• Journal of Acupuncture Research
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• 제28권2호
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• pp.49-55
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• 2011

Objectives : This study was to develop programmable and rechargeable electronic moxibustion device as an interdisciplinary research focusing on traditional Korean medicine. Methods : This device deployed several advances on safety and conveniences with the advantage of programmable heat stimulation, heating material and recharging method. The gradient of heat stimulation was programmed with the reference of previous studies and own measurements. The heat curve reached its efficacious stimulus temperature after three minutes, and maintained until 13 minutes with $42^{\circ}C$. We also incorporated feedback from field hospital experiences with the help of hospital staffs. Results : This device can prevent damages from skin burn and fire accidents, and control the smoke, smell and residue of moxa itself. Conclusions : This study will contribute for the development and improvement of efficacious and safe treatment methods for the traditional Korean medicine.

• 대한의용생체공학회:의공학회지
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• 제31권5호
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• pp.344-350
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• 2010

The aim of this study was to investigate the characteristics of the flexion withdrawal reflex modulated during Lokomat treadmill walking in people with spinal cord injury. The influence of the limb position and movement were tested in 5 subjects with chronic spinal cord injury. EMG activities from tibialis anterior and moments of the hip joint elicited by the foot stimulation were examined during Lokomat treadmill walking. To trigger the flexion withdrawal reflex during Lokomat treadmill walking, a train of 10 stimulus pulses was applied at the skin of the medial arch. The TA EMG activity was modulated during gait phase and the largest TA reflex was obtained after heel-off and initial swing phase. During swing phase, TA EMG was 40.9% greater for the extended hip position (phase 6), compared with flexed hip position (phase 8). The measured reflex moment of the hip joint was also modulated during gait phase. In order to characterize the neural contribution of flexion reflex at the hip joint, we compared estimated moments consisted of the static and dynamic components with measured moment of the hip joint. The mean static gains of reflex hip moments for swing and stance phase are -0.1, -0.8, respectively. The mean dynamic gains of reflex hip moments are 0.25 for swing, 0.75 for stance phase. From this study, we postulate that the joint moment and muscle response of flexion withdrawal reflex have the phase-dependent modulation and linear relationship with hip angle and angular velocity for swing phase during Lokomat treadmill walking.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년 학술대회 논문집 정보 및 제어부문
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• pp.232-234
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• 2006

Diabetic neuropathy is one of the most common diabetic complications. In clinical practices, nerve conduction velocity (NCV) has been used as a standard method for diagnosing diabetic neuropathy. However, it applies maximum of 100mA electric stimulus to nerves causing stress and pain to patients. In this study. as a non-invasive method, $TcpO_2$ was utilized to investigate the difference and relationship between $TcpO_2$ and $SpO_2$ of normal and diabetic neuropathy subjects. In addition, a new method of diagnosing diabetic neuropathy using $TcpO_2$ is suggested. 50 normal subjects and 50 diabetic patients with neuropathy diagnosed by NCV participated in this study. Parameters used in this study were $TcpO_2,\;TcpCo_2$, and $SpO_2$. As a result of the $TcpO_2$ measurements, statistical significances were found from $TcpO_2$ of hands and feet from normal and patients group (p<0.01). $SpO_2$ measured from index finger of normal and patient groups showed no statistical significance (p>0.05). On the other hand, $SpO_2$ measured from great toes of normal and patient group showed statistical significance (p<0.01). Correlation coefficient between $SpO_2$ of finger and $TcpO_2$ of hand was 0.400 (p<0.01) and $SpO_2$ of toe and $TcpO_2$ of foot was 0.471 (p<0.01). Both correlation values were statistically significant. Sensitivities and specificities of the $TcpO_2$ method were found to be 66 % and 92 %, respectively. If suggested $TcpO_2$ method is used periodically. prevention and early diagnosis of diabetic neuropathy is possible.

• 생물정신의학
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• 제11권1호
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• pp.40-48
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• 2004

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.

• Archives of Plastic Surgery
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• 제32권3호
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• pp.311-313
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• 2005

Generally, many Asian women tend to dislike the square jaw, as they believe it makes the face look wider, giving a stubborn and strong impression. Contouring of the mandible is therefore a relatively common aesthetic procedure among Asians. These days, the use of botulinum toxin for contouring of the lower face offer simple alternative to surgery. Motor point, which is the site over a muscle where its contraction may be elicited by a minimal intensity short duration electrical stimulus, is the optimal injection point of botulinum toxin. Study was undertaken to identify the location of motor point of the masseter muscle and the skin surface landmark. First, the thickest point of the masseter muscle was inspected through palpation and inspection by 3 different individual plastic surgeons and then compound muscle action potentials(CMAPs) of masseter muscle in 15 health volunteers were recorded using EMG. For the localization of the measured points, line between lateral canthus to the mandibular angle was used. Location of motor points were mapped to skin surface from lateral canthus in a percentage of the distance along the landmark line and in distance in millimeters. The clinical injection point was located at 71.69 percentile and 7.3 mm of the landmark line. The motor point test was located at 72.54 percentile and 7.1 mm of the landmark line. The depth of motor point was 16mm. There was no statistically significant difference between the clinical injection point and the motor point. We conclude that surface mapping of motor point of the masseter muscle would increase accessibility and accuracy in botulinum toxin injection for contouring of the lower face.

• 대한의용생체공학회:의공학회지
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• 제20권3호
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• pp.307-314
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• 1999

M-wave 는 신경전도 연구에 있어서 후기반응 현상 중 직접적인 반응으로, 반응 후 일정시간내에 정보가 존재하는 단발 반응의 특성을 가지고 있다. 이러한 M-wave 는 신경계통의 질환을 진단하기 위한 유용한 요소이며, 따라서 M-wave 의 형태 및 시간에 관한 정보가 간단히 표현될 수 있다면 신경질환 연구에 많은 도움이 될 것이다. 따라서 본 연구에서는 Ar 모델링 방법이 이러한 M-wave 의 정보 압축에 있어서 효과적임을 증명하였다. 이로 인해 먼저 실제로 측정된 M-wave 신호에서 Ar 파라메터를 추정하였으며, 추정된 파라메터를 가지고 근사화한 곡선과 최근의 M-wave의 정보압축에 관한 연구인 Hermite 변환을 이용한 방법에 따른 근사화 곡선을 비교하였다. 제안된 방법의 구체적인 검증을 위해 실신호와 근사화 곡선의 정규화 평균자승오차(NMSE)를 구하여 비교하였다. 결론적으로 M-wave 의 정보를 압축하는데 있어 Hermite 변환은 30개의 파라메터가 필요한 반면, 본 연구에서 제시한 AR 모델링방법은 3개의 파라메터만 가지고도 효과적으로 M-wave 의 특징을 압축할 수 있음을 보였다.

• 전기전자학회논문지
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• 제21권4호
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• pp.381-387
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• 2017

직장에서의 스트레스는 많은 직업, 생활환경 및 연령대의 사람들에게 영향을 끼치는 심각한 문제가 되었다. 스트레스 관리는 스트레스가 질병을 일으키기 시작하기 훨씬 전에 시작해야 한다. 본 연구에서는 영상 및 소음 자극 시 발생하는 전기피부반응도, 심전도 및 뇌파를 측정하여 스트레스를 평가하는 연구를 수행하였다. GRS 진폭은 스트레스 상황이 안정 상태(baseline)보다 27.9% 높게 나타났다. 그리고 자극 후 baseline의 응답시간은 스트레스 상황보다 71.6% 이상 시간이 더 길었다. 심박변이도에서 스트레스 응답 특성은 RMSSD의 변화율이 16.4% 차이가 났으며, HF power의 변화율은 29.7% 차이를 보였다. 뇌파는 스트레스 자극 시 주파수 대역이 ${\theta}$파 대역으로 점점 변함을 알 수 있었다. 우리는 영상자극 및 소음자극이 스트레스와 상관관계를 파악함으로써 객관적지표로 활용 가능할 것이다.

• The Korean Journal of Physiology and Pharmacology
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• 제12권5호
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• pp.267-274
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• 2008

Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, $Ca^{2+}$ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated $Na^+$ channel, whereas the later phase was driven by the reverse-mode operation of $Na^+/Ca^{2+}$ exchange current secondary to the accumulation of $Na^+$ and $Ca^{2+}$ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.

• 대한임상검사과학회지
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• 제54권2호
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• pp.157-162
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• 2022

본 술기의 목적은 운동피질 주변에 발생한 뇌종양 환자의 수술에서 TceMEP로 인해 발생하는 위양성을 방지하고 수술 중 운동영역의 정확한 매핑과 피질척수로 보존하기 위함이다. 또한 검사과정에서 발생하는 시행착오를 줄이고 검사시간을 최소화하여 검사결과에 대한 빠른 피드백으로 수술하는 의사에게 정확한 정보를 전달함에 있다. 본 술기의 가장 중요한 요소는 첫번째로 일정 세기의 자극역치로 검사해야 하는 것과 두번째로는 일정 수준의 마취농도를 적정 수준으로 유지하는 것이 수술 중 발생하는 위양성을 막는 기본적이 요소이다. 세번째로는 수술하는 반대쪽 부위에 다중 채널을 이용한 기록전극의 설치로 최대한 많은 근육에서 TceMEP파형과 집접피질자극 및 직접피질하 자극에 대한 반응을 측정하는 것이다. 이런 조건들이 수술이 진행되는 동안 원활하게 유지된다면 검사에서 오는 위양성이 아닌 그 밖의 요인들에서 발생할 수 있는 원인들을 예측할 수 있다.

• 대한의용생체공학회:의공학회지
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• 제25권2호
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• pp.151-156
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• 2004

편마비 환자에서 상지 기능을 효과적으로 회복시키기 위하여 근전도 유발 기능적 전기자극기 개발과 편마비 환자를 대상으로 손목, 수지신전 운동 시 가장 효과적으로 근수축을 감지 할 수 있는 위치와 전기 자극 시 가장 이상적인 손목, 수지 신전 운동이 일어나는 부위를 탐색하여 두 부과가 일치하는 이상적인 전극부착 위치를 설정하였다. 1) 전기자극 시스템으로 EMC 계측부, 정전류 회로부를 개발하고 프로그램으로는 근전도 유발 전기자극기와 Passive FES의 동작이 가능한 형태로 개발하였다 자극조건은 주파수 35 Hz, 펄스폭 150 ${\mu}\textrm{s}$, 비대칭적 이상성 파형을 선택하였다. 2) 상지 편마비 환자 15명을 대상으로 전완의 근위부 1/2부위를 12개의 영역으로 나눈 후 근위부의 외측으로부터 영역의 순서를 정하였다. 각 영역에서 환자의 손목을 신전 하였을 때 근전도 유발 자극기가 감지하는 활동전위의 진폭을 측정하였으며 가장 크게 감지된 영역은 4, 5 영역이었고, 전기자극을 시행하였을 때 손목과 수지부위가 신전 되는 모양이 이상적인 영역은 4, 5, 7, 8 영역이었다. 근전도 유발 전기자극을 시행하였을 때 근 수축을 감지하여 근전도 유발 전기자극이 일어나는 일련의 과정이 이상적인 영역은 해부학적으로 4, 5 영역이었다.