• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.1351-1358
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• 2009

새로운 서비스 개발 초기 단계에서 지식의 창조는 서비스의 성공에 중요한 역할을 한다. 개발 초기 단계에서 사용자는 지식을 창조하는 데 중요한 자원으로 활용되며, 이를 위해 사용자와 개발자 간의 계속적인 상호 작용, 즉 사용자 관여가 필요하다. 사용자의 역할은 정보를 제공하는 역할, 자문하는 역할, 참여하는 역할, 3 가지로 나눌 수 있으며, 역할의 차이에 따라 지식 창조의 과정 또한 달라지게 된다. 이러한 배경에서 본 연구는 인터넷 서비스 개발 초기 단계에서 사용자의 역할에 따라 어떠한 지식 창조 과정을 거쳐야 실제 서비스 개발에 긍정적인 영향을 주는 지 알아보기 위해 2 가지의 신규 프로젝트를 대상으로 사례 연구를 실시하였다. 이러한 연구 결과는 개발 초기 단계에서 지식 창조의 과정과 사용자 역할 간의 관계를 규명함과 동시에 실제 서비스 개발을 위한 사용자 관여의 가이드라인을 제시할 수 있을 것이다.

• Molecules and Cells
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• 제38권3호
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• pp.236-242
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• 2015

Intake of caffeine during pregnancy can cause retardation of fetal development. Although the significant influence of caffeine on animal development is widely recognized, much remains unknown about its mode of action because of its pleiotropic effects on living organisms. In the present study, by using Caenorhabditis elegans as a model organism, the effects of caffeine on development were examined. Brood size, embryonic lethality, and percent larval development were investigated, and caffeine was found to inhibit the development of C. elegans at most of the stages in a dosage-dependent fashion. Upon treatment with 30 mM caffeine, the majority ($86.1{\pm}3.4%$) of the L1 larvae were irreversibly arrested without further development. In contrast, many of the late-stage larvae survived and grew to adults when exposed to the same 30 mM caffeine. These results suggest that early-stage larvae are more susceptible to caffeine than later-stage larvae. To understand the metabolic responses to caffeine treatment, the levels of expression of cytochrome P450 (cyp) genes were examined with or without caffeine treatment using comparative microarray, and it was found that the expression of 24 cyp genes was increased by more than 2-fold (p < 0.05). Among them, induction of the cyp-35A gene family was the most prominent. Interestingly, depletion of the cyp-35A family genes one-by-one or in combination through RNA interference resulted in partial rescue from early larval developmental arrest caused by caffeine treatment, suggesting that the high-level induction of cyp-35A family genes can be fatal to the development of early-stage larvae.

• 한국HCI학회논문지
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• 제4권1호
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• pp.1-10
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• 2009

새로운 서비스 개발 초기 단계에서 지식의 창조는 인터넷 서비스의 성공에 중요한 역할을 한다. 개발 초기 단계에서 사용자는 지식을 창조하는데 중요한 자원으로 활용되며, 이를 위하여 사용자와 개발자 간의 지속적인 상호작용, 즉 사용자 관여가 필요하다. 사용자의 역할은 정보를 제공하는 역할, 자문하는 역할, 참여하는 역할 등의 세가지로 구분될 수 있으며, 역할의 차이에 따라 지식 창조의 과정 또한 달라지게 된다. 따라서 본 연구는 인터넷 서비스의 개발 초기 단계에서 사용자의 역할에 따라 어떠한 지식 창조 과정을 거쳐야 실제 서비스 개발에 긍정적인 영향을 줄 수 있는지 파악하기 위하여 두 가지의 신규 프로젝트를 대상으로 사례 연구를 실시하였다. 이러한 연구 결과는 개발 초기 단계에서 지식 창조의 과정과 사용자 역할 간의 관계를 규명함과 동시에 실제 서비스 개발을 위한 사용자 관여의 가이드라인을 제시할 수 있을 것이다.

• 아동학회지
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• 제37권6호
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• pp.95-106
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• 2016

Objective: The purpose of this study was to examine the effects of authentic parental competence and awareness of early childhood educational community on the life satisfaction of mothers with preschoolers depending on mothers' employment status. Methods: A total of 238 mothers (98 employed, 130 unemployed) whose children were attending early childhood institutes participated in a survey measuring three variables. Results and Conclusion: The findings of the study were as follows: First, there were positive correlations between authentic parental competence, awareness of early childhood educational community, and life satisfaction, regardless of employment status. Second, comparing employed mothers with unemployed mothers, a common variable affecting life satisfaction was social competence, a sub-variable of authentic parental competence. Further, self-system competence, a sub-factor of authentic parental competence, influenced life satisfaction for employed mothers, and sharing core values, a sub-variable of awareness of the early childhood educational community, influenced life satisfaction for unemployed mothers.

• Clinical and Experimental Pediatrics
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• 제64권1호
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• pp.12-20
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• 2021

The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (<12 years) is 22.3%. Female adolescents who experience early menarche are known to be at greater risk of psychosocial and behavioral problems along with several physical health problems such as menstrual problems. They also tend to achieve a shorter final height and develop obesity. Population-based Korean studies have shown a strong association between early menarche and the risk of obesity, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, breast cancer, and cardiovascular disease in adulthood. Although the exact mechanism of how early menarche causes cardiometabolic derangement in later adulthood is unknown, childhood obesity and insulin resistance might be major contributors. Recent studies demonstrated that an excessive consumption of fructose might underlie the development of obesity and insulin resistance along with an earlier AAM. A positive association was observed between sugar-sweetened beverages (a major source of fructose) intake and obesity, metabolic syndrome, insulin resistance, and cardiometabolic risk in Korean females. In pediatrics, establishing risk factors is important in preventing disease in later life. In this regard, early menarche is a simple and good marker for the management of cardiometabolic diseases in adulthood. Decreasing one's fructose intake might prevent early menarche as well as the development of obesity, insulin resistance, and cardiometabolic diseases.

• 한국보육지원학회지
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• 제20권2호
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• pp.1-16
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• 2024

Objective: The objective of this study was to develop a refugee education program for early childhood and apply it in daycare center settings to examine the reactions of children aged 5. Methods: Referring to Kemmis and McTaggart(1988) action research model, the refugee education program recommended by UNHCR, and linking it with the national Nuri-curriculum in Korea, a total of five sessions of a refugee education program for early childhood were developed and applied to 20 children aged 5. Results: The application of the preschool refugee education program resulted in positive changes in cognitive, emotional, and behavioral aspects. These changes provided opportunities for early childhood to practice respect towards others, fostering a broader understanding and appreciation of diverse cultures. Conclusion/Implications: This study holds significance in contributing to the discourse on the necessity and direction of refugee education through the development and application of a refugee education program for early childhood. It is anticipated that this research will stimulate in-depth discussions on educational approaches that foster early childhood interest in global issues and cultivate a sense of global citizenship and attitude in the future.

• Reproductive and Developmental Biology
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• 제30권2호
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• pp.107-113
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• 2006

Development of placenta is a complex process that is critical for the pregnancy and controlled by many factors including cytokines, hormones, growth factors and apoptotic molecules. Recently, it has been shown that progranulin (PGRN) functions in growth of embryo and trophectoderm as well as cell migration. To initiate understanding the role of PGRN in human placental development, we investigated the expression of PGRN mRNA and protein in early and late gestation human placentas, term cytotrophoblast cells and two choriocarcinoma cell lines, JEG-3 and Jar. Reverse transcriptase polymerase chain reaction identified mRNAs derived from the PGRN gene in all samples. Immunoblot analysis showed that PGRN proteins are present in early and late gestation human placentas with decreasing levels over gestation and that PGRN proteins are present in normal and transformed trophoblast cells. Immunohistochemical analysis using paraformaldehyde-fixed tissue sections taken from early and late stages of pregnancy showed that PGRN proteins are present in cytotrophoblast cells, syncytiotrophoblast and extravillous cytotrophoblast cells and that expression pattern of PGRN differed according to the stage of cell differentiation. The results of this study are consistent with the hypothesis that PGRN proteins have critical roles in placental development and suggest that PGRN may function in trophoblast cell growth and differentiation.

• Asian-Australasian Journal of Animal Sciences
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• 제16권6호
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• pp.800-805
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• 2003

The early embryos are obtained in different time after the former egg had been laid, and the aim of the present study was to observe the development law of chicken early embryo.The embryo development has been divided into the two periods according to morphology of blastodisc. Cleavage period, from 5.5 h (0 h uterine age) to 15.5 h (10-10.5 h uterine age) after the former egg had laid, formation blastodisc of 6-7 layers cell. Later blastocyst period, from 17.5 h (12-12.5 h uterine age) to area pellucida formation after the former egg had been laid. The first division took place at 5 h (0 h uterine age), morular at 11.5 h (6-6.5 h uterine age), and blastocyst at 15.5 h (10-10.5 h uterine age) after the former egg had been laid.

• 교육시설 논문지
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• 제18권6호
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• pp.57-64
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• 2011

This study is the spatial characteristics of child education facilities through the cognitive development of child. Early childhood is the most important period in every human developmental stage; physical, emotional, and mental parts. Thus, the education in early childhood should be conducted naturally by a variety of experiences, sensibility, and physical activities, not by knowledge-oriented education which has been conducted until today. The education based on experience has been adapted, not only domestically, but internationally, and the early childhood education focused on child's development is especially emphasized in Europe. It's because the industrialization started earlier in Europe than in other countries, and it leaded to the entry of women in public affair. Consequently, early childhood education was taken charge of by the nation. While it has gone through trial and error, and Now it leaded to the better way. This study checks the common factors which shows the spatial characteristics based on experience and the relationship between the features of infants and concept of space in Piaget's theory. And then, I am going to systemize the relationship of each factor and suggest the design plan so that it could be applied methodologically when the space is designed for child education facilities beyond the current education only focused on programs.

• 한국동물생명공학회지
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• 제34권2호
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• pp.123-129
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• 2019

Many transcription factors are involved in directing the growth of porcine oocytes. The localization and expression level of a given transcription factor often differ at each stage of early embryonic growth, which spans from fertilization to the formation of the blastocyst. A hallmark of the blastocyst stage is the separation of the endodermal and mesodermal ectoderm. The embryo's medium and its effects are known to be crucial during early development compared to the other developmental stages, and thus require a lot of caution. Therefore, in many experiments, early development is divided into the quality of oocyte and cumulus cells and used in experiments. We thought that we were also heavily influenced by genetic reasons. Here, we examined the expression patterns of five key transcription factors (CDX2, OCT4, SOX2, NANOG, and E-CADHERIN) during porcine oocyte development whose expression patterns are controversial in the pig to the literature. Antibodies against these transcription factors were used to determine the expression and localization of them during the early development of pig embryos. These results indicate that the expressions of key transcription factors are generally similar in mouse and pig early developing embryos, but NANOG and SOX2 expression appears to show speciesspecific differences between pig and mouse developing embryos. This work helps us better understand how the expression patterns of transcription factors translate into developmental effects and processes, and how the expression and localization of different transcription factors can crucially impact oocyte growth and downstream developmental processes.