• YAKHAK HOEJI
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• v.39 no.6
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• pp.593-599
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• 1995

Erythromycin was formulated as enteric-coated pellets in order to reduce degradation in stomach and gastromtestmal irritation, and to maximize the absorption in intestine followmg its oral administration. Core pellets were prepared using fluid-bed granulator with two different methods (powder layering and solvent spraying) and enteric-coated with two different coating polymers (HPMCP and Eudragit E30D). Physical characteristics md dissolution rates of core pellets and enteric-coated pellets were evaluated to optimize the formulation. Powder layering method resulted in shorter initial dissolution time than solvent spraying method, but physicochmical properties of the product were worse than solvent spraying method with respect to hardness, ftiability and density. The dissolution rate of the drug was increased with the addition of surfactants, showing concentration-dependence. The scanning electron microscopic observation of pellets revealed significant differences on the surface appearances prepared with solvent spraying method. The core pellet made with powder layering method had crystals on the surface, which resulted in poor physical properties of the pellets. The dissolution profiles of erythromycin pellets coated with HPMCP or Eudragit L30D were close to that of commercially available erythromycin enteric-coated product.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1998.09a
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• pp.117-121
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• 1998

The Rapid Expansion of supercritical fluid Solutions (RESS) process was applied to particles coating. Experiments were conducted in a fluidized bed with an internal nozzle in the center of the reaction tube. Microcapsules (mean particle size : 49$\mu\textrm{m}$) prepared by spray drying method were used as the core particles. Supercritical CO2 solutions of paraffin were expanded through the nozzle in to the bed that was fluidized by air. Surface morphology prepared particles was observed by SEM. For the inspection of particle size change, particle size distributions were measured before and after coating. The releasing behavior of Mg2+ ions inspected by AA.

• Journal of Environmental Science International
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• v.29 no.11
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• pp.1015-1024
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• 2020

Using the waste(sand wastr and boiler ash) in fluidized bed inciverator, lightweight aggregate concrete was produced and a recycling plan was prepated. The first, the result of the leaching test shows that the waste fluid sand and boiler ash did not exceed the effluent standard. This indicates that there is no harmful effect for recycling. The second, in the lightweight aggregate test using waste fluid sand and boiler ash, the sample that combined cement, waste fluid sand, and sand showed the highest compressive strength, and the mix proportion was 10: 7: 3. Lightweight aggregate concrete that combined cement, waste fluid sand, boiler ash, and sand had a low compressive strength by and large. The third, the same results were identified in the relation between the content of SiO₂ and that of Na₂O. As the SiO₂ content is lowered, the overall viscosity and plasticity of the concrete also decrease, which is not a good condition to form concrete. As for Na₂O, as the content increases, the viscosity of the sample and the viscosity of the cement are remarkably lowered, and the strength of the finished concrete is lowered. Therefore, it was concluded that the higher the content of SiO₂ and the lower the content of Na₂O, the more suitable it is to mix with cement to produce concrete. Fourth, from the fluidized bed incinerator currently operated by company A in city B, a total of 14,188 tons/year were discharged as of 2016, including 8,355 tons/year of bottom ash (including waste fluid sand) and 5,853 tons/year of boiler ash. The cost for landfill bottom ash and boiler ash discharged is 51,000 won/ton, and the total annual landfill cost is 723,588,000 won/ year. Assuming that the landfill tax to be applied from the year 2018 is about 10,000 won/ton, and if there is no reduction in waste disposal charge, an additional landfill tax of 141,880,000 won/year will be imposed. Consequently, the sum total of the annual landfill cost will be 865,468,000 won/year. Therefore, if the entire amount is used for recycling, the annual savings of about 8.7 billion won can be expected.

• Water Engineering Research
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• v.2 no.3
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• pp.179-185
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• 2001

The time consuming and expensive nature of experimental research on scouring processes caused by flowing water makes it attractive to develop numerical tools for the predication of the interaction of the fluid flow and the movable bed. In this paper the numerical simulation of scour by a wall jet is presented. The flow is assumed to be two-dimensional, and the alluvium is cohesionless. The solution process, repeated at each time step, involves simulation of a turbulent wall jet flow, solution of the convection-diffusion of sand concentration, and prediction of the bed deformation. For simulation of the jet flow, the governing equations for momentum, mass balance and turbulent parameters are solved by the finite volume method. The SIMPLE scheme with momentum interpolation is used for pressure correction. The convection-diffusion equation is solved for sediment concentration. A boundary condition for concentration at the bed, which takes into account the effect of bed-load, is implemented. The time rate of deposition and scour at the bed is obtained by solving the continuity equation for sediment. The shape and position of the scour hole and deposition of the bed material downstream of the hole appear realistic.

• Journal of Korea Society of Waste Management
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• v.34 no.7
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• pp.685-696
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• 2017

This study focuses on computational particle fluid dynamics (CPFD) modeling for the fast pyrolysis of biomass in a conical spouted bed reactor. The CPFD simulation was conducted to understand the hydrodynamics, heat transfer, and biomass fast pyrolysis reaction of the conical spouted bed reactor and the multiphase-particle in cell (MP-PIC) model was used to investigate the fast pyrolysis of biomass in a conical spouted bed reactor. A two-stage semi-global kinetics model was applied to model the fast pyrolysis reaction of biomass and the commercial code (Barracuda) was used in simulations. The temperature of solid particles in a conical spouted bed reactor showed a uniform temperature distribution along the reactor height. The yield of fast pyrolysis products from the simulation was compared with the experimental data; the yield of fast pyrolysis products was 74.1wt.% tar, 17.4wt.% gas, and 8.5wt.% char. The comparison of experimental measurements and model predictions shows the model's accuracy. The CPFD simulation results had great potential to aid the future design and optimization of the fast pyrolysis process for biomass.

• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.387-392
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• 2008

Alfuzosin, an Alphal-adrenoceptor antagonist is used for the treatment of patients with voiding and in a lesser extent storage lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH). The objective of this study was to formulate sustained release alfuzosin HCl granules and assess their formulation variables. The $Eudragit^{(R)}$ as a polymer, sustained release membrane, and dibutyl sebacate (DBS) as a plasticizer were used. Multi-coated alfuzosin HCl delivery systems composed of sugar sphere, various excipients, $Eudragit^{(R)}$ and HPMC (hydroxy propyl methyl cellulose), Cellulose Acetate were prepared by fluid-bed coater. Membrane layer were used $Eudragit^{(R)}$ RS PO and NE 30D. And the alfuzosin HCl coated beads were coated immediate release drug layer for initial burst. Its dissolution test was carried out compared to conventional products ($XATRAL^{(R)}$ XL). The release rate of drug from coated beads was higher than that from $XATRAL^{(R)}$ XL in pH 6.8.

• Kyungpook Mathematical Journal
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• v.61 no.2
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• pp.323-351
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• 2021

The present paper addresses magnetohydrodynamic pulsating flow and heat transfer of two immiscible, incompressible, and conducting couple stress fluids between two permeable beds. The flow between the permeable beds is assumed to be governed by Stokes' [28] couple stress fluid flow equations, whereas the dynamics of permeable beds is determined by Darcy's law. In this study, matching conditions were used at the fluid-fluid interface, whereas the B-J slip boundary condition was employed at the fluid-porous interface. The governing equations were solved analytically, and the expressions for velocity, temperature, mass flux, skin friction, and rate of heat transfer were obtained. The analytical expressions were numerically evaluated, and the results are presented through graphs and tables.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3187-3190
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• 2007

Elastin-Like polypeptide (ELP) composed of elastin-based repeating units is an artificial biomaterial which is biocompatible and non-immunogenic. ELP shows a characteristic inverse phase transition between hydrophobic and hydrophilic phase by external stimuli such as salt, pH and temperature. In this study, ELP coated PS (polystyrene) beads are packed in tubing and the thermo -responsive flow characteristics of the packed bed are investigated. Preliminary test results show that the control of the fluid flow can be achieved by using the temperature driven phase transition effect of the ELP coated beads in a microchannel.

• Journal of computational fluids engineering
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• v.15 no.1
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• pp.9-16
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• 2010

The characteristics of flow and heat transfer in a bubbling fluidized bed are investigated by means of computational fluid dynamics (CFD). To simulate two-phase flow for the gas and solid flows, Eulerian-Eulerian approach is applied. Attention is paid for a heat transfer from the wall to fluidized bed by bubbling motion of the flow. From the result, it is confirmed that heat transfer is promoted by chaotic bubbling motion of the flow by enhancement of mixing among solid particles. In particular, the vortical flow motion around gas bubble plays an important role for the mixing and consequent heat transfer. Discussion is made for the time and space averaged Nusselt number which shows peculiar characteristics corresponding to different flow regimes.

• Solar Energy
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• v.12 no.1
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• pp.95-102
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• 1992

A small scale solar collector system composed of a Fresnel lens of $0.5m^2$ area as a solar concentrator and a compact fluidized-bed solar receiver was developed. Performance and temperature distribution in the fluidized bed receiver were measured using SiC for particles and air for working fluid. The maximum gas temperature was attained up to 1250K at this moment. In this study, energy efficiency achieved by the present experiment was high for the small scale solar collector system and compact receiver.