• 한국구조물진단유지관리공학회 논문집
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• 제11권6호
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• pp.87-94
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• 2007

폐콘크리트로부터 생산된 순환골재의 사용은 환경보존과 자원의 재활용 관점에서 매우 유용하며, 순환골재 콘크리트에서 압축, 인장, 휨 및 부착강도, 탄성계수 등이 중요한 기계적 특성요소로 작용하게 된다. 특히 압축을 받는 순환골재 콘크리트의 응력-변형률 관계 및 파괴진전 양상 규명은 순환골재 콘크리트를 사용한 구조물 설계 및 수치해석 등 이론적 연구에서도 매우 중요한 의미를 가진다. 따라서 본 연구에서는 순환골재 콘크리트의 파괴진전특성을 규명하기 위하여 압축하중을 받는 콘크리트의 미세균열 등 손상특성을 검출하기 위하여 AE 기법을 사용하였다. 압축거동특성 및 AE 신호특성을 분석한 결과, 순환굵은골재 콘크리트의 균열 및 파괴거동은 천연 및 순환잔골재를 사용한 콘크리트와 상이한 것으로 나타났다.

• Structural Engineering and Mechanics
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• 제44권4호
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• pp.431-448
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• 2012

In this paper, the first-order shear deformation theory (FSDT) (Mindlin) for continuum incorporating surface energy is exploited to study the static behavior of ultra-thin functionally graded (FG) plates. The size-dependent mechanical response is very important while the plate thickness reduces to micro/nano scales. Bulk stresses on the surfaces are required to satisfy the surface balance conditions involving surface stresses. Unlike the classical continuum plate models, the bulk transverse normal stress is preserved here. By incorporating the surface energies into the principle of minimum potential energy, a series of continuum governing differential equations which include intrinsic length scales are derived. The modifications over the classical continuum stiffness are also obtained. To illustrate the application of the theory, simply supported micro/nano scaled rectangular films subjected to a transverse mechanical load are investigated. Numerical examples are presented to present the effects of surface energies on the behavior of functionally graded (FG) film, whose effective elastic moduli of its bulk material are represented by the simple power law. The proposed model is then used for a comparison between the continuum analysis of FG ultra-thin plates with and without incorporating surface effects. Also, the transverse shear strain effect is studied by a comparison between the FG plate behavior based on Kirchhoff and Mindlin assumptions. In our analysis the residual surface tension under unstrained conditions and the surface Lame constants are expected to be the same for the upper and lower surfaces of the FG plate. The proposed model is verified by previous work.

• 전기전자학회논문지
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• 제19권2호
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• pp.265-270
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• 2015

본 논문에서는 높은 홀딩 전압을 갖는 SCR(silicon-controlled rectifier)기반 양 방향성 ESD 보호회로를 제안하였다. 일반적인 ESD 보호회로와 달리 양방향의 ESD Stress mode의 방전경로를 제공하며 높은 홀딩전압으로 latch-up면역 특성을 갖어 효과적인 ESD보호를 제공한다. 또한, 높은 홀딩전압을 위한 설계변수인 Gate Length와 N+bridge Length의 길이 변화에 따른 시뮬레이션을 Synopsys사의 TCAD 시뮬레이터를 사용하여 확인 하였다. 시뮬레이션 결과 2.1V에서 6.5V까지 홀딩 전압의 증가로 latch-up 면역 특성을 개선 하였으며, 기존 SCR보다 6.5V의 낮은 트리거 전압특성을 갖고 있어 제안된 ESD 보호 회로는 5V 이상의 공급전압을 갖는 application에 적용 가능하다.

• Journal of Preventive Medicine and Public Health
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• 제9권1호
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• pp.39-47
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• 1976

The organized community is the one of the best system for the effective public health administration, and a model area was selected for the study to see what would be achieved when a certain small community is placed under the special public health control based on the family unit. The 178 families involved total of 875 populations. The rate of vaccination with B.C.G. among 191 infants and children could be increased upto 100.0% from 72.5% of the time when the basic study was performed after 8 months period of this study; 99.0% from 47.1% with D.P.T.; 96,9% from 71.7% against smallpox; 83.2% from 69.1% against poliomyelitis; but only 25,7% from 21.5% against measles. The status of family planing was 36.8% among 155 women of possible conception at the time of the basic research. And, at the end of this study, the number of women utilizing one of the methods of contraception for family planning were increased upto 52.9% among the same number. The most frequently utilized method was 34.1% of oral pills followed by 30.5% of intrauterine device; but both of which had higher rate of interruption of use because of the complications, 14.3% and 16.0% respectively. The 10 pregnant women at the time of basic research experienced normal deliveries during the period of study and they had received pre and postnatal health care through this health center. The status of oral hygiene, pulmonary tuberculosis control, and parasitological examination were also reported as well as the cases with diseases seen among the population and vaccinations performed against other infectious diseases. The stress on discussion was placed upon the effectiveness of public health administration when it is undergone on the individual family unit to achieve the best results. However, the shortness of both personnel and material resources were considered to be the one of the major difficulties retarding the generalization of the idea obtained through this study based on family unit public health administration.

• 한국약용작물학회지
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• 제23권2호
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• pp.138-143
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• 2015

This study was carried out to evaluate the preventive effect of three forms of Korean ginseng roots (fresh, white and red) against bisphenol A (BPA) toxicity in mouse male germ cells (GC-2spd, TM3, TM4). ROS (reactive oxygen species) generation were measured by DCF-DA (2',7'-dichlorohydrofluorescein diacetate) assay. Also, semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was performed to quantify the mRNA expression levels of apoptosis-related genes, Bax (pro-apoptotic gene) and Bcl2 (anti-apoptotic gene). ROS generation was increased by $50{\mu}M$ BPA, but definitely decreased by treatment with Korean ginseng extracts (fresh, white and red) in mouse male germ cells. In especial, Korean fresh ginseng extract reduced significantly ROS production to normal control. In addition, Korean fresh and white ginseng extracts suppressed the apoptosis of mouse male germ cells by fine-tuning mRNA levels of apoptotic genes changed by BPA. In general, Korean fresh ginseng extract was more effective than white ginseng extract for reducing BPA-induced oxidative stress and apoptosis in mouse male germ cells. Therefore, Korean fresh and white ginseng may help to alleviate biphenol A toxicity in mouse male germ cells.

• International Journal of Industrial Entomology and Biomaterials
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• 제9권2호
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• pp.235-239
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• 2004

Drosophila melanogaster heat shock protein 70 gene promoter (Dhsp70p) is widely used in transgenic insect to drive exogenous gene, and the homologous region 3 from Bombyx mori nucleopolyhedrovirus (BmNPVhr3) functions as an enhancer for several promoters. To test whether BmNPVhr3 can enhance the Dhsp70ps transcriptional activity, the reporter plasmids, which contain the Dhsp70p, the reporter $\beta$-galactosidase gene with SV40 terminator and BmNPVhr3 fragment, are constructed and transfected into the insect cell lines (Bm-N cells and Sf-21 cells) by lipofectin-mediated method. The results from the transient expression assay show that BmNPVhr3 significantly increases transcriptional activity of Dhsp70p both under the normal condition and under the heat-shock treatment, although the effects are significantly different between in Bm-N cells and in sf-21 cells. The enhancing behavior of BmNPVhr3 on the Dhsp70p is in an orientation-independent manner. Meanwhile, the effects of heat-shock treatment on Dhsp70p alone or Dhsp70p/BmNPVhr3 combination present no significant difference, indicating that BmNPVhr3 only enhances the transcriptional activity of Dhsp70p, but cant alter its characteristic of the response to the heat-shock stress. The above results suggest that the Dhsp70p/BmNPVhr3 combination is more effective one to drive exogenous gene for transgene or stable cell expression system in insects.

• 한국수자원학회논문집
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• 제31권3호
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• pp.347-360
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• 1998

균열 암반 매질에서의 지하수 흐름과 오염물질 이송에 대한 수치모의 실험이 hydromechanic 모형과 추계적 그리고 이산적 3차원 균열망 모형에 바탕을 둔 비정상상태 흐름 수치 모형을 이용하여 수행되었다. 오염물질 이송에 대한 수치모의 실험에서 random walk의 일종인 particle following 알고리즘이 사용되었다. 이 연구의 목적은 지하 깊은 곳에 위치한 Hot dry rock에서의 지열 개발을 위해 프랑스 Soultz sous Foret 지역에 설치된 두개의 깊은 착정인 GPK1과 GPK2 사이에서의 tracer test 반응을 1995년에 실행된 유체순환 현장 실험으로 부터 얻어진 자료를 이용하여 예측하는 것이다. 모의 실험 결과 비반응입자(nonreactive particles)에 대한 평균 이송시간은 두 착정 사이에서 약 5일이었다.

• 한국항공우주학회지
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• 제47권10호
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• pp.687-694
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• 2019

초경량 항공기 구조의 날개 보로 사용되는 원통형 복합재료 날개 보는 굽힘 모멘트와 전단하중을 동시에 받고 있는 구조물이다. 하지만 기존의 일반 원통형 보는 상하부의 굽힘 모멘트, 좌우부의 전단하중을 지지하는 구조적 특성을 고려하지 못하므로 비효율적일 수 있다. 따라서 섬유각 또는 복합재료를 적절히 배열하여 효율적으로 구조물을 만드는 것이 필요하다. 본 연구에서는 원통형 복합재료 보의 굽힘강도와 전단강도의 증가를 위해 보의 단면을 상하좌우로 분할하여 적층순서를 달리함으로써 효율적인 하중지지가 가능하게 하였다. 상용 프로그램 MSC/NASTRAN을 이용한 구조해석을 통해 원호 분할각과 섬유각에 따른 수직변위, 수직변형률, 전단변형률 계산하였다. 계산 결과에 따르면 새롭게 제안된 원통형 보의 분할각과 섬유 방향각을 선택하여 구조 강도를 증가시킬 수 있음을 제시하였다.

• Neonatal Medicine
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• 제28권1호
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• pp.41-47
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• 2021

Neonatal diabetes mellitus can be categorized as transient, permanent, or syndromic, and approximately half of the cases are transient. We present a case involving a term newborn who showed overt progression of transient neonatal diabetes mellitus, with complete remission within 6 months. On the second day of life, the patient presented with tachypnea, hyperglycemia, and decreased serum levels of C-peptide and insulin. Continuous subcutaneous infusion of insulin and continuous glucose monitoring were well tolerated. The patient showed a normal growth pattern, with no hyperglycemic or hypoglycemic episodes at 6 months of age. As it is rare and often asymptomatic, hyperglycemia may be attributed to various factors, including intrauterine environment, perinatal stress, and diverse genetic background. Therefore, consistent blood glucose monitoring and prompt early insulin therapy are crucial for any term newborns with persistent hyperglycemia, to prevent further diabetic complications. Moreover, continuous subcutaneous insulin infusion and the utilization of continuous glucose monitoring devices are the most effective and practical management strategies.

• Journal of Veterinary Science
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• 제22권3호
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• pp.30.1-30.15
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• 2021

Background: New-generation adjuvants for foot-and-mouth disease virus (FMDV) vaccines can improve the efficacy of existing vaccines. Chinese medicinal herb polysaccharide possesses better promoting effects. Objectives: In this study, the aqueous extract from Artemisia rupestris L. (AEAR), an immunoregulatory crude polysaccharide, was utilized as the adjuvant of inactivated FMDV vaccine to explore their immune regulation roles. Methods: The mice in each group were subcutaneously injected with different vaccine formulations containing inactivated FMDV antigen adjuvanted with three doses (low, medium, and high) of AEAR or AEAR with ISA-206 adjuvant for 2 times respectively in 1 and 14 days. The variations of antibody level, lymphocyte count, and cytokine secretion in 14 to 42 days after first vaccination were monitored. Then cytotoxic T lymphocyte (CTL) response and antibody duration were measured after the second vaccination. Results: AEAR significantly induced FMDV-specific antibody titers and lymphocyte activation. AEAR at a medium dose stimulated Th1/Th2-type response through interleukin-4 and interferon-γ secreted by CD4⁺ T cells. Effective T lymphocyte counts were significantly elevated by AEAR. Importantly, the efficient CTL response was remarkably provoked by AEAR. Furthermore, AEAR at a low dose and ISA-206 adjuvant also synergistically promoted immune responses more significantly in immunized mice than those injected with only ISA-206 adjuvant and the stable antibody duration without body weight loss was 6 months. Conclusions: These findings suggested that AEAR had potential utility as a polysaccharide adjuvant for FMDV vaccines.