• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7261-7266
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• 2015

Breast cancer, the most common cancer in the women, is the leading cause of death. Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis-resistant cancer cells. In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. The cell death modes, caspase-3 and 8 activities and the levels of reactive oxygen species (ROS) were assessed. Cell death mainly occurred through necroptosis. In the presence of Nec-1, caspase-3 mediated apoptosis was apparent in the shikonin treated cells. Shikonin stimulates ROS generation in the mitochondria of T-47D cells, which causes necroptosis or apoptosis. Induction of necroptosis, as a backup-programmed cell death pathway via ROS stimulation, offers a new strategy for the treatment of breast cancer.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2005.09a
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• pp.111-129
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• 2005

Pop provides OEMs and EMS with a platform to cost effectively expand options for logic + memory 3D integration - Expands device options by simplifying business logistics of stacking - Integration controlled at the system level to best match stacked combinations with system requirements - Eliminates margin stacking and expands technology reuse - Helps manage the huge cost impacts associated with increasing demand for multi media processing and memory. PoP is well timed to enable and leverage: - Mass customization of systems for different use (form, fit and function) requirements o Bband and apps processor + memory stack platforms - Logic transition to flip chip enables PoP size reduction o Area and height reduction. Industry standardization is progressing. Amkor provides full turn-key support for base package, memory package and full system integration.

• Wind and Structures
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• v.9 no.6
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• pp.419-440
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• 2006

This article synthesizes the literature on the meteorology, experimental simulation, and wind engineering ramifications of intense downburst outflows. A novel design of a large-scale test facility and experimental evidence of its validity are presented. A two-dimensional slot jet is used to simulate only the outflow region of a downburst. Profiles of mean velocity and turbulence quantities are acquired using hot-wire anemometry. Comparison with the literature provides empirical evidence that supports the current approach. A geometric analysis considers the validity of applying a two-dimensional approximation for downburst wind loading of structures. This analysis is applicable to power transmission lines in particular. The slot jet concept can be implemented in a large boundary layer wind tunnel to enable large-scale laboratory experiments of thunderstorm wind loads on structures.

• Wind and Structures
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• v.9 no.6
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• pp.473-492
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• 2006

This paper presents numerical results of pedestrian-level wind environment around the base of a row of tall buildings by CFD. Four configurations of building arrangement are computed including a single square tall building. Computed results of pedestrian-level wind flow patterns and wind speeds are compared to previous wind tunnel measurement data to enable an assessment of CFD predictions. The CFD model uses the finite-volume method with RNG $k-{\varepsilon}$ model for turbulence closure. It is found that the numerical results can reproduce key features of pedestrian-level wind environment such as corner streams around corners of upwind building, sheltered zones behind buildings and channeled high-speed flow through a building gap. However, there are some differences between CFD results and wind tunnel data in the wind speed distribution and locations of highest wind speeds inside the corner streams. In locations of high ground-level wind speeds, CFD values match wind tunnel data within ${\pm}10%$.

• Journal of Korea Multimedia Society
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• v.20 no.8
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• pp.1387-1394
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• 2017

As rate in an elderly population and expanding their range of activity rapidly increase, the demographics of the elderly population on a use of transportation also rise. Elderly pedestrians often find it difficult to react promptly to the traffic accidents as they are less perceptive of the dangers present under the situation. More than half of the elderly traffic accidents are elderly pedestrian accidents in road. Therefore, we design and implement smart safety hat for safety of elderly pedestrian. The smart safety hat binds stripe-shaped LED around a hat in order for a driver to perceive pedestrian easy and quickly. Features of smart safety hat include controlling the number of LEDs by using a light sensor and warning through vibration using a sound sensor. Also, we used Bluetooth to communicate with the smartphone to enable user customization of the light and numbers of LEDs.

• Asian Journal of Innovation and Policy
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• v.6 no.1
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• pp.1-22
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• 2017

The essence of inclusive innovation is to serve poor, marginalized and underprivileged sections of society to improve their livelihoods and enable them to climb up the socio-economic ladder. In this article, we explore the contemporary Indian landscape. There is a diversity of institutions and institutional approaches, multiple methodologies and goals in promoting inclusive innovations in this landscape. There are grassroots innovation institutions. All these institutions and groups have demonstrated how to improve the living conditions of poor people and enhance their income. They have developed different methodologies of inclusive innovation to intervene, build capacities and capabilities of poor people towards bridging informal and formal sectors of economy. Indian landscape can now boast of some successful models and a "social laboratory" for inclusive innovation. The challenge, however, remains to replicate and multiply these models to impact other sectors of Indian informal economy.

• Journal of Powder Materials
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• v.25 no.3
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• pp.263-272
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• 2018

Recent developments in the field of energy harvesting technology that convert ambient energy resources into electricity enable the use of self-powered energy systems in wearable and portable electronic devices without the need for additional external power sources. In particular, piezoelectric-effect-based flexible energy harvesters have drawn much attention because they can guarantee power generation from ubiquitous mechanical and vibrational movements. In response to demand for sustainable, permanent, and remote use of real-life personal electronics, many research groups have investigated flexible piezoelectric energy harvesters (f-PEHs) that employ nanoscaled piezoelectric materials such as nanowires, nanoparticles, nanofibers, and nanotubes. In those attempts, they have proven the feasibility of energy harvesting from tiny periodic mechanical deformations and energy utilization of f-PEH in commercial electronic devices. This review paper provides a brief overview of f-PEH devices based on piezoelectric nanomaterials and summarizes the development history, output performance, and applications.

• Electronics and Telecommunications Trends
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• v.33 no.1
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• pp.68-77
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• 2018

Data deduplication is a common used technology in backup systems and cloud storage to reduce storage costs and network traffic. To preserve data privacy from servers or malicious attackers, there has been a growing demand in recent years for individuals and companies to encrypt data and store encrypted data on a server. In this study, we introduce two cryptographic primitives, Convergent Encryption and Message-Locked Encryption, which enable deduplication of encrypted data between clients and a storage server. We analyze the security of these schemes in terms of dictionary and poison attacks. In addition, we introduce deduplication systems that can be implemented in real cloud storage, which is a practical application environment, and describes the proof of ownership on client-side deduplication.

• Geomechanics and Engineering
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• v.14 no.6
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• pp.509-517
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• 2018

This paper proposes a numerical methodology for capturing the complete curve of a pressuremeter test including initial or disturbed parts and loops through a stiffness-based approach adopted in three dimensional finite difference code, FLAC3D. In order to enable this, a new hyperbolic model was used to replace the conventional linear elastic model prior to peak strength of Mohr-Coulomb soil model and update or degradation of shear modulus was considered. Presented modeling approach and implemented constitutive model are impressively successful. It leads to obtain the whole set of parameters for characterizing sands and seems promising for modeling the most of geotechnical structures.

• Journal of the Korean Magnetic Resonance Society
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• v.22 no.2
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• pp.34-39
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• 2018

The Nuclear Magnetic Resonance (NMR) technique using Dynamic Nuclear Polarization (DNP) procedures is one of the promising techniques that enable overcoming low sensitivity problems in NMR spectroscopy. We constructed an ODNP-NMR system using a commercial benchtop EPR spectrometer. The $^1H$ NMR peak area of water in aqueous solutions of 4-hydroxy-TEMPO was enhanced more than 95 times in the ODNP-NMR experiments. Our signal enhancement results were about 55% of the previously reported result. This could be due to non-uniform microwave power over a sample and unwanted sample heating by microwave. However, this portable ODNP-NMR spectrometer will be eventually useful for site-specific detection with nano-scale spatial resolutions and molecular dynamics studies with significantly improved signal sensitivity.