• Journal of Biomedical Engineering Research
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• v.30 no.2
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• pp.135-141
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• 2009

Purpose: The aim of present study is to evaluate a possibility of clinical application for the effect of low intensity ultrasound stimulation (LIUS) in mechanical characteristics of bone on osteoporotic fractures prevention. Materials and Methods: Eight virgin ICR mice (14 weeks old, approximate weight 25g) were ovariectomized (OVX) to induce osteoporosis. The right hind limbs were then stimulated with LIDS (US Group), whereas left hind limbs were not stimulated (CON Group). Both hind limbs of all mice were scanned by in-vivo micro-CT to acquire two-dimensional (2D) images at 0 week before stimulation and 3 weeks and 6 weeks after stimulation. Three-dimensional (3D) finite element (FE) models generated by scanned 2D images were used to determine quantitatively the effect of LIUS on strength related to bone structure. Additionally, distributions of Hounsfield units and elastic moduli, which are related to the bone quality, for the bones in the US and CON groups were determined to analyze quantitatively a degree of improvement of bone qualities achieved by LIUS. Results: The result of FE analysis showed that the structural strength in US Group was significantly increased over time (p<0.05), while that in CON Group was statistically constant over time (p>0.05). High values of Hounsfield units obtained from voxels on micro-CT images and high values of elastic moduli converted from the Hounsfield units were dominantly appeared in US Group compared with those in CON Group. Conclusion: These finding indicated that LIUS would improve the mechanical characteristics of osteoporotic bone via the effects of bone structure (bone strength) and quality (Hounsfield unit and elastic modulus). Therefore, the LIUS may decrease effectively the risk of osteoporotic fracture in clinics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.38 no.2
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• pp.103-118
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• 2012

In this study, the cellular protective effect of isoquercitrin against $H_2O_2$ and rose bengal-indued HaCaT cell damage was investigated. The ethosome and elastic liposome for enhanced transdermal delivery were prepared. Particle size, loading efficiency and cumulative permeated amounts of them were evaluated. Isoquercitrin didn't show any characteristic cytotoxicity at 50 ${\mu}M$. When HaCaT cells were treated with 5 mM $H_2O_2$ and 25 ${\mu}M$ rose bengal, isoquercitrin protected the cells against the oxidative damage in a concentration dependent manner (6.25 ~ 50 ${\mu}M$). The size of 0.03 % isoquercitrin loaded ethosome was 222.85 nm and the loading efficiency was 82.26 %. The ethosome loaded with 0.03 % isoquercitrin was stable and maintained the constant particle size for 2 weeks after being prepared. The ethosome exhibited more enhanced skin permeability than general liposome and ethanol solution. The optimal ratio of lipid to surfactant of 0.1 % isoquercitrin loaded elastic liposomes was observed to be 89 : 5 through evaluating particle size (341.2 nm), deformability index (59.89), loading efficiency (54.3 %), and skin permeability (54.4 %).

• Journal of the Korean Ceramic Society
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• v.50 no.3
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• pp.206-211
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• 2013

The effect of a $WO_3$ or $Ga_2O_3$ addition on the densification, phase evolution, optical reflectance, and elastic and dielectric properties of $Y_2O_3$-doped AlN ceramics sintered at $1800^{\circ}C$ for 3 h is investigated. The investigated compositions of the additives are 4.5 wt% $Y_2O_3$ (YA), 3.5 wt% $Y_2O_3$-1.0 wt% $Ga_2O_3$ (YGA), and 3.5 wt% $Y_2O_3$-1.0 wt% $WO_3$ (YWA). $YAlO_3$ and $Y_4Al_2O_9$ form as the secondary phases in all of the investigated compositions, whereas $W_2B$ appears additionally in the YWA. In the YGA, Ga is detected in the AlN grains, indicating that the dissolution of $Ga_2O_3$ into the AlN lattice occurs. The addition of $WO_3$ blackens the specimen more significantly than that of $Ga_2O_3$ does. In all of the investigated specimens, the linear shrinkage and the apparent density are above 20 percent and in the range of 3.34-3.37 $g/cm^3$, respectively. The elastic modulus, Poisson's ratio, the dielectric constant, and the dielectric loss are in the ranges of 335-368 GPa, 0.146-0.237, 8.60-8.63, $2.65-3.95{\times}10^{-3}$, respectively. The sinterability and the properties of $Y_2O_3$-doped AlN ceramics are not much altered by the addition of $WO_3$ or $Ga_2O_3$.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.2
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• pp.109-120
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• 2007

Auxiliary support systems such as the reinforced protective umbrella method have been applied before tunnel excavation to increase ground stiffness and to prevent the large deformation. However, determination procedure of geotechnical parameters along the construction sequence contains various errors. This study suggests a method to characterize the time-dependent behavior of pre-reinforced zones around the tunnel using elastic waves. Experimental results show that shear strength as well as elastic wave velocities increase with the curing time. Shear strength and strength parameters can be uniquely correlated to elastic wave velocities. Obtained results from the laboratory tests are applied to numerical simulation of tunnel considering its construction sequences. Based on numerical analysis, initial installation part of pre-reinforcement and portal of tunnel are critical for tunnel stability. Result of the time-dependent condition is similar to the results of for $1{\sim}2$ days of the constant time conditions. Finally, suggested simple analysis method combining experimental and numerical procedure which considering time-dependent behavior of pre-reinforced zone on tunnel would provide reliable and reasonable design and analysis for tunnel.

• Journal of Energy Engineering
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• v.25 no.2
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• pp.37-44
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• 2016

The demand for electricity has a considerable impact on various energy sectors since electricity is generated from various energy sources. This paper attempts to estimate the electricity demand function and obtain some quantitative information on price and income elasticities of the demand. To this end, we apply a lagged dependent variable model to derive long-run as well as short-run elasticities using the time-series data over the period 1991-2014. Our dependent variable is annual electricity demand. The independent variables include constant term, real price of electricity, and real gross domestic product. The results show that the short-run price and income elasticities of the electricity demand are estimated to be -0.142 and 0.866, respectively. They are statistically significant at the 5% level. That is, the electricity demand is in-elastic with respect to price and income changes in the short-run. The long-run price and income elasticities of the electricity demand are calculated to be -0.210 and 1.287, respectively, which are also statistically meaningful at the 5% level. The electricity demand is still in-elastic with regard to price change in the long-run. However, the electricity demand is elastic regarding income change in the long-run. Therefore, this indicates that the effect of demand-side management policy through price-control is restrictive in both the short- and long-run. The growth in electricity demand following income growth is expected to be more remarkable in the long-run than in the short-run.

• Structural Engineering and Mechanics
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• v.73 no.3
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• pp.225-238
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• 2020

This work treats the axisymmetric buckling of functionally graded (FG) porous annular/circular nanoplates based on modified couple stress theory (MCST). The nanoplate is located at the elastic medium which is simulated by Kerr foundation with two spring and one shear layer. The material properties of the porous FG nanostructure are assumed to vary through the nanoplate thickness based on power-law rule. Based on two variables refined plate theory, the governing equations are derived by utilizing Hamilton's principle. Applying generalized differential quadrature method (GDQM), the buckling load of the annular/circular nanoplates is obtained for different boundary conditions. The influences of different involved parameters such as boundary conditions, Kerr medium, material length scale parameter, geometrical parameters of the nanoplate, FG power index and porosity are demonstrated on the nonlinear buckling load of the annular/circular nanoplates. The results indicate that with increasing the porosity of the nanoplate, the nonlinear buckling load is decreased. In addition, with increasing the material length scale parameter to thickness ratio, the effect of spring constant of Kerr foundation on the buckling load becomes more prominent. The present results are compared with those available in the literature to validate the accuracy and reliability. A good agreement is observed between the two sets of the results.

• Steel and Composite Structures
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• v.20 no.4
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• pp.931-950
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• 2016

Ratcheting deformation of pressurized Z2CND18.12N stainless steel $90^{\circ}$ elbow pipe with local wall thinning subjected to constant internal pressure and reversed bending was studied using finite element analysis. Chen-Jiao-Kim (CJK) kinematic hardening model, which was used to simulate ratcheting behavior of pressurized $90^{\circ}$ elbow pipe with local wall thinning at extrados, flanks and intrados, was implemented into finite element software ANSYS. The local wall thinning was located at extrados, flanks and intrados of $90^{\circ}$ elbow pipe, whose geometry was rectangular cross-section. The effect of depth, axial length and circumferential angle of local wall thinning at extrados, flanks and intrados on the ratcheting behaviors of $90^{\circ}$ elbow pipe were studied in this paper. Three-dimensional elastic-plastic analysis with Chen-Jiao-Kim (CJK) kinematic hardening model was carried out to evaluate structural ratcheting behaviors. The results indicated that ratcheting strain was generated mainly along the hoop direction, while axial ratcheting strain was relatively small.

• Structural Engineering and Mechanics
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• v.73 no.2
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• pp.209-223
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• 2020

This paper investigates the buckling behavior of carbon nanotube-reinforced composite plates supported by Kerr foundation model. In this foundation elastic of Kerr consisting of two spring layers interconnected by a shearing layer. The plates are reinforced by single-walled carbon nanotubes with four types of distributions of uniaxially aligned reinforcement material. The analytical equations are derived and the exact solutions for buckling analyses of such type's plates are obtained. The mathematical models provided, and the present solutions are numerically validated by comparison with some available results in the literature. Effect of various reinforced plates parameters such as aspect ratios, volume fraction, types of reinforcement, parameters constant factors of Kerr foundation and plate thickness on the buckling analyses of carbon nanotube-reinforced composite plates are studied and discussed.

• Geomechanics and Engineering
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• v.13 no.1
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• pp.99-117
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• 2017

Rock physics modeling of sandstone reservoir from gas fields of Krishna-Godavari basin represents the link between reservoir parameters and seismic properties. The rock physics diagnostic models such as contact cement, constant cement and friable sand are chosen to characterize reservoir sands of two wells in this basin. Cementation is affected by the grain sorting and cement coating on the surface of the grain. The models show that the reservoir sands in two wells under examination have varying cementation from 2 to more than 6%. Distinct and separate velocity-porosity and elastic moduli-porosity trends are observed for reservoir zones of two wells. A methodology is adopted for generation of Rock Physics Template (RPT) based on fluid replacement modeling for Raghavapuram Shale and Gollapalli Sandstones of Early Cretaceous. The ratio of P-wave velocity to S-wave velocity (Vp/Vs) and P-impedance template, generated for this above formations is able to detect shale, brine sand and gas sand with varying water saturation and porosity from wells in the Endamuru and Suryaraopeta gas fields having same shallow marine depositional characters. This RPT predicted detection of water and gas sands are matched well with conventional neutron-density cross plot analysis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.6
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• pp.848-859
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• 2004

Mechanical testing methods to determine the material constants for large deformation nonlinear finite element analysis were demonstrated for natural rubber. Uniaxial tension, uniaxial compression, equi-biaxial tension and pure shear tests of rubber specimens are performed to achieve the stress-strain curves. The stress-strain curves are obtained after between 5 and 10 cycles to consider the Mullins effect. Mooney and Ogden strain-energy density functions, which are typical form of the hyperelastic material, are determined and compared with each other. The material constants using only uniaxial tension data are about 20% higher than those obtained by any other test data set. The experimental equations of shear elastic modulus on the hardness and maximum strain are presented using multiple regression method. Large deformation finite element analysis of automotive transmission mount using different material constants is performed and the load-displacement curves are compared with experiments. The selection of material constant in large deformation finite element analysis depend on the strain level of component in service.