• 스마트미디어저널
• /
• 제5권1호
• /
• pp.137-142
• /
• 2016

In this paper, a multi-scale model is applied to the simulation of thrombus growth. This model includes macroscale model and microscale model. The former is used to model the plasma flow with Navier-Stokes equations, and the latter is used to model the platelets adhesion and aggregation, thrombus motion, and the surface expansion of thrombus. The force acting on platelets and thrombus from plasma is modeled by the drag force, and the forces from biochemical reactions are modeled by the adhesion force and the aggregation force. As more platelets are merged into the thrombus, the thrombus surface expands. We proposed a thrombus growth model for simulating the expansion of thrombus surface and tracking the surface by Level Set Methods. We implemented the computational model. The model performs well, and the experimental results show that the shape of thrombus in level set expansion form is similar with the thrombus in clinical test.

• 대한교통학회지
• /
• 제18권3호
• /
• pp.55-76
• /
• 2000

실시간 통행시간관련자료의 집계시간간격은 보다 신뢰성있는 통행시간정보제공과 교통정보센터의 효율적인 운영을 위해 매우 중요한 요소이다. 그러나 대부분의 기존 VDS 및 TCS교통정보 데이터는 통계학적·공학적 차원에서의 합리적인 연구나 검증없이 경험적 간격으로 집계되고 있다. 본 연구의 목적은 링크 및 교통축(Corridor) 통행시간 산정 및 예측시의 최적 집계 시간간격을 결정할 수 있는 통계학적 모형을 개발하고 실제 도로망에서 수집되는 통행시간자료에 적용하는 것이다 첫째로, 본 연구는 링크 및 교통축 통행시간 산정 및 예측으로 인한 오차를 계량화하는 통계학적 모형을 제시하고, 제시된 모형의 의미를 교통류이론 측면과 통행시간정보 이용자측면에서 살펴보았다. 둘째로, 미국 Texas, Houston의 도시고속도로에서 AVI시스템을 통해 수집된 통행시간자료를 제시된 모형에 적용하였다. 적용결과 링크통행시간 산정을 위한 최적 집계시간간격보다 링크통행시간예측을 위한 최적 집계시간간격이 큰 것으로 나타났으며, 교통축 통행시간 산정 및 예측을 위한 최적 집계시간간격은 교통축을 구성하는 링크간의 상관관계 (Correlation)에 큰 영향을 받는 것으로 분석되었다.

• 한국산학기술학회:학술대회논문집
• /
• 한국산학기술학회 2004년도 춘계학술대회
• /
• pp.253-257
• /
• 2004

Platelet aggregation is a complex phenomenon that probably involves several intracellular biochemical pathways. When activated, platelets change shape, aggregate and release the contents of their intracellular granules. The interactions between platelets and blood vessel walls are important in the development of thrombosis and cardiovascular diseases. When blood vessels are damaged, platelet aggregation occurs rapidly to form haemostatic Plugs or arterial thrombi at the sites of vessel injury or in regions where blood flow is disturbed. These thrombi are the source of thromboembolic complications of atherosclerosis, heart attacks, stroke, and peripheral vascular disease. Therefore, the inhibition of platelet function represents a promising approach for the prevention of thrombosis. Plants constitute a rich source of bioactive chemicals such as phenolics, terpenoids and alkaloids. Plant extracts may be an alternative to currently used medicinal source because they constitute a rich source of bioactive chemicals. This study was performed to investigate the antiplatelet activity of extract of Tabebuia impetiginosa Martius ex DC (Taheebo) and find out which fractions to this activity in rabbit platelet. Taheebo was methanol extracted and solvent fractionated in to five fractions (hexane, chloroform, ethylacetate, butanol and water). And each fractions were investigated inhibitory effects on platelet aggregation induced by various agonists using washed rabbit platelets in vitro.

• Nuclear Engineering and Technology
• /
• 제43권3호
• /
• pp.205-216
• /
• 2011

Recently, many research studies have investigated the enormous critical heat flux (CHF) enhancement caused by nanofluids during pool boiling and flow boiling. One of the main reasons for this enhancement is nanoparticle deposition on the heated surface. However, in real applications, nanofluids create many problems when used as working fluids because of sedimentation and aggregation. Therefore, artificial surfaces on silicon and metal have been developed to create an effect similar to that of nanoparticle deposition. These modified surfaces have proved capable of greatly increasing the CHF during pool boiling, and good results have also been observed during flow boiling. In this study, we demonstrate that the wetting ability of a surface, i.e., wettability, and the liquid spreading ability (hydrophilic surface property), are key parameters for increasing the CHF during both pool and flow boiling. We also demonstrate that when the fuel surface in nuclear power plants is modified in a similar manner, it has the same effect, producing a large CHF enhancement.

• 동국한의학연구소논문집
• /
• 제8권2호
• /
• pp.115-129
• /
• 2000

동물성(動物性) 지방섭취량(脂肪攝取量)의 증가(增加), 운동부족(運動不足), 비만(肥滿), 스트레스의 가중(加重), 고령화(高齡化)의 증가(增加) 등(等)의 원인(原因)으로 순환기계질환(循環器系疾患)의 발병률(發病率)이 증가(增加)하고 있으며, 이러한 순환기계질환(循環器系疾患)의 위험인자(危險因子)로서 혈전증(血栓症)이 중요(重要)하게 대두되고 있다. 특히 최근 문제시되고 있는 협심증(狹心症)이나 심근경새(心筋梗塞)등의 허혈성(虛血性) 심질환(心疾患)은 혈소판응집(血小板凝集)에 의해 일어나는 혈전형성(血栓形成)에 기인(起因)하고 있다. 한의학(韓醫學)에서 혈전증(血栓症)은 어혈(瘀血)의 범주(範疇)에 속(屬)하며, 어혈(瘀血)은 각종 병리적(病理的) 원인(原因)에 의해 발생한 전신성(全身性) 또는 국소성(局所性)의 혈액순환(血液循環) 장애(障碍) 또는 혈류정체(血流停滯)와 그에 수반되는 일련의 증후(症候)를 나타내며, 경계정충, 고창(鼓脹), 적취(積聚), 미하, 전광(癲狂), 중풍등(中風等)의 발병원인(發病原因)이 된다. 또한 어혈(瘀血)에 의한 각종 증후(症候)에는 활혈거어제(活血祛瘀劑) 또는 구어혈제(驅瘀血劑)등이 사용되고 있다. 본(本) 연구(硏究)에서는 한의학(韓醫學)에서 어혈증(瘀血症)으로 야기(惹起)되는 여러 가지 증상(症狀)의 개선에 사용되는 구어혈제(驅瘀血劑)들의 혈소판응집(血小板凝集)에 미치는 영향을 검색하기 위하여 계지복령환(Geijibokryunghwan; GBH) 및 그 구성약물(構成藥物)을 사용(使用)하였다. 계지복령환은 "금궤요략" 에 있는 방(方)으로써 거사부상정(祛邪不傷正)하고 조기한열(調氣寒熱)하여 예로부터 구어혈제(驅瘀血劑)로 사용되어 왔다. 이에 계지복령환 및 그 구성약제(構成藥劑)의 ADP, AA 또는 collagen으로 유도되는 혈소판응집(血小板凝集)에 대하여 억제효과(抑制效果)를 탐색(探索)한 결과(結果), 계지복령환 및 개별(個別) 구성약물(構成藥物)의 혈소판응집억제작용(血小板凝集抑制作用)을 확인하였고, 혈소판응집(血小板凝集)으로 야기(惹起)되는 혈전증(血栓症)등에 계지복령환 및 개별(個別) 구성약물(構成藥物)은 매우 임상실험적(臨床實驗的) 응용가치(應用價値)가 있는 것으로 생각되었다.

• ETRI Journal
• /
• 제30권2호
• /
• pp.238-248
• /
• 2008

At the extremes of the complexity-performance plane, there are two exemplary QoS management architectures: Integrated Services (IntServ) and Differentiated Services (DiffServ). IntServ performs ideally but is not scalable. DiffServ is simple enough to be adopted in today' core networks, but without any performance guarantee. Many compromise solutions have been proposed. These schemes, called quasi-stateful IntServ or stateful DiffServ, however, have not attracted much attention due to their inherently compromising natures. Two disruptive flow-based architectures have been recently introduced: the flow-aware network (FAN) and the flow-state-aware network (FSA). FAN's control is implicit without any signaling. FSA's control is even more sophisticated than that of IntServ. In this paper, we survey established QoS architectures, review disruptive architectures, discuss their rationales, and points out their disadvantages. A new QoS management architecture, flow-aggregate-based services (FAbS), is then proposed. The FAbS architecture has two novel building blocks: inter-domain flow aggregation and endpoint implicit admission control.

• 대한기계학회논문집B
• /
• 제30권11호
• /
• pp.1027-1034
• /
• 2006

In order to investigate flow characteristics of chicken blood in a micro tube of 100$\mu$m in diameter, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, 2-head Nd:YAG laser, 12 bit cooled CCD camera and a delay generator. Chicken blood with 40% hematocrit was supplied into a micro tube using a syringe pump. The blood flow shows clearly the cell free layer near the tube wall and its thickness is increased with increasing the flow speed. The hemorheological characteristics of chicken blood, including shear rate and shear stress were estimated from the PIV velocity field data obtained. Since the aggregation index of chicken blood is less than 50% of human blood, non-Newtonian flow characteristics of chicken blood are smaller than those of human blood. As the flow rate increases, the degree of flatness in the velocity profile at the center region is decreased and the parabola-shaped shear stress distribution becomes to have a linear profile. Under the same flow rate, chicken blood shows higher shear stress, compared with human blood.

• 한국해양바이오학회지
• /
• 제1권2호
• /
• pp.98-104
• /
• 2006

식생활의 서구화로 인하여 심혈관계질환의 발생빈도 증가로 인한 사망률이 늘어나고 있다. 따라서 최근 이용가치가 인정 되어지고 있는 해양 심층수를 이용하여 심혈관계 질환의 개선효과를 알아보았다. 심층수의 혈소판 응집 억제능을 알아보기 위해, in vitro 실험에서 washed platelet를 분리하여 심층수를 농도별로 처리한 후, collagen으로 혈소판 응집을 유도하여 심층수의 응집억제 실험을 한 결과 그 농도별로 응집이 감소되었다. 그리고 in vivo 실험에서도 심층수를 투여하지 않은 군에 비해 심층수를 투여한 군에서 혈소판 응집이 감소하였으므로 이는 심층수가 혈소판 응집에 효과적인 것으로 보여진다. 또한 혈청 중의 중성지질 함량이 감소되었고, 고밀도 지단백은 증가하였다. 혈류 속도 측정에서도 심층수를 투여한 그룹이 투여하지 않은 군에 비해 더 빠른 속도로 모세혈관을 빠져나가는 것을 볼 수 있었으며, 이것으로 보아 심층수를 투여한 그룹에서 혈행에 있어 좋은 효과가 있음을 나타내었다. 본 실험의 결과 심층수가 혈소판 응집, 혈청 지질 농도, 혈류 속도에 유효한 효과를 나타냄을 알 수 있었다. 이는 잘못된 식습관으로 오는 비만이나, 심혈관계질환에 유익한 결과를 줄 것으로 사료된다.

• The Journal of Asian Finance, Economics and Business
• /
• 제8권11호
• /
• pp.243-251
• /
• 2021

The goal of this study is to examine the characteristics of Chinese visitors visiting Thailand, determine the rules, and give a reference for Thai tourism authorities and businesses when developing marketing strategies for the Chinese market. This paper constructs the tourism flow network and takes Bangkok as the major research target. The statistical characteristics of the network are studied using the SNA method, based on the trip notes of Thailand on www.mafengwo.cn, a prominent travel website in China as the data source. The results show that: Shanghai, Beijing, and Tianjin occupy important positions in the network; The flow direction of Chinese tourists to Thailand mainly tends to Bangkok, Chiang Mai, Pattaya, and Phuket Island; Grand Palace have strong tourism flow aggregation, diffusion, and control over other nodes in the whole network structure; Tom Yu Kuang has the greatest degree centrality in all Thai cuisine. The findings of the study can help relevant management departments create tourist policies and modify market strategies by developing the regular characteristics of China's tourism flow to Thailand in the theoretical field.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 1995년도 가을 학술발표회 논문집
• /
• pp.19-24
• /
• 1995

Most difficulties in inducing high flowability of general strength concrete arise from the segregation of aggregates due to the shortage of cementatious binders. To solve the problem, our research team has concentrated on finding the binders to link a gap between coarse and fine aggregates, under the condition not to influence a concrete strength. As a result of using stone powder or a middle class of aggregate size mostly used for asphalt pavement(Max. dia 13mm), we found that flowability of concrete increased significantly without aggregation and decrease of compressive strength.