• The Korean Journal of Food And Nutrition
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• v.29 no.3
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• pp.335-340
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• 2016

The objective of the present investigation was to obtain vitamin, mineral, flavonoid, and polyphenol profiles of Rudbeckia laciniata (RL), and to examine the effects of extract of RL (RLE) on various physiological activities of HaCaT keratinocyte for the utilization of RL as natural raw materials to develop functional food. To accomplish this purpose, we checked the contents of the general nutrients of RL. The contents of vitamin A, vitamin $B_1$ and vitamin $B_2$ were $7.49{\mu}g/g$, $51.96{\mu}g/g$, and $132{\mu}g/g$ respectively, while vitamin C and vitamin $D_3$ were not detected. The contents of mineral such as Ca, K and Fe were 2.01 mg/g, 6.06 mg/g and 0.03 mg/g respectively. Total flavonoid contents of RLE were 0.25 mg/g, and total polyphenol were estimated as 1.43 mg/g. Because RL contains high levels of vitamin A which is associated with skin aging, we investigated the effect of RLE on physiological function of keratinocytes with respect to skin aging. We found that RLE significantly increased the growth rate of HaCaT cells and reduced ultraviolet radiation B (UVB)-induced cellular toxicity. Also, the extract of Rudbeckia laciniata attenuated the UVB-induced reactive oxygen species (ROS) generation in a dose-dependent manner in HaCaT cells. In addition, treatment with the extract dose-dependently increased migration activity of HaCaT cells. Thus, these findings indicated that RLE could regulate the physiological activity of keratinocytes, and may be used to develop functional foods.

• Progress in Superconductivity and Cryogenics
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• v.26 no.3
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• pp.9-16
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• 2024

A large amount of cesium-contaminated soil was generated as a result of the decontamination work following the accident at the Fukushima Daiichi Nuclear Power Plant. To reduce the final disposal volume of contaminated soil, it is necessary to separate the contaminated soil into low- and high-dose soil components and reuse the low-dose soil under 8000 Bq/kg. We have investigated a magnetic separation technique to reduce the volume of the contaminated soil. Magnetic separation is a volume reduction technology that utilizes these differences in magnetic properties. However, the high-gradient magnetic separation technique (HGMS) we have been studied has problems such as clogging of filters and low separation accuracy due to the passage of 2:1 type clay minerals with small particle diameters. In this study, we propose a new separation method using a cyclone-type magnetic separator that focuses not only on magnetic susceptibility but also on differences in particle size. The cyclone-type magnetic separator can separate 2:1 type clay minerals from 1:1 type clay minerals by inducing 1:1 type clay minerals with large particle diameters to the outside of the cylinder and 2:1 type clay minerals with small and large particle diameters to the inside of the cylinder through the difference in the combined magnetic and centrifugal forces acting on soil particles. Separation accuracy was evaluated using simulated soil consisting of vermiculite and kaolinite. Based on these results, the reduction rate of the radioactivity concentration was estimated, and the design guidelines of the device for practical use were discussed.

• Journal of Korean Neurosurgical Society
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• v.58 no.3
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• pp.217-224
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• 2015

Objective : To investigate the efficacy and safety of fractionated stereotactic radiosurgery for large brain metastases (BMs). Methods : Between June 2011 and December 2013, a total of 38 large BMs >3.0 cm in 37 patients were treated with fractionated Cyberknife radiosurgery. These patients comprised 16 men (43.2%) and 21 women, with a median age of 60 years (range, 38-75 years). BMs originated from the lung (n=19, 51.4%), the gastrointestinal tract (n=10, 27.0%), the breast (n=5, 13.5%), and other tissues (n=3, 8.1%). The median tumor volume was 17.6 cc (range, 9.4-49.6 cc). For Cyberknife treatment, a median peripheral dose of 35 Gy (range, 30-41 Gy) was delivered in 3 to 5 fractions. Results : With a median follow-up of 10 months (range, 1-37 months), the crude local tumor control (LTC) rate was 86.8% and the estimated LTC rates at 12 and 24 months were 87.0% and 65.2%, respectively. The median overall survival (OS) and progression-free survival (PFS) rates were 16 and 11 months, respectively. The estimated OS and PFS rates at 6, 12, and 18 months were 81.1% and 65.5%, 56.8% and 44.9%, and 40.7% and 25.7%, respectively. Patient performance status and preoperative focal neurologic deficits improved in 20 of 35 (57.1%) and 12 of 17 patients (70.6%), respectively. Radiation necrosis with a toxicity grade of 2 or 3 occurred in 6 lesions (15.8%). Conclusion : These results suggest a promising role of fractionated stereotactic radiosurgery in treating large BMs in terms of both efficacy and safety.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.2
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• pp.94-98
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• 2011

Purpose: The radiation exposure from radioisotope at the hands and foots of radiation workers who works in PET/CT part at the department of nuclear medicine was investigated in this study. Materials and Methods: From 4th August 2010 to 14th January 2011, 6 radio-technologists' radiation on hands and feet were measured. All radio-technologist have been examined around 8; morning, 12; afternoon, and 16 o'clock; evening, respectively. SPSS version 17 was used for statistical analysis. Results: The statistical significances were calculated in several ways. The radiation from both hands and feet in the Morning was lower than Afternoon and Evening. In some cases, the detected radiation showed extremely high values in data. In order to find the effect of the ${\gamma}$-ray on the hand, the estimated doses were presumably calculated, however, the exposure dose on feet were unmeasured. Conclusion: Even if the radiation exposure from the radioisotope at the hands and feet were under the limitations, it is definitely needs to prevent the radiation-contamination. Therefore, the radio-technologists need to have a proper radiation-dealing-procedure of their own, and must try to prevent a radiation exposure by themselves.

• Progress in Medical Physics
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• v.20 no.4
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• pp.260-268
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• 2009

In this study, we estimated inhomogeneity correction factor in small field. And, we evaluated accuracy of treatment planning and measurement data which applied inhomogeneity correction factor or not. We developed the Inhomogeneity Correction Phantom (ICP) for insertion of inhomogeneity materials. The inhomogeneity materials were 12 types in each different electron density. This phantom is able to adapt the EBT film and 0.125 cc ion chamber for measurement of dose distribution and point dose. We evaluated comparison of planning and measurement data using ICP. When we applied to inhomogeneity correction factor or not, the average difference was 1.63% and 10.05% in each plan and film measurement data. And, the average difference of dose distribution was 10.09% in each measurement film. And the average difference of point dose was 0.43% and 2.09% in each plan and measurement data. In conclusion, if we did not apply the inhomogeneity correction factor in small field, it shows more great difference in measurement data. The planning system using this study shows good result for correction of inhomogeneity materials. In radiosurgery using small field, we should be correct the inhomogeneity correction factor, more exactly.

• Journal of Radiation Protection and Research
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• v.13 no.1
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• pp.8-20
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• 1988

The annual individual and collective doses to the thyroids of four age-dependent groups due to the in-take of I-131 released from the Younggwang nuclear power plant NU-1 & 2, Korea, are estimated using the model presented in ICRP 29. Sensitivity and robustness of the model are analyzed. In case of 0.12% fuel defect during normal operation, the collective dose is founded to be 3.05${\times}10^{-3}$man-thyroid-Sv, which is higher than the value calculated by the GASPAR code, 2.3${\times}10^{-3}$man-thyroid-Sv. The maximal individual annual doses resulting from an acute release are higher than those calculated under the assumption of continuous release by $1.4{\sim}1.7$ times. The most important pathway to the infant is milk and, in contrast, that to child, teen and adult is ingestion of crops. The model used is the calculation appears to be influenced by the variables such as roubstness-index. The weighted committed dose equivalent obtained by the ICRP 29 model is slightly higher than that calculated by the three-compartment model.

• Journal of Radiation Protection and Research
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• v.43 no.1
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• pp.29-38
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• 2018

Background: Radon contributing about 42% of annual average dose, mainly comes from soil. In this paper, standard measurement procedures for soil radon exhalation rate are suggested and their measurement uncertainties are analyzed. Materials and Methods: We used accumulation method for estimating surface exhalation rate. The closed-loop measurement system was made up with a RAD7 detector and a surface chamber. Radon activity concentrations in the system were observed as a function of time, with data collection of 5 and 15-minute and the measurement time of 4 hours. Linear and exponential fittings were used to obtain radon exhalation rates from observed data. Standard deviations of measurement uncertainties for two approaches were estimated using usual propagation rules. Results and Discussion: The exhalation rates (E) from linear approach, with 30 minutes measurement time were $44.8-48.6mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.14-2.32atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with relative measurement uncertainty of about 10%. The contributions of fitting parameter A, volume (V) and surface (S) to the estimated measurement uncertainty of E were 59.8%, 30.1% and 10.1%, in average respectively. In exponential fitting, at 3-hour measurement we had E ranged of $51.6-69.2mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.46-3.30atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with about 15% relative uncertainty. Fitting with 4-hour measurement resulted E about $51.3-68.2mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.45-3.25atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with 10% relative uncertainty. The uncertainty contributions in exponential approach were 75.1%, 13.4%, 8.7%, and 2.9% for total decay constant k, fitting parameter B, V, and S, respectively. Conclusion: In obtaining exhalation rates, the linear approach is easy to apply, but by saturation feature of radon concentrations, the slope tends to decrease away from the expected slope for extended measurement time. For linear approach, measurement time of 1-hour or less was suggested. For exponential approach, the obtained exhalation rates showed similar values for any measurement time, but measurement time of 3-hour or more was suggested for about 10% relative uncertainty.

• The Journal of Korean Society for Radiation Therapy
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• v.27 no.1
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• pp.53-60
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• 2015

Purpose : The purpose of this study is to evaluate the usefulness of a 3D printed phantom for in-vivo dosimetry of a prostate cancer patient. Materials and Methods : The phantom is produced to equally describe prostate and rectum based on a 3D volume contour of an actual prostate cancer patient who is treated in Asan Medical Center by using a 3D printer (3D EDISON+, Lokit, Korea). CT(Computed tomography) images of phantom are aquired by computed tomography (Lightspeed CT, GE, USA). By using treatment planning system (Eclipse version 10.0, Varian, USA), treatment planning is established after volume of a prostate cancer patient is compared with volume of the phantom. MOSFET(Metal OXIDE Silicon Field Effect Transistor) is estimated to identify precision and is located in 4 measuring points (bladder, prostate, rectal anterior wall and rectal posterior wall) to analyzed treatment planning and measured value. Results : Prostate volume and rectum volume of prostate cancer patient represent 30.61 cc and 51.19 cc respectively. In case of a phantom, prostate volume and rectum volume represent 31.12 cc and 53.52 cc respectively. A variation of volume between a prostate cancer patient and a phantom is less than 3%. Precision of MOSFET represents less than 3%. It indicates linearity and correlation coefficient indicates from 0.99 ~ 1.00 depending on dose variation. Each accuracy of bladder, prostate, rectal anterior wall and rectal posterior wall represent 1.4%, 2.6%, 3.7% and 1.5% respectively. In- vivo dosimetry represents entirely less than 5% considering precision of MOSFET. Conclusion : By using a 3D printer, possibility of phantom production based on prostate is verified precision within 3%. effectiveness of In-vivo dosimetry is confirmed from a phantom which is produced by a 3D printer. In-vivo dosimetry is evaluated entirely less than 5% considering precision of MOSFET. Therefore, This study is confirmed the usefulness of a 3D printed phantom for in-vivo dosimetry of a prostate cancer patient. It is necessary to additional phantom production by a 3D printer and In-vivo dosimetry for other organs of patient.

• The Journal of Korean Society for Radiation Therapy
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• v.25 no.2
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• pp.175-180
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• 2013

Purpose: Modern radiation therapy technique such as IGRT has become a routine clinical practice on LINAC for decrease patient's set-up error. CBCT can be used to adjust patient set-up error and treat patient more accurately. The Purpose of this study is to evaluate field size of CBCT for improving Image quality and suggest reference date of CBCT field size. Materials and Methods: Image date were acquired using KV CBCT and Catphan phantom (Half fan and full fan mode were scanned from 2 ~16 cm, at intervals of 2 cm). Field size were categorized by Small field size (2 cm, 4 cm), Medium field size (8 cm, 10 cm), Large field size (more than 14 cm) and evaluate. To estimated the CTDi using CTDi phantom and Ion chamber. Results: CT number linearity of Small and Large field size are greater than Medium field size. Spatial resolution are not significantly different without Small field size. But half fan mode is more different than full fan mode. In full fan, except Medium field size, all field size exceed recommendation for HU uniformity. But half pan has stability for all field except Small field size. CTDi makes radical sign function graph in Medium field size. Conclusion: The worst result was given by Small field size for Image quality and practically. Medium field size can be useful to prevent patient from radiation exposure and give better Image quality. So this study recommends that Medium field size (8~10 cm) is more suitable for CBCT.

• The Journal of the Korea Contents Association
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• v.7 no.12
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• pp.139-144
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• 2007

Radiotherapy which is the most effective for orbit lymphoma has been used increasingly due to the increase of orbit or ocular adnexal tumor patients. Curative effects and convalescence have been being more satisfied thanks to remarkable development of cancer chemotherapy and medical treatments, but side effects such as cataract, dry eye and retinopathy still break out. Thus, in this study, a Lens Shielding Device (LSD hereafter) was designed to prevent occurring of cataract due to radiation therapy for orbit lymphoma and its efficacy through dosimetry were evaluated. And in this paper, its manufacturing process was also explained. LSD is composed of a cover body covering the lens and a side fixing part supporting the cover body. To measure radiation, the patient therapy conditions were simulated and the measurement of the radiation was conducted with Thermo Luminescence Detector (TLD) and Markus chamber. The average TLD value was 5.7% and the TLD value and Markus chamber value were acquired as 4.2% and 5.1% respectively at 6 mm depth where zero lens center was located. Only 1.5Gy ($300Gy{\times}\;5%$) or 5% of total 30Gy with 9 MeV electron beam is estimated to affect on patient's lens. That is smaller dose than the threshold value of cataract (2GY) or the value (5Gy) that was reported to cause cataract in clinical conditions. Thus, these findings suggest that LSD be very useful for prevention of cataract during radiotherapy for malignant lymphoma of orbit and ocular adnexa. Furthermore, it might be possible to reduce patient's discomfort caused by alien substances and to make it easier to fix the device with customized manufacturing manners.