• Journal of Gastric Cancer
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• v.21 no.1
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• pp.49-62
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• 2021

Purpose: This study aimed to investigate the prognostic value of lymph node ratio (LNR) in patients with locally advanced gastric cancer who received neoadjuvant chemotherapy. Materials and Methods: We retrospectively enrolled gastric cancer patients treated with neoadjuvant chemotherapy and curative surgery at the First Affiliated Hospital of Zhejiang University from 2004 to 2015 as the study cohort. Patients with the same inclusion criteria treated in 2016-2017 were enrolled as the validation cohort. Kaplan-Meier curves were assessed using the log-rank test to analyze the differences in overall survival (OS). Multivariate survival analysis was performed using the Cox proportional hazards model. The areas under the receiver operating characteristic curve of ypN and LNR categories for predicting the actual 3-year OS were compared. Results: A total of 265 patients were included in the proposal cohort. The median number of retrieved lymph nodes (rLNs) was 32. The number of positive lymph nodes (pLNs) increased as rLN increased (P=0.037), but the LNR remained relatively constant (P=0.462). The LNR was categorized into 4 groups according to the prognosis: ypNr0, node-negative with rLN>25; ypNr1, node-negative with rLN≤25 or 00.3. In the validation cohort of 43 enrolled patients, there was a clear distinction in OS that significantly (P<0.001) varied depending on the LNR values and LNR was the only independent prognostic factor in multivariate analysis (P<0.001). Conclusions: LNR was an independent prognostic factor for survival of patients with gastric cancer after preoperative chemotherapy and might be an alternative predictor for ypN stage.

• Bulletin of the Korean Mathematical Society
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• v.60 no.4
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• pp.905-913
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• 2023

Suppose that M is a strictly convex hypersurface in the (n + 1)-dimensional Euclidean space 𝔼ⁿ⁺¹ with the origin o in its convex side and with the outward unit normal N. For a fixed point p ∈ M and a positive constant t, we put 𝚽_t the hyperplane parallel to the tangent hyperplane 𝚽 at p and passing through the point q = p - tN(p). We consider the region cut from M by the parallel hyperplane 𝚽_t, and denote by I_p(t) the (n + 1)-dimensional volume of the convex hull of the region and the origin o. Then Schneider's characterization theorem for ellipsoids states that among centrally symmetric, strictly convex and closed surfaces in the 3-dimensional Euclidean space 𝔼³, the ellipsoids are the only ones satisfying I_p(t) = 𝜙(p)t, where 𝜙 is a function defined on M. Recently, the characterization theorem was extended to centrally symmetric, strictly convex and closed hypersurfaces in 𝔼ⁿ⁺¹ satisfying for a constant 𝛽, I_p(t) = 𝜙(p)t^𝛽. In this paper, we study the volume I_p(t) of a strictly convex and complete hypersurface in 𝔼ⁿ⁺¹ with the origin o in its convex side. As a result, first of all we extend the characterization theorem to strictly convex and closed (not necessarily centrally symmetric) hypersurfaces in 𝔼ⁿ⁺¹ satisfying I_p(t) = 𝜙(p)t^𝛽. After that we generalize the characterization theorem to strictly convex and complete (not necessarily closed) hypersurfaces in 𝔼ⁿ⁺¹ satisfying I_p(t) = 𝜙(p)t^𝛽.

• Bulletin of the Korean Chemical Society
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• v.18 no.12
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• pp.1260-1264
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• 1997

The phase-transfer reagent (PTC), ethyl tri-n-octylammonium bromide (ETABr), strongly catalyzes the reaction of p-nitrophenyldiphenylphosphinate (p-NPDPIN) with benzimidazole (BI) and its anion (BI-). In ETABr solutions, the dephosphorylation reactions exhibit higer than first order kinetics with respect to the nucleophile, BI, and ETABr, suggesting that reactions are occuring in small aggregates of the three species including the substrate, whereas the reaction of p-NPDPIN with OH- is not catalyzed by ETABr. This behavior for the drastic rate-enhancement of the dephosphorylation is refered as 'aggregation complex model' for reactions of hydrophobic organic phosphinates with benzimidazole in hydrophobic quarternary ammonium salt solutions.

• Korean Journal of Soil Science and Fertilizer
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• v.24 no.3
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• pp.165-170
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• 1991

Effects of liming and starch application on the soil pH and mineralization of organic nitrogen were compared to control at $30+/10^{\circ}C$ incubation for six weeks in two soil types(loam, sandy loam) adjusted with 80% of field moisture capacity. 1. While soil pH was increased abruptyl one week after incubation in loam applied with lime and lime+starch, it tended to decrease at control during incubation period. Liming on sandy loam increased soil pH, and application of lime+starch together showed high pH at first week of incubation which was lowered slowly after wards. Significant changes in soil pH was not detected at control or starch application only. 2. The content of $NH_3-N$ in loam started to increse three weeks after incubation, and was maximized at fifth week. Positive correlation was shown at control during incubation period between soil pH and $NO_3-N$ content. Level of $NO_3-N$ content applied with starch or lime+starch was low compared to control. 3. The $NH_4-N$ content was high when sandy loam was applied with lime+starch together. At the first week of incubation, the $NO_3-N$ content was high at control or lime application.

• The Korean Journal of Pain
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• v.32 no.2
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• pp.105-112
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• 2019

Background: Severe pain always develops after thoracotomy; intrapleural regional analgesia is used as a simple, safe technique to control it. This study was performed to evaluate whether a small dose of naloxone with local anesthetics prolongs sensory blockade. Methods: A prospective, randomized double-blinded controlled study was conducted on 60 patients of American Society of Anesthesiologists statuses I and II, aged 18 to 60 years, scheduled for unilateral thoracotomy surgery. After surgery, patients were randomly divided into two groups: through the intrapleural catheter, group B received 30 ml of 0.5% bupivacaine, while group N received 30 ml of 0.5% bupivacaine with 100 ng of naloxone. Postoperative pain was assessed using the visual analog pain scale (VAS). Time for the first request for rescue analgesia, total amount consumed, and incidence of postoperative complications were also recorded. Results: The VAS score significantly decreased in group N, at 6 h and 8 h after operation (P < 0.001 for both). At 12 h after injection, the VAS score increased significantly in group N (P < 0.001). The time for the first request of rescue analgesia was significantly longer in group N compared to group B (P < 0.001). The total amount of morphine consumed was significantly lower in group N than in the bupivacaine group (P < 0.001). Conclusions: Addition of a small dose of naloxone to bupivacaine in intrapleural regional analgesia significantly prolonged pain relief after thoracotomy and delayed the first request for rescue analgesia, without significant adverse effects.

• Journal of Aquaculture
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• v.15 no.1
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• pp.49-60
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• 2002

Research on practices for improving water quality in channel catfish Ictalurus punctatus ponds was conducted at the Auburn University Fisheries Research Station, Auburn, Alabama, in 1998 and 1999. The objective of this two-year study was to determine better management practices to enhance water quality and improve production efficiency. In the first year, oxidation of bottom soil by drying, tilling, and applying sodium nitrate was performed (dry-till and dry-till with sodium nitrate treatments). The second year, based on the results obtained during the first year, precipitation of phosphorus (P) from water by applying gypsum was compared to the dry-till treatment (dry-till and dry-till with gypsum treatments). Control ponds were not subjected to bottom drying, tilling, sodium nitrate, or gypsum treatment. Channel catfish fingerings were stocked at 15,000/ha. In the first year, water in ponds from dry-till and dry-till with sodium nitrate treatments had lower concentrations (P < 0.01) of soluble reactive P, nitrate ($NO_{3} ^{-}) and nitrite ($NO_{2} ^{-}) nitrogen (N), total ammonia ($NH_3$) nitrogen, total suspended solids and turbidity, and higher values of pH, Secchi disk visibility, total alkalinity, total hardness, and calcium ($Ca^{2+}) hardness than water in control ponds. Ponds of the dry-till treatment also had lower concentrations (P < 0.01) of total P and total N than control ponds. Total fish production and survival rate did not differ among the treatments (P > 0.05). The findings suggested that drying and tiling pond bosoms between crops could achieve water quality improvement. Applying sodium nitrate to dry, tilled pond bosoms did not provide water quality improvement. In the second year, the treatment with the best results from the first year, dry-till, was compared with a dry-till with gypsum treatment. Enough gypsum was applied to give a total hardness of about 200 mg/L, and gypsum was reapplied as needed to maintain the hardness. Compared to the control, dry-till and dry-till with gypsum treatments had lower concentrations (P < 0.01) of total and soluble reactive P, total N, and total $NH_3$-N, and higher concentrations (P < 0.01) of dissolved oxygen. Ponds of the duty-till with gypsum treatment also had lower concentrations (P < 0.01) of chlorophyll $\alpha$, chemical oxygen demand, and total alkalinity than the control. Total fish production and survival rate did not differ (P > 0.05) among the treatments. These findings suggest that drying and tilling pond bosoms between crops and treating low hardness waters with gypsum could achieve water Quality improvement.

• The Korean Journal of Ecology
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• v.11 no.2
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• pp.55-64
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• 1988

The seasonal pattern of pool size and withdrawal from senescing or stroage organ, and the annual magintude of internal-and plant-soil cycles for nitrogen and phosphorus in a Glyceria leptolepis Ohwi population in a marsh of the Mt. Geumoh were investigared. The population pool changed from initial size of 6.8 to the maximum of 16.1gN$m^{-2}$ for N and from 1.7 to 3.9g Pm$m^{-2}$ for P, maintaining far higher relative pool size during the first half of the growth period as compared with that for biomass. A sharp increase in N and P pool was noticed in early spring before the biomass growth was recognized, The major process supplying the demand for N and P changed as the growth progressed showing the order; absorption-withdrwal-absorption-with-drawal. The annual magnitude of plant-soil cycle for N and P was 18.0-19.1 and 2.9-3.3gm$m^{-2}$, accounting for 3 and 5% of each nutrient pool in 0-20 cm humus layer, respectively. The higher exent of internal cycle and the lower rate of annual turnover for P(1.08) as compared with those for N may suggest that this population conserves and reuses P more efficiently than N.

• The Pure and Applied Mathematics
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• v.22 no.1
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• pp.35-56
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• 2015

In this paper, we classify all nonconstant smooth CR maps from a sphere $S_{n,1}{\subset}\mathbb{C}^n$ with n > 3 to the Shilov boundary $S_{p,q}{\subset}\mathbb{C}^{p{\times}q}$ of a bounded symmetric domain of Cartan type I under the condition that p - q < 3n - 4. We show that they are either linear maps up to automorphisms of $S_{n,1}$ and $S_{p,q}$ or D'Angelo maps. This is the first classification of CR maps into the Shilov boundary of bounded symmetric domains other than sphere that includes nonlinear maps.

• Journal of applied mathematics & informatics
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• v.41 no.4
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• pp.753-763
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• 2023

In this paper, we introduce a fully modified (p, q)-poly tangent polynomials and numbers of the first type. We investigate analytic properties that is related with (p, q)-Gaussian binomial coefficients. We also define (p, q)-Stirling numbers of the second kind and fully modified (p, q)-poly tangent polynomials and numbers of the first type with two variables. Moreover, we derive some identities are concerned with the modified tangent polynomials and the (p, q)-Stirling numbers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4477-4481
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• 2016

Purpose: To compare the relative merits of imatinib and allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelogenous leukemia (CML). Materials and Methods: This cohort study was designed to compare the outcomes of imatinib (n=292) versus allo-HSCT (n=141) for CML, the clinical data of these patients being retrospectively analyzed so as to compare the event free survival (EFS) and overall survival (OS) between these two groups with patients in the chronic phase (CP) and advanced phases, including accelerate (AP) and blast phases (BP). Results: (1) Patients treated with imatinib (278 in the CP) demonstrated superior EFS, OS, 5-year EFS and 5-year OS rates of 88.5% versus 70.0% (P<0.05), 93.2% versus 80.0% (P<0.05), 84% versus 75.0% (P<0.05) and 92% versus 79.0% (P<0.05), respectively, to those treated with allo-HSCT (120 patients in the CP). (2) Both treatments resulted in similar survival, with EFS and OS rates of 42.9% versus 47.6% (P>0.05), 42.9% versus 57.1% (P> 0.05), respectively, for imatinib (14 patients in the AP and BP) and allo-HSCT (21 patients in the AP and BP). Conclusions: Imatinib confers significant survival advantage (EFS and OS) for CML patients with CP compared with allo-HSCT treatment. However, the outcomes are equally good with both treatments in AP and BP patients.