• 대한전자공학회논문지SD
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• 제47권5호
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• pp.31-40
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• 2010

본 논문에서는 IEEE 802.11n 무선 랜 표준용 LDPC 복호기 프로세서를 설계하였다. 설계된 프로세서는 IEEE 802.11n 표준의 블록길이 1,944와 부호화율 1/2의 패리티 검사 행렬을 지원하며, 하드웨어 감소를 위해 최소합 알고리듬과 layered 구조를 적용하였다. 최소합 알고리듬의 특징을 이용한 검사노드 메모리 최소화 방법을 고안하여 적용하였으며, 이를 통해 기존방법의 메모리 크기의 25%만을 사용하여 구현하였다. 설계된 프로세서를 $0.35-{\mu}m$ CMOS 셀 라이브러리로 합성한 결과, 200,400 게이트와 19,400 비트의 메모리로 구현되었으며, 80 MHz@2.5V로 동작하여 약 135 Mbps의 성능을 갖는다. 설계된 회로는 FPGA 구현을 통해 하드웨어 동작 검증과 복호성능을 분석하였으며, 이를 통해 설계된 LDPC 복호기의 유용성을 입증하였다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제10권2호
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• pp.52-58
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• 2005

본 연구는 사염화에틸렌(Perchloroethylene) 또는 트리클로로에틸렌(Trichloroethylene)으로 오염된 국내 지하수 내에 국외에서 보고된 환원성 탈염소화 미생물의 존재 유무와 사염화에틸렌의 생물학적 탈염소화 활성도를 평가하였다. 마이크로코즘 테스트(microcosm tests)는 4개의 오염지역(창원 A, 창원 B, 부천 및 양산) 지하수와 다양한 전자공여체 (sodium lactate, sodium propionate, sodium butyrate, sodium fumarate)를 이용하여 수행하였다. 단일 전자공여체 와 창원 A 혹은 창원 B 지하수를 주입한 전 마이크로코즘에서 사염화에틸렌 완전 탈염소화 분해 시 발생하는 최종 산물인 에틸렌이 배양 90일 후에 검출되었고, 부천 혹은 양산 지역의 지하수를 주입한 마이크로코즘에서는 배양 90 일 후 시스-1,2-디클로로에틸렌(cis-1 ,2-Dichloroethylene)만이 검출되었고, 염화비닐(Vinyl chloride) 과 에틸렌은 검출되지 않았다. 완전 탈염소화 생분해가 확인된 창원 B 지역 지하수와 불완전 탈염소화 생분해가 확인된 양산 지역 지하수 내 미생물 군집을 비교하기 위해 분자생물학적 방법을 이용한 실험을 수행하였다. 창원 B 지역 지하수의 클론 라이브러리(Clone library)에서 사염화에틸렌 완전 탈염소화 미생물, uncultured bacterium clone DCE47과 매우 유사한 염기서열 클론이 확인되었다. 그러나 양산 지역의 클론 라이브러리에서는 기존의 염화에틸렌 탈염소화 미생물과 유사한 염기서열 클론이 확인되지 않았다. 본 연구 결과를 통하여 국내 일부 지역의 지하수 내에 사염화에틸렌을 완전 탈염소화하여 무해한 에틸렌으로 분해하는 미생물이 존재함을 확인하였고, 적절한 전자공여체를 공급하는 경우 그 분해 활성도가 증가함을 확인하였다. 이 결과는 사염화에틸렌 혹은 트리클로로에틸렌으로 오염된 국내 지하수를 경제적인 공법인 환원성 탈염소화 생물학적 공정으로 복원할 수 있는 기능성을 보여주는 중요한 지표라고 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5263-5272
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• 2012

Background: Gastric cancer (GC) is one of the most common cancers in China. Adjuvant chemotherapy (AC) is a routine auxiliary treatment for GC recommended by the guidelines issued in 2011 by the Ministry of Health of the People's Republic of China, but the relevant credible consequences in China have been insufficient because of China's late start and ethical concerns. Methods: A series of databases, including Cochrane Library, MEDLINE, EMBASE, the Chinese database of the National Knowledge Infrastructure and the VIP database, were searched by 2 reviewers independently for studies investigating AC for GC through March 2012. The retrieved literature was screened according to the eligibility criteria. Results: A total of 35 randomized control trials (RCTs) were subjected to the final analysis, including 4,043 patients in treatment group and 3,884 in the control group, as well as 4 clinical-control trials (CCTs), which accessed the final analysis with 238 and 252 patients, respectively. AC reduced the risk of death as a protective treatment with statistical significance (HR=0.91, 95%CI: [0.85, 0.97], P=0.002), and it seemed more effective for Asian than non-Asian patients. The effects of AC were not influenced by the starting time (P>0.05). D2 lymphadenectomy-based chemotherapy was effective (HR=0.89, 95%CI: [0.80, 0.99], P=0.04). Oral S-1 40 mg/m2 after D2 lymphadenectomy might be a better choice for Asians with advanced GC and might result in a greater reduction of adverse events than in non-Asian patients. GRADE quality assessment determined that the strength of the evidence from foreign studies from Europe, the United States and Asian countries other than China was high, while it was moderate for Chinese studies. Conclusion: AC was effective or even curative in Chinese patients in general, although it is still necessary to optimize a targeted AC scheme for Chinese patients with GC.

• 한국과학교육학회지
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• 제29권5호
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• pp.552-563
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• 2009

우리나라 최초의 과학영재학교인 한국과학영재학교의 과학교육을 위한 학습 지원 체제 및 학습 환경을 진단하고 그 유용성에 대한 학생들의 인식을 분석하였다. 이 조사를 위하여 자체 개발한 선다형 검사 문항을 사용하였으며 각 학년별로 학습 지원 체계의 효용성에 대한 인식의 차이를 조사하였다. 연구대상은 한국과학영재학교의 재학생 129명을 대상으로 설문 조사하였다. 연구결과로 첫째, 한국과학영재학교의 과학교육을 위한 학습 지원 체제는 대체로 유용한 것으로 나타났으며, 학생들은 교과수업, 인터넷활용, 실험 및 실습실, 독서실, 자연과학도서관, 연구회활동 및 동아리, AA(Academic Advisor)제도 , SAF(Science Academy Fair), 전자교재, 외부연사 초청특강의 순으로 유용성이 높다고 평가하였다. 둘째, 학생들이 추가로 희망하는 학습관련 지원으로는 교과교사의 학습방법 안내, 구두발표 능력 향상 프로그램, 온 오프라인 학습공동체 구축 등이 있었다. 이러한 결과는 과학영재의 잠재적 미성취 현상을 줄이고 학생들의 학교 부적응 상태를 호전시킬 수 있는 하나의 방안이 될 수 있을 것이다. 또한 학교 측면에서의 학습지원 체제를 개선하여 향후 고등학생 수준의 과학영재교육의 방향을 설정하는 데에 시사점을 제공 할 수 있을 것이다.

• 서비스연구
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• 제13권4호
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• pp.191-205
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• 2023

인공 지능 (AI), 특히 텍스트 생성 서비스 분야에서의 발전은 두드러지게 나타나고 있으며, AI-as-a-Service (AIaaS) 시장은 2028년까지 550억 달러에 달할 것으로 예상된다. 본 연구는 합성 텍스트 미디어 소프트웨어의 품질 요소를 탐구하였으며, 이를 위해 ChatGPT, Writesonic, Jasper, 그리고 Anyword와 같은 산업의 주요 서비스에 주목하였다. 소프트웨어 평가 플랫폼에서 수집된 4,000개 이상의 리뷰를 바탕으로, Gensim 라이브러리를 활용한 잠재 디리클레 할당 (LDA) 주제 모델링 기법을 적용하였다. 이 분석을 통해 11개의 주제가 도출되었다. 이후 이 주제들을 AICSQ 및 AISAQUAL과 같은 기존 논문에서 다루었던 AI 서비스 품질 차원과 비교 분석하였다. 리뷰에서는 가용성 및 효율성과 같은 차원이 주로 강조되었으며, 이전 연구에서 중요하게 여겨졌던 사람다움과 같은 요소는 본 연구에서 강조되지 않았다. 이러한 결과는 AI 서비스의 본질적 특성, 즉 사용자와의 직접적인 상호작용보다 의미론적 이해에 더 중점을 둔다는 특성 때문으로 해석된다. 본 연구는 단일 리뷰 원천 및 평가자들의 인구 통계의 특정성과 같은 잠재적 편향을 인정하며, 향후 연구 방향으로는 이러한 품질 차원이 사용자 만족도에 어떻게 영향을 미치는지, 그리고 개별 차원이 전체 평점에 어떻게 영향을 미치는지에 대한 깊은 분석을 제안한다.

• Journal of Gastric Cancer
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• 제23권1호
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• pp.3-106
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• 2023

Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology and guideline development methodology. Total of 33 key questions were updated or proposed after a collaborative review by the working group and 40 statements were developed according to the systematic review using the MEDLINE, Embase, Cochrane Library and KoreaMed database. The level of evidence and the grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. Evidence level, benefit, harm, and clinical applicability was considered as the significant factors for recommendation. The working group reviewed recommendations and discussed for consensus. In the earlier part, general consideration discusses screening, diagnosis and staging of endoscopy, pathology, radiology, and nuclear medicine. Flowchart is depicted with statements which is supported by meta-analysis and references. Since clinical trial and systematic review was not suitable for postoperative oncologic and nutritional follow-up, working group agreed to conduct a nationwide survey investigating the clinical practice of all tertiary or general hospitals in Korea. The purpose of this survey was to provide baseline information on follow up. Herein we present a multidisciplinary-evidence based gastric cancer guideline.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권5호
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• pp.375-395
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• 2006

Purpose: Lingual nerve (LN) damage may be caused by either tumor resection or injury such as wisdom tooth extraction, Although autologous nerve graft is sometimes used to repair the damaged nerve, it has the disadvantage of necessity of another operation for nerve harvesting. Moreover, the results of nerve grafting is not satisfactory. The nerve growth factor (NGF) is well-known to play a critical role in peripheral nerve regeneration and its local delivery to the injured nerve has been continuously tried to enhance nerve regeneration. However, its application has limitations like repeated administration due to short half life of 30 minutes and an in vivo delivery model must allow for direct and local delivery. The aim of this study was to construct a well-functioning $rhNGF-{\beta}$ adenovirus for the ultimate development of improved method to promote peripheral nerve regeneration with enhanced and extended secretion of hNGF from the injured nerve by injecting $rhNGF-{\beta}$ gene directly into crush-injured LN in rat model. Materials and Methods: $hNGF-{\beta}$ gene was prepared from fetal brain cDNA library and cloned into E1/E3 deleted adenoviral vector which contains green fluorescence protein (GFP) gene as a reporter. After large scale production and purification of $rhNGF-{\beta}$ adenovirus, transfection efficiency and its expression at various cells (primary cultured Schwann cells, HEK293 cells, Schwann cell lines, NIH3T3 and CRH cells) were evaluated by fluorescent microscopy, RT-PCR, ELISA, immunocytochemistry. Furthermore, the function of rhNGF-beta, which was secreted from various cells infected with $rhNGF-{\beta}$ adenovirus, was evaluated using neuritogenesis of PC-12 cells. For in vivo evaluation of efficacy of $rhNGF-{\beta}$ adenovirus, the LNs of 8-week old rats were exposed and crush-injured with a small hemostat for 10 seconds. After the injury, $rhNGF-{\beta}$ adenovirus($2{\mu}l,\;1.5{\times}10^{11}pfu$) or saline was administered into the crushed site in the experimental (n=24) and the control group (n=24), respectively. Sham operation of another group of rats (n=9) was performed without administration of either saline or adenovirus. The taste recovery and the change of fungiform papilla were studied at 1, 2, 3 and 4 weeks. Each of the 6 animals was tested with different solutions (0.1M NaCl, 0.1M sucrose, 0.01M QHCl, or 0.01M HCl) by two-bottle test paradigm and the number of papilla was counted using SEM picture of tongue dorsum. LN was explored at the same interval as taste study and evaluated electro-physiologically (peak voltage and nerve conduction velocity) and histomorphometrically (axon count, myelin thickness). Results: The recombinant adenovirus vector carrying $rhNGF-{\beta}$ was constructed and confirmed by restriction endonuclease analysis and DNA sequence analysis. GFP expression was observed in 90% of $rhNGF-{\beta}$ adenovirus infected cells compared with uninfected cells. Total mRNA isolated from $rhNGF-{\beta}$ adenovirus infected cells showed strong RT-PCR band, however uninfected or LacZ recombinant adenovirus infected cells did not. NGF quantification by ELISA showed a maximal release of $18865.4{\pm}310.9pg/ml$ NGF at the 4th day and stably continued till 14 days by $rhNGF-{\beta}$ adenovirus infected Schwann cells. PC-12 cells exposed to media with $rhNGF-{\beta}$ adenovirus infected Schwann cell revealed at the same level of neurite-extension as the commercial NGF did. $rhNGF-{\beta}$ adenovirus injected experimental groups in comparison to the control group exhibited different taste preference ratio. Salty, sweet and sour taste preference ratio were significantly different after 2 weeks from the beginning of the experiment, which were similar to the sham group, but not to the control group.

• 한국한의학연구원논문집
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• 제16권3호
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• pp.85-93
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• 2010

The aim of this review is to investigate clinical studies on oriental medicine treatment for obesity in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Electric searches were performed with NDSL, National assembly library, RISS4U, DBPIA, KISS, KMBASE, KoreaMed, Korean traditional knowledge portal and Oasis. Also, 21 major journals associated with oriental medicine in Korea were searched manually. Eighty three studies were included and analyzed in terms of study design, subjects, interventions, results and evaluation of safety. The numbers of controlled, non-controlled and case studies are respectively 26(31%), 43(52%) and 14(17%). Studies using sample size less than 30 accounts for 49% and studies using subjects diagnosed as obese or overweight by specific criteria were 35(42%). Studies which used more than 2 interventions or co-interventions were 76%. Clinical studies which used single herbal medicine were few and clinically studied single herbal medicine were limited to ephedra. More than half of 83 studies were studied for 8 weeks and less. 12% of 69 studies(except case studies) were not statistically analyzed and studies which evaluated safety of intervention were 22(27%) and reported adverse events were 9(11%). To improve the quality of clinical studies on oriental medicine treatment for obesity, studies need to use restricted number of interventions and subjects need to specifically diagnosed as overweight or obese. In addition, various kinds of single herbs need to be clinically studied based on experimental studies and herbalogy.

• 대한한의학방제학회지
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• 제31권4호
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• pp.361-371
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• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• 산업융합연구
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• 제18권5호
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• pp.42-53
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• 2020

본 연구는 국내 노인을 대상으로 가상현실 프로그램 중재가 균형에 미치는 효과를 알아보기 위한 체계적 고찰 연구로, 가상현실 프로그램에 대한 근거자료를 제공하고자 하였다. 2005년 1월부터 2020년 5월까지 출판된 문헌을 대상으로 데이터베이스 누리미디어(DBpia), 학술교육원(earticle), 한국학술정보(KISS), 국가과학기술정보센터(NDSL), 한국교육학술정보원(RISS), 교보문고스콜라, 학지사뉴논문을 통해 총 94편의 논문이 검색되었고, PRISMA flow chart를 사용한 문헌선정과정을 바탕으로 최종 6편의 문헌이 분석에 사용되었다. 문헌의 질적수준은 근거수준 I이 3편(50.0%), II가 1편(16.7%), III이 2편(33.3%)으로 나타났고, 가상현실 프로그램 종류는 wii fit 밸런스가 4편(66.7%)으로 가장 많았으며, 균형능력 및 보행능력에 대한 평가도구를 통해 가상현실 프로그램 중재의 효과는 전반적으로 유의미하게 나타났다. 이는 일반 노인을 대상으로 가상현실 프로그램을 효과적으로 적용할 수 있을 것으로 기대하며 임상적 적용 근거를 제공하였으며, 앞으로 다양한 가상현실 프로그램 중재를 적용한 연구가 많이 다루어져야 할 필요가 있다.