• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.1
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• pp.31-46
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• 2006

Purpose : The Purpose of this research was to investigate the effects of antithromb otic activities of Honghwadangguisan(HDS) Methods : Measured the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Each of the groups consisted in 8 mice, was divided into Normal, Control, and HBS. All of these 3 group were supplied a saline solution and after an hour the control group brought the dextran extravasated blood. Also the HDS group was dosed to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood as well as the Control group. Results : The results were obtained as follows. In vitro, HDS inhibited platelet aggregation induced by ADP and epinephrine significantly as compared with the control group. HDS showed fibrinolytic activity insignificantly as compared with the control group. HDS reduced blood flow rate in significantly as compared with the control group. In vivo HDS inhibited pulmonary embolism induced by collagen and epinephrine (inhibitive rate 50%). HDS increased number of platelet, fibrinogen amount and shortened prothrombin time, activated partial thromboplastin time significantly but reduced blood flow rate insignificantly as compared with the control group in thrombus model induced by dextran. Conclusion : HDS is effective antithrombotic activity from experimental result.

• Journal of Life Science
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• v.20 no.1
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• pp.90-96
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• 2010

Menopause increases the onset of hypertension and heart disease. Whereas it increases the blood LDL-cholesterol, triglyceride and total-cholesterol levels, the HDL-cholesterol concentration is reduced. Accordingly, we examined the effect of internal organs of Todarodes pacificus (IOT) on improvement in blood flow ability and changes in serum lipid content by using ovariectomized rats. For this study, the following four groups of 9-week-old Sprague-Dawley strain female rats were evaluated over 6 weeks: normal rats (SHAM), ovariectomized rats (CON) and ovariectomized rats that were treated with IOT extracts. Ovary removal promoted platelet aggregability. However, IOT administration in the CON group after ovary excision resulted in a hinderance of coherence. The blood vessel passing time of ovariectomized rats was slower than the SHAM group. But the blood flow ability, which was slowed down for ovary removal, was improved by IOT administration. Serum triglyceride levels were significantly reduced by IOT administration. Moreover, blood HDL-cholesterol levels were reduced by ovary removal. However, IOT administration after ovary excision significantly increase HDL-cholesterol levels. The biological activity of IOT could be confirmed from these results. Moreover, IOT can be used in the development of functional foods which are meant to improve blood circulation and anti-platelet aggregation function. According to these results, we could know that IOT improved blood flow and anti-platelet aggregation. Therefore, it is expected that IOT can be used for the development of functional foods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.4B
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• pp.235-245
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• 2005

In this paper, a simplified QoS model of MPLS-based backbone network. Conventional scheme proposed by IETF(IETF schem) is to embed a DiffServ model in MPLS network. However, this approach results in overall upgrade of MPLS system and so it is difficult to deploy this approach. Our proposed model, however, uses a Vidual Link which is a set of Label Switched Path(LSP) connected from an Ingress Label Edge Router(LER) to an Egress LER. In this model, Per-Hop-Behavior(PHB) is implemented only at each LSP in ingress LER and Core Label Switch Routers(LSRs) just guarantee each LSP's bandwidth, not service. This bandwidth guarantee service is fully provided by legacy MPLS model. Also we propose flow allocation mechanism and the flow distribution among LSPs of the virtual link by the flow according to the network status. To evaluate the simplified approach, the characteristics of the approach are compared logically with these of IETF's one through simulations.

• Journal of Korea Water Resources Association
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• v.49 no.6
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• pp.495-507
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• 2016

This study aims at hydrologically demonstrating the universality of power law distribution by analyzing runoff aggregation structures of river basins. Power law distribution is fitted to cumulative drainage area of basins of interest by maximum likelihood, which results in the power law exponents. And then those exponents are assessed in terms of the shape of catchment plan-form. As a main result all of the basins in this study have similar distributions of catchment area. The exponents from this study tend to be higher than the ones from previous researches reflecting self-similar property of the catchment plan-forms of interest. Further study is required about the universality of power law distribution by means of the more realistic flow routing scheme within the framework of DEM.

• The Journal of Internal Korean Medicine
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• v.20 no.1
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• pp.57-72
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• 1999

This study was designed to elucidate the anti-inflammatory, cardiovascular, anti-thrombotic, and analgesic effect of Whalrakdan. The anti-inflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Whalrakdan on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit. and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity, antithrombin activity was observed for the measurement of the anti-thrombotic effect of Whalrakdan, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows: 1. After 2 or 3hour of Whalrakdan administration, carrageenin induced edema and CMC-pouch protein leakage was significantly decreased. 2. The slight anagesic effect of Whalrakdan extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time. 3. The droplet of Ringer solution increased according to the increase of concentration of Whalrakdan extract, and the vasoconstriction decreased dependantly to the concentration of Whalrakdan extract. 4. The anti-thrombotic effect of Whalrakdan was observed by the decrease of death rate, the inhibition of platelet aggregation, and the increase of anti-thrombin activity.

• Korean Journal of Veterinary Research
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• v.56 no.2
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• pp.67-74
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• 2016

Tomato extract has been shown to exert antiplatelet activity in vitro and to change platelet function ex vivo, but with limitations. In this study, antiplatelet activity of water soluble tomato concentrate (Fruitflow I) and dry water soluble tomato concentrate (Fruitflow II) was investigated using rat platelets. Aggregation was induced by collagen and adenosine diphosphate and granule-secretion, $[Ca^{2+}]_i$, thromboxane B2, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels were examined. The activation of integrin ${\alpha}_{IIb}{\beta}_3$ and phosphorylation of signaling molecules, including mitogen-activated protein kinase (MAPK) and PI3K/Akt, were investigated by flow cytometry and immunoblotting, respectively. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were examined. Moreover, in vivo thrombus weight was tested by an arteriovenous shunt model. Fruitflow I and Fruitflow II significantly inhibited agonist induced platelet aggregation, adenosine triphosphate and serotonin release, $[Ca^{2+}]_i$, and thromboxane B2 concentration, while having no effect on cAMP and cGMP levels. Integrin ${\alpha}_{IIb}{\beta}_3$ activation was also significantly decreased. Moreover, both concentrates reduced phosphorylation of MAPK pathway factors such as ERK, JNK, P38, and PI3K/Akt. In vivo thrombus formation was also inhibited. Taken together, these concentrates have the potential for ethnomedicinal applications to prevent cardiovascular ailments and can be used as functional foods.

• Korean Journal of Materials Research
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• v.16 no.1
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• pp.11-18
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• 2006

[ $Co_3O_4$ ] particles with non-aggregation characteristics were prepared by various conditions such as preparation temperature, flow rate of carrier gas, and concentration of spray solution using spray pyrolysis. The morphology and crystallinity of the preformed particles obtained by spray pyrolysis at various conditions affected the mean size and morphology of the post-treated $Co_3O_4$ particles. The preformed particles with hollow and porous morphology obtained from spray solution with citric acid and ethylene glycol turned to $Co_3O_4$ particles with nano size, regular morphology and non-aggregation characteristics after post-treatment at $800^{\circ}C$. On the other hand, the preformed particles obtained by the preparation conditions of short residence time of particles inside hot wall reactor and high reactor temperature turned to $Co_3O_4$ particles with aggregated morphology after post-treatment. The mean crystallite size and particle size of the $Co_3O_4$ particles prepared from optimum preparation conditions were 47 nm and 210 nm at post-treatment temperature of $800^{\circ}C$.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10a
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• pp.383-385
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• 1998

MPLS망은 레이블 스위칭을 통해 고속의 라우팅은 제공하지만 서비스 질은 보장하지 않는다. 따라서 MPLS망을 통해 종단간 서비스 질을 보장하기 위한 방법으로 RSVP 흐름 군집을 이용한다. 즉, 입구 라우터와 출구 라우터 간의 흐름들이 요구하는 자원들의 군집하여 예약함으로써 각 흐름들을 요구하는 서비스 질을 보장하게 된다. 이와같이 각 흐름들이 요구하는 자원들을 군집하여 예약하는 이유는 각 흐름별로 예약하고 그 예약에 따라 처리를 하게 되었을 때 흐름 별 상태 정보 저장 및 처리하는 데 많은 비용이 들기 때문이다. 특히 이러한 흐름의 수가 매우 많은 코어 망에서 문제가 크다. 이처럼, 입구 라우터와 출구 라우터간의 흐름들이 요구하는 자원들을 군집하여 예약했을 때, 군집된 흐름들이 입구 라우터와 출구 라우터까지 레이블 스위칭을 통해 전달되면서 이렇게 예약된 자원을 이용하여 서비스 질을 보장 받을 수 있어야 한다. 본 논문에서는 군집된 RSVP 메시지를 통해 자원 예약이 이루어질 때 레이블을 할당하고 바인딩 시킴으로써(레이블이 자원 예약 상태 정보에 대한 구분자 역할을 함) 레이블 스위칭을 통해 패킷이 전달되면서 예약된 자원의 서비스를 받을 수 있게 된다. 자원예약 상태 정보를 레이블 운송 테이블에 저장함으로써 레이블 교환 시 자연적으로 자원 예약에 대한 구분이 됨으로 빠른 구분이 가능하다.

• 한국공간정보시스템학회:학술대회논문집
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• 2007.06a
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• pp.333-338
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• 2007

원격탐사 자료를 이용한 토지피복도로부터 유역의 식생상황을 고려한 지표면 조도계수를 추정하기 위한 물리적 기반의 지표면 조도계수 추정방법을 제안하였다. 사전 연구로써 지표면 조도계수의 변화에 따른 첨두유량, 유출체적, 첨두시간에 대한 반응을 분석하기 위하여 NWS-PC 모형을 사용하였다. predominant, arithmetic mean, aggregation방법으로 구해진 지표면 조도계수가 강우-유출 모형의 매개변수에 미치는 영향을 분석하였다. 지표면 조도계수에 대한 민감도 분석에서는 첨두유량이 약 10%의 변화를 나타내었고, 유출체적의 경우 약 2%의 변화를 나타내었다. 첨두시간은 지표면 조도계수에 비례하여 증가하는 것으로 나타났다.

• YAKHAK HOEJI
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• v.53 no.5
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• pp.298-302
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• 2009

Mume Fructus extract is used in folk medicine in Eastern Asian countries including Korea. However, its therapeutic effect on thrombosis is not known. Mume Fructus methanol extract (ME) dose-dependently inhibited ADP-induced platelet aggregation and also exhibited about 130% fibrinolytic activity compared to the natto. Oral administration of ME to mice significantly extended tail-bleeding time. ME prolonged both aPTT and PT in human citrated plasma also. These results suggest that the methanol extract from Mume Fructus have antithrombosis activity.