• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2012년도 한국컴퓨터종합학술대회논문집 Vol.39 No.1(B)
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• pp.414-416
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• 2012

고차 주성분 방법으로는 텐서 분석이 있었다. Electroencephalography(EEG) 데이터나 Social Network 데이터에 텐서 분석이 적용되어 주요한 성분들을 찾는 연구들이 있었다. 그러나 텐서 분석은 직관적으로 이해하기에 어려움이 있으며 중요한 노드를 찾는데에는 다소 어려움이 있다. 본 논문에서는 고차 하이퍼에지로 이차원 행렬을 만들고 주성분분석법을 이용하여 중요한 노드를 찾는 새로운 방법론을 제시한다. 데이터로는 Multimodal Memory Game(MMG) 수행시 촬영한 EEG 데이터를 사용하였다. MMG는 TV 드라마 기반의 기억인출게임이다. 베타파의 Power Spectrum Density(PSD)는 각 위치의 채널들의 활성도를 나타내는 지표이다. 우리는 Random Sampling을 바탕으로 PSD 상위 50%의 채널들간의 전이행렬을 구하였다. 그 후 고유치와 고유벡터를 구하였다. 가장 큰 고유치의 고유벡터는 주성분을 나타내며 고유벡터의 각 원소들은 중요도를 나타내는 centrality 이다. 세 명의 피험자에 대한 centrality 상위 30개의 중요한 채널들을 구하였고 세명에 공통적으로 포함되는 채널을 확인하였다.

• Annals of Clinical Neurophysiology
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• 제21권1호
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• pp.16-29
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• 2019

Background: Sex influences is important to understand behavioral manifestations in a large number of neuropsychiatric disorders. We found electrophysiological differences specifically related to the influence of sex on psychopathic traits. Methods: The resting electroencephalography (EEG) activity and low-resolution brain electromagnetic tomography (LORETA) for the EEG spectral bands were evaluated in 38 teenagers with conduct disorder (CD). The 25 male and 13 female subjects had psychopathic traits as diagnosed using the Antisocial Process Screening Device. All of the included adolescents were assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria. The visually inspected EEG characteristics and the use of frequency-domain quantitative analysis techniques are described. Results: Quantitative EEG (QEEG) analysis showed that the slow-wave activities in the right frontal and left central regions were higher and the alpha-band powers in the left central and bitemporal regions were lower in the male than the female psychopathic traits group. The current source density showed increases in paralimbic areas at 2.73 Hz and decreases in the frontoparietal area at 9.37 Hz in male psychopathics relative to female psychopathics. Conclusions: These findings indicate that QEEG analysis and techniques of source localization can reveal sex differences in brain electrical activity between teenagers with CD and psychopathic traits that are not obvious in visual inspections.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제25권3호
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• pp.156-162
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• 2014

Objectives : The aim of this study was to estimate the prevalences of electroencephalographic (EEG) abnormalities and epilepsy in children and adolescents with autism spectrum disorder (ASD). In addition, we intended to identify demographic and clinical correlates of epilepsy in ASD. Methods : A total of 140 children and adolescents (age $7.3{\pm}4.8yrs$, 106 boys) with ASD underwent EEG from January 2010 to December 2013 at Asan Medical Center. Medical records were reviewed for demographic information, clinical characteristics, psychiatric diagnoses and comorbidities, EEG findings and neurological diagnoses. Results : The prevalences of EEG abnormalities and epilepsy in children and adolescents with ASD was 62.1% and 38.6%, respectively. In subjects with seizure-like movements, EEG abnormalities and epilepsy were more frequent than those without seizure-like movements (EEG abnormalities : 92.5% vs. 43.7%, p<.001 ; epilepsy : 90.6% vs. 5.7%, p<.001). ASD subjects who had epilepsy were older (p=.001), had lower full scale intelligence quotient (p<.001) and took more antipsychotics (p=.006) than those who did not. Conclusion : The prevalences of EEG abnormalities and epilepsy in our sample were similar to those from Western countries. Our results suggested a possible association of older age, lower intelligence quotient, and antipsychotics use with epilepsy in ASD. Conduct of further prospective study in a larger sample is needed.

• 생물정신의학
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• 제22권4호
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• pp.205-215
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• 2015

Objectives Sex hormones exposure during the prenatal period has an effect on cerebral lateralization. Male brains are thought to be more lateralized than female brains. Bipolar disorder was known to show abnormalities in cerebral laterality whose characteristics could be estimated by electroencephalography (EEG) coherences. We studied sex-related differences of EEG coherences between healthy controls and patients with bipolar disorder to examine the sex effects in the genesis of bipolar disorder. Methods Participants were 25 patients with bipolar disorder (11 male, 14 female) and 46 healthy controls (23 male, 23 female). EEG was recorded in the eyes closed resting state. To examine dominant EEG coherence associated with sex differences in both groups within five frequency bands (delta, theta, alpha, beta, and gamma) across several brain regions, statistical analyses were performed using analysis of covariance. Results Though statistically meaningful results were not found, some remarkable findings were noted. Healthy control females showed more increased interhemispheric coherences than control males in gamma frequency band. There were no differences in the intrahemispheric coherences between the healthy control males and females. In patients with bipolar disorder, female dominant pattern in interhemispheric coherences was attenuated compared with healthy control. Conclusions Sex differences of EEG coherences, which could be a marker for cerebral laterality, were attenuated in patients with bipolar disorder compared with healthy controls. These results imply that abnormal sex hormone exposure during early development might play some role in the pathogenesis of bipolar disorder.

• Annals of Clinical Neurophysiology
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• 제20권2호
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• pp.97-100
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• 2018

Nonconvulsive status epilepticus (NCSE) is an unusual complication in patients treated with cefepime. An 82-year-old woman on maintenance hemodialysis was given cefepime for pneumonia. Her level of consciousness decreased since the administration of cefepime, and she was diagnosed with NCSE based on electroencephalography (EEG) findings. After discontinuation of cefepime, improvement was seen both in the level of consciousness and EEG findings. Clinicians should be aware of cefepime-induced NCSE, particularly in patients with renal failure.

• 대한의용생체공학회:의공학회지
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• 제17권2호
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• pp.209-214
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• 1996

The display of biological signals in raster scan monitors often involves a multirate sampling operation which consists of decimation .and interpolation. All electroencephalouaphic (EEG) samples of 10 to 30 seconds (2, 500 to 7, 500 samples at 250[Hz] sampling frequency) must be displayed in the computer screen to keep the aspect ratio of the paper polygraph output. Since the current afrorclable display technology Plots at most 2, 000 Pixels Per row, sDme signal samples need to be discarde4 This Paper studies methods to perform this operation characterizing them from the signal processing viewpoint and compares the display quality among several decimation techniques. Experimental results show that a nonlinear operation such as the peak detection method could be preferable to the canonical linear filtering to reduce aliasing.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2018년도 추계학술발표대회
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• pp.853-855
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• 2018

현재 맥파(ECG; Electrocardiogram) 및 뇌파(EEG: electroencephalography)의 파형 분석기술은 다양하게 적용되고 있으니 이들을 종합적으로 활용한 개인용 건강서비스 개발은 아직 미비 한 상태이다. 본 논문에서는 측정대상자의 정신적 혹은 육체적 피로도를 나타내는 8가지의 지표로서 집중도, 전두엽 비대칭 정도, 좌우뇌 활성도 대칭 값, 알파파 및 베타파 훈련도 (이상은 뇌파 분석 결과), 스트레스 레벨, 심박 수, 자율신경균형도 (이상은 맥파 분석 결과)]를 개인에게 알려주는 생체정보기반 개인건강 관리 소프트웨어 시스템의 설계 및 개발 결과에 대하여 서술한다.

• 한국컴퓨터정보학회논문지
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• 제28권10호
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• pp.133-153
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• 2023

본 논문에서 우리는 뇌 신호 측정 기술 중 하나인 뇌전도를 활용한 새로운 접근방식을 제안한다. 전통적으로 연구자들은 감정 상태의 분류성능을 향상시키기 위해 뇌전도 신호와 생체신호를 결합해왔다. 우리의 목표는 뇌전도와 결합된 생체신호의 상호작용 효과를 탐구하고, 뇌전도+생체신호의 조합이 뇌전도 단독사용 또는 임의로 생성된 의사 무작위 신호와 결합한 경우에 비해 감정 상태의 분류 정확도를 향상시킬 수 있는지를 확인한다. 네 가지 특징추출 방법을 사용하여 두 개의 공개 데이터셋에서 얻은 데이터 기반의 뇌전도, 뇌전도+생체신호, 뇌전도+생체신호+무작위신호, 및 뇌전도+무작위신호의 네 가지 조합을 조사했다. 감정 상태 (작업 대 휴식 상태)는 서포트 벡터 머신과 장단기 기억망 분류기를 사용하여 분류했다. 우리의 결과는 가장 높은 정확도를 가진 서포트 벡터 머신과 고속 퓨리에 변환을 사용할 때 뇌전도+생체신호의 평균 오류율이 뇌전도+무작위신호와 뇌전도 단독 신호만을 사용한 경우에 비해 각각 4.7% 및 6.5% 높았음을 보여주었다. 우리는 또한 다양한 무작위 신호를 결합하여 뇌전도+생체신호의 오류율을 철저하게 분석했다. 뇌전도+생체신호+무작위신호의 오류율 패턴은 초기에는 깊은 이중 감소 현상으로 인해 감소하다가 차원의 저주로 인해 증가하는 V자 모양을 나타냈다. 결과적으로, 우리의 연구 결과는 뇌파와 생체신호의 결합이 항상 유망한 분류성능을 보장할 수 없음을 시사한다.

• Korean Journal of Acupuncture
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• 제21권2호
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• pp.1-28
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• 2004

Objectives : Human physiological changes in the state of qigong has been measured using EEG(Electroencephalography), functional MRI(functional Magnetic Resonance Image), EAV(Electro-Acupuncture according to Voll) and SQUID(Superconducting Quantum Interference Device) measurements. Methods & Results : EEGs were measured to study the differences between Qigong masters and Qi receiver on the changes of EEG. During Qigong, an alpha waves were increased. The power spectra indicate that the peak frequency of alpha waves increased during Qigong. Qi receiver's EEG signals seemed to affected by the state of himself. Brain activation did not observed when qigong master concentrates the Qi at Laogong(P8). But a localization of fMRI signal in the sensory cortex was observed by electric acupuncture stimulation at Laogong(P8). Five phase deviation of EAV were clearly changed in the both cases of Qigong master and Qi receiver. When a Qigong master concentrates the Qi at Yintang, Laogong(P8), Qihai(CV6) meridian points during Qigong state, the change of magnetic field around acupoints Yintang, Laogong points has been measured using 40-Channel DROS-SQUID apparatus. After smoothing process of the continuously measured magnetic signal around acupoints for a few minutes, we could observe that a series of peaks, magnitude of -1.0~2.5pT appeared. But there was no significant difference in changes of magnetic signal around acupoints. Physical signals of magnetocardiogram has been measured by using 2-Channel DROS SQUID(Magnetocardiogram). Physical signals of magnetocardiogram were clealy changed at the ST segments after S-wave when qigong master concentrates the Qi.

• 디지털융복합연구
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• 제17권2호
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• pp.155-161
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• 2019

뇌파는 두뇌 활동의 변화를 시간적, 공간적으로 파악할 수 있는 대표적인 수단으로써 인간의 두피에서 측정 가능한 자발적 전기활동이다. 뇌파 전기활동을 제어하기 위해 다양한 인터페이스 기술들이 제공되고 있으며, 뇌파를 통한 휠체어나 로봇과 같은 기계의 조작이 가능하다. 뇌파 데이터의 특성은 실시간으로 다양한 채널 유형으로 수집되며, 이를 분석하기 위한 서버시스템은 플랫폼에 대해 독립적이고 경량화 된 시스템이 요구된다. 스프링 플랫폼은 독립적이고 경량화 된 서버시스템으로서, 엔터프라이즈급의 서버 프레임워크로 비즈니스 영역에서 활용되고 있다. 본 논문에서는 독립적이고 경량화 된 스프링 서버시스템을 활용한 뇌파 분석 시스템을 제안한다. 제안된 시스템을 활용하여 뇌파제어의 신뢰성을 높이고, 분석 및 제어 인터페이스 확장이 가능하다. 또한 게임과 의료용 등 다양한 방면으로도 활용이 가능하다.