Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Occupational Exposure to Trichloroethylene and Non-hodgkin Lymphoma Risk

직업적 트리클로로에틸렌 노출과 비호지킨림프종의 연관성

  • Chun, Jae-Buhm (Department of Environmental Health, Korea National Open University) ;
  • Han, So-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoon, Hyung-Suk (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Lee, Eun-Jung (Department of Environmental Health, Korea National Open University) ;
  • Lee, Kyoung-Mu (Department of Environmental Health, Korea National Open University)
  • 전재범 (한국방송통신대학교 환경보건학과) ;
  • 한소희 (서울대학교 의과대학 예방의학교실) ;
  • 윤형석 (서울대학교 의과대학 예방의학교실) ;
  • 이은정 (한국방송통신대학교 환경보건학과) ;
  • 이경무 (한국방송통신대학교 환경보건학과)
  • Received : 2011.08.16
  • Accepted : 2011.10.19
  • Published : 2011.10.31
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Abstract

Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.

Keywords

References

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