The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Study on the Anti-inflammatory, Analgesic and Anticoagulative effects of Whalrakdan in the experimental animals

활락단(活絡丹)이 항염(抗炎), 진통(鎭痛) 및 항혈전(抗血栓)에미치는 영향(影響)에 대(對)한 연구(硏究)

  • Kang, Seung-Bum (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Park, Jong-Woon (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Kim, Jong-Gil (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Jo, Nam-Soo (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Moon, Byung-Soon (Dept. of Oriental Medicine, Graduate School of Won kwang University)
  • 강승범 (원광대학교 한의과대학 심계내과학 교실) ;
  • 박종운 (원광대학교 한의과대학 심계내과학 교실) ;
  • 김종길 (원광대학교 한의과대학 심계내과학 교실) ;
  • 조남수 (원광대학교 한의과대학 심계내과학 교실) ;
  • 문병순 (원광대학교 한의과대학 심계내과학 교실)
  • Published : 1999.09.29
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Abstract

This study was designed to elucidate the anti-inflammatory, cardiovascular, anti-thrombotic, and analgesic effect of Whalrakdan. The anti-inflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Whalrakdan on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit. and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity, antithrombin activity was observed for the measurement of the anti-thrombotic effect of Whalrakdan, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows: 1. After 2 or 3hour of Whalrakdan administration, carrageenin induced edema and CMC-pouch protein leakage was significantly decreased. 2. The slight anagesic effect of Whalrakdan extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time. 3. The droplet of Ringer solution increased according to the increase of concentration of Whalrakdan extract, and the vasoconstriction decreased dependantly to the concentration of Whalrakdan extract. 4. The anti-thrombotic effect of Whalrakdan was observed by the decrease of death rate, the inhibition of platelet aggregation, and the increase of anti-thrombin activity.

Keywords

References

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