• Journal of Acupuncture Research
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• v.20 no.6
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• pp.80-88
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• 2003

Objective : This study was performed in order to evaluate the effect of bee venom therapy on rheumatoid arthritis by randomized controlled double blind method. Methods : RA patients were recruited and divided into an experiment group and a control group by random selection. As a double blind test, the experiment group was treated with bee venom injection on acupoints, and the control group was treated with normal saline injection on acupoints twice a week for 8 weeks. Tender joint count, swollen joint count, morning stiffness, pain, health assessment questionnaire, ESR, and CRP were estimated and analyzed at baseline, and at 1 month and 2 months after bee venom therapy. Results : Compared to the control group, the experiment group showed significant decrease in tender joint count, swollen joint count, morning stiffness, and health assessment questionnaire after 2 months. Pain, ESR and CRP showed significant decrease in the experiment group after 1 & 2 months. Conclusions : These results suggests that bee venom therapy could be an effective method in the treatment of patients with rheumatoid arthritis.

• Proceedings of the KIEE Conference
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• 2001.07d
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• pp.2579-2581
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• 2001

넓은 가변 범위를 가지는 LC 탱크 전압 제어 발진기에 관해 본 논문에서 소개하고자 한다. LC 탱크 전압 제어 발진기의 발진을 소멸시키는 밀러 증폭기의 ESR을 제거함으로써 넓은 가변 범위를 얻을 수 있다. LC 탱크 전압 제어 발진기는 발진기 코어와 버퍼, 밴드갭(bandgap) 기준 전압 발생기 그리고 드라이브 증폭기로 구성되어 있다. 발진기 코어는 1.3mA의 전류를 소모하고 약 1GHz의 가변 범위를 가진다. 출력주파수의 가변 범위내에 발진기의 출력 전력은 3dBm 이내로 변한다. 이러한 LC 탱크 전압 제어 발진기는 BiCMOS 공정을 이용하여 제작되었고 2.7V 단일 전원에서 31.5mW의 전력을 소모한다.

• Proceedings of the KIPE Conference
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• 2014.07a
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• pp.17-18
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• 2014

전기자동차는 내연기관 대신 배터리를 동력으로 하여 전기모터를 구동하는 방식으로, 배터리를 충전하기 위해서는 차량 탑재형 충전기(OBC)가 필요하다. 자동차라는 특성상 OBC는 2단 AC/DC 컨버터로 구성되어 있다. 역률 보정을 위한 PFC 단과 절연과 충전을 위한 DC/DC 컨버터로 구성되어 있다. 손실을 최소화하기 위해 고전압을 이용한 링크 캐패시터가 필수적이고, 그 캐패시터는 전력밀도가 큰 고전압 전해 캐패시터가 사용된다. 하지만, 전해 캐패시터는 그 수명이 온도와 리플 전류에 따른 ESR 발열과 주변온도에 따라 좌우된다. 따라서 본 논문에서는 6.6kW 차량용 탑재형 충전기를 위한 링크 캐패시터용 고전압 전해 캐패시터의 최적 설계 방법을 제안한다.

• Journal of the Korean institute of surface engineering
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• v.52 no.3
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• pp.123-129
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• 2019

With recent demand for the renewable energy resources, we conducted a research on the energy conversion and storage device of supercapacitor. The hybrid graphene-zinc oxide(GZO) electrodes for the supercapacitors (SCs) were fabricated and investigated. To increase the electrical conductivity of the GZO electrode, the rapid thermal annealing(RTA) in $Ar/H_2$(10%) atmosphere was applied and the effect was examined by comparing it with RTA at Ar atmosphere. In Raman spectroscopy, the electrodes annealed at 400? in $Ar/H_2$ atmosphere showed a lower ratio of D/G peak than that of annealed at Ar atmosphere, and had a larger specific capacitance(Sc) in the cyclic voltammetry(CV), and a lower the equivalent series resistance(ESR) in the electrochemical impedance spectroscopy(EIS). The reason seems to come from the better mixing of the graphene and zinc oxide by the RTA in $Ar/H_2$(10%).

• Journal of Korean Public Health Nursing
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• v.14 no.2
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• pp.203-215
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• 2000

The purpose of this study is to identify the effects of the supportive program for arthritis patients. who are attending a rheumatoid arthritis clinic. To achieve this purpose. this study adopted a quasi-experimental. pre- and post-test research design. comparing experimental group with control one. Supportive program was composed of in-depth. 3 times of direct interview and 2 times of advice using telephone for 8 weeks. The object of these interviews and phone was focused on the improvement of patients' preception for health. During this period. the level of pain, hemato-immunologic indices(ESR, CRP). self-efficacy, depression. and perception for health were measured in both grooups. Data were analysed by $x^2-test$, t-test. repeated measures ANOVA and Pearson's correlations. The results were as follows : 1. There were no significant differences in physiological data. 2. The feeling of self-efficacy was significantly increased in experimental group(P=.012), 3. There was no significant differences in depression. 4. The perception for health status was significantly increased in experimental group(P=.002). Thus, the supportive program. which is focused on the close interpersonal communication. proved to be effective. This result justifies the following suggestion that the role of the nursing professionals in out-patient clinic should be extended for more qualified care for the patients.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.4
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• pp.321-326
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• 2016

This study aimed to analyze the changes of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) measured in acute infection within four weeks post artificial joint surgery to predict potential infection in early stages, provide rapid treatment, and prevent the abuse of antibiotics. This study included 50 patients with acute infection and 50 patients without any symptoms of infection, among patients who received artificial joint replacement surgery on the lower limbs in a four-week period. CRP was the highest two-to-three days after surgery. with $5.77{\pm}3.69$ and $5.17{\pm}3.48$, respectively, in those with infection and without infection. Thereafter, the value rapidly reduced in those without infection. However, it increased again to $3.16{\pm}2.87$ in the group with infection according to the bimodal curve (p<0.001). ESR was the highest two-to-three days after surgery, with $58.8{\pm}24.63$ and $44.08{\pm}21.48$, respectively. Thereafter, the value slowly reduced in those without infection. However, it was increased again to $47.62{\pm}26.26$ in those with infection according to the bimodal curve p<0.001). As this study shows, if there is an increasing trend for CRP and ESR after artificial joint replacement surgery, it may be possible to question whether patients are acutely infected post surgery. In particular, this result is expected and regarded as a useful factor for diagnosing infection due to the high level of sensitivity and uniqueness for CRP.

• Clinical and Experimental Pediatrics
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• v.46 no.8
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• pp.811-816
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• 2003

Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL) in Kawasaki disease. Methods : We measured sVEGF levels in 11 patients with Kawasaki disease in acute phase(patient group)and 11 normal children(control group) by enzyme-linked immunosorbent assay(ELISA) method. We investigated the relationship between sVEGF levels and the lumen diameters of coronary artery and other potential CAL risk factors; duration of fever, hemoglobin, WBC counts, platelet counts, ESR, CRP and LDH levels. Results : SVEGF levels of patients in the acute phase of Kawasaki disease(mean $847.9{\pm}495.7pg/mL$) were significantly higher than that of normal controls(mean $279.9{\pm}150.6pg/mL$; P<0.05). SVEGF levels showed significant positive correlation with the lumen diameters of the coronary artery(P<0.05, $r_s=0.75$) in the patient group. There was no significant correlation between sVEGF levels and duration of fever or other laboratory measurements. Conclusion : Our results support the notion that sVEGF level may be considered as a predictive indicator for the occurrence of coronary artery lesions in Kawasaki disease.

• The Korean Journal of Pain
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• v.2 no.2
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• pp.198-202
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• 1989

The Tolosa-Hunt syndrome is one of the rare disease with facial, especially peri-orbital pain, and ophthalomoplegia associated mostly with granulomatous lesions in cavernous sinus or superior orbital fissure. In addition to ophthalmoplegia by multiple cranial nerve involvement, the sympathetic nervous system may also be involved leading to Horner's syndrome. A typical Tolosa-Hunt syndrome has a neuro-radiologic finding of an increased density in the involved region, and a laboratory finding of an elevated ESR, as well as a dramatic response to systemic corticosteroid therapy. An unusual case of the Tolosa-Hunt syndrome with normal radiologic and laboratory findings, unresponsive to systemic corticosteroid, and some response of pain relief to a stellate ganglion block, is presented.

• Pediatric Infection and Vaccine
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• v.25 no.3
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• pp.113-122
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• 2018

Purpose: The aim of this study was to evaluate the clinical characteristics of children diagnosed as cryopyrin-associated periodic syndrome (CAPS) in Korea. Methods: Diagnosis was made based on clinical features and confirmed by a mutation in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene. Especially, osteocartilaginous overgrowth in the patella or distal femur was so characteristic that its presence warranted a diagnosis of chronic infantile neurologic cutaneous and articular/NOMID. Results: We observed the clinical features of 9 Korean CAPS patients. All the patients suffered from an urticarial rash with recurrent fever. Among the 9 patients, 6 presented with rash and 4 with fever on the 1st or 2nd days of birth. Eight patients showed myalgia, and 7 patients showed arthralgia in the joints, and 6 patients showed radiologic findings of arthropathy including cupping of the metaphysis, excessive growth of the epiphysis, osteopenia or overgrowth of the cartilage. Four patients showed brain atrophy, enlarged ventricles or leptomeningeal enhancement on magnetic resonance imaging. Intellectual disability was observed in 1 patient. Five patients had eye involvement as conjunctivitis, uveitis, chorioretinitis, avascular area or papillary edema, and 3 patients showed progressive hearing loss. All 9 patients showed increased C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Conclusions: All the patients carried a mutation on exon 3 of the CIAS1 gene. After the anakinra (interleukin-1 receptor antagonist) therapy, the fever and rash immediately disappeared, and CRP and ESR were improved.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.180-187
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• 2008

Purpose : We wanted to determine the characteristics of patients with Kawasaki disease (KD) who were unresponsive to intravenous immunoglobulin (IVIG). Methods : The patients with KD were divided into two groups: the IVIG responsive group (25 cases) and the IVIG unresponsive group (14 cases). We analyzed various parameters before and after the administration of IVIG, including the complete blood cell count with the differential count (%), the erythrocyte segmentation rate (ESR), the C-reactive protein (CRP) level and the protein and lipid profiles. Results : The IVIG unresponsive group had a prolonged duration of fever and a higher incidence of CAL compared to the IVIG responsive group (P<0.001, respectively). Before IVIG infusion, the neutrophil differential, the ESR and the CRP values were higher (P<0.001), and the total protein and albumin values were lower in the IVIG unresponsive group (P=0.01) compared to the IVIG responsive group. After IVIG infusion, there were no significant changes in the WBC count and CRP levels in the IVIG unresponsive group. The reduction of the HDL-cholesterol levels by IVIG was more significant in the unresponsive group (P=0.02). Conclusion : A more severe and prolonged inflammatory response occurred in the IVIG unresponsive group at an early stage, and this finding can be detected by such inflammatory parameters as the neutrophil count and the CRP and HDL-cholesterol levels after IVIG infusion.