• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1465-1470
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• 2014

Inhibitor of DNA binding 1 (Id1) plays an important role in genesis and metastatic progression of prostate cancer. We previously reported that down regulation of Id1 by small interfering RNA could inhibit the proliferation of PC3 cells and growth of its xenografted tumors. Curcumin, the active ingredient of turmeric, has shown anti-cancer properties via modulation of a number of different molecular regulators. Here we investigated whether Id1 might be involved in the anti-cancer effects of curcumin in vivo and in vitro. We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1. Similar effects of curcumin were observed in tumors of the PC3 xenografted mouse model with introperitoneal injection of curcumin once a day for one month. Tumor growth in mice was obviously suppressed by curcumin during the period of 24 to 30 days. Both mRNA and protein levels of Id1 were significantly down-regulated in xenografted tumors. Our findings point to a novel molecular pathway for curcumin anti-cancer effects. Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.

• The Research Journal of the Costume Culture
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• v.23 no.5
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• pp.793-806
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• 2015

This study is to explore the effect of music characteristics (i.e., likeliness and familiarity of music) on the relationship between mood and attitude toward the product in the online shopping mall selling hand-made shoes. A total of 319 consumers participated in experiments with online shopping mall stimuli with a variety of background music. In results, consumer mood positively affected attitude toward the hand-made shoe products in the online shopping mall under background music. A moderating effect of music likeliness was found in the relationship between mood and product attitude, indicating that mood more strongly affected product attitude under more liked music than under less liked music. When consumers are listening to more liked music and are in good mood, they may build their attitudes toward products independently from their mood, whereas they may build positive attitude under good mood versus negative attitudes under bad mood if they are listening to less liked music. A moderating effect of music familiarity was not found in the relationship between mood and product attitude. Based on results, it was confirmed that the S-O-R model could be applied to explain the effect of background music on consumer responses in online shopping malls. Marketers may be able to select and adjust the likeliness and familiarity of background music to better serve consumers in diverse shopping conditions, referring to the study findings.

• Bulletin of the Korean Chemical Society
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• v.35 no.3
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• pp.770-774
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• 2014

The bond dissociation energy (BDE) of the chemical bond between the carbon and oxygen atoms of a simple TEMPO-derivative is calculated by employing the density functional theory, the $2^{nd}$ order M${\phi}$ller-Plesset (MP2) perturbation theory, and complete basis set (CBS) methods. We find that BDE of the positive ion of the TEMPO-derivative is larger at least by 7 kcal/mol than that of the negative ion, which implies that the dissociation reaction rate of the positive ion should be slower than that of the negative ion. Such theoretical predictions are contrary to the results of our previous experiments (Anal. Chem. 2013, 85, 7044), in which the larger energy was required for negative o-TEMPO-Bz-C(O)-peptides to undergo the dissociation reactions than for the positive ones. By comparing our theoretical results to those of the experiments, we conclude that the dissociation reaction of o-TEMPO-Bz-C(O)-peptide should occur in a complicated fashion with a charge, either positive or negative, probably being located on the amino acid residues of the peptide.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.10a
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• pp.433-436
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• 2004

In this paper, we introduce a new Fuzzy Polynomial Neural Networks (FPNNS)-like structure whose neuron is based on the Fuzzy Set-based Fuzzy Inference System (FS-FIS) and is different from that of FPNNS based on the Fuzzy relation-based Fuzzy Inference System (FR-FIS) and discuss the ability of the new FPNNS-like structure named Fuzzy Set-based Polynomial Neural Networks (FSPNN). The premise parts of their fuzzy rules are not identical, while the consequent parts of the both Networks (such as FPNN and FSPNN) are identical. This difference results from the angle of a viewpoint of partition of input space of system. In other word, from a point of view of FS-FIS, the input variables are mutually independent under input space of system, while from a viewpoint of FR-FIS they are related each other. The proposed design procedure for networks architecture involves the selection of appropriate nodes with specific local characteristics such as the number of input variables, the order of the polynomial that is constant, linear, quadratic, or modified quadratic functions being viewed as the consequent part of fuzzy rules, and a collection of the specific subset of input variables. On the parameter optimization phase, we adopt Information Granulation (IC) based on HCM clustering algorithm and a standard least square method-based learning. Through the consecutive process of such structural and parametric optimization, an optimized and flexible fuzzy neural network is generated in a dynamic fashion. To evaluate the performance of the genetically optimized FSPNN (gFSPNN), the model is experimented with using the time series dataset of gas furnace process.

• Journal of Communications and Networks
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• v.10 no.2
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• pp.137-147
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• 2008

This paper proposes a novel approach to interference avoidance via inter-cell relaying in cellular OFDMA-TDD (orthogonal frequency division multiple access - time division duplex) systems. The proposed scheme, termed asymmetry balancing, is targeted towards next-generation cellular wireless systems which are envisaged to have ad hoc and multi-hop capabilities. Asymmetry balancing resolves the detrimental base station (BS)-to-BS interference problem inherent to TDD networks by synchronizing the TDD switching points (SPs) across cells. In order to maintain the flexibility of TDD in serving the asymmetry demands of individual cells, inter-cell relaying is employed. Mobile stations (MSs) in a cell which has a shortage of uplink (UL) resources and spare downlink (DL) resources use free DL resources to off-load UL traffic to cooperating MSs in a neighboring cell using ad hoc communication. In an analogous fashion DL traffic can be balanced. The purpose of this paper is to introduce the asymmetry balancing concept by considering a seven-cell cluster and a single overloaded cell in the center. A mathematical model is developed to quantify the envisaged gains in using asymmetry balancing and is verified via Monte Carlo simulations. It is demonstrated that asymmetry balancing offers great flexibility in UL-DL resource allocation. In addition, results show that a spectral efficiency improvement of more than 100% can be obtained with respect to a case where the TDD SPs are adapted to the cell-specific demands.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.38 no.3
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• pp.13-23
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• 2001

In this paper, we design and implement a virtual environment which forms the basis of constructing a virtual world in a systematic fashion. Though virtual environments have been developed in several systems using the virtual reality, they are designed without a systematic method of constructing. In our framework, a virtual environment is structured in six layers according to their functions and ranges based on a classification of environmental factors of which the real world is composed. These layers compose a universal environment in our virtual world by operating independently and exchanging information with one another periodically. The designed environment shows that it Can provide diverse real life situations and is easily extensible to enhance its functionalities. We present effective design schemes for several important environmental factors. We demonstrate viability of our framework through implementing a plausible virtual world based on the proposed schemes.

• Journal of Mechanical Science and Technology
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• v.19 no.9
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• pp.1695-1705
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• 2005

Reaction wheels and thrusters are commonly used for the satellite attitude control. Since satellites frequently need fast maneuvers, the minimum time maneuvers have been extensively studied. When the speed of attitude maneuver is restricted due to the wheel torque capacity of low level, the combinational use of wheel and thruster is considered. In this paper, minimum time optimal control performances with reaction wheels and thrusters are studied. We first identify the features of the maneuvers of the satellite with reaction wheels only. It is shown that the time-optimal maneuver for the satellite with four reaction wheels in a pyramid configuration occurs on the fashion of single axis rotation. Pseudo control logic for reaction wheels is successfully adopted for smooth and chattering-free time-optimal maneuvers. Secondly, two different thrusting logics for satellite time-optimal attitude maneuver are compared with each other: constant time-sharing thrusting logic and varying time-sharing thrusting logic. The newly suggested varying time-sharing thrusting logic is found to reduce the maneuvering time dramatically. Finally, the hybrid control with reaction wheels and thrusters are considered. The simulation results show that the simultaneous actuation of reaction wheels and thrusters with varying time-sharing logic reduces the maneuvering time enormously. Spacecraft model is Korea Multi-Purpose Satellite (KOMPSAT)-2 which is being developed in Korea as an agile maneuvering satellite.

• Molecules and Cells
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• v.38 no.3
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• pp.236-242
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• 2015

Intake of caffeine during pregnancy can cause retardation of fetal development. Although the significant influence of caffeine on animal development is widely recognized, much remains unknown about its mode of action because of its pleiotropic effects on living organisms. In the present study, by using Caenorhabditis elegans as a model organism, the effects of caffeine on development were examined. Brood size, embryonic lethality, and percent larval development were investigated, and caffeine was found to inhibit the development of C. elegans at most of the stages in a dosage-dependent fashion. Upon treatment with 30 mM caffeine, the majority ($86.1{\pm}3.4%$) of the L1 larvae were irreversibly arrested without further development. In contrast, many of the late-stage larvae survived and grew to adults when exposed to the same 30 mM caffeine. These results suggest that early-stage larvae are more susceptible to caffeine than later-stage larvae. To understand the metabolic responses to caffeine treatment, the levels of expression of cytochrome P450 (cyp) genes were examined with or without caffeine treatment using comparative microarray, and it was found that the expression of 24 cyp genes was increased by more than 2-fold (p < 0.05). Among them, induction of the cyp-35A gene family was the most prominent. Interestingly, depletion of the cyp-35A family genes one-by-one or in combination through RNA interference resulted in partial rescue from early larval developmental arrest caused by caffeine treatment, suggesting that the high-level induction of cyp-35A family genes can be fatal to the development of early-stage larvae.

• Journal of Life Science
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• v.17 no.8 s.88
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• pp.1100-1103
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• 2007

In proton therapy, the Bragg peak is spread out by modulating or degrading the energy of the particles to cover a well-defined target volume at a given depth. Proton transfer plays a key role in a variety of biological, the origin of the elements, tests of the standard model along with applications in medicine, industry and chemical phenomena such as water autoionization, fast proton diffusion, acid-base neutralization. We have studied the radiolysis of various natural resources and have evaluated the antioxidant activity of radiolysis products by proton beam. The most of antioxidant activities of natural resources were decreased with increasing proton fluence. Proton beam induced antioxidant activities both in 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and 2,2'-azinobis(3-ethylbenzot hialozinesulfonic acid) cation radical $(ABTS^{.+})$ assay by a dose dependent fashion.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3977-3982
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• 2012

Inhibitors of histone deacetylase activity are emerging as a potentially important new class of anticancer agents. In this study, we assessed the anticancer effects of valproic acid (VPA) on ovarian cancer in vitro and in vivo. Cultured SKOV3 cells were treated by VPA with different concentrations and time, then the effects on cell growth, cell cycle, apoptosis, and related events were investigated. A human ovarian cancer model transplanted subcutaneously in nude mice was established, and the efficacy of VPA used alone and in combination with diammine dichloroplatinum (DDP) to inhibit the growth of tumors was also assessed. Proliferation of SKOV3 cells was inhibited by VPA in a dose and time dependent fashion. The cell cycle distribution changed one treatment with VPA, with decrease in the number of S-phase cells and increase in G1-phase. VPA could significantly inhibit the growth of the epithelial ovarian cancer SKOV3 cells in vivo without toxic side effects. Treatment with VPA combined with DDP demonstrated enhanced anticancer effects. The result of flow cytometry (FCM) indicated that after VPA in vitro and in vivo, the expression of E-cadherin was increased whereas vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were decreased. This study suggests that VPA could be a novel attractive agent for treatment of ovarian cancer.