• Title/Summary/Keyword: Expression patterns

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Immunohistochemistry Subtypes (ER/PR/HER) of Breast Cancer: Where Do We Stand in the West of Saudi Arabia?

  • Khabaz, Mohamad Nidal
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8395-8400
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    • 2014
  • In Saudi Arabia, cancer of breast is ranked the most frequent neoplasm and second source of cancer death in the female population. Breast cancer (BC) fast diagnosis, prognosis and medication management necessitate, these days, immunohistochemistry (IHC) assessment of hormone receptors and HER2 expression profile. The present report defines the IHC profile of ER, PR and HER2 in Saudi female breast neoplasms of ductal and lobular types and associations ER, PR and HER2 expression patterns with various clinicopathological factors (age, type of tumor, size, laterality, histological grade, and involvement of axillaries lymph nodes). Ninety nine cases of breast tumors were recruited from the pathology department archive of King Abdulaziz University Hospital, Kingdom of Saudi Arabia. ER, PR and HER2 expression was assessed using IHC staining. Ductal carcinomas with a variety of histological grades constituted 88 (88.8%) of total cases. Seventy four (77.8%), 59 (62.1%), and 35 (36.8%) of ductal carcinomas showed positive staining for ER, PR and HER2, in that order. Remaining breast cancer cases were four (4%) lobular carcinomas and two (2%) mixed form of ductal and lobular types, which were ER+, PR+, and HER2-. Breast cancer expression pattern of ER, PR and HER2 in Saudi female is different from that of Tunisian and Jordanian female populations and closer to the expression pattern of Egyptian, Lebanese, Iraqi and western country females. Furthermore, the present study found two IHC patterns of breast cancer ER+/PR-/HER2+ (5%) and ER+/PR-/HER2- (11.1%), which had not been reported in other Arabic studies. Thus the rates of IHC expression patterns in breast cancer show some variation among Arabic female populations.

Design and Implementation of a Real-Time Emotional Avatar (실시간 감정 표현 아바타의 설계 및 구현)

  • Jung, Il-Hong;Cho, Sae-Hong
    • Journal of Digital Contents Society
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    • v.7 no.4
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    • pp.235-243
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    • 2006
  • This paper presents the development of certain efficient method for expressing the emotion of an avatar based on the facial expression recognition. This new method is not changing a facial expression of the avatar manually. It can be changing a real time facial expression of the avatar based on recognition of a facial pattern which can be captured by a web cam. It provides a tool for recognizing some part of images captured by the web cam. Because of using the model-based approach, this tool recognizes the images faster than other approaches such as the template-based or the network-based. It is extracting the shape of user's lip after detecting the information of eyes by using the model-based approach. By using changes of lip's patterns, we define 6 patterns of avatar's facial expression by using 13 standard lip's patterns. Avatar changes a facial expression fast by using the pre-defined avatar with corresponding expression.

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A Hardware Architecture of Regular Expression Pattern Matching for Deep Packet Inspection (심층 패킷검사를 위한 정규표현식 패턴매칭 하드웨어 구조)

  • Yun, Sang-Kyun;Lee, Kyu-Hee
    • Journal of the Korea Society of Computer and Information
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    • v.16 no.5
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    • pp.13-22
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    • 2011
  • Network Intrusion Detection Systems use regular expression to represent malicious packets and hardware-based pattern matching is required for fast deep packet inspection. Although hardware architectures for implementing constraint repetition operators such as {10} were recently proposed, they have some limitation. In this paper, we propose hardware architecture supporting constraint repetitions of general regular expression sub-patterns with lower logic complexity. The subpatterns supported by the proposed contraint repetition architecture include general regular expression patterns as well as a single character and fixed length patterns. With the proposed building block, we can implement more efficiently regular expression pattern matching hardwares.

Expression Analysis of Flower Color Related Genes in Spray-type 'ARTI-purple' Developed by Gamma-ray Mutagenesis (감마선 변이체 스프레이 국화 'ARTI-purple'의 화색 관련 유전자 발현 분석)

  • Sung, Sang Yeop;Lee, Yu-Mi;Kim, Sang Hoon;Ha, Bo-Keun;Kang, Si-Yong;Kim, Jin-Baek;Kim, Hong Gi;Kim, Dong Sub
    • Journal of Radiation Industry
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    • v.6 no.2
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    • pp.147-152
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    • 2012
  • Anthocyanins are major plant pigment and produced through phenylpropanoid pathway. In this study, anthocyanin biosynthesis mechanisms of chrysanthemum flowers were studied using 'Argus' and flower color mutant 'ARTI-purple' which were induced by 40 Gy gamma irradiation ($Co^{60}$). And, three chrysanthemums, 'Ford', 'Yeonja' and 'Orando' were additionally used as the check varieties to understand the relationship between flower color and expression patterns of genes. The expression patterns of the anthocyanin biosynthetic genes were matched with the flower color of the check varieties. High anthocyanin concentration of 'Orando' showed the high expression of anthocyanin biosynthetic genes. In the white flower of 'Ford', expressions of CHI, DFR and ANS were not identified. Despite different flower color, 'Argus' and 'ARTI-purple' showed different expression patterns compared with the check varieties. From the dot blot analysis, we screened the seven genes showing the different expressions between 'Argus' and 'ARTI-purple'.

Expression of B Cell Activating Factor Pathway Genes in Mouse Mammary Gland

  • Choi, S.;Jung, D.J.;Bong, J.J.;Baik, M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.2
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    • pp.153-159
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    • 2007
  • In our previous study, overexpression of extracellular proteinase inhibitor (Expi) gene accelerated apoptosis of mammary epithelial cells, and induced expression of B cell activating factor (BAFF) gene. In this study, we found induction of BAFF-receptor (BAFF-R) gene expression in the Expi-transfected cells. A proliferation-inducing ligand (APRIL) gene is another TNF family member and the closest known relative of BAFF. We found induction of APRIL gene expression in the Expi-overexpressed apoptotic cells. NF-${\kappa}$B gene was also induced in the Expi-overexpressed cells. Expression patterns of BAFF and APRIL pathway-related genes were examined in in vivo mouse mammary gland at various reproductive stages. Expression levels of BAFF gene were very low at early pregnancy, increased from mid-pregnancy, and peaked at lactation, and thereafter decreased at involution stages of mammary gland. Expression of BAFF-R gene was highly induced in involution stages compared to lactation stages. Thus, expression patterns of BAFF-R gene were correlated to apoptotic status of mammary gland: active apoptosis of mammary epithelial cells occurs at involution stage of mammary gland. Expression levels of NF-${\kappa}$B gene were higher in involution stages compared to lactation stages. We analyzed mRNA levels of bcl-2 family genes from different stages of mammary development. Bcl-2 gene expression was relatively constant during lactation and involution stages. There was a slight increase in bcl-xL gene expression in involution stages compared to lactation state. Bax gene expression was highly induced in involution stage. Our results suggest that signaling pathways activated by both BAFF and ARRIL in mammary gland point towards NF-${\kappa}$B activation which causes upregulation of bax.

Studying the frequencies of sentence pattern for a entence patterns dictionary (문형 사전을 위한 문형 빈도 조사)

  • Kim Yu-Mi
    • Korean Journal of Cognitive Science
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    • v.16 no.2
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    • pp.123-140
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    • 2005
  • The purpose of this paper is to examine the frequency and usage of sentence patterns appearing in electronic dictionaries used in Korean language education in order to design an automatic sentence patterns checking. First, the concept of sentence patterns is defined and it is classified into sentence structure patterns and sentencial expression patterns. Sentence structure patterns and sentencial expression patterns are analyzed how they are expressed in the Korean Learner's Corpus. learner's Corpus is built into the Standard Corpus, which all Korean Learners must learn, and the Errors Corpus made by learners. From these research, we will find out how frequently the Sentential Patterns are being used in the Standard Corpus which has been made of Korean Texts and how the Sentential Pattern are being used in the Errors Corpus which were constructed from Korean learner's writings. Finally, having described the Sentential Patterns on the Sentential Electric Dictionary, we determine the optimum speed in the search for the Sentential Pattern.

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Comparative Analysis of Transgene Copy Numbers and Expression Characteristics across Multiple Transgenic Marine Medaka Oryzias dancena Strains carrying the β-Actin Promoter-Driven GFP Reporter

  • Cho, Young Sun;Lee, Sang Yoon;Vu, Nguyen Thanh;Kim, Dong Soo;Nam, Yoon Kwon
    • Fisheries and Aquatic Sciences
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    • v.18 no.2
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    • pp.183-193
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    • 2015
  • Several transgenic marine medaka Oryzias dancena strains harboring a green fluorescent protein (GFP) reporter construct regulated by an endogenous ${\beta}$-actin promoter were established and their expression characteristics in relation to transgene copy numbers were examined in 21 transgene genotypes. Most of the transgenic strains displayed transgene insertion patterns typical of microinjection-mediated introduction of foreign DNA into fish embryos, characterized by the random integration of multiple transgene copies (ranging from 1 - 282 copies per cell), often accompanied by the formation of concatemer(s), as assessed by genomic Southern blot hybridization analysis and qPCR. Transgenic strains showed ubiquitous and continued temporal and spatial expression patterns of the transgenic GFP during most of their life cycle, from the embryonic stage to adulthood, enabling assessment of the expression pattern of the endogenous ${\beta}$-actin gene. However, a comparative evaluation of transgene copy numbers and expression levels showed that copy number-dependent expression, the stability of the ubiquitous distribution and expression efficiency per transgene copy varied among the transgenic strains. Fluorescence expression levels were positively correlated with absolute transgene copy numbers, whereas the expression efficiency per transgene copy was inversely related to the number of transgene integrant copies. Data from this study will guide the selection of potentially desirable transgenic strains with ubiquitous expression of a fluorescent transgene, not only in this marine medaka species but also in other related model fish species.

A Study on the Characteristics of Japanese Traditional Patterns (일본 전통문양의 특징에 관한 연구)

  • Kim, Se-Na;Oh, Kyung-Wha
    • Fashion & Textile Research Journal
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    • v.5 no.5
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    • pp.511-519
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    • 2003
  • The traditional culture has been developed for a long time with an unique property according to folk character, custom and environment within an area. Especially in 1906, when the westerners were interested in oriental cultures more and more, Paul Poiret presented Japanese traditional dress of napping sleeve coats and harem pants, henceforth japanese fashion theme began to rise. The Japanese style rose as an important fashion item of the modern fashion, with various fashion themes such as orientalism, ethnic, folklore, ecology, etc., needless to say of activities of Japanese designers. The revealed patterns on Japanese dress and it's ornament plays a role of expressive decoration as well as stand for the nation, the ideology of the age and aesthetic consciousness. For this reason, it is necessary to study Japanese traditional patterns expressed in modern fashion systematically. Therefore, in this research, the demonstrated Japanese traditional patterns on the modern fashion were divided into natural, artificial and complex design and were looked out the characteristic, furthermore it was studied in regard that Japanese patterns were how to apply in modern fashion. It was concluded that the characteristics of the Japanese traditional patterns presented in the modern fashion were as follows: first, creation of environmental friendly design using plenty of natural materials; second, expression of paint-like impression and beauty of margins by simplifying of patterns; third, expression of amusing design by using bright colors and print; finally, various patterns were spreaded out complicated on dress. The characteristics of Japanese traditional patterns in the above were expressed in the modern fashion.

Exploring phoenix patterns - Dunhuang Mogao Grottoes and fashion design expressions - (봉황문양 탐구 - 둔황 막고굴과 패션디자인 표현기법 -)

  • Jingyi Zhang;Myung Hee Lee
    • The Research Journal of the Costume Culture
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    • v.31 no.4
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    • pp.504-518
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    • 2023
  • The objective of this study was to explore the symbolism associated with phoenix patterns in China and the temporal aesthetic characteristics of these patterns found in Dunhuang Mogao Grottoes. The study involved collecting examples of clothing designs featuring phoenix patterns from China Fashion Week and the Vogue website, spanning from spring and summer of 2016 to fall and winter of 2022. After collecting and organizing these examples, representative cases were selected for analysis. The objective was to identify effective techniques for incorporating phoenix patterns within the context of Dunhuang Mogao Grottoes and provided insights for future clothing design and textile pattern design research. Phoenix patterns boasted a lengthy history and were laden with symbolic meaning. Early renditions of phoenix patterns found at Mogao Grottoes in Dunhuang were relatively simplistic in design, mainly employing elements like rhythm, coordination, balance and symmetry to convey a sense of nature and gravity. Over time, these patterns evolved under the influence of the prevailing cultural backdrop, employing repeated emphasis to portray notions of abundance and tenacity. Furthermore, regarding the use of phoenix patterns in clothing, there were four prevalent expression techniques: embroidery, beading, printing, and knitting. Traditional techniques like embroidery and beadwork often prioritized aesthetic features like coordination, emphasis, and symmetry, thereby showcasing the opulent characteristics of phoenix patterns. On the other hand, printing and knitting techniques used a single phoenix pattern or a modified version to simplify designs by emphasizing or repeating aesthetic characteristics while adhering to a modern artistic approach.

Characteristics of Pattern Design from Dries Van Noten Collection (드리스 반 노텐의 컬렉션에 나타난 문양디자인 특성)

  • Kim, Chanju;Ro, Mikyung
    • Journal of the Korean Society of Costume
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    • v.63 no.5
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    • pp.115-131
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    • 2013
  • Dries Van Noten, one of the Antwerp Six, focused on recreating traditional attire from each region to complex contemporary attire and has shown designs that interpreted ethnic image in contemporary perspective from his very first collection. He has positioned himself as a designer with creative expression of ethnic image through broad use of various patterns. This paper analyze the use of pattern in Dries Van Noten's designs by season and item, and reflects on the characteristics of pattern use and influence on fashion image. Total of 887 clothing items were collected from Noten's collections on the Internet. Through analysis of frequency and percentage and cross tab of expression techniques, types, patterns of each motif, and classifications of print combinations, it was shown that Noten has applied six aesthetic rules in the use of pattern design. Pattern played the most significant role in his design. It was possible to achieve the balance of ethnic image and modern image with the mix of flower and abstract motives. Overall pattern was mostly used for practical purpose: border patterns and spaced patterns played a vital role in rendering uniqueness. Noten exhibited unity and variation in combining prints. He expressed the beauty of Oriental style by inserting solid color blocks in between patterns and decorations along trim lines.