대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제30권2호
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  • Pages.135-141
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  • 2009
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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역학적 강도 분석을 이용한 저강도 초음파의 조사 부위의 골다공증 골절 방지 효과 평가

In vivo Evaluation of Osteoporotic Fracture Prevention of the site to which low Intensity Ultrasound is Irradiated using Mechanical Strength Simulations

  • Woo, Dae-Gon (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University) ;
  • Kim, Chi-Hoon (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University) ;
  • Park, Ji-Hyung (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University) ;
  • Ko, Chang-Young (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University) ;
  • Kim, Han-Sung (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University) ;
  • Kim, Jin-Man (College of Medicine, Chungnam National University) ;
  • Kim, Sang-Hee (Electronics and Telecommunications Research Institute) ;
  • Lim, Do-Hyung (Department of Biomedical Engineering and Institute of Medical Engineering, Yonsei University)
  • 발행 : 2009.04.30
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초록

Purpose: The aim of present study is to evaluate a possibility of clinical application for the effect of low intensity ultrasound stimulation (LIUS) in mechanical characteristics of bone on osteoporotic fractures prevention. Materials and Methods: Eight virgin ICR mice (14 weeks old, approximate weight 25g) were ovariectomized (OVX) to induce osteoporosis. The right hind limbs were then stimulated with LIDS (US Group), whereas left hind limbs were not stimulated (CON Group). Both hind limbs of all mice were scanned by in-vivo micro-CT to acquire two-dimensional (2D) images at 0 week before stimulation and 3 weeks and 6 weeks after stimulation. Three-dimensional (3D) finite element (FE) models generated by scanned 2D images were used to determine quantitatively the effect of LIUS on strength related to bone structure. Additionally, distributions of Hounsfield units and elastic moduli, which are related to the bone quality, for the bones in the US and CON groups were determined to analyze quantitatively a degree of improvement of bone qualities achieved by LIUS. Results: The result of FE analysis showed that the structural strength in US Group was significantly increased over time (p<0.05), while that in CON Group was statistically constant over time (p>0.05). High values of Hounsfield units obtained from voxels on micro-CT images and high values of elastic moduli converted from the Hounsfield units were dominantly appeared in US Group compared with those in CON Group. Conclusion: These finding indicated that LIUS would improve the mechanical characteristics of osteoporotic bone via the effects of bone structure (bone strength) and quality (Hounsfield unit and elastic modulus). Therefore, the LIUS may decrease effectively the risk of osteoporotic fracture in clinics.

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참고문헌

  1. Carvalho DCL and Cliquet Jr A: The action of low-intensity pulsed ultrasound in bones of osteopenic rats. Artificial Organs, 28: 114-118, 2004 https://doi.org/10.1111/j.1525-1594.2004.07091.x
  2. Duarte LR: The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg., 101: 153-159, 1983 https://doi.org/10.1007/BF00436764
  3. Heckman JD, Ryabi JP, McCabe J, Frey JJ and Kilcoyne RF: Acceleration of tibial fracture-healing by non-invasive, low-intensity, pulsed ultrasound. Journal of Bone Joint Surg., 76A: 226-234, 1994
  4. Kang JD, Kim HC, Kyoung CW and Seo HC: Case-control study of risk factors of fracture due to osteoporosis. The Journal of the Korean Society of Fractures, 15: 8, 2002
  5. Kim HJ, Han SM, Lee J and Lee MR: Study of Ultrasound Imaging Technique for Diagnosing Osteoporosis. Journal of the Korea Society for Nondestructive Testing, 22: 386, 2002
  6. Knoch HG and Klug W: Stimulation of Fracture Healing with Ultrasound. Springer-Verlag, 1: 1-87, 1990.
  7. Ko CY, Woo DG, Lee TW, Kim HS, Lee BY and Tack GR: Detecting and Tracking Changed of Mechanical Characteristics of the Trabecular and Cortical Bone in the Lumbar Vertebrae of an OVX Rat -Use of In-Vivo Micro-CT and Micro-FE Analysis-. Korean Society for Precision Engineering, 24: 110-117, 2007
  8. Lee HY: A Study of Correlation among the Knowledge of the Disease Health Promoting Behaviors and the Quality of Life in the Female Patients with Osteoporosis. The Journal of Rheumatology Health, 8: 68, 2001
  9. Lee JY and Park HH: Osteoporosis. Human science, 14(4): 473-479, 1990
  10. Pilla AA, Mont MA, Nasser PR, Khan SA, Figueiredo M, Kaufman JJ and Siffert RS: Non-invasivelow intensity pulsed ultrasound accelerates bone healing in the rabbit. J Orthop Trauma, 4: 246-253, 1990 https://doi.org/10.1097/00005131-199004030-00002
  11. Rantanen J, Thorsson O, Wollmer P, Hurme T and Kalimo H: Effects of therapeutic ultrasound on the regeneration of skeletal myofibers after experimental muscle injury. American Journal of Sports Medicine, 27: 54-59, 1999
  12. Rho JY, Hobatho MC and Ashman RB: Relations of Mechanical Properties to Density and CT Numbers in Human Bone. Medical Engineering and Physics, 17: 347-355, 1995 https://doi.org/10.1016/1350-4533(95)97314-F
  13. Rubin CD: Osteoporosis: Considerations in evaluation and managing older patients. Texas Medicine, 89: 67-74, 1993
  14. The Korean Society of Bone Metabolism: Physician's guideline for osteoporosis. Seoheung: 2007
  15. Warden SJ, Bennell KL, Forwood MR, McMeeken JM and Wark JD: Skeletal effects of low-intensity pulsed ultrasound on the ovariectomized rodent. Ultrasound in Medicine and Biology, 27: 989-998, 2001 https://doi.org/10.1016/S0301-5629(01)00376-3
  16. Wiltink A, Nijweide PJ, Oosterbaan WA, Hekkenberg RT and Helders PJM: Effect of therapeutic ultrasound on endochondral ossification. Ultrasound Med Biology, 21: 121-127, 1995 https://doi.org/10.1016/0301-5629(94)00092-1
  17. Yang KH Choi CH and Cho JH: Stimulation of fracture Healing by Low-Intensity Pulsing Ultrasound. The Journal of the Korean Society of Fractures, 11: 248, 1998