• Journal of Ginseng Research
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• 제37권1호
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• pp.100-107
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• 2013

This study examined the effect of fermented ginseng (FG) on memory impairment and ${\beta}$-amyloid ($A{\beta}$) reduction in models of Alzheimer's disease (AD) in vitro and in vivo. FG extract was prepared by steaming and fermenting ginseng. In vitro assessment measured soluble $A{\beta}42$ levels in HeLa cells, which stably express the Swedish mutant form of amyloid precursor protein. After 8 h incubation with the FG extract, the level of soluble $A{\beta}42$ was reduced. For behavioral assessments, the passive avoidance test was used for the scopolamine-injected ICR mouse model, and the Morris water maze was used for a transgenic (TG) mouse model, which exhibits impaired memory function and increased $A{\beta}42$ level in the brain. FG extract was treated for 2 wk or 4 mo on ICR and TG mice, respectively. FG extract treatment resulted in a significant recovery of memory function in both animal models. Brain soluble $A{\beta}42$ levels measured from the cerebral cortex of TG mice were significantly reduced by the FG extract treatment. These findings suggest that FG extract can protect the brain from increased levels of $A{\beta}42$ protein, which results in enhanced behavioral memory function, thus, suggesting that FG extract may be an effective preventive or treatment for AD.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.231-231
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• 2017

Drought limits rice production under upland condition. This study quantified the effect of rhizobacteria inoculation on rice root system developmental response to drought and its role in maintaining high soil water use, and dry matter production under drought using NSIC Rc192 (rainfed lowland rice variety). The source of inoculant was Streptomyces mutabilis, a recently isolated rhizobacteria containing plant growth promoting compounds such as ACC deaminase, indole-3-acetic acid and phosphatase (Cruz et al., 2014, 2015). In the first experiment, pre-germination inoculation of seeds with S. mutabilis significantly increased the shoot and root (radicle) length as well as root hair lengths, relative to the non-inoculated control. In the second experiment, rice plants inoculated with S. mutabilis and grown in rootbox with soil generally had greater total root length under drought regardless of the timing of inoculations, relative to the non-inoculated control. Consequently, improved root system development contributed to the increase in soil water uptake under drought and thus, dry matter production. Among inoculation treatments, one-time inoculation of S. mutabilis either at pre-germination or pre-drought stress at 14 days after sowing (DAS), had significantly greater shoot dry matter production than three-time inoculation at pre-germination, at thinning (3 DAS) and at pre-drought (14 DAS). This study demonstrated the effectiveness of rhizobacteria (S. mutabilis) containing growth promoting compounds for enhancing drought dehydration avoidance root traits and improving the growth of rice plants under drought condition.

• 한국축산식품학회지
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• 제40권2호
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• pp.183-196
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• 2020

The protective effect of pig skin gelatin water extracts (PSW) and the low molecular weight hydrolysates of PSW generated via enzymatic hydrolysis with Flavourzyme® 1000L (LPSW) against scopolamine-induced impairment of cognitive function in mice was determined. Seventy male ICR mice weighing 20-25 g were randomly assigned to seven groups: Control (CON); scopolamine (SCO, 1 mg/kg B.W., intraperitoneally (i.p.); tetrahydroaminoacridine 10 [THA 10, tacrine; 10 mg/kg B.W. per oral (p.o.) with SCO (i.p.)]; PSW 10 (10 mg/kg B.W. (p.o.) with SCO (i.p.); PSW 40 (40 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 100 (100 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 400 (400 mg/kg B.W. (p.o.) with SCO (i.p.). All treatment groups, except CON, received scopolamine on the day of the experiment. The oxygen radical absorbance capacity of LPSW 400 at 1 mg/mL was 154.14 μM Trolox equivalent. Administration of PSW and LPSW for 15 weeks did not significantly affect on physical performance of mice. LPSW 400 significantly increased spontaneous alternation, reaching the level observed for THA and CON. The latency time of animals receiving LPSW 400 was higher than that of mice treated with SCO alone in the passive avoidance test, whereas it was shorter in the water maze test. LPSW 400 increased acetylcholine (ACh) content and decreased ACh esterase activity (p<0.05). LPSW 100 and LPSW 400 reduced monoamine oxidase-B activity. These results indicated that LPSW at 400 mg/kg B.W. is a potentially strong antioxidant and contains novel components for the functional food industry.

• 대한간호학회지
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• 제37권6호
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• pp.872-882
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• 2007

Purpose: This study aimed at exploring relationships among Internet addiction, smoking, and drinking and examining the effect factors on Internet addiction, smoking and drinking. Methods: By using stratified sampling, 1,529 participants representing high school students in the Kangwon province were selected. Data was analyzed by SPSS 12.0. using ${\chi}^2$, Pearson correlation coefficient and multiple regression. Results: One-fifth of the total participants were at the mild or moderate stage of Internet addiction. Regarding smoking, 22.7% of male subjects and 4.5% of female subjects were current smokers. Regarding drinking, the percentages of subjects who drank alcohol once or twice per month were 53.5% of male students and 40.7% of female students. Internet addiction positively correlated with depression, novelty seeking, harm avoidance and reward dependence, Internet addiction negatively correlated with persistence, self-directness, cooperativeness, and self-transcendence. Significant factors affecting Internet addiction were depression, gender, novelty seeking, and self-transcendence. Important factors influencing smoking were drinking, gender, school type, satisfaction with school, novelty seeking, and reward dependence. Significant factors affecting drinking were smoking, novelty seeking, school type and ages. Conclusion: This study shows the necessity of developing and implementing effective intervention programs in order to prevent adolescents from experiencing Internet addiction and health risk behaviors.

• Journal of Dental Anesthesia and Pain Medicine
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• 제17권2호
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• pp.105-111
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• 2017

Background: Dental fear is usually associated with hemodynamic changes. Fear of pain during the surgical removal of a lower impacted third molar might cause patients anxiety, thereby leading to avoidance of any future dental therapy. This study aimed to determine the effect of experiencing a surgical impacted-tooth removal on the pain perception-related anxiety and hemodynamic status. Method: Twenty-seven healthy patients aged 15-30 years (mean age, 24 years), for whom surgical removal of bilateral lower third molars was advised, were included. This prospective, randomized, controlled, split-mouth study involved operations on both sides of the mandibular arch, with a 1-month washout period in between. Blood pressure and heart rate were measured before the surgical procedure, during and after the injection, preoperatively, and postoperatively. Pain perception was evaluated using a 100-mm visual analog scale during the injection, preoperatively, and postoperatively after the numbness disappeared. Differences in the blood pressure, heart rate, and pain perception between the two appointments were analyzed using the paired t-test. For all statistical analyses, SPSS version 11.5 was used. Results: The mean pain perception values during the injection and preoperatively showed no significant differences between the two appointments (P > 0.05); however, significant differences in the blood pressure and heart rate were noted before the surgical procedure; preoperatively, the blood pressure alone showed a significant difference (P < 0.05). Conclusion: There was a significant decrease in the blood pressure and heart rate preoperatively; hence, experiencing a surgical impacted-tooth removal can reduce the subsequent preoperative anxiety in healthy patients.

• Journal of Microbiology and Biotechnology
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• 제21권8호
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• pp.874-883
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• 2011

Many studies have shown that the steamed root of Rehmannia glutinosa (SRG), which is widely used in the treatment of various neurodegenerative diseases in the context of Korean traditional medicine, is effective for improving cognitive and memory impairments. The purpose of this study was to examine whether SRG extracts improved memory defects caused by administering scopolamine (SCO) into the brains of rats. The effects of SRG on the acetylcholinergic system and proinflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses of SRG (50, 100, and 200 mg/kg, i.p.) for 14 days, 1 h before scopolamine injection (2 mg/kg, i.p.). After inducing cognitive impairment via scopolamine administration, we conducted a passive avoidance test (PAT) and the Morris water maze (MWM) test as behavioral assessments. Changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) and the reactivity of acetylcholinesterase (AchE) in the hippocampus. Daily administration of SRG improved memory impairment according to the PAT, and reduced the escape latency for finding the platform in the MWM. The administration of SRG consistently significantly alleviated memory-associated decreases in cholinergic immunoreactivity and decreased interleukin-$1{\beta}$ (IL-$1{\beta}$) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) mRNA expression in the hippocampus. The results demonstrated that SRG had a significant neuroprotective effect against the neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that SRG may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.

• 한국사회복지학
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• 제38권
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• pp.180-205
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• 1999

이 연구의 목적은 장애아모의 스트레스에 대한 대처전략과 적응 간의 관계를 정립하는 것이었다. 특히 장애아모의 적응에 영향을 미친다고 알려진 장애아모와 장애자녀의 개인 및 환경적 특성의 영향력을 통제한 상태에서 대처전략의 적응에의 순수한 독립적 영향력을 분석하는 데에 연구의 초점을 두었다. 서울, 창원, 대구의 장애인복지관에 등록된 장애아동의 어머니 92명을 대상으로 한 설문조사 분석결과, 대처전략과 장애아모의 적응간의 유의미한 관계가 입증되었다. Stepwise multiple regression 분석을 통해 밝혀진 장애아모의 적응 예측에 기여한 대처전략은 직면전략, 책임수용 전략 그리고 긍정적 재평가전략이었다. 직면과 책임수용전략은 장애아모의 적응에 부정적인 영향을 미친 반면, 긍정적 재평가전략은 장애아모의 적응에 긍정적인 영향을 미쳤다. 이들 직면, 책임수용, 긍정적 재평가전략의 적응에의 효과는 다른 예측변수의 영향력을 보수적인 방법으로 통제한 상태에서도 통계학적으로 유의미한 것으로 나타났다. 연구결과를 바탕으로 장애아모를 위한 사회사업개입방안이 논의되었다.

• 디지털융복합연구
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• 제15권11호
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• pp.271-283
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• 2017

사내기업가정신 통합교과 교육에 학습자 중심의 융복합 디자인씽킹 교수법을 적용하고 사회적 문제해결능력 향상효과를 평가함으로써 예비보건행정가의 사회적 문제해결능력 향상 효과를 확인하고자 하였다. 대구광역시 일개 대학의 보건행정과 2학년 학생 45명을 대상으로 2016년 3월부터 2016년 6월까지 총 15주간 융복합 디자인씽킹을 적용한 후 사전-사후 설문조사를 실시하였다. 주요 결과로써 예비보건행정가들의 사회적 문제해결능력 향상 효과는 부정적 문제지향과 충동-부주의적 반응양식, 회피적 반응양식에 긍정적 효과가 있는 것으로 나타났다. 특히 여학생과 근로경험이 없는 경우, 충동-부주의적 반응양식에 각각 긍정적 효과가 나타났다. 통합교과 교육에 융복합 디자인씽킹 교수법이 사회적 문제해결능력향상에 긍정적인 영향을 미침을 확인하였다. 사회적 문제해결능력 향상을 위한 통합교과 프로그램 개발과 이 연구와 같은 창의적 교수법의 적용을 권장한다.

• 산업경영시스템학회지
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• 제39권4호
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• pp.117-124
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• 2016

Stress is resistance to stimuli to destroy a balance of mind and body in order to maintain an original steady state : A type of response and avoidance. Mild stress, which happens in tension, has a positive effect to improve concentration, but most of stress is likely to be a main factor to damage health. This is because it causes physical ailments and psychological diseases (e.g., depression, anger, frustration, loneliness, and anxiety). The purpose of this study is to analyze the difference between two groups, daytime and night university students, on ego-state, stressors, and stress coping types to improve their academic achievement by reducing their stress. There were 266 university students, who participated in a survey from November 30, 2015 until September 30, 2016. The study employed three measuring instruments : Ego-gram, stressor scale, and stress coping type scale. All the collected data were analyzed through regression analysis and t-test. The results of the regression analysis showed no significant differences in ego-state, stressors, and stress coping types between two groups. However, the results of t-test showed significant difference between the two groups : In terms of ego-state, a CP (Critical Parent) average of the night university students was significantly higher than the daytime university students'. Also, there is a significant difference in employment, future issues, and economic issues : the daytime university students considered employment and future issues more serious, while the night university students had more mental burdens of economic issues. When it comes to coping stress types, there was no significant difference between the two groups.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.55-64
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• 2017

Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features a memory and learning impairment that is related to changes in acetylcholine and abnormal ${\beta}$-amyloid ($A{\beta}$) deposition in the brain. In the present study, we investigated the effects of dehydroevodiamine HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a $A{\beta}_{1-42}$-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. Moreover, DHED significantly improved learning and memory in the $A{\beta}_{1-42}$-infused rat model. Furthermore, the mechanism of these behavioral effects of DHED was investigated using a cell viability assay, reactive oxygen species (ROS) measurement, and intracellular calcium measurement in primary cortical neurons. DHED reduced neurotoxicity and the production of $A{\beta}$-induced ROS in primary cortical neurons. In addition, similar to the effect of MK801, DHED decreased intracellular calcium levels in primary cortical neurons. Our results suggest that DHED has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.