• IMMUNE NETWORK
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• v.20 no.3
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• pp.25.1-25.13
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• 2020

Acinetobacter baumannii is known for its multidrug antibiotic resistance. New approaches to treating drug-resistant bacterial infections are urgently required. Cathelicidin-related antimicrobial peptide (CRAMP) is a murine antimicrobial peptide that exerts diverse immune functions, including both direct bacterial cell killing and immunomodulatory effects. In this study, we sought to identify the role of CRAMP in the host immune response to multidrug-resistant Acinetobacter baumannii. Wild-type (WT) and CRAMP knockout mice were infected intranasally with the bacteria. CRAMP^-/- mice exhibited increased bacterial colony-forming units (CFUs) in bronchoalveolar lavage (BAL) fluid after A. baumannii infection compared to WT mice. The loss of CRAMP expression resulted in a significant decrease in the recruitment of immune cells, primarily neutrophils. The levels of IL-6 and CXCL1 were lower, whereas the levels of IL-10 were significantly higher in the BAL fluid of CRAMP^-/- mice compared to WT mice 1 day after infection. In an in vitro assay using thioglycollate-induced peritoneal neutrophils, the ability of bacterial phagocytosis and killing was impaired in CRAMP^-/- neutrophils compared to the WT cells. CRAMP was also essential for the production of cytokines and chemokines in response to A. baumannii in neutrophils. In addition, the A. baumannii-induced inhibitor of κB-α degradation and phosphorylation of p38 MAPK were impaired in CRAMP^-/- neutrophils, whereas ERK and JNK phosphorylation was upregulated. Our results indicate that CRAMP plays an important role in the host defense against pulmonary infection with A. baumannii by promoting the antibacterial activity of neutrophils and regulating the innate immune responses.

• Economic and Environmental Geology
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• v.22 no.2
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• pp.103-115
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• 1989

The Tongyoung deposits are epithermal gold and silver bearing quartz-rhodochrosite vein type deposits of late Cretaceous. They occurs in the andesite and tuff breccia member called Gyeongsang basin. Four mineralizations can be distinguished at the mine based on macrostructures. From earlist stage to lastest stage they are: stage I, base-metal quartz vein; stage II, rhodochrosite vein (IIA) and Pb-Zn vein (IIB); stage III, barren quartz vein; stage IV, calcite-ankeritic rhodochrosite veins. Gold and silver mineralizations occur predominantly in the stage I and IIB. Electrum is closely associated with galena, sphalerite and pyrite, and has chemical compositions of 50.98-64.05 atom % Ag. Sphalerite contains 2.09-5.05 mol % FeS and 0.34-2.01 mol % MnS in the stage I, and 2.01-3.41 mol % FeS and 0.21-2.80 mol % MnS in the stage IIB. The FeS and MnS contents are in general correlated, and shows a characteristic zonal arrangement of electrum. It reveals rhat FeS contents of sphalerite which precipitated before electrum, gradually decreases in a grain during its deposition ranging from about 3.3 to 2 mol %. It may be considered from the above data that an increase of $fs_2$ caused by the oxidation of ore forming fluid is more important that the decrease of temperature.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.848-853
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• 2010

Bone maintains its homeostasis through balance between bone resorbing osteoclasts and bone forming osteoblasts. Thus, unusual balance between osteoclasts and osteoblasts leads to pathological bone diseases, such as osteoporosis, rheumatoid arthritis, autoimmune arthritis, periodontitis. Schisandra chinensis well known traditional herbal has been used for treatment of diseases in China, Korea, Japan, andothers. Recently, research studies have demonstrated that the lignans found in Schisandra chinensis stimulate osteoblasts and suggest that it may be helpful against osteoporosis. However, the inhibitory effect of water extract of Schisandra chinensis on osteoclast differentiation remains largely unknown. In this study, Water extract of Schisandra chinensis markedly suppressed RANKL-induced osteoclast differentiation in cultures of BMMs without cytotoxicity. The mRNA expression of c-Fos, NFATc1, and TRAP induced by RANKL was inhibited by water extract of Schisandra chinensis. It also suppressed c-Fos and NFATc1 protein expression. Taken together, these results suggest that water extract of Schisandra chinensis has the potential to serve as a treatment of bone disease such as osteoporosis.

• Korean Journal of Pharmacognosy
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• v.14 no.3
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• pp.125-129
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• 1983

To examine effects of oriental pharmaceutical preparations on immunity, four of such preparations which are currently being used were examined. After their fluid extracts were injected intraperitoneally to ICR mice, the counts of total cell number, PMN and macrophage in the peritoneal cavity were made by using non-specific esterase staining method, and plaque-forming cells (PFC) were measured by using the modified method of Cunningham and Jerne. The results showed that 'Bo-Jung-Ik-Ki-Tang', 'Ih-Jung-Tang', 'Ohn-Kyeong-Tang' and 'Ke-Ji-Bok-Ryeong-Hwan-Ka-Dae-Hwang' increased both the macrophages and the total cells of the peritoneal cavity and that these preparations increased the number of PFC in the spleen. Therefore the data indicate that they potentiate both of the cell­mediated and humoral immunities in the mice.

• Journal of Ocean Engineering and Technology
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• v.24 no.5
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• pp.8-15
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• 2010

The flow around a two-dimensional, rectangular cylinder that is freely falling in a channel was simulated using the immersed boundary method with direct forcing to determine the interactions between the fluid and the structure. The results of the present study were in good agreement with previous experimental results. Regardless of the H/L ratio (where H and L are the height and width of the rectangular cylinder, respectively), the flow structures had essentially the same pattern as the two symmetrical circulations that form about the horizontal center of the cylinder, with those centers located at each lateral position near the wake. When the cylinder approaches very close to the bottom, a jet-like flow appeared between the bottom of the rectangular cylinder and the channel. When the jet-like flow goes through the channel, surrounding fluids are sucked into this jet, forming the secondary vortices.

• Archives of Craniofacial Surgery
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• v.19 no.2
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• pp.157-161
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• 2018

A sialocele is a subcutaneous cavity containing saliva, most often caused by facial trauma or iatrogenic complications. In subcondylar fractures, most surgeons are conscious of facial nerve injury; however, they usually pay little attention to the parotid duct injury. We report the case of a 41-year-old man with a sialocele, approximately $5{\times}3cm$ in size, which developed 1 week after subcondylar fracture reduction. The sialocele became progressively enlarged despite conservative management. Computed tomography showed a thin-walled cyst between the body and tail of the parotid gland. Fluid leakage outside the cyst was noted where the skin was thin. Sialography showed a cutting edge of the inferior interlobular major duct before forming the common major duct that seemed to be injured during the subcondylar fracture reduction process. We decided on prompt surgical treatment, and the sialocele was completely excised. A duct from the parotid tail, secreting salivary secretion into the cyst, was ligated. Botulinum toxin was administrated to block the salivary secretion and preventing recurrence. Treatment was successful. In addition, we found that parotid major ducts are enveloped by the deep lobe and extensive dissection during the subcondylar fracture reduction may cause parotid major duct injury.

• Tunnel and Underground Space
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• v.29 no.6
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• pp.542-557
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• 2019

The behavior of rock mass is influenced by its microscopic feature of internal structure generating from forming and metamorphic process. This study investigated a new methodology for characterization of rock based on the X-ray CT (computed tomography) images reflecting the spatial distribution characteristics of internal constituent materials. The X-ray image based analysis is capable of quantification of heterogeneity and anisotropy of rock fabric, size distribution and shape parameter analysis of rock mineral grains, fluid flow simulation based on pore geometry image and roughness evaluation of unexposed joint surface which are hardly acquired by conventional rock testing methods.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.143.2-143.2
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• 2011

Energy foundations and other thermo-active ground structure, energy wells, energy slab, and pavement heating and cooling represent an innovative technology that contributes to environmental protection and provides substantial long-term cost savings and minimized maintenance. This paper focuses on earth-contact concrete elements that are already required for structural reasons, but which simultaneously work as heat exchangers. Pipes, energy slabs, filled with a heat carrier fluid are installed under conventional structural elements, forming the primary circuit of a geothermal energy system. The natural ground temperature is used as a heat source in winter and heat sink in summer season. The system represented very high heating and cooling performance due to the stability of EWT from energy slab. Maximum heat pump unit COP and system COP were 4.9 and 4.3.

• Korean Journal of Head & Neck Oncology
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• v.34 no.1
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• pp.55-58
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• 2018

Auricular endochondral pseudocyst is a very rare, benign intracartilaginous cystic lesion which most commonly presents as a cystic mass in the anterior plane of the auricle. We present a case report of a 48-year-old man with a fluctuating lesion of 3 week's duration on the left auricle, with no specific history of trauma or disease. Initial incisional drainage revealed an abundance of serous fluid, which quickly recurred. Surgical removal of the hypertrophic perichondrium forming the pseudocyst anterior wall and ear cartilage curettage was carried out with intraoperative absolute alcohol sclerotherapy, followed by compression dressings. The auricle healed uneventfully, with a good final cosmetic result and no recurrence within a 6-month follow-up period. We report this unusual case as the first in Korean plastic surgery with a review of the literature.

• Corrosion Science and Technology
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• v.7 no.1
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• pp.27-34
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• 2008

In industrial and fluid handling systems, frequently the protective film forming materials suffer from severe corrosion due to microbial effects. As an example, various micro-organisms, including bacteria, exist in seawater normally fed to power and desalination plants. Unless seawater intakes are properly disinfected to control these microbial organisms, biological fouling and microbial induced corrosion (MIC) will be developed. This problem could destroy metallic alloys used for plant construction. Seawater intakes of cogeneration plants are usually disinfected by chlorine gas or sodium hypochlorite solution. The dose of disinfectant is designed according to the level of contamination of the open seawater in the vicinity of the plant intake. Higher temperature levels, lower pH, reduced flow velocity and oxidation potential play an important role in the enhancement of microbial induced corrosion and bio-fouling. This paper describes, in brief, the different types of bacteria, mechanisms of microbiological induced corrosion, susceptibility of different metal alloys to MIC and possible solutions for mitigating this problem in industry. A case study is presented for the power plant steam condenser at Al-Taweelah B-station in Abu Dhabi. The study demonstrates resistance of Titanium tubes to MIC.