• Genomics & Informatics
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• v.21 no.4
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• pp.46.1-46.10
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• 2023

Colon adenocarcinoma (COAD) is the predominant type of colorectal cancer. Early diagnosis and treatment can significantly improve the prognosis of COAD patients. Anoctamin 7 (ANO7), an anion channel protein, has been implicated in prostate cancer and other types of cancer. In this study, we analyzed the expression of ANO7 and its correlation with clinicopathological characteristics among COAD patients using the Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and the University of Alabama at Birmingham CANcer (UALCAN) databases. The GEPIA2, Kaplan-Meier plotter, and the Survival Genie platform were employed for survival analysis. The co-expression network and potential function of ANO7 in COAD were analyzed using GeneFriends, the Database for Annotation, Visualization and Integrated Discovery (DAVID), GeneMANIA, and Pathway Studio. Our data analysis revealed a significant reduction in ANO7 expression levels within COAD tissues compared to normal tissues. Additionally, ANO7 expression was found to be associated with race and histological subtype. The COAD patients exhibiting low ANO7 expression had lower survival rates compared to those with high ANO7 expression. The genes correlated with ANO7 were significantly enriched in proteolysis and mucin type O-glycan biosynthesis pathway. Furthermore, ANO7 demonstrated a direct interaction and a positive co-expression correlation with mucin 2 (MUC2). In conclusion, our findings suggest that ANO7 might serve as a potential prognostic biomarker and potentially plays a role in proteolysis and mucin biosynthesis in the context of COAD.

• Nuclear Engineering and Technology
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• v.45 no.6
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• pp.731-744
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• 2013

Energy security is a topic of high importance to many countries throughout the world. Countries with access to vast energy supplies enjoy all of the economic and political benefits that come with controlling a highly sought after commodity. Given the desire to diversify away from fossil fuels due to rising environmental and economic concerns, there are limited technology options available for baseload electricity generation. Further complicating this issue is the desire for energy sources to be sustainable and globally scalable in addition to being economic and environmentally benign. Nuclear energy in its current form meets many but not all of these attributes. In order to address these limitations, TerraPower, LLC has developed the Traveling Wave Reactor (TWR) which is a near-term deployable and truly sustainable energy solution that is globally scalable for the indefinite future. The fast neutron spectrum allows up to a ~30-fold gain in fuel utilization efficiency when compared to conventional light water reactors utilizing enriched fuel. When compared to other fast reactors, TWRs represent the lowest cost alternative to enjoy the energy security benefits of an advanced nuclear fuel cycle without the associated proliferation concerns of chemical reprocessing. On a country level, this represents a significant savings in the energy generation infrastructure for several reasons 1) no reprocessing plants need to be built, 2) a reduced number of enrichment plants need to be built, 3) reduced waste production results in a lower repository capacity requirement and reduced waste transportation costs and 4) less uranium ore needs to be mined or purchased since natural or depleted uranium can be used directly as fuel. With advanced technological development and added cost, TWRs are also capable of reusing both their own used fuel and used fuel from LWRs, thereby eliminating the need for enrichment in the longer term and reducing the overall societal waste burden. This paper describes the origins and current status of the TWR development program at TerraPower, LLC. Some of the areas covered include the key TWR design challenges and brief descriptions of TWR-Prototype (TWR-P) reactor. Selected information on the TWR-P core designs are also provided in the areas of neutronic, thermal hydraulic and fuel performance. The TWR-P plant design is also described in such areas as; system design descriptions, mechanical design, and safety performance.

• Journal of Music and Human Behavior
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• v.2 no.1
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• pp.47-65
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• 2005

One of important goals for early childhood music learning program is to build a positive attitude toward music. Positive attitude toward music is a basic condition on effective music education for all ages of children including early childhood. Although scholars realize such importance of positive music attitude, much research for creating educational environment to foster a positive music attitude has not been performed. Edwin E. Gordon who found a music learning theory for early childhood emphasized the importance of enriched musical environment. Very young children should be provided best quality of music in an interactive way. Audie's important method of education is to provide young children with a variety of musical activities containing the materials in the ordinary life. Through this method, children accept music as close as friends who are always beside themselves, which naturally builds a solid foundation for audiation for children.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.9
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• pp.1537-1543
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• 2004

The purpose of this study was to determine the effect of dietary linseed oil and canola oil on the deposition n-3 polyunsaturated fatty acid in pork. Twelve pigs weighing 50 kg were offered one of four diets based on corn and soybean meal and containing tallow, linseed oil, canola oil or mixed oil (linseed oil plus canola oil). The pigs were slaughtered at approximately 110 kg of their market live weight. Linseed oil, canola oil or mixed oil did not affect any of the three indicators of growth performance-body weight gain, feed intake and feed efficiency. Saturated fatty acid content of plasma was the highest in tallow oil group, while the plasma proportion of saturated fatty acid was lowered in linseed oil, canola oil and mixed oil group from 11.84% to 16.54% than tallow group (p<0.05). The plasma n-3 polyunsaturated fatty acid was not detected at all in the tallow-fed pigs, while the plasma proportion of n-3 polyunsaturated fatty acid were higher in linseed oil, canola oil and mixed oil from 4.68% to 12.83% than tallow group (p<0.05). All three lipid supplements containing n-3 poly-unsaturated fatty acid increased the content of pork belly $\alpha$-linolenic acid (18:3n-3) by 9.43% relative to the tallow values (p<0.05). Feeding linseed oil or canola oil increased the n-3 : n-6 ratio in pork belly to 0.68, and increased the polyunsaturated fatty acid : saturated fatty acid ratio to 0.70 (p<0.05). This result showed that feeding linseed oil and canola oil can produce novel functional pork enriched in n-3 polyunsaturated fatty acid.

• Economic and Environmental Geology
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• v.28 no.3
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• pp.259-269
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• 1995

Column leaching tests were conducted using fresh and weathered pulverised fuel ash of some 17 and 40 years old from two major British power plants, with deionised water and simulated synthetic industrial leachate. The former was to see the leaching behaviour of weathered ash and the latter was to see if the formation of secondary products from water and PFA interaction and ameliorating effect in removing metals from industrial leachates. Fresh PFA liberates elevated concentrations of surface-enriched inorganics, including Ca, Na, K, B, $Cr_{total}$, Li Mo, Se and $SO^{2-}_4$. This might indicate their association with the surface of PFA particles. In the column leaching tests using weathered ash and deionised water, elements are not readily leached but are released more slowly, showing relatively constant concentrations. For the case of weathered ash, some readily soluble surface-enriched elements appears to have been liberated in their early stage of leaching and the liberation of glass associated elements are thought to be more important function in controlling the element concentration. The result from column leaching tests exceed for a number of elements when compared with various Water Standards and suggests the leachate from PFA disposal mound needs dilution to achieve target concentrations. PF A shows element retention effect for many elements, including B, Fe, Zn, Hg, Ni, Li and Mo, in the order of fresh Drax ash > weathered Drax ash > Weathered Meaford ash in retaining capacity. Geochemical modelling using a computer program WATEQ4F reveals some solubility controlling secondary solid products. These include $CaSO_4{\cdot}2H_2O$ for Ca, $Al(OH)_3$ for Al and $Fe(OH)_3$ for Fe.

• Economic and Environmental Geology
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• v.32 no.4
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• pp.385-398
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• 1999

The Narim gold mine is located approimately 200km southeast of Seoul within the Muju mineralized district of the Sobaegsan gneiss complex, Korea. Environmental geochemistry were undertaken for various kinds of water (surface, ground and mine water) collected of April, September and November in 1998 from the narim mine creek. Hydrogeochemical compositions of water samples are characterized by the relatively significant enrichment of Na+K, alkali ions, $HCO_{3}$, $NO_{3}$, Cl and F in groundwater, wheras the mine and surface waters are relatively enriched in Ca+Mg, hea표 metals and $SO_{4}$. Therefore, the groundwaters belong to the (Na+Ca)-( $HCO_{3}+SO_{4}$) type, respectively. The pH and EC values of the non-mining creek surfers are relatively lower compared with those of the surface water of the mine and ore dump area. The d values ($\delta$D-8$\delta^{18}$O) of all kinds of water from the Narim mine creek are 5.8 to 13.1 The range of $\delta$D and $\delta^{18}$O values (relative to SMOW) are shown in distinct two groups as follows: for the April waters of -64.8 to -67.8$\textperthousand$ and -9.6 to -10.0$\textperthousand$(d value=10.1 to 13.1), and for the November waters of -65.9 to -70.2$\textperthousand$ and -9.3 to -9.6$\textperthousand$ (d value=5.8 to 7.9), respectively. This range variation indicates that two group water were composed of distinct waters with seasonal difference. Geochemical modeling showed that mostly toxic metals (As, Fe, Mn, Ni, Pb, Zn) may exist largery in the from of metal $(M2^+)$ and metal-sulfate $(MSO_4\;^{2-$\mid$),\; and \;SO_4^{2-$\mid$}$ concentration influenced the speciation of heavy metals in the meteoric water. These metals in the groundwater could be formed of $CO_3 \;and \;(OH)_3$ complex ions. Using computer program, saturation index of albite, calcite, dolomite in meteoric water show undersaturated and progreddively evolved toward the saturation state, however, ground and mine water are nearly saturated. The gibbsited water-mineral reaction and stabilities suggest that the weathering of silicate minerals may be stable kaolinite, illite and Nasmectite. The clay minerals will be transformed to more stable kaolinite owing to the contiunous reaction.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3913-3923
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• 2023

Todays, medium energy resolution detectors are preferably used in radioisotope identification devices(RID) in nuclear and radioactive material categorization. However, there is still a need to develop or enhance « automated identifiers » for the useful RID algorithms. To decide whether any material is SNM or NORM, a key parameter is the better energy resolution of the detector. Although masking, shielding and gain shift/stabilization and other affecting parameters on site are also important for successful operations, the suitability of the RID algorithm is also a critical point to enhance the identification reliability while extracting the features from the spectral analysis. In this study, a RID algorithm based on Bayesian statistical method has been modified for medium energy resolution detectors and applied to the uranium gamma-ray spectra taken by a LaBr3:Ce detector. The present Bayesian RID algorithm covers up to 2000 keV energy range. It uses the peak centroids, the peak areas from the measured gamma-ray spectra. The extraction features are derived from the peak-based Bayesian classifiers to estimate a posterior probability for each isotope in the ANSI library. The program operations were tested under a MATLAB platform. The present peak based Bayesian RID algorithm was validated by using single isotopes(²⁴¹Am, ⁵⁷Co, ¹³⁷Cs, ⁵⁴Mn, ⁶⁰Co), and then applied to five standard nuclear materials(0.32-4.51% at.²³⁵U), as well as natural U- and Th-ores. The ID performance of the RID algorithm was quantified in terms of F-score for each isotope. The posterior probability is calculated to be 54.5-74.4% for ²³⁸U and 4.7-10.5% for ²³⁵U in EC-NRM171 uranium materials. For the case of the more complex gamma-ray spectra from CRMs, the total scoring (ST) method was preferred for its ID performance evaluation. It was shown that the present peak based Bayesian RID algorithm can be applied to identify ²³⁵U and ²³⁸U isotopes in LEU or natural U-Th samples if a medium energy resolution detector is was in the measurements.

• Economic and Environmental Geology
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• v.46 no.5
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• pp.375-390
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• 2013

The Kenticha rare-element (Ta-Li-Nb-Be) mineralized zone is located in ophiolitic fold and thrust complex of southern Ethiopia and was firstly discovered by joint exploration program of Ethiopia-Soviet in 1980s. It includes Dermidama, Kilkele, Shuni Hill, Kenticha, and Bupo pegmatites from south to north. The Kenticha pegmatite intruded parallel to NS-striking serpentinite and talc-chlorite schist, and is exposed approximately 2 km length and 400-700 m width. The Kenticha pegmatite is internally zoned and subdivided into lower quartz-muscovite-albite granite, intermediate muscovite-quartz-albite-microcline pegmatite, and upper spodumene-quartz-albite pegmatite, based on their mineral assemblage. The major, trace elements (e.g., Rb, Li, Nb, Ta, and Ga), and element ratios (e.g., K/Rb, Nb/Ta, Mg/Li, and Al/Ga) suggest that the fractionation and solidification of pegmatite have progressed from the lower towards upper pegmatite. In contrast, unlike general magmatic fractionation, Mg/Li ratios of the Kenticha pegmatite tend to be increased towards the upper pegmatite. It may result from post-magmatic hydrothermal alteration and/or interaction with upper ultramafic rock. Rare-element mineralization in Kenticha pegmatite concentrates on the upper pegmatite, which contains up to 3.0 wt % $Li_2O$, 3,780 ppm Rb, 111 ppm Cs, 1,320 ppm Ta, and 332 ppm Nb. Ore minerals in Kenticha pegmatite mostly include tantalite, spodumene, and lepidolite, and tantalite has an association with coarser quartz-spodumene and relatively fine sacchroidal albite. The tantalite is classified into Mn-tantalite as a function of $Mn^*[Mn/(Mn+Fe)]$ and $Ta^*[Ta/(Ta+Nb)]$ values. Its compositions ($Mn^*$, $Ta^*$, and Nb/Ta) between coarse and fine tantalites are different and the former is strongly enriched in Ta and depleted in Nb compared to latter one. In conclusion, rare-element mineralization in the Kenticha pegmatite may has occurred in the latest stage of magmatic fractionation.