• Environmental Analysis Health and Toxicology
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• v.22 no.3
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• pp.235-245
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• 2007

Toxicity of nonlyphenol (NP) one of EDCs was studied with focus on reproduction of the crucian carp, Carassius auratus. Fishes were cultured under control and nonylphnol exposure conditions for 32 weeks. Experimental group was composed of total of 4 groups, 1 control condition and 3 nonylphenol exposure condition ($18\;{\mu}g\;NP\;L^{-1},\;37\;{\mu}g\;NP\;L^{-1}\;and\;83\;{\mu}g\;NP\;L^{-1}$). Survival rate was found to be similar in control and $18\;{\mu};NP\;L^{-1}$. However, it is lower In the $37\;{\mu};NP\;L^{-1}$ and $83\;{\mu};NP\;L^{-1}$ in comparison to the control group. Deformation of gonads was the highest in the exposure condition of $18{\mu};NP\;L^{-1}$ with the female illustrating higher ratio than the male. GSI was not much different in the male but in the female, NP exposure group illustrated lower value compared to the control group. HSI and GI did not illustrate any clear differences between the control and exposure group for both male and female. Intersex was 0% in the wild group, 4.16% in the laboratory control group, and 25.67% in the NP exposure condition with female illustrating higher compared to male. Concentration of blood vitellogenin in female illustrated no clear differences between the control and NP exposure group. However, in the male, it was higher in the NP exposure group in comparison to the control group, and illustrated higher values of vitellogenin compared to the figures found in the female of same con-centration condition.

• Fisheries and Aquatic Sciences
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• v.12 no.4
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• pp.324-330
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• 2009

Cadmium (Cd) accumulation and elimination were assessed in the tissues of the clam R. philippinarum at four experimental concentrations (control, 10, 20, 100, and $200\;{\mu}g/L$) over an exposure period of 2 weeks and an elimination period of 1 week. Cd accumulated in the digestive gland, gill, and residual clam tissues, and accumulation increased with time of exposure and concentration (100 and $200\;{\mu}g/L$). After 2 weeks of Cd exposure, the order of Cd accumulation in tissues was gill > digestive gland > residual tissues. An inverse relationship was observed between concentration factor (CF) and exposure level, but the CF showed an increase with exposure time. During the depuration period, Cd concentrations in the digestive gland, gill, and residual tissues decreased immediately on the cessation of exposure, except in individuals at the $200\;{\mu}g/L$ concentration. The Cd elimination rate from tissues decreased in the order of digestive gland > gill > residual tissues during the depuration period.

• Journal of Environmental Health Sciences
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• v.43 no.3
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• pp.167-175
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• 2017

Objectives: Children may be more exposed to certain environmental contaminants because they react with greater sensitivity and have different food intakes and breathing rate per unit of body weight compared to adults. The aim of this study was to determine general exposure factors such as skin surface area, period and frequency of exposure, and others among Korean children aged ${\leq}18$ years old. This study was carried out as the first of its kind in Korea. Methods: We developed 23 recommended exposure factors for Korean children aged 0 to 18 years by reclassifying raw data from the National Health and Nutrition Examination Survey and the National Statistical Information Service, as well as through investigation by experiments in the absence of related data. Results: Reflecting the activity patterns of about 9,000 children, the daily inhalation rates for long-term exposure ranged from $9.49m^3/day$ for children from birth to <2 years to $14.98m^3/day$ for children aged 16 to <18 years. The research found that Korean children spent an average of 22.21 hours indoors, 0.67 hours outdoors, and 1.12 hours in-transit every day. Young children (${\leq}2$ years old) spent approximately 34 more minutes outdoors on weekends than they did on weekdays. Conclusion: Various physiological variables in the human body reflect characteristics of children that can directly influence risk exposure. Therefore, the identification of general exposure factors based on Korean children is required for appropriate risk assessment.

• Asian Journal of Atmospheric Environment
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• v.6 no.3
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• pp.206-221
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• 2012

Hazardous chemicals can be released from artificial turf used in some school playgrounds. To distinguish between Health risk assessment (HRA) exposure scenarios for this study, the ratio of elementary, middle and high schools was considered before final selection. Considering exposure pathways (inhalational, oral and dermal), media and materials were examined, targeting hazardous chemicals released from artificial turf playground-related products. Upon evaluation, the quantity of infill chips was shown to exceed the domestic product content standard (90 mg/kg) at eight (16%) out of 50 schools. PAHs were shown to exceed standards (10 mg/kg) at two (4%) out of the 50 schools. The excess cancer risk (ECR) of carcinogens was shown to be $1{\times}10^{-6}$ in most users for the worst exposure scenario. In children with pica, who represented the most extreme exposure group, the ECR was expected to be as high as $1{\times}10^{-4}$, showing the low risk level of carcinogens. The hazard index (HI) for individual chemicals was shown to be low, at around 0.1 or less, except for children with pica, according to the mean exposure scenario of artificial turf playground exposure. However, the HI was shown to exceed 1.0 in children with pica. Therefore, no direct health risk was found in using artificial turf playgrounds and urethane flooring tracks for the mean exposure scenario, except in children with pica.

• Journal of Environmental Health Sciences
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• v.37 no.5
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• pp.358-368
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• 2011

Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.

• Journal of Environmental Health Sciences
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• v.45 no.2
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• pp.173-185
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• 2019

Objectives: The objectives of this study are to evaluate the accuracy and precision of exposure model ECETOC TRA v.3.1 by comparing model predictions with repeated exposure measurements in Korean workplaces and to investigate the applicability of ECETOC TRA to Korean workplace exposure assessment in K-REACH. Methods: Measured values and work conditions for 14 kinds of chemicals collected from exposure field surveys conducted at 10 companies in Korea were utilized for this study. All possible process categories (PROCs) considered to be relevant to each work process classification were selected and applied to ECETOC TRA as major determining parameters. In order to quantify the accuracy of the model, the lack of agreement (bias, relative bias, precision) was calculated and the risk ratios for each exposure situation between estimated and measured were also compared. Results: The estimated values varied between five and 25 times according to the PROCs for all exposure situations (ESs) based on tasks/chemicals. The results showed that most of the estimated values were below the measured values, and just 13 of 53 tasks were above the measured values. The overall bias and precision were $-2.91{\pm}1.62$ with ECETOC TRA, and we found that ECETOC TRA showed a low level of conservatism when applied to Korean workplaces, similar to previous studies. Conclusions: This study demonstrates that the existed PROC codes have limitations in fully covering various ESs in Korea. In order to improve the applicability of ECETOC TRA in K-REACH, the addition of new PROCs for Korean industries are necessary.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.1
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• pp.9-19
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• 2012

Objectives: The aim of this study is to critically review the exposure surrogates and estimates used to associate health effects in wafer fabrication workers such as spontaneous abortion and cancer, as well as to identify the limitations of retrospective exposure assessment methods Methods: Epidemiologic and exposure-assessment studies of wafer fabrication operations in the semiconductor industry were collected. Retrospective exposure-assessment methods used in cancer risk and mortality and reproductive toxicity were reviewed. Results: Eight epidemiologic papers and two reports compared cancer risk among workers in wafer fabrication facilities in the semiconductor industry with the risk of the general population. Exposure surrogates used in those cancer studies were fabrication(vs. non-fabrication), employment duration, manufacturing eras, job title (operator vs. maintenance worker) and qualitative classifications of agents without assessing specific agent or job-specific exposure. In contrast, specific operation, job title and agents were used to classify the exposure of fabrication workers, contributing to finding a significant association with spontaneous abortion (SAB). Conclusion: Further epidemiologic studies of fabrication workers using more refined exposure assessment methods are warranted in order to examine the associations between fabrication work, environment, and specific agents with cancer risk or mortality as used in SAB epidemiologic studies.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.32 no.1
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• pp.1-9
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• 2022

Objectives: The purpose of this study is to evaluate exposure characteristics of lead using data from the domestic occupational exposure literature. Methods: Occupational airborne exposure data on lead reported in the domestic literature from 1981 to 2018 were collected and re-analyzed. The exposure levels in the data were expressed as an estimated arithmetic mean and a weighted arithmetic mean (WAM) of the number of samples. Lead exposure characteristics were analyzed by industry, process, and year. Results: From a total of 14 documents, 8,305 airborne lead measurements for 17 industries were identified, and the WAM concentration in eight industries exceeded the occupational exposure limit of 50 ㎍/m³. Three industries (battery manufacturing, lead smelting, and litharge manufacturing) accounted for 95% of the total data, and exposure trends could be confirmed over 10 years. Exposure levels continue to decrease in all three industries. Conclusions: Considering the distribution outlook of lead and lead compounds, the main management targets are lead storage battery manufacturing and secondary smelting for lead regeneration.

• Environmental Analysis Health and Toxicology
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• v.30
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• pp.5.1-5.8
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• 2015

Objectives We aimed to assess the radiation exposure for epidemiologic investigation in residents exposed to radiation from roads that were accidentally found to be contaminated with radioactive cesium-137 ($^{137}Cs$) in Seoul. Methods Using information regarding the frequency and duration of passing via the $^{137}Cs$ contaminated roads or residing/working near the roads from the questionnaires that were obtained from 8875 residents and the measured radiation doses reported by the Nuclear Safety and Security Commission, we calculated the total cumulative dose of radiation exposure for each person. Results Sixty-three percent of the residents who responded to the questionnaire were considered as ever-exposed and 1% of them had a total cumulative dose of more than 10 mSv. The mean (minimum, maximum) duration of radiation exposure was 4.75 years (0.08, 11.98) and the geometric mean (minimum, maximum) of the total cumulative dose was 0.049 mSv (<0.001, 35.35) in the exposed. Conclusions An individual exposure assessment was performed for an epidemiological study to estimate the health risk among residents living in the vicinity of $^{137}Cs$ contaminated roads. The average exposure dose in the exposed people was less than 5% of the current guideline.

• Journal of Environmental Health Sciences
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• v.48 no.3
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• pp.151-158
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• 2022

Background: Chemical emissions in the environment have rapidly increased with the accelerated industrialization taking place in recent decades. Residents of industrial complexes are concerned about the health risks posed by chemical exposure. Objectives: This study was performed to suggest modeling methods that take into account multimedia and multi-pathways in human exposure and risk assessment. Methods: The concentration of benzene emitted at industrial complexes in Daesan, South Korea and the exposure of local residents was estimated using the Caltox model. The amount of human exposure based on inhalation rate was stochastically predicted for various activity stages such as resting, normal walking, and fast walking. Results: The coefficient of determination (R²) for the CalTOX model efficiency was 0.9676 and the root-mean-square error (RMSE) was 0.0035, indicating good agreement between predictions and measurements. However, the efficiency index (EI) appeared to be a negative value at -1094.4997. This can be explained as the atmospheric concentration being calculated only from the emissions from industrial facilities in the study area. In the human exposure assessment, the higher the inhalation rate percentile value, the higher the inhalation rate and lifetime average daily dose (LADD) at each activity step. Conclusions: Prediction using the Caltox model might be appropriate for comparing with actual measurements. The LADD of females was higher ratio with an increase in inhalation rate than those of males. This finding would imply that females may be more susceptible to benzene as their inhalation rate increases.