• 대한핵의학회지
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• 제7권2호
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• pp.1-12
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• 1973

The most commonly used methods for determining thyroxine binding globulin(TBG) concentration as the total thyroxine-binding capacity utilize electrophoretic seperation of serum. Although technically simple, the electrophoretic method is time consuming and is limited in the number of samples which can be run in a single assay. The author presented a single $T_4$ load ion exchange resin method as an approach to simplify the technique as with clinical practicability and results were analyzed. For construction of the standard curves, serum mixtures were diluted with barbital buffer.which effectively blocked $T_4$-binding to TBPA. For each serum dilution, a constant amount of $T_4-^{125}I$ and increments of unlabelled $T_4$ were added. After incubation in water bath, resin beads were dispensed to the samples which binded all $T_4$ not bound to TBG. The radioactivity in the supernatant was counted in the gamma scintillation counter. Each standard curve was plotted from the percent counts in the supernatant and total $T_4$ in each tube. Unknown samples were diluted to 1:40 and ran at a single $T_4$ loading concentration, and the TBG capacity of the samples was able to be read on the standard isobars. The following results were obtained. 1) Mean and standard deviation for TBG capacity in normal population was $28.6{\pm}5.09{\mu}g\;T_4/100ml$. 2) $24.9{\pm}3.87{\mu}g\;T_4/100ml$ in hyperthyroidism showed low TBG capacity comparing to normal population.(p<0.025) 3) $31.0{\pm}2.40{\mu}g\;T_4/100ml$ in hypothyroidism showed high TBG capacity tendency comparing to normal population. 4) Reversed correlationship existed between TBG capacity and $T_3$ resin uptake(r=-0.624), TBG capacity and serum $T_4$ value (r=-0.859), and TBG capacity and free thyroxine index(r=-0.623). The author assumes that this method of assay is considerably simpler in instrumentation and technique than any other assays traditionally being used, and seems to be more practical for routine clinical laboratory use.

• Journal of Nutrition and Health
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• 제50권5호
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• pp.504-518
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• 2017

본 연구는 가공식품의 섭취량이 증가하는 현실에서 국민건강영양조사 자료를 통한 정확한 영양소 섭취량 산출을 위해 국민건강영양조사의 원자료 중 최근 5년간 (2010~2014) 등장한 가공식품 4,858건에 대한 영양성분 DB를 구축하고, 이를 제6기 1차 년도 국민건강영양조사 (2013년) 자료에 적용하여 영양소 14종의 섭취량을 산출하여 구축한 DB에 대한 유용성을 검토하였다. 가공식품의 영양성분 DB 구축을 위해 국내 국가기관에 신고된 가공식품 목록 8,785건, 반조리 식품 자료배합비, 국내 국립기관에서 발간된 식품성분표 1종, 제조사 및 인터넷 등을 통해 수집된 자료를 모아 가공식품에 대한 수준별 DB를 구축하였다. 매칭 식품과 유사 식품 DB를 모두 적용 후 가공식품 섭취량은 505.8 g (30.8%)로 추정되었으며 총섭취량에 대한 기여율은 각각 에너지 29.5%, 탄수화물 27.0%, 단백질 36.7%, 지방 26.5%, 식이섬유 16.1%로 나타났다. 또한 DB 적용 후 대부분의 영양소 섭취량이 유의한 차이를 보여 구축된 DB의 유용성을 보여준다고 사료된다. 나트륨의 경우 가공식품으로 부터의 섭취량이 DB 적용 전 후 2,527.6 mg에서 3,006.2 mg으로 증가하였다. 국민건강영양조사자료의 영양소 섭취량 추정에 필요한 에너지 및 영양소 14종에 대한 국내 분석값 자료가 거의 없는 현실에서 본 연구는 DB 구축을 위한 계산값이나 대체값의 원칙을 세우고 문서화하여 가공식품 DB 구축을 위한 틀을 만들어 향후 DB 구축, 유지, 확대 등 식품영양 DB의 체계적 관리의 기초를 제공하였으며 국민건강영양조사자료를 이용하여 가공식품을 통한 영양소 섭취량 추정을 했다는 측면에서 의미가 있다고 사료된다. 향후 지속적이고 체계적인 가공식품 DB 구축과 관리가 필요하다.

• 환경생물
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• 제28권1호
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• pp.30-39
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• 2010

남해안 고흥, 해남, 완도, 보길도지역에 분포하는 황칠나무개체군 생육지의 군락구조와 종조성, 그리고 입지환경 등을 조사하였으며, 자생지의 기상요인을 분석하여 생육가능지역을 추정하였다. 황칠나무군락은 종조성의 차이에 의해 구실잣밤나무군과 서어나무군으로 구분되었다. 상대기여도에 의한 우점도값은 전체적으로 동백나무(100.0), 붉가시나무(88.6), 구실잣밤나무(55.8), 황칠나무(41.4), 마삭줄(23.8), 사스레피나무 (19.9), 광나무(11.5) 등 상록활엽수의 분포가 높게 나타났다. 개체군 분포는 서어나무군이 흉고직경 5 cm 미만의 개체가 전체의 94.2%로 구실잣밤나무군(54.2%)에 비하여 대부분 소경목과 유목의 개체로 구성되어 있었다. 생육지의 토양환경은 약산성의 토양산도, 유기물과 토양함수량이 양호하며 배수성이 좋은 지역인 것으로 나타났다. 생육지의 분포 범위는 대체로 연평균기온이 $13^{\circ}C$ 이상, 일 최저기온이 $7.4^{\circ}C$ 이상, 온량지수(WI) $100^{\circ}C{\cdot}month$ 이상, 그리고 연강수량은 1,344 mm 내외로서 우리나라 서남부 도서와 해안에 인접한 상록활엽수림대 지역들이 해당되는 것으로 분석되었다. 황칠나무의 자연생육지에서 확인된 연평균기온 $13^{\circ}C$를 토대로 한 생육가능 등치선은 군산-정읍-광주-진주-포항-영덕을 잇는 선으로 나타났다.

• 한국물환경학회지
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• 제36권2호
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• pp.98-108
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• 2020

The purpose of this study was to evaluate water quality in Hapcheon dam via using the Hydrological Simulation Program-Fortran (HSPF) model and applied livestock reduction scenarios. Hapcheon dam watershed input data for the HSPF model were established using the stream, land use, digital elevation map and meteorological data and others. The HSPF model was calibrated and validated using the observed water quality data from 2000 to 2016. For water quality simulation, we calculated the generated and discharge loads of the population, livestock, industry and land use following the guideline provided by the Ministry of Environment. The pollutant data were obtained from National Institute of Environmental Research (NIER). The monthly discharge load were estimated by applying the delivery rate. The calibration and validation results showed that the annual mean BOD had a difference of 0.22 mg/L and an error of ±13 %, T-N had a difference of 0.66 mg/L and an error of ±16 % and T-P had a difference of 0.027 mg/L and an error of ±13 %. In order to evaluate the nonpoint pollutants management effects, we applied livestock reduction scenarios because livestock consists of the largest portion of pollutants. As a result of the 20 % of livestock reduction, BOD, T-N and T-P decreased by 3 %, 1 % and 3 %, respectively. When 40 % of livestock reduction was applied, BOD, T-N and T-P decreased by 5 %, 3 % and 4 %, respectively. Based on the results of this study, effective pollutant management methods can be applied to improve the water quality and achieve the target water quality of Hapcheon dam watershed.

• 한국유기농업학회지
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• 제12권4호
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• pp.451-461
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• 2004

In an animals, identification system has been widely used by ear tag with dummy code and blood typing for parernity. Also, genotyping methods were using for useful mean of individual identification for live animals. In the case of genotyping estimation of gene in population of korean native chicken. In this study, we tested for development of genetic markers used it possible to determination of individual identification system. The candidate genetic markers were used already bow 10 of microstalite DNA sequence information in chromosome No. 1 and 14. Result of analysis for genotyping, the number of alleles of those microstatelites DNA was shown minimal 3 to 12 and the heterozygote expression frequency range was shown from 0.617 to 0.862. In our result, effective number of allele for each microsatellites DNA was shown 3~7, and the accuracy of individual identification was shown nearly 100%, when used with 6 genetic marker. This study was about genotyping method for identification used specific genetic marker form microsatellite DNA in the brand marketing of korean native chicken. Our results suggest that genotyping method used specific genetic marker from microsatellite DNA might be very useful for determination of individual identification.

• Journal of Preventive Medicine and Public Health
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• 제53권3호
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• pp.151-157
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• 2020

Objectives: The outbreak of coronavirus disease 2019 (COVID-19) is one of the main public health challenges currently facing the world. Because of its high transmissibility, COVID-19 has already caused extensive morbidity and mortality in many countries throughout the world. An accurate estimation of the basic reproduction number (R₀) of COVID-19 would be beneficial for prevention programs. In light of discrepancies in original research on this issue, this systematic review and meta-analysis aimed to estimate the pooled R₀ for COVID-19 in the current outbreak. Methods: International databases (including Google Scholar, Science Direct, PubMed, and Scopus) were searched to identify studies conducted regarding the R₀ of COVID-19. Articles were searched using the following keywords: "COVID-19" and "basic reproduction number" or "R₀." The heterogeneity among studies was assessed using the I² index, the Cochran Q test, and T². A random-effects model was used to estimate R₀ in this study. Results: The mean reported R₀ in the identified articles was 3.38±1.40, with a range of 1.90 to 6.49. According to the results of the random-effects model, the pooled R₀ for COVID-19 was estimated as 3.32 (95% confidence interval, 2.81 to 3.82). According to the results of the meta-regression analysis, the type of model used to estimate R₀ did not have a significant effect on heterogeneity among studies (p=0.81). Conclusions: Considering the estimated R₀ for COVID-19, reducing the number of contacts within the population is a necessary step to control the epidemic. The estimated overall R₀ was higher than the World Health Organization estimate.

• 한국습지학회지
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• 제15권2호
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• pp.281-288
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• 2013

본 연구는 현재 강화도 남단 조간대의 마도요류(알락꼬리마도요 Numenius madagascariensis와 마도요 Numenius arquata) 서식지로서의 질을 평가하고자 환경수용능력(Carrying capacity)을 추정하였다. 저서무척추동물(칠게 Macrophthalmus japonicus)의 생물량 추산에 있어 토양 입도(Sediment grain size)의 공간 분포를 고려하였으며, GIS의 공간 분석 기법을 이용하였다. 추정 결과 2012년 봄철은 약 153일 동안 11,767개체가 이용할 수 있는 수준이었으며, 가을철은 약 122일 동안 16,275개체가 이용할 수 있는 수준이었다. 환경수용능력 대비 평균 도래 개체군의 차지 비율은 봄철 9.4%, 가을철 5.9%의 수준이었으며, 이는 분석 방법이 달라 직접 비교는 어려우나 1993-94년 선행 연구 대비 2.8-6.3% 수준이 감소한 수치였다. 과거에 비해 환경 수용 능력이 감소한 현재의 상황에서 향후 서식지 보전을 위한 지속적인 연구와 관리가 매우 시급하다고 판단되며, 나아가 향후 조간대의 다양한 서식지 특성을 반영한 공간 분석을 통해 더욱 정교한 예측이 필요하다.

• 한국도로학회논문집
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• 제15권2호
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• pp.1-9
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• 2013

PURPOSES : The PMS(Pavement Management System) has been utilized in order to efficiently allocate the limited budget for the maintenance of national highway system. In the PMS of national highway, surface pavement condition is evaluated by using the VI (Visual Index). However, the VI is determined only by considering the cracking rate (%) and rut depth (mm), which is not reflecting the IRI (International Roughness Index) that is known as an important factor of pavement performance. In this study, the NHPCI (National Highway Pavement Condition Index) which includes the cracking rate (%), rut depth (mm), and IRI (m/km) is suggested for determining the rehabilitation methods group. METHODS : First, the rehabilitation methods performed between 2008 and 2010 on the national highway is classified and then, NHPCI is determined for each rehabilitation method. Next, the NHPCI for each rehabilitation method is grouped through the interval estimation of the population mean and T-test analysis. RESULTS : According to NHPCI range, the rehabilitation methods are divided into four categories: Not Required, Preventive Maintenance, Overlay Treatment (with or without cutting), and Full-scale Treatment (i.e., reconstruction). CONCLUSIONS : Based on this study, it is recommended that the appropriate NHPCI range should be determined through the combination of the rehabilitation categories and Decision Procedure of Pavement Distress Condition Visual Index.

• 대한교통학회지
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• 제26권2호
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• pp.135-145
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• 2008

기종점자료(Origin-Destination 자료: 이하 OD)는 교통수요예측에 있어 필수적인 정보로서 이를 실제조사하거나 또는 추정하기 위하여 수많은 기법들이 활용되었다. 기존의 OD 추정기법은 일정한 가구 표본을 추출하여 이를 전수화하는 것이 일반적이었으나, 정확도의 문제점을 내포하고 있었다. 이를 보완하기 위하여 링크 교통량, 표본링크이용비 등의 추가 정보를 활용하여 OD를 추정하는 연구들이 지속적으로 이루어지고 있다. 본 연구는 프로브 차량자료에서 수집된 정보를 추가 정보로 활용하여 OD를 추정하는 연구로 시 공간적으로 변동하는 적정 표본율을 찾아내는 것을 목표로 한다. 본 연구에서는 각 링크의 교통량 오차율을 목적함수로 설정하였으며, 가상 네트워크에 대한 사례분석 결과 전수화된 OD와 실제OD 간의 MAE는 약 5.28%로 나타났다. 유비퀴터스 환경 하에서 획득된 다양한 실시간 정보는 본 연구에서 제시된 방법에 의해 활용될 수 있을 것으로 판단되며, 이와 관련한 연구의 한계와 향후 과제를 제시하였다.

• 한국응급구조학회지
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• 제3권1호
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• pp.65-76
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• 1999

Objectives: This study sought to examine the impact of alcohol use and misuse on mortality in korea during the 1991-l997. Methods: Alcohol-Related Disease Impact estimation software and Korea vital statistics data were used to calculate alcohol related-mortality, mortality rates, and YPLL(years of potential life lost). The major findings are as follows : An estimated 23,528 Korean died during 1997 from causes related to alcohol. Such deaths accounted for 17,052(12.60%) of all deaths for men and 6,206(5.88%) for women. Motor vehicle accidents were major contributors to the total estimated number of alcohol related deaths and years of potential life lost before age 65. Alcohol related mortality rates were significantly higher for men. For men, major causes of the deaths were motor vehicle accidents(4,147 deaths, 17.90 per 100,000 population), cancer of the stomach(1,467 deaths, 16.60 per 100,000 population) and chronic liver diseases and cirrhosis(1,233 deaths, 13.10). For women, the largest contributors to alcohol related mortality were motor vehicle accidents(1,509 deaths, 6.61), cerebrovascular diseases(1,114 deaths, 11.3) and cancer of the stomach(810 deaths, 8.24). Kleinman's method was used for obtaining on regional(Dongs, ups and Myons) differential of the alcohol related mortality in 1995. In general, The alcohol-related death rate for men was significantly higher than that for women, and the rate for ups and myons was significantly higher than that for dongs During 1997, approximately 356,667(male: 282, 510, female: 74, 157)YPLL to age 65 and 572,708(male:424,338, female:148,370)YPLL to life expectancy were attributable to alcohol related causes. Men accounted for 79% of the total YPLL to age 65 and 74% of the total YPLL to life expectancy The major contributors to these alcohol related years lost were the diagnostic categories of unintentional injuries. Particullary, In male, Motor vehicle accidents and accidental drowning-YPLL are considerably higher for other causes. Male-female YPLL differentials were greatest for mental disorder. Male-female mean-YPLL to age 65, accidental drowning(male;36.47, female;37.67) is higher for other causes. In both sexes, The YPLL and M-YPLL to life expectancy was significantly higher than the YPLL and M-YPLL to life expectancy.