochemical analyses, a rat calvarial bone defect model was used. Results: The concentrations of IGF-1, VEGF, and $TGF-{\beta}1$ in MSC-CM were $1515.6{\pm}211.8pg/mL$, $465.8{\pm}108.8pg/mL$, and $339.8{\pm}14.4pg/mL$, respectively. Tube formation of HUVECs, bone formation, and blood vessel formation were increased in the MSC-CM group but decreased in the MSC-CM + anti-VEGF group. Histological findings suggested that new bone formation in the entire defect was observed in the MSC-CM group although it was decreased in the MSC-CM + anti-VEGF group. Immunohistochemistry indicated that angiogenesis and migration of endogenous stem cells were much more abundant in the MSC-CM group than in the MSC-CM + anti-VEGF group. Conclusions: VEGF is considered a crucial factor in MSC-CM, and MSC-CM is proposed to be an adequate therapeutic agent for bone regeneration with angiogenesis.

• Journal of Periodontal and Implant Science
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• 제35권2호
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• pp.383-399
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• 2005

The successful implantation necessitate tissue regeneration m site of future implant placement, there being severe bone defect. Therapeutic approaches to tissue regeneration in the site have used bone grafts, root surface treatments, barrier membranes, and growth factors, the same way being applied to periodontal tissue regeneration. Great interest in periodontal tissue regeneration has lead to research in bone graft, guided-tissue regeneration, and the administration of growth factors as possible means of regenerating lost periodontal tissue. The blood component separated by centrifuging the blood is the platelet-rich plasma. There are growth factors, PDGF, $TGF{beta}1$, $TGF{beta}2$ and IGF in the platelet-rich plasma. The purpose of this study was to study the histopathological correlation between the use of platelet-rich plasma and the healing of bone defect around implant fixture site. Implant fixtures were inserted and graft materials were placed into the left femur of in the experimental group, while the control group received only implant fixtures. In the first experimental group, platelet-rich plasma and BBP xenograft were placed at the implant fixture site, and the second experimental group had platelet-rich plasma, BBP xenograft, and the e-PTFE membrane placed at the fixture site. The degree of bone regeneration adjacent to the implant fixture was observed and compared histopathologically at 2, 4, and 8 weeks after implant fixture insertion. The results of the experiment were as follows: 1. Bone remodeling in acid etched surface near the implant fixture of all experimental groups was found to be greater than new bone formation. 2. Bone remodeling in acid etched surface distant to the implant fixture of all experimental groups was decreased and new bone formation was not changed. 3. Significant new bone formation in machined surface near the implant fixture of bothl experimental groups was observed in 2 weeks. 4. New bone formation in machined surface distant to the implant fixture of both experimental groups was observed. Bone remodeling was significant in near the implant fixture and not in distant to the implant fixture. The results of the experiment suggested that the change of bone formation around implant. Remodeling in machined surface distant to the implant fixture of both experimental groups, and new bone formation and remodeling near the implant fixture were significant.

• International Journal of Oral Biology
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• 제40권4호
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• pp.189-196
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• 2015

Minimal inhibitory concentration (MIC) is the lowest antibiotic concentration that inhibits the visible growth of bacteria. Sub-minimal inhibitory concentration (Sub-MIC) is defined as the concentration of an antimicrobial agent that does not have an effect on bacterial growth but can alter bacterial biochemistry, thus reducing bacterial virulence. Many studies have confirmed that sub-MICs of antibiotics can inhibit bacterial virulence factors. However, most studies were focused on Gram-negative bacteria, while few studies on the effect of sub-MICs of antibiotics on Gram-positive bacteria. In this study, we examined the influence of sub-MICs of doxycycline, tetracycline, penicillin and amoxicillin on biofilm formation and coaggregation of Streptococcus gordonii, Streptococcus mutans, Actinomyces naeslundii, and Actinomyces odontolyticus. In this study, incubation with sub-MIC of antibiotics had no effect on the biofilm formation of S. gordonii and A. naeslundii. However, S. mutans showed increased biofilm formation after incubation with sub-MIC amoxicillin and penicillin. Also, the biofilm formation of A. odontolyticus was increased after incubating with sub-MIC penicillin. Coaggregation of A. naeslundii with S. gordonii and A. odontolyticus was diminished by sub-MIC amoxicillin. These observations indicated that sub-MICs of antibiotics could affect variable virulence properties such as biofilm formation and coaggregation in Gram-positive oral bacteria.

• 한방안이비인후피부과학회지
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• 제16권3호
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• pp.96-115
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• 2003

Introduction and Objectives : Administrating the Sopungchengyoungtanggami-bang (SCG) extract on to the atopic dermatitis(AD) is to study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide and this study is done through forcing injury to rat's back skin which are lipid protect formation in stratum corneum. Materials and Methods : The AD which caused intentionally using the external application on the rat's back skin was used the SCG. The change of leukocytes in vasculature has been identified through optima 5.2 and student t-test and the results were made into dermal formation graph. Results : After dispensing SCG extract into the AD, the dermal injury was decreased. Especially, recover of lipid protection formation which include lipid and ceramide in stratum corneum is suppressing acute inflammation that some factors are PKC, TNF-${\alpha}$, IL-12B which controled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and the decrease of degranulated mast cell. In addition, the decrease of epithelial injury also caused the growth of cell to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease AD Conclusions : Thus, SCG has effect on AD suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.

• 천문학회보
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• 제39권1호
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• pp.33.2-33.2
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• 2014

Halo merger trees are essential backbones of semi-analytic models for galaxy formation and evolution. Recent studies have pointed out that extracting merger trees from numerical simulations of structure formation is non-trivial; different algorithm can give differing merger histories. Thus they should be carefully understood before being used as input for models of galaxy formation. As one of the projects proposed in the SUSSING MERGER TREES Workshop, we investigate the impact of different halo merger trees on a semi-analytic model. We find that the z = 0 global galaxy properties in our model show differences between trees when using a common parameter set, but that these differences are not very significant. However, the star formation history of the Universe and the properties of satellite galaxies can show marked differences between trees with different methods for constructing a tree. Calibrating the SAM for each tree individually to the empirical data can reduce the discrepancies between the z = 0 global galaxy properties, however this is at cost of increasing the differences in evolutionary histories of galaxies. Furthermore, the underlying physics implied can vary, resulting in key quantities such as the supernova feedback efficiency differing by factors of 2. Such a change alters the regimes where star formation is primarily suppressed by supernovae. Therefore, halo merger trees extracted from a common halo catalogue using different, but reliable, algorithms can result in a difference in the semi-analytic model, however, given the enormous uncertainties in galaxy formation physics, these are not necessarily significant.

• 한국해양공학회지
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• 제36권1호
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• pp.11-20
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• 2022

Generally, tsunamis are generated by the rapid crustal movements of the ocean floor. Other factors of tsunami generation include landslides on coastal and ocean floor slopes, glacier collapses, and meteorite collisions. In this study, two numerical analyses were conducted to examine the formation, propagation, and deformation properties of landslide tsunamis. First, LS-DYNA was adopted to simulate the formation and propagation processes of tsunamis generated by dropping rigid bodies. The generated tsunamis had smaller wave heights and wider waveforms during their propagation, and their waveforms and flow velocities resembled those of theoretical solitary waves after a certain distance. Second, after the formation of the landslide tsunami, a tsunami based on the solitary wave approximation theory was generated in a numerical wave tank (NWT) with a computational domain that considered the stability/steady phase. The comparison of two numerical analysis results over a certain distance indicated that the waveform and flow velocity were approximately equal, and the maximum wave pressures acting on the upright wall also exhibited similar distributions. Therefore, an effective numerical model such as LS-DYNA was necessary to analyze the formation and initial deformations of the landslide tsunami, while an NWT with the wave generation method based on the solitary wave approximation theory was sufficient above a certain distance.

• 과학교육연구지
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• 제38권1호
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• pp.103-119
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• 2014

이 연구의 목적은 중학교 일정성분비의 법칙 수업에서 드러난 과학교사의 교수지향과 이의 형성에 영향을 준 요인을 알아보는 것이었다. 이를 위해 이 연구에 참여한 과학 교사 8명의 수업을 녹화 및 분석하고 면담, CoRe 질문지 등을 통하여 자료를 수집하였다. 수업 과정에서 드러난 교사의 활동으로부터 그의 과학교수 지향을 알아내고, 수집한 자료의 분석을 통하여 각 교사의 교수지향 형성에 영향을 준 요인을 추출하였다. 연구 결과, 과학교사들의 교수지향은 크게 활동 지향과 강의 지향으로 구분되었으며, 활동 지향은 다시 탐구적 혹은 비탐구적, 강의 지향은 상호작용 중심 혹은 내용전달 중심으로 범주화 되었다. 과학교사들의 교수지향 형성에 영향을 준 요인은 수업경험을 통한 반성적 사고, 동료교사와의 상호작용, 교육환경에 대한 고려, 학습자로서의 수업 및 연수내용, 교사 자신의 흥미와 호기심이었는데, 그 중에서 수업 경험을 통한 반성적 사고가 가장 큰 영향을 주었고, 교사 자신의 흥미와 호기심은 제한적이지만 긍정적인 과학교수 지향 형성에 강력한 영향을 주었다. 반면에 교육환경에 대한 고려는 다른 요인들과는 달리 교사들의 과학교수 지향 형성에 부정적인 영향을 미치는 것으로 나타났다. 동료교사와의 상호작용, 대학이나 대학원에서의 수업 내용 및 현직 교사를 위한 연수 내용은 과학교수 지향 형성에 일정 부분 영향을 주었으나, 주로 교과내용 지식의 형성에 영향을 주는 수준으로 나타났다.