Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Electroencephalographic Abnormalities in Children and Adolescents with Autism Spectrum Disorder

자폐스펙트럼장애 아동청소년에서 뇌파 이상

  • Kim, Yangsik (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ko, Tae-Sung (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yum, Mi-Sun (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Eun-Hee (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Hyo-Won (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine)
  • 김양식 (울산대학교 의과대학 서울아산병원 정신과학교실) ;
  • 고태성 (울산대학교 의과대학 서울아산병원 소아청소년과학교실) ;
  • 염미선 (울산대학교 의과대학 서울아산병원 소아청소년과학교실) ;
  • 김은희 (울산대학교 의과대학 서울아산병원 소아청소년과학교실) ;
  • 김효원 (울산대학교 의과대학 서울아산병원 정신과학교실)
  • Received : 2014.06.11
  • Accepted : 2014.08.28
  • Published : 2014.09.30
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Abstract

Objectives : The aim of this study was to estimate the prevalences of electroencephalographic (EEG) abnormalities and epilepsy in children and adolescents with autism spectrum disorder (ASD). In addition, we intended to identify demographic and clinical correlates of epilepsy in ASD. Methods : A total of 140 children and adolescents (age $7.3{\pm}4.8yrs$, 106 boys) with ASD underwent EEG from January 2010 to December 2013 at Asan Medical Center. Medical records were reviewed for demographic information, clinical characteristics, psychiatric diagnoses and comorbidities, EEG findings and neurological diagnoses. Results : The prevalences of EEG abnormalities and epilepsy in children and adolescents with ASD was 62.1% and 38.6%, respectively. In subjects with seizure-like movements, EEG abnormalities and epilepsy were more frequent than those without seizure-like movements (EEG abnormalities : 92.5% vs. 43.7%, p<.001 ; epilepsy : 90.6% vs. 5.7%, p<.001). ASD subjects who had epilepsy were older (p=.001), had lower full scale intelligence quotient (p<.001) and took more antipsychotics (p=.006) than those who did not. Conclusion : The prevalences of EEG abnormalities and epilepsy in our sample were similar to those from Western countries. Our results suggested a possible association of older age, lower intelligence quotient, and antipsychotics use with epilepsy in ASD. Conduct of further prospective study in a larger sample is needed.

Keywords

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