• The Journal of Korean Society for Radiation Therapy
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• v.21 no.1
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• pp.1-7
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• 2009

Purpose: The purpose is to evaluate the accuracy of correcting the targeting error through the Target Location System (TLS) for the location change error of the reference point which arises from the movement or motion of patient during the treatment using the CyberKnife. Materials and Methods: In this test, Gafchromic MD-55 film was inserted into the head and neck phantom to analyze the accuracy of the targeting, and then the 6 MV X-ray of CyberKnife (CyberKnife Robotic Radiosurgery System G4, Accuray, US) was irradiated. End to End (E2E) program was used to analyze the accuracy of targeting, which is provided by Accuray Corporation. To compute the error of the targeting, the test was carried out with the films that were irradiated 12 times by maintaining the distance within the rage of $0{\pm}0.2\;mm$ toward x, y, z from the reference point and maintaining the angle within the rage of $0{\pm}0.2^{\circ}$ toward roll, pitch, yaw, and then with the films which were irradiated 6 times by applying intentional movement. And the correlation in the average value of the reference film and the test film were analyzed through independent samples t-test. In addition, the consistency of dose distribution through gamma-index method (dose difference: 3%) was quantified, compared, and analyzed by varying the distance to agreement (DTA) to 1 mm, 1.5 mm, 2 mm, respectively. Results: E2E test result indicated that the average error of the reference film was 0.405 mm and the standard deviation was 0.069 mm. The average error of the test film was 0.413 mm with the standard deviation of 0.121 mm. The result of independent sampling t-test for both averages showed that the significant probability was P=0.836 (confidence level: 95%). Besides, by comparing the consistency of dose distribution of DTA through 1 mm, 1.5 mm, 2 mm, it was found that the average dose distribution of axial film was 95.04%, 97.56%, 98.13%, respectively in 3,314 locations of the reference film, consistent with the average dose distribution of sagittal film that was 95.47%, 97.68%, 98.47%, respectively. By comparing with the test film, it was found that the average dose distribution of axial film was 96.38%, 97.57%, 98.04%, respectively, at 3,323 locations, consistent with the average dose distribution of sagittal film which was 95.50%, 97.87%, 98.36%, respectively. Conclusion: Robotic CyberKnife traces and complements in real time the error in the location change of the reference point caused by the motion or movement of patient during the treatment and provides the accuracy with the consistency of over 95% dose distribution and the targeting error below 1 mm.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2006.08a
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• pp.92-92
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• 2006

• Progress in Medical Physics
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• v.21 no.2
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• pp.218-222
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• 2010

As radiation is irradiated from various directions in intensity modulated radiation therapy (IMRT), longer treatment time than conventional treatment method is taken. In case of the patients who have problem to keep same posture for long time because of pain and injury, reducing treatment time through increased dose rate is a way for effective treatment. This study measured and found out the variation of dose and dose distribution in accordance with dose rate variation. IMRT treatment plan was set up to investigate from 5 directions - $0^{\circ}$, $72^{\circ}$, $144^{\circ}$, $216^{\circ}$, $288^{\circ}$ - using ECLIPSE system (Varian, SomaVision 6.5, USA). To confirm dose and dose rate in accordance with dose rate variation, dose rate was set up as 100, 300, 500 MU/min, and dose and dose distribution were measured using ionization chamber (PTW, TN31014) and film dosimeter (EDR2, Kodak). At this time, film dosimeter was inserted into acrylic phantom, then installed to run parallel with beam's irradiating direction, 21EX-S (Varian, USA) was utilized as linear accelerator for irradiation. The measured film dosimeter was analyzed using VXR-16 (Vidar System Corporation) to confirm dose distribution.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.05
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• pp.148-151
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• 1992

There is a definite requirement to continuously monitor the operating characteristics of radiation therapy machines. It is advisable to monitor the symmetry, flatness, and energy stability of x-ray beams. The semiconductor system was developed using commercially available rectifier diode for th assessment of quality assurance In radiation therapy, which is capable of the above measurements. The beam characteristics of 6MV, 10MV and 21MV photon of Microtron electron accelerator were measured using seven-diodes as detectors and the results were compared with that of using a film results dosimetry with a X-Y plotter. The seven-diode detetor is versatile enough to be used for checking beam profile, flatness, symmetry and energy.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.183-185
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• 2002

Heavy ion and proton therapy necessitate range weeks, which are time consuming. Three types of variable compensator, membrane type liquid variable compensator, are proposed by some of the authors to overcome the difficulties, by those arbitrarily thickness distribution of compensator obtained from treatment planning is created at the site of treatment. None of the ideas, however, is yet realized. In this research, we are trying to construct prototype membrane-type liquid variable compensator. This variable compensator partitions air and liquid with elasticity membrane and changes the surface of the elasticity membrane with the thread. The air and oil move through holes to and from the out of beam side of two boxes in which they are contained. The boxes are made of Plexiglas(PMMA), the thread which is made of nylon, the elasticity film which is made from latex for the moment.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.97-99
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• 2002

A radiation incident took place during treatment on MEDNIF Tele cobalt-60 therapy machine in B.P.KOIRALA MEMORIAL CANCER HOSPITAL in Bharatpur, Nepal. This Chinese made machine has activity of 6240 Curies of cobalt -60. This machine has fulfilled safety requirements. ICRP recommendations, safety rules are followed and practiced. The source was struck up during treatment and a technician was exposed to equivalent dose of 13.75 mSv. recorded by Personal film badge. Risks of workers are comparable to other safe industries. All exposures shall be kept as low as reasonably possible. The higher level of safety is achieved only when every one is dedicated to common goal. A lesson is learnt for future. Good practice is essential but not sufficient. A high demand for tele Cobalt therapy convinced management to replace Mednif machine with a new efficient Elite Tele Cobalt theratron Machine.

• Journal of Periodontal and Implant Science
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• v.24 no.2
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• pp.421-432
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• 1994

The local route of antibiotic administration can accomplish higher therapeutic doses in subgingival sites than those possible by systemic therapy. This investigation assessed on the clinical and microbiological effect of 30% Minocycline loaded polycaprolactone film (Mino-strip) on rapidly progressive periodontitis. Mino-strip was applied in the periodontal pockets of 15 patients with clinically diagnosed as a rapidly progressive periodontitis. 8sites for each patient with a 5mm probing pocket depth were selected in split mouth design and were assigned into group. i.e., placebo(group 1), supragingival scaling and R/P(group 2), Mino-strip applied only(group 3), R/P and Mino-strip applied(group 4). Supragingival scaling and oral hygiene instruction were performed 1 wk before experiment. Mino-strip was applied weekly on day 0 and 7. Clinical and microbiological test were performed on day 0, 7, 14, 28, 56. In R/P and Mino-strip applied group, Gingival index, GCF volume, probing depth and loss of attachment level were significantly reduced after the first weeks following treatment. In R/P and Mino-strip applied group, the relative proportions of spirochetes and motile rods were significantly reduced and the proportions of cocci and non motile rod were correspondingly increased for eight weeks following treatment. In R/P and Mino-strip treated group, total anaerobic and aerobic bacterial count were significantly decreased for the first two weeks following treatment and streptococcus count was decreased for eight weeks following treatment. In R/P and Mino-strip applied group, P. gingivalis, P. intermedius, B. forsythus, A. actinomycetemcomitans, F. nucleatum, E. corrodens, C. rectus counts were significantly reduced after the first week following treatment. According to this study, it is appeared that 30% Minocycline-loaded polycaprolacton film was effective in the treatment on rapidly progressive periodontitis.

• Child Health Nursing Research
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• v.13 no.1
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• pp.33-42
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• 2007

Purpose: This study was conducted to investigate the effects of multimodal sensory stimulation on growth and mother-infant interaction in infants with low birth weight (LBW). Method: A non-equivalent control group time-series study design was used. The participants were 38 LBW infants and their mothers (19 in the intervention group and 19 in the control group). The data were collected from September 1, 2003 to March 31, 2004. For the mothers in the intervention group, this researcher instructed mothers in the multimodal sensory stimulation therapy, in turn the mothers used these techniques on their infants once a day during the 4-week research period. The researcher measured weight, length, and head circumference of the LBW infants once a week for 4 weeks and made a film of the mother playing with the infant for 5 minutes in the last week of the research period. Results: Compared to the control group, LBW infants in the intervention group showed significant increases in weekly weight gain (F=3.82, p=.012) and had significantly higher scores for mother-infant interaction (t=3.93, p>.000). Conclusion: The results suggest that multimodal sensory stimulation therapy can be used to increase the growth of LBW infants and improve mother-infant interaction.

• Journal of Korean Physical Therapy Science
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• v.5 no.4
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• pp.763-775
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• 1998

Some segment or segments of the body must compensate for the heel, and the higher the heel the greater the compensation. Such compensation was once generally thought to take place in the lumbar region and therefore to increase the lumbar lordosis. The purpose of this study is to analyze changes of lumbar sagittal curvature in barefoot and 6cm 12cm high-heel stance. We selected 19 subjects(11 males, 8 females} without history of lower back pain, significant spinal abnormality. And lateral view X-ray of lumbar region from T12 to S1 was taken of each individual. On each X-ray film, lumbar lordotic angle lumbosacral angle and lumbar segmental angles were measured by Cobb method. We drew the following interpretations from the analysis of measured variables of the lumbar region. 1. In comparison of barefoot 6cm heel 12cm heel stance, lumbar lordotic angle had a tendency to decrease according as the heel height was higher. The change in lumbar lordosis measured in high-heel stance was inconsistent with clinical forkelord of hyperlordosis in wearers of high-heeled. 2. Lumbar lordotic angle from T12 to L5 showed sex difference, and was more lordotic in female(p<0.05). 3. There was no sex difference in lumbosacral angle and lumbar segmental angles(p>0.05). 4. There was a significant correlation between lumbar lordotic angle and lumbosacral angle(r>0.60).

• Restorative Dentistry and Endodontics
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• v.16 no.1
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• pp.226-235
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• 1991

Therapeutic use of antibiotics in the pulpal disease should reduce the clinical symptoms and pathogenic microflora in the pulp. The purpose of this study was focused on local drug delivery into the root canal in endodontic therapy. Monolithic films from polycaprolactone and polyethylene glycol preparations with minocycline were prepared, and then the antimicrobial effect of these films on necrotic canal was tested. A total 17 necrotized pulp teeth were sampled before and 1 week after insertion of film into the pulp. Bacterial culture were performed with anaerobical condition and seeded in the 5 selective and non - selective media for 7 days in $37^{\circ}C$ of anaerobic chamber. Bacterial identification were performed with Gram staining, biochemical test, and API kit There was significantly decreased of anaerobic and aerobic microflora of 13 among 17 patients after therapy. Among the identified microflora, Streptococcus species, black - pigmented species and Fusobacterium species were significantly reduced 1 week after treatment with local delivery antibiotics. Furthermore, clinical symptoms included in pain and local swelling were continuousely reduced after therapy. These results suggest that local drug delivery with minocycline is effeicient to treat the endodontic involved teeth for releasing clinical symptoms and microbiological shifting.