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An Open-Label Study of the Improvements in Clinical Symptoms and Neurocognitive Functions in Korean Children and Adolescents with Attention-Deficit Hyperactivity Disorder after Treatment with Metadate CD (국내 주의력결핍 과잉행동장애 아동 및 청소년에서 메타데이트CD의 임상증상 및 신경인지기능 개선 효과에 대한 개방 연구)

  • Yoo, Han-Ik K.;Kim, Bong-Seog;Joung, Yoo-Sook;Bahn, Geon-Ho;Song, Dong-Ho;Ahn, Dong-Hyun;Lee, Young-Sik
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.22 no.4
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    • pp.253-261
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    • 2011
  • Objectives : This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neuro-cognitive functions. Methods : Ninety-one subjects with ADHD (mean age 8.6${\pm}$2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects. Results : After 0.92${\pm}$0.32mg/kg/day of MCD were administered for 57.4${\pm}$7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%). Conclusion : This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.

Dietary Factors Associated with Attention Deficit Hyperactivity Disorder (ADHD) in School-aged Children (학동기 어린이 주의력결핍 과잉행동장애에서 식이요인의 역할 규명)

  • An, Minji;An, Hyojin;Hwang, Hyo-Jeong;Kwon, Ho-Jang;Ha, Mina;Hong, Yun-Chul;Hong, Soo-Jong;Oh, Se-Young
    • Korean Journal of Community Nutrition
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    • v.23 no.5
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    • pp.397-410
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    • 2018
  • Objectives: An association between dietary patterns and mental health in children has been suggested in a series of studies, yet detailed analyses of dietary patterns and their effects on ADHD (attention deficit hyperactivity disorder) are limited. Methods: We included 4569 children who had dietary intake data as part of the CHEER (Children's Health and Environmental Research) study conducted nationwide from 2005 to 2010. We assessed ADHD (Attention Deficit Hyperactivity Disorder) by the DuPaul's ADHD Rating Scales and dietary intake by a semi-quantitative food frequency questionnaire. Using intake data, we constructed five dietary patterns: "Plant foods & fish," "Sweets," "Meat & fish," "Fruits & dairy products," and "Wheat based." Results: The overall proportion of ADHD was 12.3%. Boys (17.8%) showed a higher rate of ADHD than girls (6.5%). The total intake of calories (85 kcal) and plant fat (2g) in the ADHD group was significantly higher than that of the normal group. ADHD was significantly negatively associated with dietary habits such as having breakfast and meal frequency, and positively associated with eating speed, unbalanced diet, overeating, and rice consumption. Regarding dietary patterns, the "Sweets" category was relevant to high ADHD risk (OR 1.59, 95% CI: 1.18, 2.15 for Q5 vs. Q1) in a linear relationship. An inverse, non-linear association was found between "Fruits & dairy products" and ADHD (OR 0.55, 95% CI: 0.39, 0.76 for Q4 vs. Q1). Conclusions: Our study confirms both positive and negative associations between diet and ADHD in elementary school age children. Moreover, linear or nonlinear associations between diet and ADHD draw attention to the possible threshold role of nutrients. Further studies may consider characteristics of diet in more detail to develop better intervention or management in terms of diet and health.

The development of the teaching.learning process plan applying Keller's motive induction strategy to 'Nutrition and Meal' unit of the revised 7th middle school home economics curriculum (Keller의 동기유발 전략을 적용한 중학교 가정 '영양과 식사' 단원 교수.학습 과정안 개발)

  • Pyun, Eun-Young;Park, Mi-Jeong;Chae, Jung-Hyun
    • Journal of Korean Home Economics Education Association
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    • v.21 no.4
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    • pp.159-173
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    • 2009
  • The purpose of this study was to develop a teaching learning process plan applying Keller's motive induction strategy to 'Nutrition and Meal' unit of the middle school home economics(HE). Five different problems were developed based on the 7th revised HE curriculum: "What should I do for a physical and mental health?", "What should I do to intake a required nutrient of my body?", "What should I do to take a well balanced diet?", "What should I do to build a desirable eating habits?" and "What should I do to deal with a nutrition issues?". This study was performed as the following procedures: the 'Nutrition and Meal' unit of the revised 7th middle school HE curriculum and the present HE textbooks were analyzed. And then the teaching learning process plan was designed, developed, evaluated, and revised. The motive induction strategies were developed based on the Keller's Motivational Tactics Checklist.

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Study on the Obese Students' Stress and Coping Method in Middle and High Schools (비만 중.고등학생의 스트레스와 대처방법에 관한 연구)

  • Kim, Yi-Soon
    • Research in Community and Public Health Nursing
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    • v.12 no.3
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    • pp.732-745
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    • 2001
  • This study attempted to identify obese students' stress and coping method in middle and high schools. The data were collected from the total of 600 obese students from middle and high schools in Pusan. The author used a convenience sampling method. The data collection was done from March 2 to April 30. 2001. The analysis of the data was done with SPSS Win(10.0) for descriptive statistics. t-test. and ANOVA. The instrument used for the obese students' stress and coping method was a questionnaire developed by Kim. Yi-Soon and Kim. Young-Hae(200l). The tool was composed of 65 items (33stress items: 32coping method items) with the five-point Likert scale. The results were as follow: 1. The average score of stress was 2.49 (SD = .86) points in the male students. and 2.83(SD= .86) points in the female students. The subcategories were: (outward appearance), (boyfriend/girlfriend), (occurrence of an outbreak of a disease), (relationship within the family), (an obese appearance), (difficulty in exercise). The highest degree of stress came from 'an obese appearance' for the male students (mean=2.64. SD=0.87) and (mean=2.64. SD=0.87) for the female students. 2. The subcategories of the coping method were: (be concerned about other matters), (recreation activities), (self-violence), (relaxation), (hobby activities), (avoid a situation), (communication), (music), (negative behavior), (positive thinking). The highest degree of coping method were (recreation activities) in the male students (mean=3.07. SD=0.86) and (music) in the female students (mean=3.47. SD=1.01). 3. The results comparing stress with demographic variables were significant for gender (t=7.010. p=0.000). grades at school (F=2.918. p=0.02l), degree of obesity (F=5.205. p=0.006). grades (F=2.550. p=0.027). standard of living(F=8.277. p=0.000). the state of health (F=2.882, p=0.022), relationship with the father (F=4.790, p=0.001), relationship with the mother (F=6.080, p=0.000), and the educational level of the father (F=3.192, p=0.013). 4. The results comparing the coping method with demographic variables were significant for gender (t=4.597. p=0.000). These findings contribute to the understanding of the degree of stress and the type of coping methods of obese students in middle and high schools. Therefore, the result of this study aids in an effective nursing intervention to improve the mental health program for the obese.

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A Study on Service Satisfaction of Users' Family in Charged Recuperation Facilities Specializing in the Old (유료노인전문요양시설 이용자 가족의 서비스 만족도 및 요구조사)

  • Chung, Yeon-Kang;Han, Seung-Eui;Lee, Young-Mi
    • Research in Community and Public Health Nursing
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    • v.14 no.3
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    • pp.397-406
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    • 2003
  • The purpose of this study is to provide the basic data in order to improve the quality of charged recuperation facilities which are specialized in the old. after finding out the satisfaction degree for the services which are provided in the current charged recuperation facilities specialized in the old and surveying the services which are demanded by users. As for the research method. the subjects were 88 family members of the users in the five charged recuperation facilities, which are specialized in the old and located in Seoul and Incheon. The survey research was executed from 27th July to 15th September, 2002. Then the collected data were analyzed by using the SPSS 10.0 for windows program. The research results are as follows. Firstly, in the satisfaction degree of the user's family about the daily service showed the highest satisfaction degree for the kind service of the staff to the users. In the satisfaction degree about the specialized service of the user's family, the satisfaction degree was high in bedsore prevention, periodical health care, proper medical treatment, family counsel, and adequate disease management. In the satisfaction degree about the facility and environmental service, the satisfaction degree about the surrounding environment of the facility or safety facility, and the comfort condition was high. In the satisfaction degree about the services related to the local society, it was high in the hospital and medical-related field. Secondly, in the demanded services, the demanding degree for worship, mental and spiritual nursing, hospice, funeral service, family meeting, and support for the special vehicle were not so high, but it was shown that they were generally demanded. Thirdly, it was shown that the provided services had an overall high satisfaction degree. In the service satisfaction degree according to the general characteristics of the user's family, it was recognized that there was a significant difference between the distinction of sex and local society related services. Also, there was a significant difference in the satisfaction degree between age and specialized service. Through the above research results, detailed rehabilitation programs such as linguistic treatment and working treatment should be more and more compensated in order to supplement the insufficient points of the services provided by the charged recuperation facility specialized in the old. Additionally, the correlation with the local society such as education and training for specialized human labor, close cooperation among the facilities, and positive participation in local society events are thought to be reinforced.

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The Development of Noise Management Model using Active Noise Control Technique on Construction Site (능동소음제어를 이용한 건설현장의 소음관리모델 개발 - 도심지 공사현장을 중심으로 -)

  • Kwon, Nahyun;Park, Moonseo;Lee, Hyun-Soo;Ahn, Joseph;Kim, Sunwoo
    • Korean Journal of Construction Engineering and Management
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    • v.15 no.2
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    • pp.12-22
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    • 2014
  • Recently, many people have been damaged seriously by construction noise. Accordingly, there have been increased the complaints and disputes. These complaints should be controlled strictly. Otherwise there could be delays or stops of project and losses of time and money. For this reasons, the Korean government is trying to convert from depending on the soundproof wall to noise control system focusing on noise sources. However, it is difficult to control the noise which is generated from construction site because construction equipment has very high noise level and construction noise generates temporarily and irregularly. Also, people do not know how much low frequency affect human body adversely because they cannot perceive low frequency noise easily. Hence, recently developed countries have conducted the research on the low frequency noise which damages on human physically and mentally. However, passive noise control is insufficient to reduce the low frequency noise, but only efficient to lower the high frequency noise. Thus, an approach which can complement limitations of passive noise control is needed. Therefore, the purpose of this research is to suggest the noise management model using active noise control on construction site. Also, ANC simulation has been conducted to examine its applicability on construction equipment. As a result, it is expected that there will be a reduction of construction noise and demages, as well as both mental and physical damages.

Cognitive Profile of Children with Williams Syndrome: Comparison with Children with Prader-Willi Syndrome and Down Syndrome

  • Yim, Shin-Young;Cho, Kye-Hee;Kim, Hyon-J.
    • Journal of Genetic Medicine
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    • v.7 no.1
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    • pp.45-52
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    • 2010
  • Purpose: The objectives were to examine following 2 questions related to cognitive profile for the children with Williams syndrome (WS); 1) Is there a significant advantage for verbal IQ over performance IQ in WS?; 2) Is there selective impairment in visuospatial ability in the children with WS? Materials and Methods: Five children with WS with the age of $90.86{\pm}20.73$ months were compared with 12 children with Prader-Willi syndrome (PWS) or Down syndrome (DS) with comparable age and IQ. Results: All 5 children with WS showed intellectual disability whose mean scaled scores were $15.71{\pm}9.27$ in verbal subtests and $14.29{\pm}7.50$ in performance subtests, which did not show significant difference. There was no significant difference in the total sum of scaled scores of verbal subtests among WS, PWS and DS. There was no selective impairment in subtests which represented visuospatial tasks for the children with WS. However, the scaled score of object assembly was significantly lower in WS ($2.29{\pm}0.95$) compared to that of PWS ($4.75{\pm}2.77$; P <0.05). Conclusion: The general notion that the children with WS would be relatively strong in verbal function when compared with their overall cognitive function was not observed in this study. The verbal function of the children with WS was not better when compared to the children with DS or PWS. There was no selective impairment of visuospatial function in the children with WS at this age. However, the visuospatial function was significantly low in the children with WS only when compared to the children with PWS.

Traumatic Brain Injury in Children under Age 24 Months : Analysis of Demographic Data, Risk Factors, and Outcomes of Post-traumatic Seizure

  • Yoon, Sang-Youl;Choi, Yeon-Ju;Park, Seong-Hyun;Hwang, Jeong-Hyun;Hwang, Sung Kyoo
    • Journal of Korean Neurosurgical Society
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    • v.60 no.5
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    • pp.584-590
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    • 2017
  • Objective : Traumatic brain injury (TBI) in children under age 24 months has characteristic features because the brain at this age is rapidly growing and sutures are opened. Moreover, children this age are completely dependent on their parents. We analyzed the demographic data and risk factors for outcomes in TBI patients in this age group to elucidate their clinical characteristics. Methods : We retrospectively reviewed the medical records and radiological films of children under 24 months who were admitted to Kyungpook National University Hospital from January 2004 to December 2013 for TBI. Specifically, we analyzed age, cause of injury, initial Glasgow coma scale (GCS) score, radiological diagnosis, seizure, hydrocephalus, subdural hygroma, and Glasgow outcome scale (GOS) score, and we divided outcomes into good (GOS 4-5) or poor (GOS 1-3). We identified the risk factors for post-traumatic seizure (PTS) and outcomes using univariate and multivariate analyses. Results : The total number of patients was 60, 39 males and 21 females. Most common age group was between 0 to 5 months, and the median age was 6 months. Falls were the most common cause of injury (n=29, 48.3%); among them, 15 were falls from household furniture such as beds and chairs. Ten patients (16.7%) developed PTS, nine in one week; thirty-seven patients (61.7%) had skull fractures. Forty-eight patients had initial GCS scores of 13-15, 8 had scores of 12-8, and 4 had scored 3-7. The diagnoses were as follows : 26 acute subdural hematomas, 8 acute epidural hematomas, 7 focal contusional hemorrhages, 13 subdural hygromas, and 4 traumatic intracerebral hematomas larger than 2 cm in diameter. Among them, two patients underwent craniotomy for hematoma removal. Four patients were victims of child abuse, and all of them had PTS. Fifty-five patients improved to good-to-moderate disability. Child abuse, acute subdural hematoma, and subdural hygroma were risk factors for PTS in univariate analyses. Multivariate analysis found that the salient risk factor for a poor outcome was initial GCS on admission. Conclusion : The most common cause of traumatic head injury in individuals aged less than 24 months was falls, especially from household furniture. Child abuse, moderate to severe TBI, acute subdural hematoma, and subdural hygroma were risk factors for PTS. Most of the patients recovered with good outcomes, and the risk factor for a poor outcome was initial mental status.

A Computed Tomography Analysis of the Success of Spinal Fusion Using Ultra-Low Dose (0.7 mg per Facet) of Recombinant Human Bone Morphogenetic Protein 2 in Multilevel Adult Degenerative Spinal Deformity Surgery

  • Liu, Gabriel;Tan, Jun Hao;Yang, Changwei;Ruiz, John;Wong, Hee-Kit
    • Asian Spine Journal
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    • v.12 no.6
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    • pp.1010-1016
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    • 2018
  • Study Design: Retrospective cohort study. Purpose: To report on spinal fusion assessment using computed tomography (CT) after adult spinal deformity (ASD) surgery using ultra-low dose recombinant human bone morphogenetic protein 2 (RhBMP-2). Overview of Literature: The reported dose of RhBMP-2 needed for successful spinal posterolateral fusion in ASD ranges from 10 to 20 mg per spinal level. This study reports the use of ultra-low dose of RhBMP-2 (0.07 mg per facet) to achieve spinal fusion in multilevel ASD surgery. Methods: Consecutive patients who underwent ASD surgery using ultra-low dose RhBMP-2 were recruited. Routine postoperative CT analysis for spinal fusion was performed by two spine surgeons. Inter-observer agreement was calculated for facet fusion (FF) and interbody fusion (IBF) at 6 and 12 months after the procedure. Results: Six consecutive ASD patients with a mean age of 62 years (28-72 years) were examined. Each patient received a total dose of 12 mg with an average dose of $0.69{\pm}0.2mg$ (0.42-1 mg) per single FF and $1.38{\pm}0.44mg$ (0.85-2 mg) for IBF. Total 131 FF and 15 IBF were examined in the study, with 88 FFs and nine IBFs being analyzed specifically at 6 months after the surgery. FF and IBF reported by surgeons A and B at 6 months were 97.7% vs. 91.9% FF, respectively (${\kappa}=0.95$) and 100% vs. 100% IBF, respectively (${\kappa}=1$). Two patients underwent longitudinal follow-up CT at 12 months, and the FF rates reported by surgeons A and B were 100% vs. 95.8%, respectively (${\kappa}=0.96$). Five out of nine facet (56%) non-unions were identified at the cross-links. The remaining four facet pseudarthrosis were noted at 1-2 spinal levels caudal to the cross-links. At the final clinical follow-up, there was no rod breakage, deformity progression, neurological deficit, or symptom recurrence. The Oswestry Disability Index improved by an average of $32.8{\pm}6.3$, while the mental component summary of the 36-item Short-Form Health Survey improved by an average of $4.7{\pm}2.1$, and physical component summary improved by an average of $10.5{\pm}2.1$. Conclusions: To our knowledge, this is the first study to report a CT that defined 92%-98% FF and 100% IBF using the lowest reported dose of RhBMP-2 in multilevel ASD surgery. The use of ultra-low dose RhBMP-2 reduces the RhBMP-2 related complications and healthcare costs.

A Study on Spirituality Experience of Recovering Drug Addicts (회복기 마약중독자의 영성 체험에 관한 연구 -기독교·가톨릭인 회복자를 중심으로-)

  • Lim, Hae Young;Kim, Hakju
    • The Journal of the Korea Contents Association
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    • v.18 no.11
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    • pp.98-112
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    • 2018
  • In order to find out policy and practical implications to support recovering drug addicts in a holistic way, This study conducted in-depth interviews with five research participants using Giorgi's phenomenological study method to understand the meaning of spiritual experience of recovering drug addicts. According to data analysis, these spirituality experiences appeared as two thematic themes: 'experience of relationship with a divine being' and 'experience of inherent transcendence'. Three sub-themes of 'fear and scary existence', 'hanging object' and 'embracing existence' were derived from the essence theme of 'experience of relationship with a divine being' and 'immanent transcendental experience' was conceptualized into four sub-themes: 'facing existence', 'psychological reconstruction', 'mental maturity', and 'a way to go alone'. Based on this, spiritual experiences of recovery drug addicts showed that religion itself exerted a considerable influence on their spiritual experience and their spiritual experience was closely related to the recovery of humanity. Also, 'intrinsic transcendental experience' suggested that two essential themes of spiritual experience were closely interrelated in a mutual cyclical relationship. Based on the results, We discusses the major intervention plan for the recovery drug addicts that the social welfare system can consider.